# Vol 10 (2021): Материалы XVII Международной Бурденковской научной конференции 22-24 апреля 2021 года

## Акушерство и гинекология

### THE POSSIBILITIES OF USING INSTRUMENTAL DIAGNOSTICS OF SCAR INTEGRITY IN THE CONDITIONS OF AN EXPERIMENTAL MODEL OF THE UTERINE CAVITY

Alekseeva A.

#### Abstract

Relevance.Currently, the rate of delivery by caesarean section is steadily increasing. Independent childbirth in women with a scar on the uterus is one of the mechanisms for its reduction. Meanwhile, the delivery of this category of patients through the natural birth canal requires the development of a safe and effective way to assess the integrity of the scar in the early postpartum period.
The purpose of the work. To develop a method of instrumental diagnostics that allows to examine the inner surface of the uterine cavity and assess the condition of the scar area in the first minutes of the postpartum period without the risk of embolic complications and without requiring an anesthetic aid.
Materials and methods. The analysis of the information content of the developed method was carried out in comparison with a manual study in an experimental model of the uterus. Each model was made from a bovine heart and had 3 defects with diameters less than 0.5 cm, 0.5-0.8 cm and 0.8-1.2 cm.
Results. Defects of less than 0.5 cm were not detected by any of the methods studied. Defects with a diameter of 0.5-0.8 cm were detected using the developed device in 90% (45/50), using manual revision in 44% (22/50) of cases (χ2 = 23.93, p < 0.001), defects with a diameter of 0.8-1.2 cm - in 100% (50/50) and 98% (49/50) of cases, respectively (χ2 = 1.01, p = 0.32). The informativeness of the instrumental assessment of the model integrity exceeds the informativeness of the manual study by 1.34 times (RR = 1.34, 95% CI 1.09-1.65, p < 0.057.
Conclusion. Given the high information content of the developed method, it is necessary to consider the possibility of testing this device in clinical trials.

Молодежный инновационный вестник. 2021;10(S1):4-8
4-8

### EFFICIENCY AND POTENTIAL TERATOGENICITY OF PROGESTERONE-DRUG WHICH APPLY IN FIRST TRIMESTER OF PREGNANCY

Borshchenko I.

#### Abstract

Currently, the demographic policy of the Russian Federation strives to increase the birth rate, as well as to strengthen the reproductive health of the population, the health of children and adolescents. In this regard, a set of measures are being implemented to reduce the number of premature termination of pregnancy. Today, gestagenic drugs are used for various purposes, including to prevent spontaneous abortion.

The aim of this work is to review current clinical studies examining the effect of gestagens on the embryo in the first trimester of pregnancy.
This review includes 2 multicenter, randomized, double-blind, placebo-controlled studies, a retrospective controlled cohort, and a retrospective case-control study. The presented clinical studies have a larger sample of participants and their results contradict those of other earlier studies.

Analysis of these data allowed us to conclude that there is no effect and potential teratogenic risks associated with the use of gestagenic drugs by pregnant women in the first trimester in order to prevent spontaneous abortion. Updated data on the teratogenic effect of dydrogesterone preparations confirm an increased risk of congenital heart defects, hypospadias, cryptorchidism, and neural tube defects.
Today, there is a need for further scientific research to confirm the presented results, which in the future will help to make a qualitative assessment of the risks and benefits, create conditions for improving the quality of medical care for women during pregnancy.

Молодежный инновационный вестник. 2021;10(S1):8-12
8-12

### MODERN POSSIBILITIES OF PREVENTION OF CERVICAL CANCER

Bublikova A., Kozarezov S.

#### Abstract

Background:Cervical cancer remains one of the most common oncological diseases of the female reproductive system, with no downward trend. The increase in morbidity, the" rejuvenation " of the disease, and the persistence of high mortality determine the need to find new approaches to solving this problem. The leading role of the human papillomavirus in the pathogenesis of cervical cancer points to vaccination as a priority area for the prevention of sexually transmitted diseases.

The aim of the study: It is necessary to systematize current data on the vaccination of cases of cervical cancer associated with the human papillomavirus, to prove the effectiveness, to confirm the safety and to justify the need for immediate practical application of vaccination.

Materials and methods: Аnalysis of foreign and domestic publications (including those using databases) devoted to the vaccination of cervical cancer.

Results: Analysis of statistical data shows a decrease in the incidence of cervical cancer after the introduction of primary prevention against human papillomavirus in Europe, the United States and Australia.

Conclusion: the demonstration of the effectiveness of state programs for primary prevention of cervical cancer, the depressing forecast of experts regarding the increase in the incidence in our country in the coming years indicates the need for urgent implementation of the "ideal" national calendar of preventive vaccinations, including vaccination against the human papillomavirus.

Молодежный инновационный вестник. 2021;10(S1):12-16
12-16

### THE EFFECT OF TESTOSTERONE ON THE BODY OF A WOMAN IN THE PERIMENOPAUSAL PERIOD

Golovko E.

