# Vol 11, No 1 (2022): XVI МЕЖДУНАРОДНАЯ НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ-МЕДИКОВ

## Результаты фундаментальных и прикладных исследований

### CLINICAL AND SOCIAL FACTORS IN ROSACEA PATIENTS

Ayupova K.

#### Abstract

The article presents data on the study of clinical and social factors in 19 rosacea patients. The results of the study found that the age of the examined rosacea patients correlated with the duration of dermatosis. In patients in the older age group, a longer duration of rosacea was recorded.

Молодежный инновационный вестник. 2022;11(1):4-5
4-5

### THE ROLE OF CERULOPLASMIN IN ROSACEA PATIENTS

Ayupova K.

#### Abstract

The article provides information about rosacea. We examined 19 rosacea patients in whom the concentration of ceruloplasmin was determined by spectrophotometric method. As a result of the study, it was found that the aggravation of the clinical picture of rosacea was accompanied by a decrease in the concentration of ceruloplasmin in the blood serum.

Молодежный инновационный вестник. 2022;11(1):5-6
5-6

### PATHOGENETIC FEATURES OF ROSACEA PATIENTS

Ayupova K.

#### Abstract

The article provides information on the study of the content of the products of the transformation of nitrates and nitrites in rosacea patients. The results of the study in 19 rosacea patients found that the more severe the clinical picture, the greater the change in free radicals is observed. An increase in the concentration of total nitrates and nitrites was accompanied by an increase in the severity of rosacea patients.

Молодежный инновационный вестник. 2022;11(1):7-8
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### PHARMACOGENETIC FEATURES OF THE USE OF FLUVOXAMINE IN THE TREATMENT OF DEPRESSIVE DISORDER

Babkin M.O.

#### Abstract

The article discusses the features of the use of fluvoxamine for the treatment of depressive disorder from the point of view of pharmacogenetics. The aim of the study was to evaluate the efficacy of fluvoxamine in patients with various polymorphic variations of the CYP2D6 gene and suffering from newly diagnosed depressive disorder. Methods. For the study, 48 patients with newly diagnosed DR and who had not previously received antidepressant therapy were selected. Fluvoxamine was prescribed at a dosage of 100 mg/day with the possibility of dose adjustment for a period of 3 weeks. The effectiveness of the drug was assessed by evaluating the results of a survey on the Galminton Scales (HAMD) and the Hospital Anxiety and Depression Scale (HADS). Polymorphisms were determined using genotyping. Results. It has been established that patients with heterozygous GA variation have a slower metabolism of the drug, which is expressed in greater resistance to treatment, while GG homozygotes, which are represented in the population in a much smaller number, demonstrate a good therapeutic response. The results of this study can be used to select tactics for prescribing antidepressants.

Молодежный инновационный вестник. 2022;11(1):8-9
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### WATERJET DISSECTION OF HARD TO ACCESS LIVER SEGMENTS

Baimashev A.S., Kolimanov E.D.

#### Abstract

Surgical oncology of the liver over the past decades has significantly increased the surgical aggressiveness in relation to tumors. It has become possible to perform surgical interventions on hard-to-reach segments of the liver, thanks to the progress in the field of pharmacology and the improvement of medical equipment, for example, the advent of water-jet vascular-saving dissectors.
The main reasons for the complexity of the posterior-superior segments are poor visualization, limitations in manipulation, as well as the proximity of large hepatic veins at their confluence with the inferior vena cava. For these reasons, parenchyma-sparing resections of the posterior-superior segments of the liver, according to the IWATE scale, are on the same level of complexity as extensive resections.
The advantages and effectiveness of water-jet vessel-sparing dissection of hard-to-reach segments of the hepatic parenchyma during enucleation of liver hemangiomas in segments II and IVA were evaluated. Resection using a water scalpel required less time and suture material to achieve final hemostasis of the wound surface of the liver stump. The study of the dynamics of scar formation showed that the water-jet dissector leads to the formation of a wider area of ​​damage when crossing due to the impregnation of the liver parenchyma with a working solution, but, despite this, the disappearance of the scar occurs earlier and, as a result, the patient is discharged faster.

Молодежный инновационный вестник. 2022;11(1):9-14
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### THE STATE AND TRENDS IN THE INCIDENCE OF MENTAL DISORDERS IN THE KURSK REGION

Barybina E.S.

#### Abstract

Relevance. On the territory of the Russian Federation, about 40% of the population have signs of mental activity disorders, which affect all segments of the population, including children [1, 2]. These disorders entail serious consequences for the social spheres of human life. As a result, monitoring the incidence of mental disorders in dynamics remains an urgent task. The purpose of the study: to analyze the state of the incidence of mental disorders in the Kursk region and make a forecast for 2021-2022. Materials and methods of research. Based on the data of the Federal State Statistics Service, the Unified Interdepartmental Information and Statistical System (EMISS), an analysis of the state of general and primary morbidity of mental disorders in the Kursk region for 2011-2020 was carried out. The following methods of analysis were used: the method of averages, tabular, calculation of indicators of dynamics series.

