Vol 11, No 1 (2022): XVI МЕЖДУНАРОДНАЯ НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ-МЕДИКОВ

The article presents data on the study of clinical and social factors in 19 rosacea patients. The results of the study found that the age of the examined rosacea patients correlated with the duration of dermatosis. In patients in the older age group, a longer duration of rosacea was recorded.

The article provides information on the study of the content of the products of the transformation of nitrates and nitrites in rosacea patients. The results of the study in 19 rosacea patients found that the more severe the clinical picture, the greater the change in free radicals is observed. An increase in the concentration of total nitrates and nitrites was accompanied by an increase in the severity of rosacea patients.

Surgical oncology of the liver over the past decades has significantly increased the surgical aggressiveness in relation to tumors. It has become possible to perform surgical interventions on hard-to-reach segments of the liver, thanks to the progress in the field of pharmacology and the improvement of medical equipment, for example, the advent of water-jet vascular-saving dissectors.
The main reasons for the complexity of the posterior-superior segments are poor visualization, limitations in manipulation, as well as the proximity of large hepatic veins at their confluence with the inferior vena cava. For these reasons, parenchyma-sparing resections of the posterior-superior segments of the liver, according to the IWATE scale, are on the same level of complexity as extensive resections.
The advantages and effectiveness of water-jet vessel-sparing dissection of hard-to-reach segments of the hepatic parenchyma during enucleation of liver hemangiomas in segments II and IVA were evaluated. Resection using a water scalpel required less time and suture material to achieve final hemostasis of the wound surface of the liver stump. The study of the dynamics of scar formation showed that the water-jet dissector leads to the formation of a wider area of ​​damage when crossing due to the impregnation of the liver parenchyma with a working solution, but, despite this, the disappearance of the scar occurs earlier and, as a result, the patient is discharged faster.

Rational nutrition is an important component for maintaining the health of every person, including students, as they constantly need to keep a high concentration of attention and efficiency. Recent statistical investigations show that diseases provoked by disturbed nutrition tend to increase. Purpose: to research and comparatively evaluate the actual nutrition of students, using the examples of high education institutions in Uzbekistan and Russia. Methods: to study the problem was created the questionnaire, including questions that allow to determine the quality of nutrition and the regimen of students. 206 students from Russia (101) and Uzbekistan (105) were interviewed. Results: an analysis of the received responses shows that almost all students in both countries have poor-quality and unbalanced nutrition. There are also certain differences in some aspects of nutrition among students from different countries, mainly due to geographical location, cultural features and differences in the educational process. It was determined that due to disturbed nutrition, students can be at risk of developing diseases of the digestive system and other nutrition-related diseases. Conclusion: measures are needed that will help in solving this problem and will help prevent the increase in diseases associated with the gastrointestinal tract, not only among students, but also among the entire population. Scientific novelty lies in the comparison of the data obtained from students of universities in the two countries, which allows a more comprehensive assessment of the problem of food hygiene.

Relevance: The recurrence rate in acute osteomyelitis ranges from 20% to 30%, and disability of patients reaches 25% of cases. Complications in the treatment of this pathology can be traced in 14-32%, and according to some sources in 54.6% of patients.Goal: Determination of the effect of deer antlers in combination with amikacin on the course of chronic osteomyelitis.Materials and methods: The study was conducted at the Research Institute of Experimental Biology and Medicine on laboratory rats of the Wistar line with a mass of 270-290 grams. The study was carried out on 180 laboratory animals, which were divided into 5 groups: 2 control and 3 experimental: in the first control group, treatment was not carried out, in the remaining groups, 2-stage surgical rehabilitation was performed. In the first experimental group, powdered deer antlers with a particle size of 200-250 microns were introduced into the formed cavity before it was filled. In the second experimental group - a semi-synthetic antibiotic amikacin at a dose of 15 mg/ kg, and an inorganic component - calcium hydroxyapatite until the cavity is completely filled. In the third experimental group - amikacin at a dosage of 15 mg / kg and maral antlers in a ratio of 2:1, the remaining volume of the cavity was filled with hydroxyapatite. The effectiveness was evaluated by evaluating the indicators of oxidative stress and X-ray methods of investigation on 7, 14, 28, 60, 90- the e and 120th days of the study. Research results: in the 1st control group, there was no decrease in the indicators of DFNG and MDA during the entire experiment. In the 2nd control group, the indicators decreased by 53.8% and 28.12% by the 120th day. In the 1st experimental group, the indicators of MDA and DFNG decreased by about 6%, by the 120th day. In the 3rd experimental group, the indicators returned to normal by the 90th day. Conclusions: The most effective method of relieving chronic osteomyelitis is a technique based on the use of surgical sanitation, amikacin at a dosage of 15 mg / kg / day and deer antlers in a ratio of 2:1.