#### Abstract

The purpose of the study. To clarify the data and expand the understanding of the role of androgens on the body of women in the perimenopausal period.Material and methods. Analysis of 26 sources of literature, including Russian and foreign monographs, articles dated 2010-2021.Result. According to the literature reviewed, the role of androgens in the perimenopausal period is very ambiguous.The negative effects of androgens associated with an excess of these hormones have been sufficiently studied: the development of acne, hirsutism, hypertension and obesity, menstrual disorders. However, very few studies are aimed at studying the reverse properties of these hormones on the female body. Studies have shown that due to the lack of male sex hormones in women during perimenopause, muscle tone, performance, libido may decrease, and physical weakness may develop. Thus, during this period of life, there is a shortage of both estrogens and androgens, which significantly affects the quality of life of women. Recent studies have shown the effect of androgen therapy associated with a decrease in dyspareunia, recovery of sexual activity, and increased performance. In addition, the normal concentration of androgens has a positive effect on the prevention of the development of the risk of diseases of the cardiovascular system. In addition, there is reason to believe that free testosterone is involved in the processes of hematopoiesis, since in studies its deficiency correlates with the development of anemia.Sufficient levels of androgens also reduce overall and abdominal adipose tissue and lower blood glucose levels. The effect of testosterone in the nervous system is associated with the improvement of a woman's cognitive functions and mood. In addition, testosterone has an anabolic effect on the musculoskeletal system. Androgens in the processes of carcinogenesis have a twofold effect, which can be both pro-carcinogenic and antiproliferative.Androgen therapy in the postmenopausal period has a positive effect on urogenital disorders in women.

Молодежный инновационный вестник. 2021;10(S1):16-18
16-18

### FEATURES OF SOMATIC AND OBSTETRIC-GYNECOLOGICAL ANAMNESIS IN PATIENTS WITH ANEMIA DURING GESTATION

Dutova o.I.

#### Abstract

Background: Anemia is a common phenomenon during pregnancy. A great importance in the diagnosis of anemic conditions is given to somatic and obstetric-gynecological anamnesis.Objective: to study the features of somatic and obstetric-gynecological anamnesis in patients with anemia during gestation.Research methods: in the period from 01.12.2020 to 20.02.2021, the analysis of exchange cards, birth histories, and newborn histories was carried out in 38 patients delivered on the basis of the 2nd building of the VOKBNo1 maternity hospital. We performed a statistical assessment of complications of somatic and obstetric-gynecological anamnesis in women with reduced hemoglobin and with normal hemoglobin values.Results of the study: Patients with hemoglobin levels below 110 g/l in 89.64% had a complicated somatic history, which is 2 times higher than in the control group. Infertility, erosion, cervical dysplasia, STDs, abortions, and miscarriages were much more frequently diagnosed in the anamnesis.

Молодежный инновационный вестник. 2021;10(S1):18-20
18-20

### DIFFERENTIAL DIAGNOSIS BETWEEN PARTIAL BUBBLE TRANSFER AND ENDOMETRITIS CAUSED BY HERPES SIMPLE VIRUS (CLINICAL CASE)

Zolotukhin v., Arzhanykh Y.

#### Abstract

RELEVANCE. The demographic situation in the Russian Federation is such that every desired pregnancy, if possible, should end with the birth of a child (1).

OBJECTIVE demonstrate difficult for the practitioner clinical case, claiming the first non-trivial solution - Differential first diagnosed between the partial molar pregnancy, and viral endometritis.

MATERIALS AND METHODS: A case of uterine pregnancy developing against the background of endometritis caused by the herpes simplex virus type 1 and aggravated by the threat of miscarriage

RESULTS OF THE STUDY: Bubble drift is one of the most dangerous obstetric complications, in which it is necessary to take urgent and drastic measures to terminate pregnancy with further treatment by a gynecological oncologist . The disease is characterized by severe nausea, vomiting, bleeding from the genital tract. On examination, a discrepancy between the size of the uterus and the gestational age is revealed.

RESULTS: A iagnoz "partial molar pregnancy Pregnancy 6-7 weeks" had to be set at this stage, and the subsequent medical tactic was to Ack its approved or refutation of this disease.

DISCUSSION: Among the diseases that can cause these complaints with complaints of scanty bleeding from the genital tract, delayed menstruation, nausea, vomiting in the morning are rare, viral infections, in particular endometritis caused by HSV, have been identified .

CONCLUSION: Full or partial cystic drift is a life-threatening condition for a woman, as it refers to precancerous diseases. Therefore, in the case of the slightest suspicion of a PP, it is necessary, based on the principle of oncological vigilance , first of all, to exclude it

Молодежный инновационный вестник. 2021;10(S1):20-23
20-23

### RELATIONSHIP BETWEEN ANXIETY LEVELS IN PREGNANT WOMEN AND LABOR MANAGEMENT PLAN

Katsura K.