Results. According to the results of the analysis, it was found that the direction of the indicators of general and primary morbidity of mental disorders changed significantly during the analyzed period. Thus, the average growth rate of the overall incidence of mental disorders in the Kursk region was 0.8%, while against the background of a dynamic decline in indicators in 2013-2016, a significant increase was noted in 2017-2019. During the assessment of primary morbidity, a general trend was established to reduce morbidity by an average of 2.0% over the analyzed period. Among the possible reasons for the increase in the indicators of general and primary morbidity can be identified improvements in the organization of psychiatric care, changes in diagnostic criteria, etc. The reasons for the decrease in morbidity include improvements in the system of development of preventive and rehabilitation measures, improvement of pharmacotherapy and drug provision, reduced availability of medical care, etc.

The calculation of the forecast of possible morbidity showed a downward trend in both the general (2667.1 and 2688.4 cases per 100 thousand people) and primary morbidity (218.9 and 214.5 cases per 100 thousand people) of mental disorders in 2021-2022. Conclusions. Thus, dynamic changes in the indicators of general and primary morbidity of mental disorders indicate the need for a systematic analysis aimed at timely identification of alarming trends in the field of mental health of the population.

Молодежный инновационный вестник. 2022;11(1):14-15
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### STUDY AND HYGIENIC ASSESSMENT OF THE ACTUAL NUTRITION OF STUDENTS

Valiulin R.I.

#### Abstract

Rational nutrition is an important component for maintaining the health of every person, including students, as they constantly need to keep a high concentration of attention and efficiency. Recent statistical investigations show that diseases provoked by disturbed nutrition tend to increase. Purpose: to research and comparatively evaluate the actual nutrition of students, using the examples of high education institutions in Uzbekistan and Russia. Methods: to study the problem was created the questionnaire, including questions that allow to determine the quality of nutrition and the regimen of students. 206 students from Russia (101) and Uzbekistan (105) were interviewed. Results: an analysis of the received responses shows that almost all students in both countries have poor-quality and unbalanced nutrition. There are also certain differences in some aspects of nutrition among students from different countries, mainly due to geographical location, cultural features and differences in the educational process. It was determined that due to disturbed nutrition, students can be at risk of developing diseases of the digestive system and other nutrition-related diseases. Conclusion: measures are needed that will help in solving this problem and will help prevent the increase in diseases associated with the gastrointestinal tract, not only among students, but also among the entire population. Scientific novelty lies in the comparison of the data obtained from students of universities in the two countries, which allows a more comprehensive assessment of the problem of food hygiene.

Молодежный инновационный вестник. 2022;11(1):15-16
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### RESULTS OF A MORPHOLOGICAL STUDY OF THE REGULATION OF POSTNATAL OSTEOGENESIS

Zatolokina E.

#### Abstract

Objective: to study the morphological features of bone tissue regeneration in postnatal ontogenesis under the condition of implantation of corral granules.

Methods: experimental. The study was performed on laboratory animals - rats, in which coral granules were implanted in the area of the bone defect. They were removed by overdosing of drugs for inhalation anesthesia. The criterion for evaluating changes was descriptive morphology.

Results. Changes were revealed: the cortical plate or compact substance was thinned for a considerable length. At the same time, there is some division of it into two zones. It should be noted that in most osteons of the cortical part of the bone, an expanded central channel is detected, thus a positive, so-called "porosity symptom" or "cortical osteopenia".

Conclusions. Thus, the conducted experiment showed the presence of qualitative and quantitative changes in the structural organization of bone tissue and a change in the rate of its neoplasm.

Молодежный инновационный вестник. 2022;11(1):17-18
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### OXIDATIVE STRESS IN THE CURE OF CHRONIC OSTEOMYELITIS WITH THE APPLICATION OF MARAL PANTS

Zolotukhin v.O.

#### Abstract

Relevance: The recurrence rate in acute osteomyelitis ranges from 20% to 30%, and disability of patients reaches 25% of cases. Complications in the treatment of this pathology can be traced in 14-32%, and according to some sources in 54.6% of patients.Goal: Determination of the effect of deer antlers in combination with amikacin on the course of chronic osteomyelitis.Materials and methods: The study was conducted at the Research Institute of Experimental Biology and Medicine on laboratory rats of the Wistar line with a mass of 270-290 grams. The study was carried out on 180 laboratory animals, which were divided into 5 groups: 2 control and 3 experimental: in the first control group, treatment was not carried out, in the remaining groups, 2-stage surgical rehabilitation was performed. In the first experimental group, powdered deer antlers with a particle size of 200-250 microns were introduced into the formed cavity before it was filled. In the second experimental group - a semi-synthetic antibiotic amikacin at a dose of 15 mg/ kg, and an inorganic component - calcium hydroxyapatite until the cavity is completely filled. In the third experimental group - amikacin at a dosage of 15 mg / kg and maral antlers in a ratio of 2:1, the remaining volume of the cavity was filled with hydroxyapatite. The effectiveness was evaluated by evaluating the indicators of oxidative stress and X-ray methods of investigation on 7, 14, 28, 60, 90- the e and 120th days of the study. Research results: in the 1st control group, there was no decrease in the indicators of DFNG and MDA during the entire experiment. In the 2nd control group, the indicators decreased by 53.8% and 28.12% by the 120th day. In the 1st experimental group, the indicators of MDA and DFNG decreased by about 6%, by the 120th day. In the 3rd experimental group, the indicators returned to normal by the 90th day. Conclusions: The most effective method of relieving chronic osteomyelitis is a technique based on the use of surgical sanitation, amikacin at a dosage of 15 mg / kg / day and deer antlers in a ratio of 2:1.