Aim. To establish the prognostic value of the serum estradiol to testosterone (E/T) ratio for the development of drug-induced long QT syndrome (LQTS).

Materials and methods. 59 male patients were examined, mainly with ischemic heart disease, hypertension and cardiac arrhythmias, 29 (49.2%) of them with drug-induced LQTS and 30 (50.8%) with normal values ​​of the QT interval while receiving antiarrhythmic therapy.

Results. Patients with drug-induced LQTS have higher E/T ratio values ​​compared to patients without LQTS (median 9.18 vs 4.72, p<0.001). An E/T ratio value ≥6.08 can be used to predict the development of drug-induced LQTS in male patients taking amiodarone and sotalol (OR=3.43 [95% CI 2.27; 5.19]).

Conclusion. Our data indicate the important physiological role of sex hormones, in particular, estradiol and testosterone, as well as their ratio in the genesis of drug-induced LQTS in male patients.

Relevance: for a long time, coronary heart disease (CHD) has been the main cause of death of the population worldwide [1]. In 2016, for the first time, "revolutionary" lipid-lowering drugs, monoclonal antibodies- inhibitors of the PCSK9 protein were used in practical medicine, allowing achieving the target values of low-density lipoprotein cholesterol of LDL cholesterol in more than 90% of patients [2]. Studies by various scientists have proved that the concentration of PCSK9 in women is higher than in men [3]. In addition, with age, the level of plasma PCSK9 in men decreases, and in women, on the contrary, increases, which is most likely due to the level of estrogens in the body [4].Objective: to evaluate the effect of estradiol on the expression of PSCK9 in patients with IHD Materials and methods: 39 men (average age 60.95±5.89 years) participated in the study IHD sufferers from a group of very high cardiovascular risk. Prior to the start of the study, for 8 weeks, all patients took a combination of the maximum tolerated dose of HMG-CoA Reductase inhibitor (Atorvastatin 80mg 1p / day) with an inhibitor of intestinal cholesterol absorption (Ezetemib) and did not reach the target values of LDL cholesterol < 1.4 mmol. After that, Alirocumab 150mg 1 injection per 14 days was added to the treatment (PRALUENT, SANOFI, France), followed by monitoring of LDL cholesterol and estradiol levels every 4 weeks. The median of the study was months. The program SPSS 23.0 (IBM USA) was used for statistical data processing.Results: at the start of the study, the average LDL cholesterol level was 2.28±0.08 mmol, the estradiol level was 149.13±87.3 pg/ml. A large variation in estradiol indicators (standard deviation) was associated with individual characteristics of the endocrine status of men. The use of Alirocumab showed high statistical significance after 4 weeks of using the drug (2 injections), the level of LDL cholesterol decreased by 34.2% and amounted to 1.5±0.1 mmol (p<0.001), the level of estradiol in the same control increased by 8.39% and did not show statistical significance (p=0.64). After 6 months of treatment, the LDL cholesterol level decreased by 43.86% 1.28±0.14 mmol (p<0.001), the estradiol level increased by 15.15% after 6 months of treatment (p=0.47). At the end of the study, after 12 months of treatment with PCSK9 inhibitors, the level of LDL cholesterol decreased by 49.56% from the baseline level and amounted to 1.15±0.15 mmol (p<0.001); the target values of LDL cholesterol reached 97.43% of patients (n=38). The estradiol level after 12 months of treatment with PCSK9 inhibitors was 162.64±86.14 pg/ml, increased by 19.37% from the baseline values and showed no statistical significance (p=0.39). In the correlation analysis, no significant relationship was found between the dynamics of LDL cholesterol reduction and an increase in estradiol levels.Conclusions: the revealed features of changes in endogenous risk factors in patients with coronary heart disease expand modern ideas about the role of PCSK9 inhibitors in the context of correction of atherogenic lipoprotein fractions.