#### Abstract

Relevance: The process of pregnancy and childbirth requires high adaptive capabilities from the mother's body. The mental and emotional background can change dramatically under the influence of internal (for example, hormonal) and external (for example, social) factors, influencing the course of pregnancy. Given the variety of reasons affecting the tactics of childbirth, it is not always possible to know in advance the method of delivery in a pregnant woman, which, of course, causes a feeling of uncertainty and increases the patient's level of anxiety.
Purpose: To study the level of personal and situational anxiety in patients with full-term pregnancy and to analyze its indicators for different modes of delivery.
1. To establish the level of personal and situational anxiety in patients with full-term pregnancy;
2. Analyze the plan for the management of childbirth in pregnant women of the surveyed group;
3. Evaluate the presence or absence of a relationship between the level of personal and situational anxiety before childbirth and the choice of the method of delivery in a conservative expectant management plan.
Methods: The Spielberger-Khanin questionnaire was used to assess the indicators of personal and situational anxiety. The analysis of the labor management plan and the finally chosen method of delivery was based on the data of case histories and exchange cards of 35 pregnant women with a gestational age of 37 weeks or more. When comparing the information obtained, the relationship between the level of personal and situational anxiety before childbirth and the choice of the method of delivery with a conservative expectant management of labor was studied. The results were assessed using descriptive statistics methods.
Results: Based on the results of the analysis of the available data, it was found that there are more patients with a high level of personal anxiety among pregnant women with a conservative expectant management plan than with an operative plan. At the same time, indicators of situational anxiety do not have significant differences. The percentage of high and moderate levels of anxiety in two different outcomes of conservative expectant management of labor was the same.
Conclusion: Pregnancy is a difficult period in the life of every family. Anxiety before childbirth is determined by a number of factors, external and internal, including awareness of the method of delivery. It is worth paying special attention to the emotional background of pregnant patients, taking into account the entire set of existing influences and providing timely and correct psychological support.

Молодежный инновационный вестник. 2021;10(S1):23-25
23-25

### THE MAIN FACTORS OF THE IMPLEMENTATION OF INTRAUTERINE INFECTION AND THE PROGNOSIS OF INFECTION OF NEWBORNS

Kulinchenko A.

#### Abstract

Recently, issues related to intrauterine infection and the prognosis of infection in newborns have been updated,since intrauterine infection is the main cause of neonatal morbidity and mortality among newborns.The aim of the work is to identify the factors of intrauterine infection and predict the risks of infection in newborns by analyzing the mother's anamnestic data, the results of PCR diagnostics, pathomorphological examination of the placenta, the data of the study were carried out on the basis of VGKBSMP No. 10,Voronezh maternity hospital.In the course of the work, the results were obtained, on the basis of which it can be concluded that the risk factors for the development of infection in newborns are the presence of a history of infectious and inflammatory pathology in the mother and the prenatal outflow of amniotic fluid during a long anhydrous period contribute to an increase in the risk of ascending infection with microorganisms of the birth canal,and this in turn will lead to an increase in the risk of

Молодежный инновационный вестник. 2021;10(S1):26-28
26-28

### FREQUENCY OF OCCURRENCE OF VARIOUS FORMS OF NEW CORONAVIRUS INFECTION COVID-19 IN PREGNANT WOMEN

Morozov A.

#### Abstract

This article describes the frequency of occurrence of various forms of the new coronavirus infection COVID-19 in pregnant women. A new coronovirus infection caused by the SARS-CoV - 2 (COVID-19) virus strain occurs in various forms-from asymptomatic to extremely severe with the development of bilateral pneumonia, multiple organ failure and sepsis. It is known that pregnant women are more susceptible to viral infection due to physiological immunosuppression, in this regard, it can be assumed that they belong to the risk group for the development of severe forms of new coronavirus infection. Information on the frequency of occurrence of various forms of the clinical course of the new coronavirus infection in pregnant women is very limited. A retrospective analysis of 1162 birth histories of patients who received specialized medical care in the maternity hospital of the city of Sevastopol was carried out. Standard definition of a COVID-19 case (suspected COVID-19 case, probable-clinically confirmed.
Молодежный инновационный вестник. 2021;10(S1):28-29
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### MODERN POSSIBILITIES FOR CORRECTING CONSTIPATION IN POSTPARTUM WOMEN

Orlova D.

#### Abstract

Relevance: The frequency of constipation during puerperia is 10-50% and is one of the reasons for the complicated course of the postpartum period. However, this problem is rarely discussed by specialists; the algorithm for managing patients with intestinal dysfunction after physiological and surgical delivery has not yet been developed.
Objective of the study: to assess the clinical efficacy and tolerability of the Enema Klin enema in puerperas with constipation after spontaneous and surgical delivery, to determine the adherence of patients to this type of therapy.
Materials and methods: 26 puerperas (16 after spontaneous and 10 after surgical delivery) with no spontaneous emptying of the intestines for more than 3 days. The method of therapy is a disposable enema Enema Klin (laxative). Before use and one day after the use of the enema, a survey of patients was carried out according to the author's questionnaire about the effectiveness, tolerance and adherence of patients to this method of therapy for constipation.
Results: in patients with constipation during puerperia, constipation before pregnancy occurred in 50%, pregnancy - in 63.4%. In addition to stool retention for more than 3 days, clinical symptoms of constipation in the form of a feeling of discomfort in the intestines (34.6%), distention (26.9%) and / or pain (19.2%) in the anus were significantly more frequent in patients after spontaneous delivery than after surgery. The use of a disposable enema laxative Enema Klin led to a soft discharge of formed feces in 92.3%, the presence of a feeling of complete bowel movement in 73.1% of cases. Adverse events in the form of discomfort, pain or itching in the anal area on the first day after the enema were registered only in the group of patients after spontaneous childbirth. This type of therapy for constipation was recognized as comfortable in 73.1% of cases, 92.3% of patients are ready to use it in the future, 96.2% of patients are ready to introduce relatives and friends.
Conclusion: Enema Wedge enema is one of the effective and safe methods for correcting constipation in postpartum women, regardless of the method of delivery.