Молодежный инновационный вестник. 2022;11(1):18-19
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### PHYSIOLOGICAL EFFECTS OF TEA

Karapetyan A.S.

#### Abstract

The purpose of the study is to identify the most and least frequently reported physiological effects of tea by respondents. The influence of tea on certain systems and organs is still a topical issue. The proven physiological effects of tea (hypotonic, sedative, stimulating the nervous system) are often denied.
Молодежный инновационный вестник. 2022;11(1):19-20
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### SERUM ESTRADIOL TO TESTOSTERONE RATIO AS A PREDICTOR OF DRUG-INDUCED QT INTERVAL PROLONGATION IN MALE PATIENTS

Kalatsei L.V.

#### Abstract

Aim. To establish the prognostic value of the serum estradiol to testosterone (E/T) ratio for the development of drug-induced long QT syndrome (LQTS).

Materials and methods. 59 male patients were examined, mainly with ischemic heart disease, hypertension and cardiac arrhythmias, 29 (49.2%) of them with drug-induced LQTS and 30 (50.8%) with normal values ​​of the QT interval while receiving antiarrhythmic therapy.

Results. Patients with drug-induced LQTS have higher E/T ratio values ​​compared to patients without LQTS (median 9.18 vs 4.72, p<0.001). An E/T ratio value ≥6.08 can be used to predict the development of drug-induced LQTS in male patients taking amiodarone and sotalol (OR=3.43 [95% CI 2.27; 5.19]).

Conclusion. Our data indicate the important physiological role of sex hormones, in particular, estradiol and testosterone, as well as their ratio in the genesis of drug-induced LQTS in male patients.

Молодежный инновационный вестник. 2022;11(1):21-22
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### THE STATE OF THE OBLIGATE MICROFLORA OF THE LARGE INTESTINE IN THIRAM INTOXICATION

#### Abstract

The article discusses the effect of the systemic disinfectant thiram on the quantitative and qualitative composition of the obligate microflora of the large intestine of experimental animals.

Молодежный инновационный вестник. 2022;11(1):22-23
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### CORRECTION OF ENDOGENOUS RISK FACTORS FOR CORONARY HEART DISEASE

Kuznetsov A.

#### Abstract

Молодежный инновационный вестник. 2022;11(1):24-25
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### BIOCHEMICAL FEATURES OF THE EFFECT OF INTRAHEPATIC ADMINISTRATION OF DRUGS ON POST RESECTION LIVER REGENERATION

Laptiyova A.Y., Ostroushko A.P., Andreev A.A., Antakova L.N., Yashkova M.A.

#### Abstract

Relevance. Liver diseases affect about 500 million people in the world, of which 1 million die annually. Liver resections are an effective way of treating both a tumor lesion of the liver and many other non-tumor diseases, however, with an increase in resectability, the risk of developing post-resection liver failure increases annually. Thus, the search for new methods aimed at activating the reparative regeneration of the liver remains an urgent task.

The aim of the study was to improve the results of treatment of postresection hepatic insufficiency by intrahepatic administration of ademethionine and cyanocobalamin in an experiment.

Materials and methods. The experiments were performed on 72 mature male Wistar rats, which were divided into 4 groups. In all groups, a typical resection of ~ 70% of the liver volume was performed, according to the model proposed by G. Higgins and R. Anderson. In the 1st control group, prevention of postresection hepatic insufficiency was not carried out; in the 2nd control group, 0.9% sodium chloride solution was intrahepally administered; in the 1st experimental group, cyanocobalamin (patent RU 2720451); in the 2nd experimental group, ademethionine. Blood sampling was performed on the 1st, 7th and 14th days after surgery, and the indicators of cytolytic, cholestatic syndromes, as well as hepatic cell insufficiency syndrome were evaluated. Statistical processing was performed using the Statistica 6.0 program.

Results. By the 14th day after the operation in the 1st experimental group, the indicators of cytolytic and cholestatic syndromes in 92.04± 6.14% of animals, liver cell insufficiency syndrome in 83.12± 3.09% of animals were normalized, in the 2nd experimental group, this indicator was lower by 27% and 21%, respectively. In the control groups, normalization of biochemical parameters was observed in less than 70% of animals.

Conclusion. Intraoperative administration of ademethionine or cyanocobalamin during liver resection are effective ways to increase the reparative potential of the liver. The most optimal method is intrahepatic administration of cyanocobalamin, which significantly reduces the indicators of cytolysis, cholestasis and hepatic cell insufficiency syndromes in more than 75% of operated animals.

Молодежный инновационный вестник. 2022;11(1):25-27
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### STUDY OF THE INFLUENCE OF DIETARY FEATURES ON THE DEVELOPMENT OF ACNE IN KSMU STUDENTS

Minenok V.