To date, acne is considered as a disease of civilization, paying great attention to the role of the alimentary factor. In the course of the work, the analysis of the menu layout of the diet of healthy students and students suffering from acne was carried out, and appropriate conclusions were drawn.

Due to the increase in the number of patients with soft tissue injuries, the treatment of this category of patients remains an important problem in modern surgery. Currently, combined methods of wound treatment are especially in demand.

Purpose: to study the frequency and structural features of side effects of glucocorticosteroid drugs. Materials and methods: 58 patients of the rheumatology department who received glucocorticosteroid therapy for a long time were examined. Results. The frequency of side effects of hormone therapy with glucocorticoids was revealed. The structural features of side effects were also analyzed and it was found that arterial hypertension is the most common. The least common is osteoporosis.

The change in the ratio of type I and type III collagens, as a manifestation of connective tissue dysplasia, has attracted the attention of surgeons in recent years. In this connection, hernioimplants with collagen-stimulating coating are of great interest to surgeons.

The aim is to investigate the possibility of reparative effects in a new thymogen analog modified with D-Ala from the C-terminus of the molecule.
Materials and methods. In 60 Wistar rats, skin damage was modeled, after which thymogen and its analogue modified with D-Ala from the C-terminus of the peptide were injected intraperitoneally at equimolar concentrations. A histological examination of sections of skin wounds was carried out.
Results. An increase in lymphocytes and fibroblasts was found in the groups receiving peptides. The action of the analog was more pronounced in relation to fibroblasts (p<0.05).
Conclusions. Thus, the reparative activity of the experimental analogue of thymogen turned out to be higher than that of the original preparation.

Purpose: to evaluate the dynamics of hemodynamic parameters of cardiotoxicity of targeted therapy of colorectal cancer with bevacizumab in complex therapy in the development of grade I-II AH.
Materials and methods. The study analyzed 58 case histories of patients who underwent complex therapy for colorectal cancer in the Ostroverkhov Regional Clinical Center. The study group took bevacizumab in addition to chemotherapy. The average age of the patients was 65.8±7.5 (from 51 to 80) years, the ratio of men and women was 68.42% and 31.58%. Stage III cancer was determined - 56.67%, stage IV - 30%, stage II - 13.33%. Variants of localization of colorectal cancer: 42.1% of patients - cancer of the rectum, sigmoid and colon - 26.32% of patients, anal canal - 5.26% of cancer patients. Prior to the start of chemotherapy, pathology of the cardiological profile in 94.73% of patients, in the structure of which AH accounted for 44.42% of the total number of diseases. 62.5% of patients had II degree of AH, I degree of AH was observed in 37.5% of the patients.
The parameters of the cardiovascular system were assessed: systolic and diastolic pressure (SBP and DBP) by the method of N.I. Korotkov and heart rate (HR) according to the main control points: before chemotherapy, after 1, 3 and 6 months from its start. The indicators are described with the calculation of the mean value (M) and standard deviation (SD) and subjected to evaluation by Student's t-test for dependent variables. Statistically significant differences were considered between the indicators at p <0.05.
Results. There is a significant maximum change in SBP after 3 months of treatment, regardless of the location of colorectal cancer (rectum - 160 ± 5.8; sigmoid colon - 165 ± 4.2; colon - 164 ± 3.9; anal canal - 164 ± 4.1 mm Hg), DBP (rectum - 105 ± 3.6; sigmoid colon - 102 ± 2.9; colon - 105 ± 4.1; anal canal - 108 ± 3.3 mm Hg) , heart rate (rectum - 104 ± 7.3; sigmoid colon - 94 ± 6.2; colon - 106 ± 5.8; anal canal - 98 ± 6.9 bpm) (p<0.05).
Conclusions. In the treatment of PCT + bevacizumab, cardiotoxicity was registered according to the type of bevacizumab-induced hypertension of I-II degree. It is of interest to develop treatment regimens for bevacizumab-induced hypertension.