Молодежный инновационный вестник. 2021;10(S1):29-32
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### OBSTETRIC AND PERINATAL COMPLICATIONS IN WOMEN WITH MULTIPLE PREGNANCIES

Orlova D., Tatarinova A.

#### Abstract

Relevance: Currently, multiple pregnancy is one of the urgent problems of obstetrics, due to the high risk of complicated pregnancy and adverse outcomes. The aim of the study: to conduct a comparative analysis of obstetric and perinatal complications in women with multiple and single pregnancies. Material and methods: Retrospective a single-stage cross-sectional study, which included the study of the characteristics of the course of pregnancy, complications, perinatal outcomes in 36 women, 13 of them with multiple pregnancies, 23 with single pregnancies. Comparative analysis was carried out by analyzing medical documentation, including a full range of general clinical, laboratory, and results of functional research methods. Results: The compared groups of patients were comparable in age, place of residence, extragenital pathology. Patients with multiple pregnancies more often had a history of primary infertility, therefore, in 23.1% of cases, pregnancy occurred as a result of assisted reproductive technologies. Pregnancy complications were found more often in women of the main group, primarily due to isthmic-cervical insufficiency, edema of pregnant women, gestational diabetes mellitus and iron deficiency anemia of pregnant women. Women with multiple pregnancies had preterm birth in 23.1% of cases. The condition of newborns born from multiple pregnancies was characterized by a lower birth weight: 2400 ± 202.2 and 2300 ± 222.3 g, respectively, for 1 and 2 children, in the control group the weight was 3400 ± 152.2 g (p = 0.01 ), as well as the complicated course of the early neonatal period (cerebral ischemia, 38.5 and 8.7%, respectively (p = 0.0001)). Conclusion: The incidence of obstetric and perinatal complications in women with multiple pregnancies is significantly higher than in the control group. It is necessary for all patients with multiple pregnancies to be monitored in the high-risk group, timely prevention and detection of complications during pregnancy, which, of course, will improve perinatal outcomes.

Молодежный инновационный вестник. 2021;10(S1):32-35
32-35

### COMPARATIVE ASSESSMENT OF THE LEVEL OF MORPHOLOGICAL, FUNCTIONAL, SOMATIC AND REPRODUCTIVE HEALTH OF YOUNG WOMEN OF DIFFERENT AGE GROUPS

Savvin V., Kolesnikov N., Sudakova O.

#### Abstract

The study and preservation at the proper level of female reproductive health has always been one of the important components of the direction of medicine, regardless of time and state system. A particular demographic crisis that began in our country in the nineties of the last century gives particular relevance to this topic. The decline in the population and the decline in the birth rate has led to the need to take a number of measures aimed at preserving the reproductive health of women and at increasing the birth rate, while a number of measures are not only medical, but also social in nature. In addition, in our country, there is a number of medical and social reforms aimed at changing the very attitude of the state towards its citizens. One of the most significant was the increase in the retirement age and the change in the concept of "youth". Since December 2020, this category of citizens includes persons under 35 years old, inclusive.
Objectives
The aim of the study was an attempt to determine the main morphofunctional, somatic, reproductive characteristics of the body of young women in the modern world.
Materials and methods
The objects of this retrospective study were the birth histories of 144 women. All of them were divided into 2 groups, depending on their age. The first group included women from 17 to 25 years old; the second group consisted of patients aged from 26 to 35 years. The study was based on collecting a detailed anamnesis, studying the features of gynecological status, determining the main anthropometric data and concomitant pathology, identifying "bad habits", etc.
results
It was found that the majority of women could be attributed to the dolichomorphic body type with leptosomy. The main features of the gynecological status and history were determined, including the study of concomitant pathology, the presence of bad habits, etc. For group 1 compared with group 2, sexual illiteracy was more characteristic, partly affecting the earlier onset of sexual activity, an increase in the incidence of gynecological diseases, including sexually transmitted diseases, and a greater adherence to bad habits. Moreover, they more often than women from the second group resorted to abortions and their pregnancy, at the first birth, was often not the first.
Conclusion
The data obtained make it possible to judge the state of women's reproductive health and the factors that can influence it. As the age of young women decreases, as a rule, the number of "problems" in their gynecological sphere increases. This study is of interest not only for practicing obstetricians-gynecologists, but also for teachers who train students in gynecological departments.