#### Abstract

To date, acne is considered as a disease of civilization, paying great attention to the role of the alimentary factor. In the course of the work, the analysis of the menu layout of the diet of healthy students and students suffering from acne was carried out, and appropriate conclusions were drawn.

Молодежный инновационный вестник. 2022;11(1):29-30
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### PREVALENCE OF AUTONOMIC DYSFUNCTION SYNDROME AMONG PATIENTS WITH NON-DELUSIOUS HYPOCHONDRIA

Levchenko E., Gureeva A.

#### Abstract

The aim of the study was to determine the prevalence of autonomic dysfunction in patients with non-delusional hypochondria.

Methods: a survey was conducted using the questionnaire of A.M. Wayne 18 patients diagnosed with non-delusional hypochondria of the Kursk Clinical Psychiatric Hospital named after the Holy Great Martyr and Healer Panteleimon.

Results: all respondents scored more than 15 points, 39% of the respondents had more than 50 points calculated according to the questionnaire used.

Conclusions: the study revealed a high prevalence of the syndrome autonomic dysfunction among patients with non-delusional hypochondria.

Молодежный инновационный вестник. 2022;11(1):28-29
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### APPLICATION OF JET OXYGEN-SORBION TREATMENT IN THE TREATMENT OF SOFT TISSUE WOUNDS

Mikhailov N.O.

#### Abstract

Due to the increase in the number of patients with soft tissue injuries, the treatment of this category of patients remains an important problem in modern surgery. Currently, combined methods of wound treatment are especially in demand.

Молодежный инновационный вестник. 2022;11(1):30-32
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### THE USE OF ANTLERS AND MARAL BLOOD IN THE TREATMENT OF SOFT TISSUE WOUNDS

Mikhailov N.O.

#### Abstract

Every year, the number of patients with purulent soft tissue wounds is increasing. In modern conditions, this group of patients mainly consists of people of working age, which makes this problem relevant not only from a medical, but also from an economic point of view. Now biological agents for the treatment of soft tissue wounds have become very popular.

Молодежный инновационный вестник. 2022;11(1):32-33
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### ANALYSIS OF THE FREQUENCY OF SIDE EFFECTS OF GLUCORTICOSTEROID DRUGS

Panarina N.

#### Abstract

Purpose: to study the frequency and structural features of side effects of glucocorticosteroid drugs. Materials and methods: 58 patients of the rheumatology department who received glucocorticosteroid therapy for a long time were examined. Results. The frequency of side effects of hormone therapy with glucocorticoids was revealed. The structural features of side effects were also analyzed and it was found that arterial hypertension is the most common. The least common is osteoporosis.

Молодежный инновационный вестник. 2022;11(1):33-35
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### FEATURES OF SELF-CONSCIOUSNESS IN SOMATOFORM DISORDERS

Polozhentsev R.

#### Abstract

The article presents clinical and psychological studies of the characteristics of self-awareness in somatoform disorders and personal characteristics that affect the awareness of the disease in patients with this disorder. The results obtained can used as the basis for recommendations for the correction and diagnosis of somatoform disorder in the working environment of psychiatric clinics and primary health care.

Молодежный инновационный вестник. 2022;11(1):35-37
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### REACTIVE CHANGES OF CONNECTIVE TISSUE TO HERNIOPLASTY IMPLANTS

Ponomareva I., Tsukanov A.V., Zatolokina M.A., Ivanov I.S., Ivanov S.V.

#### Abstract

The change in the ratio of type I and type III collagens, as a manifestation of connective tissue dysplasia, has attracted the attention of surgeons in recent years. In this connection, hernioimplants with collagen-stimulating coating are of great interest to surgeons.

Молодежный инновационный вестник. 2022;11(1):37-38
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### THE CONTENT OF MALODIATEHYDE IN PLASMA AND ERYTHROCYTE BLOOD MASS OF RATS UNDER CONDITIONS OF PESTICIDE INTOXICATION AND CORRECTION WITH VITAMIN E AND MILK THISTLE

Sedykh A.V., Korolev E.V.

#### Abstract

Target. To study the change in the quantitative content of MDA in the plasma and erythrocyte mass of the blood of laboratory animals during intoxication with thiram and correction with antioxidant drugs - vitamin E and milk thistle.
Methods. The experiment was carried out on 240 male Wistar rats, aged 2 months and weighing 200-220 grams. To solve the tasks set, the animals were divided into 8 groups of 30 animals in each group. The process of lipid peroxidation was evaluated by the quantitative content of MDA in the plasma and erythrocyte mass of the blood of rats by the spectrophotometric method. The results were expressed in µmol/mg.
Results. On the basis of the study, it was found that during the period of subchronic thiram intoxication, an increase in the content of MDA in plasma and in the erythrocyte mass of blood was noted. Conclusions. With subchronic intoxication with thiram, activation of LPO processes is observed, which is expressed in an increase in the level of MDA in the blood plasma of rats. To maintain the prooxidant-antioxidant balance in pesticide intoxication, it is necessary to use antioxidant drugs.

Молодежный инновационный вестник. 2022;11(1):38-39
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### WOUND-HEALING ACTIVITY OF THE EXPERIMENTAL THYMOGEN ANALOGUE

Smakhtina A.M., Chulanova A.A., Rukavitsyn V.R., Gunov S.R.