The purpose of the study is to study the affordability of a range of drugs used to treat neurotic disorders.
Materials and research methods. For the study, data presented on the official websites of the Ministry of Health of the Russian Federation (the state register of medicines, clinical recommendations for treatment) were used as information resources; World Health Organization (International Classification of Diseases 10 edition); online pharmacies: ZdravCity, Apteka.ru, Sber Eapteka, AptekaMos.
Research methods: structural, comparative, logical, systemic types of analysis.
Results. Drug treatment of neurotic disorders includes the use of such groups of drugs as sedatives, anxiolytics, antidepressants, nootropics, psychostimulants, adaptogenic and antianginal agents [2]. Based on the indications for use indicated in the instructions for the use of drugs of the above groups, an assortment of drugs was compiled for the treatment of increased irritability, nervous excitability, neurotic and neurosis-like conditions. The range includes 15 international non-proprietary names (INN), 73 trade names (TN), 249 drug names (MP).
For the analysis of retail prices, the average prices of drugs presented in the assortment were calculated. In the course of the analysis, prices were calculated for 104 MD items from this assortment (41.77%), 145 MD items were not available in the studied pharmacy organizations. According to the average prices of drugs, price ranges were identified: low (16-306 rubles), medium (306-596 rubles), high (580-885 rubles). The majority of MDs (79.81%), including 12 INNs, are represented in the low price range. In the average price range, there are 15 drug names (14.42%) under 1 INN. There are 6 drugs under 1 INN in the high price range.
Conclusions. As a result of the analysis of retail prices, it was found that the maximum share (79.81%) falls on drugs of the low price segment (16-306 rubles). This indicates a high level of affordability of drugs for the treatment of neurotic disorders for the population.

The presence of counterfeit pharmaceutical products is one of the threats to the development of the pharmaceutical market in Russia. The reasons for the introduction of drugs of inadequate quality (substandard, falsified and counterfeit) are the high cost of original drugs, the imperfection of the legislative framework, high tariffs for the release of drugs to the market and others.

Staffing in health care is an urgent problem in the regions. The aim of the study was to analyze the data of employment in polyclinics and assess the dynamics of staff turnover. Materials and methods were the data of official reports of polyclinics № 1, № 2, № 3 of State Budgetary Institution "City Clinical Hospital № 7" in Tver. The analysis of indicators of three time intervals: 2011-2014, 2015-2017, 2018-2020 was carried out. According to the results of the study in Polyclinic No. 1 there was a decrease in the percentage of employment among doctors by 38% and among nurses by 17.5%. Nursing staff employment remained below 50% throughout the decade. The underemployment rates of Polyclinic №2 and Polyclinic №3 were unchanged for 10 years. Conclusions: over the period 2011-2020, we can observe underemployment rates in polyclinics, as well as their decrease from the beginning to the end of the decade, mostly among physicians.

Target. Study of Pharmaceutical Care (PC) from the perspective of a three-level analysis.

Methods. In the course of a three-level analysis, from the position of a product, the essence of the PC, the actual product, the added product.