Молодежный инновационный вестник. 2021;10(S1):35-39
35-39

## Влияние факторов внешней среды на здоровье человека

### MOTIVATIONAL COUNSELING AS A METHOD OF PREVENTION OF NON-COMMUNICABLE DISEASES DURING PREVENTIVE MEDICAL EXAMINATIONS OF STUDENTS FOR THE PURPOSE OF EARLY DETECTION OF ILLEGAL USE OF NARCOTIC DRUGS AND PSYCHOTROPIC SUBSTANCES

Sabha R., Alekseyenko A.

#### Abstract

Relevance: the importance of developing the prevention of noncommunicable diseases (NCDs)At the present stage of human development, the UN is designated as one of the tasks that must be solved in order to achieve the "Sustainable Development Goals". The prevention of NCDs is also of great importance at the national level in the Russian Federation, which is reflected in the"Strategy of the Anti-Drug Policy of the Russian Federation for the period up to 2030". Objective: to develop health-saving technologies in the field of prevention of NCDs during preventive medical examinations of students for the purpose of early (timely) detection of illegal use of narcotic drugs and psychotropic substances. Materials and methods: the study is based on a retrospective analysis of data from the federal statistical observation form, analysis and synthesis of literature on the prevention of NCDs, and empirical results of preventive medical examinations of students. Results: according to the survey identified a large number of students involved in preventive medical examinations for early (timely) detection of illicit use of narcotic drugs and psychotropic substances and low prevalence of illicit substance use problems according to the results of preventive medical examinations. At the same time, earlier epidemiological studies among students indicate a higher level of drug and psychotropic substance use (ESPAD project in Moscow 2011). Currently, there are a large number of heterogeneous methods in the field of prevention of addictive behavior, but the lack of theoretical research and evaluation of the effectiveness of such methods makes it difficult to implement the most effective and effective programs in practice. Thus, in order to improve the efficiency and quality of preventive medical examinations of students in order to early detect the illegal use of narcotic drugs and psychotropic substances, the authors propose the introduction of an adapted method of Motivational interviewing. Conclusion: the implementation of Motivational interviewing of students during preventive examinations will preserve a personalized therapeutic approach to the patient and increase awareness and motivation of the population to adhere to a healthy lifestyle (HLS) at the population level.

Молодежный инновационный вестник. 2021;10(S1):40-42
40-42

### REFLECTION OF NATURAL DISASTERS OF A METEOROLOGICAL NATURE IN THE VISUAL ARTS

Borzilova A., Minakova A.

#### Abstract

Relevance: Natural disasters of a meteorological nature have an increasing impact on people and our civilization from year to year. Numerous victims, destruction, irreparable damage to the environment make this problem as global, catastrophically unchanged in time. Modern classifications of natural disasters cover different-scale phenomena of the rendered phenomena: social, anthropological, cultural, ecological. Just as extensive and diverse is the life of images of natural disasters in the history of art. Having become a work of art and a part of culture, meteorological phenomena have acquired an image. They are an eternal theme of art and a constant subject of reflection of great artists.
Objective: To identify the main images of natural disasters of a meteorological nature in the visual arts. In accordance with this goal, the following tasks are defined: to consider the concept of natural disasters of a meteorological nature in the history of art of domestic and foreign artists; to find out the prerequisites for the appearance of natural disasters in the visual arts; to identify the most characteristic types of images of natural disasters; to form a holistic view of the role and significance of the theme of natural disasters of a meteorological nature in the visual arts.
Methods: The research was conducted based on the works of domestic and foreign artists, as well as the works of scientists in the field of art history, cultural studies and aesthetics, devoted to the topic of natural disasters of a meteorological nature in the history of art. The work is based on the cultural and historical method, which involves the consideration of works of art in the cultural context and taking into account their formation and development; structural and typological, which helps to identify images of natural disasters in the visual arts; - figurative-stylistic method, which implies the analysis of the artistic language of the work.
Results: The image of natural disasters is one of the universal artistic images in the history of art, it has philosophical, aesthetic, social, ethnopsychological prerequisites.

Conclusion: Natural disasters of a meteorological nature cause huge damage to humanity, its achievements, as well as the environment, leading to a significant imbalance in nature, victims and wrecks. These phenomena are widely reflected in the works of art of domestic and foreign painters.

Молодежный инновационный вестник. 2021;10(S1):43-46
43-46

### THE COMMITMENT OF THE POPULATION TO OBSERVE THE MASK REGIME IN THE CONTEXT OF THE NEW CORONAVIRUS PANDEMIC

Gurova D.I., Djumack R.E., Timashova A.A.

#### Abstract

Молодежный инновационный вестник. 2021;10(S1):46-49
46-49

### THE COVID-19 EPIDEMIC AND ITS IMPACT ON THE QUALITY OF LIFE OF MEDICAL UNIVERSITY STUDENTS

Eskina A.