#### Abstract

The aim is to investigate the possibility of reparative effects in a new thymogen analog modified with D-Ala from the C-terminus of the molecule.Materials and methods. In 60 Wistar rats, skin damage was modeled, after which thymogen and its analogue modified with D-Ala from the C-terminus of the peptide were injected intraperitoneally at equimolar concentrations. A histological examination of sections of skin wounds was carried out.Results. An increase in lymphocytes and fibroblasts was found in the groups receiving peptides. The action of the analog was more pronounced in relation to fibroblasts (p<0.05).Conclusions. Thus, the reparative activity of the experimental analogue of thymogen turned out to be higher than that of the original preparation.

Молодежный инновационный вестник. 2022;11(1):40-41
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### FEATURES OF INFECTION OF THE GENITAL TRACT IN WOMEN WITH CHRONIC ENDOMETRITIS WITH INFERTILITY

Smirnova D.V.

#### Abstract

Chronic endometritis (CE) is one of the main causes of reproductive health disorders in women and occupies a leading place in the structure of intrauterine pathology in patients with infertility. According to most researchers, it is the infectious agent that is the triggering factor in the development of this pathology. The article presents the features of infection of the genital tract in women with CE in infertility.

Молодежный инновационный вестник. 2022;11(1):41-43
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### BEVACIZUMAB-INDUCED ARTERIAL HYPERTENSION AS A ASPECT OF STUDYING CARDIOTOXICITY IN THE TREATMENT OF COLORECTAL CANCER

Khlyamov S.V., Mal G.S., Artyushkova E.B.

#### Abstract

Purpose: to evaluate the dynamics of hemodynamic parameters of cardiotoxicity of targeted therapy of colorectal cancer with bevacizumab in complex therapy in the development of grade I-II AH.
Materials and methods. The study analyzed 58 case histories of patients who underwent complex therapy for colorectal cancer in the Ostroverkhov Regional Clinical Center. The study group took bevacizumab in addition to chemotherapy. The average age of the patients was 65.8±7.5 (from 51 to 80) years, the ratio of men and women was 68.42% and 31.58%. Stage III cancer was determined - 56.67%, stage IV - 30%, stage II - 13.33%. Variants of localization of colorectal cancer: 42.1% of patients - cancer of the rectum, sigmoid and colon - 26.32% of patients, anal canal - 5.26% of cancer patients. Prior to the start of chemotherapy, pathology of the cardiological profile in 94.73% of patients, in the structure of which AH accounted for 44.42% of the total number of diseases. 62.5% of patients had II degree of AH, I degree of AH was observed in 37.5% of the patients.
The parameters of the cardiovascular system were assessed: systolic and diastolic pressure (SBP and DBP) by the method of N.I. Korotkov and heart rate (HR) according to the main control points: before chemotherapy, after 1, 3 and 6 months from its start. The indicators are described with the calculation of the mean value (M) and standard deviation (SD) and subjected to evaluation by Student's t-test for dependent variables. Statistically significant differences were considered between the indicators at p <0.05.
Results. There is a significant maximum change in SBP after 3 months of treatment, regardless of the location of colorectal cancer (rectum - 160 ± 5.8; sigmoid colon - 165 ± 4.2; colon - 164 ± 3.9; anal canal - 164 ± 4.1 mm Hg), DBP (rectum - 105 ± 3.6; sigmoid colon - 102 ± 2.9; colon - 105 ± 4.1; anal canal - 108 ± 3.3 mm Hg) , heart rate (rectum - 104 ± 7.3; sigmoid colon - 94 ± 6.2; colon - 106 ± 5.8; anal canal - 98 ± 6.9 bpm) (p<0.05).
Conclusions. In the treatment of PCT + bevacizumab, cardiotoxicity was registered according to the type of bevacizumab-induced hypertension of I-II degree. It is of interest to develop treatment regimens for bevacizumab-induced hypertension.

Молодежный инновационный вестник. 2022;11(1):44-45
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### STRUCTURAL CHANGES IN THE JAW BONE TISSUE AFTER IMPLANTATION

Shkarin N., Baroyan M.

#### Abstract

Relevance. At the moment, dental implantation is the leader among dental services. Target. The article considers the study of reparative osteogenesis of bone tissue during dental implantation. The article also considers one of the methods of bone grafting. Materials and methods. For the study, we chose the method of computed tomography and studied 40 patients after dental implantation. Result. As a result, the analysis of bone structures (in three patients out of 40) showed that in these clinical cases, due to insufficient pressure on the dental implant, thinning and loss of the bone around it occurred.Conclusion. Thus, an important aspect of this direction is the study of bone tissue regeneration, as well as the processes occurring during recovery.

Молодежный инновационный вестник. 2022;11(1):45-46
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## Менеджмент в здравоохранении

### ANALYSIS OF THE AFFORDABILITY OF MEDICINES FOR THE TREATMENT OF NEUROTIC DISORDERS

Arnautova A.