Results. At the first level of analysis, the essence of the PC was considered: PC is a system for providing drug treatment that provides for a set of measures to improve the quality of life of the patient, which provides for the interaction of the pharmacist-patient-physician and their responsibility for the patient's health based on the actions and decisions made by the doctor and a pharmacist, and the main result of the PC is the preservation of health and improvement of the quality of life of patients. At the second level, the elements of the PC are defined from the perspective of the actual product: 1) the consumer properties of the PC include the timeliness, availability and quality of drug treatment; 2) the category of "quality" includes the functioning of the logistics service, pricing, assortment policy, the absence of falsified, low-quality drugs, the presence of highly qualified personnel; 3) the "design" of the PC includes the appearance of the pharmacist - his neatness, the presence of a uniform, compliance with the code of corporate culture, etc.; 4) “packaging” of the PC implies the correspondence of the personal (empathy, tact, politeness, etc.) and professional qualities of the pharmacist to the requirements of buyers; 5) “brand name” (patients are often adherents of not only one manufacturer, but also one specialist pharmacist, and turn to him specifically for help). From the point of view of the added product, PC includes the readiness of the pharmacist for qualified pharmaceutical advice on the use, storage, and interaction of drugs.

Conclusions. All three levels of PC are closely interconnected and represent a complex multifaceted structure aimed at ensuring the health of the population of our country.

Reference and information medical platforms are one of the progressive directions of the development of mobile healthcare. The purpose of the study is to assess the use of such applications, awareness of them. The research method was a survey of 58 students of different training areas of Kursk State Medical University. As a result of the study, it was found that the majority of students have a positive attitude to such platforms, but are not sufficiently aware of them. So, we can conclude that it is necessary to raise awareness and trust in this area among the younger generation of physicians.

Relevance. In 2008, on the basis of VSMU. N.N. Burdenko Museum of Space Biology and Medicine. V.V. Antipov, which presents unique expositions related to the study of space. It conducts excursions for students and schoolchildren of the city and region; its expositions take part in city exhibitions. In addition, the Center for Space Education was established in June 2014. As part of the work of the center, numerous projects are being implemented, such as the development of educational activities in the field of astronautics and the upbringing of a patriotic generation of young people. Students and teachers conduct research on space topics. This is one of the promising areas of research activities of the Voronezh State Medical University. N.N. Burdenko.
Target. Using the materials of the library fund, get acquainted with the history of the creation of the museum, study its role in the development of the student as a person.
Materials and methods. The work used the general scientific method of research and the literature of the electronic fund.
Results. The special significance of the museum in the educational process and the formation of student competencies is emphasized.
Conclusion. A visit to a museum is an important component in preparing medical students for their future careers.

The purpose of the study is to analyze the contribution of Andrey Fedorovich Tretyakov to the development of medicine in the Kursk region.Materials and methods of research. Historical-genetic, problem-chronological and comparative-historical research methods are used in the work.The results of the study.On June 13, 1934, the Kursk Region was formed. The head of the Kursk City Health Department, A.F. Tretyakov, was appointed the first head of the regional health department. In 1934-1935, he was directly involved in the opening and organization of the KGMI. February 9 , 1935All responsibility for the creation of the administrative structure of the KSMI and the organization of departments was borne by the head of the Kursk Regional health Department A.F. Tretyakov and, appointed from Moscow, the first director of the KSMI V.I. Deshevoy. The result of such personnel policy of A.F. Tretyakov and V.I. Deshevoy was that the main departments of preclinical training of KSMI began their educational activities already in 1935.

The paper assessed the effectiveness of the use of mexicor in the correction of cardiac disorders in patients with COVID-19 during post-hospital rehabilitation.

With the appearance of the Omicron strain, the prevalence of coronavirus infection among a younger group of the adult population has increased significantly [1-3], which means that statistical data on the incidence of a new coronavirus infection, their absolute and relative growth determine the relevance of improving approaches to CoViD-2019 therapy within the framework of current temporary clinical recommendations. According to the results of the study of this sample, it can be said that special attention deserves the fact that most cases of transmission of a new coronavirus infection in the studied population are not confirmed by PCR testing for the detection of SARS-CoV-2 RNA, which may affect the incidence statistics, as well as the treatment protocol in each individual clinical case. The highest frequency of use in the treatment of NKVI was observed in such drugs as umifenovir (27.9%), gripferon in the form of nasal drops (27.9%), vitamin C (60.5%), vitamin D (44.2%), and vitamin B (20.9%). The therapy of a new coronavirus infection used by students corresponds to the schemes described in the temporary clinical recommendations for the treatment of NCVI [2], and is also effective.