#### Abstract

In 2020, a new coronavirus infection (COVID-19) has created a common problem. Despite the fact that the SARS-CoV-2 virus appeared locally, it quickly spread to all continents and reached Russia. In order to delay the transmission of the disease, a general isolation regime was introduced in the country at the end of March 2020. Restrictive and sanitary-anti-epidemic measures affected, among other things, public spaces. These measures have significantly affected the daily lives of young people and students. Public spaces play a fundamental role in meeting the basic needs of citizens. Access to public spaces is directly correlated with the quality of life and human relationships. Young people are highly socially active and are the most frequent users of public spaces. The aim of this study was to determine the impact of social distancing, isolation, and restricted access to public spaces during the COVID-19 pandemic on the quality of life and subjective well-being of young people. The study was conducted by a remote survey conducted among students of the medical university. Questions related to the quality of life of students and access to public spaces during the epidemic. The results of the study revealed a significant decrease in the level of students ' activity in public spaces, a deterioration in physical and psychological well-being and the overall quality of life. Social distancing, isolation, and restricted access to public spaces during the COVID-19 pandemic had a negative impact on the quality of life and subjective well-being of young people.

Молодежный инновационный вестник. 2021;10(S1):49-53
49-53

### PROBLEMS OF ORGANIZING MEDICAL EVACUATION IN CASE OF AN ACCIDENT IN THE VORONEZH REGION RUSSIAN CENTER OF DISASTER MEDICINE (ON THE EXAMPLE OF THE WORK RUSSIAN CENTER OF DISASTER MEDICINE)

Zemlyankina I.N., Medvedev A.D.

#### Abstract

A road traffic accident is an event that occurred while driving on the road of a vehicle and with its participation, while people were killed / injured, or the vehicle was damaged, or other material damage was caused. The problem of road transport accidents remains relevant for decades [1]. Statistics for the countries of the world show that the Russian Federation  ranks 72nd out of 175 as of early 2021 in terms of the number of accidents. On the territory of the Voronezh region in 2020, about 2774 road accidents were registered, of which 1194 occurred in the city of Voronezh.

Aims: To determine what are the features of the medical evacuation of victims of road accidents in the Voronezh region, affecting the indicators of adverse outcomes.

Methods: In this work, we used the following materials and methods: reporting forms of the traffic police in the Voronezh region for 2018-2020; analytical reports of the territorial center of disaster medicine (MC) in Voronezh (TCMC); statistical analysis of the data obtained; graphic method.

The research work was carried out under the leadership of the Department of MC and Life Safety in the person of the head of the department, Doctor of Medical Sciences, Professor Mekhantieva L.E., Candidate of Medical Sciences, Associate Professor of the Department Ilyichev V.P.

Results: As a result of the analysis of the obtained statistical data, we obtained the following results: 1) In 2018, 1176 road accidents were registered in Voronezh, 1467 people were injured, 64 died. 2) In 2019, there were 1307 road accidents in Voronezh, 1598 people were injured, 90 were killed. 3) In 2020, for the first 9 months in Voronezh, 1194 road accidents, 1465 people were injured, 62 died.

Conclusions: Based on the results obtained, it can be concluded that over the past three years there has been a tendency towards a decrease in the total number of road accidents in the territory of the voronezh region and, accordingly, affected by this type of emergency.

Молодежный инновационный вестник. 2021;10(S1):53-55
53-55

### TOPICAL QUESTIONS OF BIOLOGICAL SAFETY IN THE CONTEXT OF THE CORONAVIRUS PANDEMIC

Voronina A.A., Kolyagina A.V.

#### Abstract

Аctuality

SARS-CoV-2 is a virus with a single-stranded RNA of positive polarity, belonging to the family Coronaviridae, the genus Betacoronavirus. The most common clinical manifestation of this coronavirus infection is bilateral pneumonia. Some patients develop hypercoagulation syndrome with thrombosis and thromboembolism, which leads to the defeat of most body systems. The epidemic situation in different countries is extremely heterogeneous. As of 2.03.2021, the coronavirus was detected in 4,257,650 people in Russia, of which 86,455 were recorded deaths from the coronavirus. Due to the danger to health, the relevance and prevalence of this disease, it was decided to investigate the features of the course of the epidemic process on the example of a separate region (Voronezh region). In the Voronezh Region, 68,451 cases of COVID-19 diseases were registered. The incidence rate is 2940.56 cases per 100 thousand of the population.

Goal

To analyze the current data of the COVID-19 morbidity statistics and to track the possible pattern between the introduced safety measures and the level of epidemiological safety in the territory of the Voronezh Region.

Methods

Almost during the year, dynamic monitoring of the state of the epidemic situation in the Voronezh Region was conducted, namely from 1.04.2020 to 1.03.2021. The official statistical data on the number of cases and the number of deaths in chronological order were evaluated, compared with the anti-epidemic measures introduced in the city and in the region.

Results

It should be noted that measures to prevent the spread of a new coronavirus infection were introduced even before the first infected person appeared in the region. This fact contributed to the delayed onset of the epidemic. In addition, the main ups and downs of morbidity and mortality are visible (the first peak in June 2020, a decline in July 2020, a sharp rise in the fall of 2020 (October), a noticeable decline in February 2021). At the moment, there is a positive trend, which can be attributed not only to the increase in collective immunity, which was also noted throughout the country by the Ministry of Health and Social Development of the Russian Federation, but also, of course, the introduction of vaccination, in December 2020, mainly for medical personnel, then in January 2021 everywhere.