#### Abstract

The purpose of the study is to study the affordability of a range of drugs used to treat neurotic disorders.
Materials and research methods. For the study, data presented on the official websites of the Ministry of Health of the Russian Federation (the state register of medicines, clinical recommendations for treatment) were used as information resources; World Health Organization (International Classification of Diseases 10 edition); online pharmacies: ZdravCity, Apteka.ru, Sber Eapteka, AptekaMos.
Research methods: structural, comparative, logical, systemic types of analysis.
Results. Drug treatment of neurotic disorders includes the use of such groups of drugs as sedatives, anxiolytics, antidepressants, nootropics, psychostimulants, adaptogenic and antianginal agents [2]. Based on the indications for use indicated in the instructions for the use of drugs of the above groups, an assortment of drugs was compiled for the treatment of increased irritability, nervous excitability, neurotic and neurosis-like conditions. The range includes 15 international non-proprietary names (INN), 73 trade names (TN), 249 drug names (MP).
For the analysis of retail prices, the average prices of drugs presented in the assortment were calculated. In the course of the analysis, prices were calculated for 104 MD items from this assortment (41.77%), 145 MD items were not available in the studied pharmacy organizations. According to the average prices of drugs, price ranges were identified: low (16-306 rubles), medium (306-596 rubles), high (580-885 rubles). The majority of MDs (79.81%), including 12 INNs, are represented in the low price range. In the average price range, there are 15 drug names (14.42%) under 1 INN. There are 6 drugs under 1 INN in the high price range.
Conclusions. As a result of the analysis of retail prices, it was found that the maximum share (79.81%) falls on drugs of the low price segment (16-306 rubles). This indicates a high level of affordability of drugs for the treatment of neurotic disorders for the population.

Молодежный инновационный вестник. 2022;11(1):47-48
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### ANALYSIS OF THE EFFICIENCY OF USING THE RESOURCES OF A MEDICAL ORGANIZATION

Gromenko D.I.

#### Abstract

The main priority of the healthcare system is to increase the availability and quality of medical care. Achieving this goal largely depends on the state and rational use of financial, material and labor resources available to the healthcare organization. This is due to the fact that they are the base, without which the main activity of a medical organization cannot be carried out.

Молодежный инновационный вестник. 2022;11(1):48-49
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### MARKETING ANALYSIS OF THE COST OF COUNTERFEIT MEDICINES IN THE PHARMACEUTICAL MARKET OF RUSSIA

Levchuk Y.

#### Abstract

The presence of counterfeit pharmaceutical products is one of the threats to the development of the pharmaceutical market in Russia. The reasons for the introduction of drugs of inadequate quality (substandard, falsified and counterfeit) are the high cost of original drugs, the imperfection of the legislative framework, high tariffs for the release of drugs to the market and others.

Молодежный инновационный вестник. 2022;11(1):50-51
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### ANALYSIS OF INCOME AND EXPENSES OF A HEALTHCARE INSTITUTION

Mezentseva K.N.

#### Abstract

In modern conditions, financial resources are an important management tool in health care, as they contribute to attracting human and material resources to medical institutions, increasing the level of providing the population with quality and affordable medical care. The study of income and expenses, improving the efficiency of financial support allows healthcare organizations to maintain a competitive position.

Молодежный инновационный вестник. 2022;11(1):52-53
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### STAFFING CAPACITY OF OUTPATIENT SERVICES IN THE CITY OF TVER

Pototskaya L.A., Morozov A.M.

#### Abstract

Staffing in health care is an urgent problem in the regions. The aim of the study was to analyze the data of employment in polyclinics and assess the dynamics of staff turnover. Materials and methods were the data of official reports of polyclinics № 1, № 2, № 3 of State Budgetary Institution "City Clinical Hospital № 7" in Tver. The analysis of indicators of three time intervals: 2011-2014, 2015-2017, 2018-2020 was carried out. According to the results of the study in Polyclinic No. 1 there was a decrease in the percentage of employment among doctors by 38% and among nurses by 17.5%. Nursing staff employment remained below 50% throughout the decade. The underemployment rates of Polyclinic №2 and Polyclinic №3 were unchanged for 10 years. Conclusions: over the period 2011-2020, we can observe underemployment rates in polyclinics, as well as their decrease from the beginning to the end of the decade, mostly among physicians.

Молодежный инновационный вестник. 2022;11(1):53-54
53-54

### ANALYSIS OF PATIENT SATISFACTION WITH THE ACTIVITIES OF THE HOSPITAL LABORATORY SERVICE

Pisklakov S.

#### Abstract

An assessment of patient satisfaction with the activities of the laboratory service of the hospital was carried out, which made it possible to establish that 9 out of 10 respondents were completely satisfied with the range of laboratory services provided.

Молодежный инновационный вестник. 2022;11(1):54-56
54-56

### PHARMACEUTICAL CARE FROM THE POSITION OF A THREE-LEVEL ANALYSIS

Simakova S.

#### Abstract

Target. Study of Pharmaceutical Care (PC) from the perspective of a three-level analysis.

Methods. In the course of a three-level analysis, from the position of a product, the essence of the PC, the actual product, the added product.

Results. At the first level of analysis, the essence of the PC was considered: PC is a system for providing drug treatment that provides for a set of measures to improve the quality of life of the patient, which provides for the interaction of the pharmacist-patient-physician and their responsibility for the patient's health based on the actions and decisions made by the doctor and a pharmacist, and the main result of the PC is the preservation of health and improvement of the quality of life of patients. At the second level, the elements of the PC are defined from the perspective of the actual product: 1) the consumer properties of the PC include the timeliness, availability and quality of drug treatment; 2) the category of "quality" includes the functioning of the logistics service, pricing, assortment policy, the absence of falsified, low-quality drugs, the presence of highly qualified personnel; 3) the "design" of the PC includes the appearance of the pharmacist - his neatness, the presence of a uniform, compliance with the code of corporate culture, etc.; 4) “packaging” of the PC implies the correspondence of the personal (empathy, tact, politeness, etc.) and professional qualities of the pharmacist to the requirements of buyers; 5) “brand name” (patients are often adherents of not only one manufacturer, but also one specialist pharmacist, and turn to him specifically for help). From the point of view of the added product, PC includes the readiness of the pharmacist for qualified pharmaceutical advice on the use, storage, and interaction of drugs.

Conclusions. All three levels of PC are closely interconnected and represent a complex multifaceted structure aimed at ensuring the health of the population of our country.

Молодежный инновационный вестник. 2022;11(1):57-58
57-58

### DYNAMICS OF DISABILITY IN THE CITY OF TVER

Pototskaya L.A., Morozov A.M.

#### Abstract

Studies of the epidemiology of disability play an important role in preventing the growth of the number of disabled citizens. The aim of the work was to estimate the structure of disability among the patients of the surgical department in Tver. Materials and methods were the data of the official reports of the polyclinic No.1 of "City Clinical Hospital No.7" in Tver for the period from 2010 to 2020. The dynamics of the frequency of registration of persons with disabilities was studied, the structure of disability by group was analyzed. According to the results of the study, from 2010 to 2020 the total number of disabled workers increased by 3.3 times. The largest proportion of patients had diseases of the musculoskeletal system and the vascular system. The largest number of patients each year received disability group III. Conclusions: The number of persons with disabilities tends to increase. This leads to a decrease in the able-bodied population, an increase in social inequality, which is an urgent problem in the regions.

Молодежный инновационный вестник. 2022;11(1):56-57
56-57

## Современные информационные системы и технологии в медицине

### ANALYSIS OF THE USE OF ONLINE REFERENCE PLATFORMS AND APPLICATIONS IN MEDICINE

Vanina A.A.

#### Abstract

Reference and information medical platforms are one of the progressive directions of the development of mobile healthcare. The purpose of the study is to assess the use of such applications, awareness of them. The research method was a survey of 58 students of different training areas of Kursk State Medical University. As a result of the study, it was found that the majority of students have a positive attitude to such platforms, but are not sufficiently aware of them. So, we can conclude that it is necessary to raise awareness and trust in this area among the younger generation of physicians.

Молодежный инновационный вестник. 2022;11(1):59-60
59-60

### MODERN APPROACHES IN THE FIGHT AGAINST SCOLIOTOIC DISEASE OF THE SPINE AMONG STUDENTS

Vanina A.A., Kichigina A.O.

#### Abstract

The purpose of this study was to evaluate the effectiveness of the use of remote technologies in the fight against scoliosis among students. The method was examinations and surveys of students before and after using the training application "BackExercises" for two months. As a result of the study, an improvement in the state of the musculoskeletal system of students and a decrease in scoliotic deformities were found. The following conclusions were obtained: the use of remote technologies in the fight against scoliosis is expedient, which is confirmed by the positive dynamics in the subjects.

Молодежный инновационный вестник. 2022;11(1):60-61
60-61

## История медицины

### MUSEUM OF SPACE BIOLOGY AND MEDICINE them. V.V. ANTIPOV AS AN IMPORTANT ELEMENT OF THE EDUCATIONAL PROCESS

Zatsepina E.A.

#### Abstract

Relevance. In 2008, on the basis of VSMU. N.N. Burdenko Museum of Space Biology and Medicine. V.V. Antipov, which presents unique expositions related to the study of space. It conducts excursions for students and schoolchildren of the city and region; its expositions take part in city exhibitions. In addition, the Center for Space Education was established in June 2014. As part of the work of the center, numerous projects are being implemented, such as the development of educational activities in the field of astronautics and the upbringing of a patriotic generation of young people. Students and teachers conduct research on space topics. This is one of the promising areas of research activities of the Voronezh State Medical University. N.N. Burdenko.
Target. Using the materials of the library fund, get acquainted with the history of the creation of the museum, study its role in the development of the student as a person.
Materials and methods. The work used the general scientific method of research and the literature of the electronic fund.
Results. The special significance of the museum in the educational process and the formation of student competencies is emphasized.
Conclusion. A visit to a museum is an important component in preparing medical students for their future careers.

Молодежный инновационный вестник. 2022;11(1):62-65
62-65

### ORIGINS AND DEVELOPMENT OF THE SCIENTIFIC SCHOOL OF THE DEPARTMENT OF HISTOLOGY, EMBRYOLOGY, CYTOLOGY OF KURSK STATE MEDICAL UNIVERSITY

Puchkov V.