Conclusions

The results of our study emphasize not only the need for early preparedness for the upcoming escalation of epidemiological risk in a certain area, but also the responsibility of the population for the spread of infection. For example, the arrival from the southern regions at the end of the summer, the relaxation of quarantine measures, the introduction of universal vaccination, etc. are reflected in the logic of the ups and downs of the incidence in the region.

Молодежный инновационный вестник. 2021;10(S1):55-59
55-59

### DIFFERENCES IN STUDENTS ' EATING BEHAVIOR AND THE ROLE OF DIGITALIZATION FACTORS IN THE FORMATION OF EATING DISORDERS

Legostaeva A.V.

#### Abstract

Progress in the development of digital technologies is seriously changing the world and communication between people. Information is becoming more and more accessible, but it is impossible to control its quality. Often, the ill-considered use of available information can lead to a violation of people's health. The promotion of abnormal standards of beauty and the pursuit of society for them leads to the loss of public health. The vast majority of people, from schoolchildren to the elderly, have access to the Internet. Every year, the problem of eating disorders becomes more acute.
The purpose of this research paper is to analyze the aspects of eating behavior of students and to assess the role of digitalization factors in the formation of eating disorders among students.
To solve the above problems, general scientific, hygienic, sociological and analytical methods of scientific research were used. The analysis of the obtained data was carried out using the capabilities of the Excel program, which is part of the Microsoft Office software package.
The results revealed that only 5% of respondents spend 1-2 hours a day on the Internet, while 28.2% spend 3-4 hours a day on the Internet, 30% - 5-6 hours a day, and 36.8% - 7 or more hours a day on the Internet. More than half of the respondents (53%) are interested in fashion, the same percentage of respondents have ever searched for methods of losing weight on the Internet. 57.3% have ever followed a diet.
The relationship between the fact of active development of digital technologies and their influence on the formation of eating disorders among students is revealed. Methods for the prevention of eating disorders are also proposed.

Молодежный инновационный вестник. 2021;10(S1):59-62
59-62

### ASSESSMENT OF THE IMPACT OF SMOKING ON THE OCCURRENCE OF CANCER

Lytkina A.S., Markova J.L.

#### Abstract

Rationale: Smoking is one of the biggest problems in modern society. Tobacco addiction can cause irreparable harm to the physical and mental health of the smoker, in addition, people exposed to secondhand smoke are also at risk. According to the WHO, about 16% of all deaths of people over the age of thirty are associated with tobacco use.

Objective: To assess the impact of smoking on the development of cancer.

Methods: 100 medical records of male and female patients with cancer of the stomach and intestines were analyzed. The patients were treated at the Stary Oskol District Hospital of St. Luke of the Crimea.

Results: As a result of the conducted studies, it was found that the majority of patients suffering from cancer of the intestine and stomach are men, 72 people out of 100. In addition, 80% of the patients whose medical histories were analyzed had a life history that indicated

Молодежный инновационный вестник. 2021;10(S1):62-65
62-65

### ORGANIZATION OF MEDICAL SUPPORT IN CASE OF FIRES IN THE VORONEZH REGION

Manzhosov O.O., Marshalova V.A.

#### Abstract

Relevance: Fire is a fairly common phenomenon these days, which can harm not only the flora and fauna, but also cause serious damage to property, health and human life. In order to preserve the natural heritage and prevent numerous victims and economic losses, it is necessary to create a well-established mechanism for preventing and eliminating fires.
Purpose: To analyze the statistics of fires and the organization of medical support in the territory of the Voronezh region in comparison with the indicators for the Russian Federation.
Materials and methods: Analysis of statistics on the number of fires and victims of fires in Russia and the Voronezh region for 2016-2019.
Results: In the course of the work, it was revealed that the number of fires in the Voronezh Region in 2019 increased compared to 2016(by 39.33%), 2017(by 39.81%) and 2018 (by 39.86%). A higher percentage of deaths are recorded in rural areas. The average arrival time of a fire department in rural areas has increased and decreased in rural areas.

Молодежный инновационный вестник. 2021;10(S1):65-69
65-69

### EFFECT OF ALCOHOL ON THE RATE OF RECOVERY AFTER TRAUMATIC BRAIN INJURY

Manykian R., Medvedeva V.O.

#### Abstract

Relevance: In recent decades, there has been a significant increase in traumatic brain injury. Often after the acquisition of TBI, people experience neuropsychiatric disorders that are aggravated by alcohol consumption.

Purpose: To conduct a comparative analysis of laboratory and clinical parameters in order to assess the severity of neuropsychiatric disorders in patients with TBI who consume alcohol during treatment, and, who don't.