#### Abstract

The purpose of the article is to analyze the origins of scientific research directions at the Department of Histology and Embryology of the KSMU, the formation of the object, subject, methodology and subject of scientific research.Materials and methods of research. Historical-genetic, problem-chronological and comparative-historical research methods are used in the work.Results. At the Department of Histology, Embryology, Cytology of KSMU in the first 10 years of its history, the subject of research and the main method of research were formed. After the Great Patriotic War of 1941-1945, the main direction of scientific research at all departments of histology in the USSR was the study of the mechanisms of physiological and reparative regeneration. The founder of the scientific school of the Department of Histology, Embryology, Cytology of KSMU is Doctor of Biological Sciences, Professor I.D. Richter, a representative of the scientific histological school of A.S. Dogel.

Молодежный инновационный вестник. 2022;11(1):66-67
66-67

### A.F. TRETYAKOV'S CONTRIBUTION TO THE FORMATION OF THE KURSK STATE MEDICAL INSTITUTE

Puchkov V.

#### Abstract

The purpose of the study is to analyze the contribution of Andrey Fedorovich Tretyakov to the development of medicine in the Kursk region.Materials and methods of research. Historical-genetic, problem-chronological and comparative-historical research methods are used in the work.The results of the study.On June 13, 1934, the Kursk Region was formed. The head of the Kursk City Health Department, A.F. Tretyakov, was appointed the first head of the regional health department. In 1934-1935, he was directly involved in the opening and organization of the KGMI. February 9 , 1935All responsibility for the creation of the administrative structure of the KSMI and the organization of departments was borne by the head of the Kursk Regional health Department A.F. Tretyakov and, appointed from Moscow, the first director of the KSMI V.I. Deshevoy. The result of such personnel policy of A.F. Tretyakov and V.I. Deshevoy was that the main departments of preclinical training of KSMI began their educational activities already in 1935.

Молодежный инновационный вестник. 2022;11(1):68-69
68-69

## Современные вызовы медицинского сообщества. COVID-19 - прикладные и клинические исследования

### EFFECTIVENESS OF MEXICOR IN COMPLEX THERAPY IN PATIENTS WITH HIGH VASCULAR RISK WHO SURVIVED COVID-19 DURING POST-HOSPITAL REHABILITATION

Breusov D.A.

#### Abstract

The paper assessed the effectiveness of the use of mexicor in the correction of cardiac disorders in patients with COVID-19 during post-hospital rehabilitation.

Молодежный инновационный вестник. 2022;11(1):70-71
70-71

### STATISTICAL ANALYSIS OF THE USE OF MEDICINES IN THE TREATMENT OF COVID-19

Vanina A.A., Karapetyan A.S.

#### Abstract

Treatment of a new coronavirus infection is one of the most pressing problems of our time. The purpose of the study is to analyze the drugs used, the validity of their use, and to evaluate the use of clinical recommendations in prescribing treatment for COVID-19 patients. The research method was a survey of 56 KSMU students who had been ill. As a result, it was found out that treatment is not always prescribed in accordance with the recommendations and is followed by patients. Conclusion. Thus, the treatment regimens presented in the recommendations are not always followed, most often glucocorticoids and anticoagulants are not consciously used by patients.

Молодежный инновационный вестник. 2022;11(1):71-73
71-73

### ANALYSIS OF PHARMACOLOGICAL THERAPY OF A NEW CORONAVIRUS INFECTION IN KSMU STUDENTS

Dubinina M., Boldina N.V.

#### Abstract

With the appearance of the Omicron strain, the prevalence of coronavirus infection among a younger group of the adult population has increased significantly [1-3], which means that statistical data on the incidence of a new coronavirus infection, their absolute and relative growth determine the relevance of improving approaches to CoViD-2019 therapy within the framework of current temporary clinical recommendations. According to the results of the study of this sample, it can be said that special attention deserves the fact that most cases of transmission of a new coronavirus infection in the studied population are not confirmed by PCR testing for the detection of SARS-CoV-2 RNA, which may affect the incidence statistics, as well as the treatment protocol in each individual clinical case. The highest frequency of use in the treatment of NKVI was observed in such drugs as umifenovir (27.9%), gripferon in the form of nasal drops (27.9%), vitamin C (60.5%), vitamin D (44.2%), and vitamin B (20.9%). The therapy of a new coronavirus infection used by students corresponds to the schemes described in the temporary clinical recommendations for the treatment of NCVI [2], and is also effective.

Молодежный инновационный вестник. 2022;11(1):73-75
73-75

### EPIDEMIC SITUATION ON SOCIALLY SIGNIFICANT INFECTIONS IN THE REGION DURING THE COVID19 PANDEMIC

Polshikova N.A.

#### Abstract

Relevance. The epidemiological situation of tuberculosis in the Russian Federation remains tense, although the level of incidence rate regulated by the Decree of the Government of the Russian Federation by 2020 (61.6 per 100 thousand of the total population) has been reached. It was assumed that the COVID-19 pandemic could have an adverse impact on morbidity rates, since, first of all, due to lockdowns, examinations for tuberculosis and studies for chronic socially significant infectious diseases (HIV infection, parenteral hepatitis) may be reduced
Молодежный инновационный вестник. 2022;11(1):75-77
75-77

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