Methods: The study was based on 20 case histories of patients with TBI who were on outpatient treatment at BUZ VO VGP No. 3 GP 11. The following research methods were carried out: neuropsychic, clinical, laboratory and immunological studies. Results: According to the results obtained in patients, consuming alcoholic beverages, an immunodeficiency state was revealed, as well as a reduced function of the central nervous system. In addition, it was found that people who abuse alcohol have a higher risk of hematomas than people who adhere to a healthy lifestyle at the time of treatment of traumatic brain injury.

Conclusions: Based on the study, it was found that alcohol consumption at the time of TBI treatment not only slows down the recovery process, but also worsens the general condition of the body. Alcohol abuse leads to a change in the rheological properties of the blood and an increased risk of developing cardiovascular diseases. All this has a detrimental effect on the human condition.

Молодежный инновационный вестник. 2021;10(S1):69-72
69-72

### REFLECTION OF NATURAL DISASTERS OF A GEOLOGICAL NATURE IN THE VISUAL ARTS

Moskovkin S., Denekin S.

#### Abstract

Relevance: The urgency of the problem of natural disasters is indicated by the fact that humanity is constantly faced with a variety of different natural hazards. On Earth, they happen every year. Natural emergencies are unavoidable, and one of the largest groups of emergencies is seismic, which includes volcanic eruptions, tsunamis, and earthquakes. These are some of the most global geological disasters. They cannot be prevented, because they are caused by the movement of the lithospheric plates. There are many areas with high seismic activity on Earth. Only in Russia there are 5 of them – Kamchatka, the Kuril Islands, Southern Siberia, the North Caucasus and the Baikal Region.Goal: to draw public attention to the problem; the study of dangerous and emergency situations of geological nature and their reflection in the works of Russian and foreign artists.Materials and methods: analysis and study of paintings dedicated to geological emergencies, painted by Russian and foreign artists in different historical periods.Results: In the course of the work, about 40 paintings were found, viewed and studied, dedicated to geological emergencies, starting with the events of 79 AD and ending with the events of our time. Conclusion: The problem of geological emergencies has been relevant throughout the history of mankind and will never cease to be relevant because they cannot be prevented or avoided. These natural disasters have always affected all spheres of human life, which is reflected in the art of many artists of different historical periods.

Молодежный инновационный вестник. 2021;10(S1):72-75
72-75

### ANALYSIS OF RESPIRATORY DISEASES IN CHILDREN UNDER 14 YEARS OF AGE IN THE KURSK REGION IN 2014-2018

Narykov A.K.

#### Abstract

The quality of the environment has a tangible impact on the health of the child population. The aim of the work is to study the dynamics of respiratory diseases in children till 14 years old in the Kursk and Zheleznogorsk districts of the Kursk region in 2014-2018. As a result of statistical processing and analysis, differences in the incidence of respiratory diseases in children till 14 years old in the two studied areas were revealed, which is associated with an increased anthropogenic influence in the region.

Молодежный инновационный вестник. 2021;10(S1):76-77
76-77

### ASSESSMENT OF THE DYNAMICS OF ATMOSPHERIC AIR POLLUTION IN UFA AND THE REPUBLIC OF BASHKORTOSTAN

Oshibaev R.A., Ilyasova R.R., Nagimova E.M., Sharafutdinov A.Y.

#### Abstract

Ufa, the capital of the Republic of Bashkortostan (RB), is one of the most saturated with industrial enterprises city, which accounts for about 40% of all products manufactured in the republic. There are over 900 enterprises in Ufa that emit pollutants into the atmosphere. [5] In 2016, the volume of gross emissions from stationary sources in Ufa amounted to 153 thousand tons, in 2018 - 130 thousand tons. The number of enterprises that emit pollutants into the atmosphere, compared to 2016, increased from 850 to 960 by 2018

Молодежный инновационный вестник. 2021;10(S1):77-78
77-78

### FEATURES OF THE STUDENTS ' DAY MODE DURING DISTANCE LEARNING

Popov M.

#### Abstract

The COVID-19 coronavirus pandemic caused by the SARS-CoV-2 virus has become the most serious challenge that humanity has faced in the twenty-first century. It affected all spheres of life, including education, changed the usual social way of life, way of life and thinking of people [1].
Objective: to evaluate the daily routine of students studying remotely during the pandemic of the new coronavirus infection COVID-19.
Methods. The main study group was students of the Voronezh Medical University (160 people). The studies were performed simultaneously. The created questionnaire included questions concerning the students ' daily routine. The hygienic assessment of the students ' learning conditions included the determination of the microclimate parameters (air temperature, air humidity, air ionization level and light parameters) in 15 living rooms. Processing and analysis of the obtained material was carried out using standard software packages Microsoft Excel 2007.
Results. According to the results of the survey, the majority (65%) of the students surveyed observed the self-isolation regime during distance learning and stayed at home. The self-isolation regime greatly affected the activity of students, significantly limiting it. Among the surveyed students, 100% noted that they used electronic devices (computer, laptop, tablet, smartphone) daily in a time volume significantly exceeding the normal user mode. At the same time (88%) of the surveyed students increased the amount of time spent at the computer and other gadgets. The conducted analysis of the assessment of the parameters of the microclimate revealed a discrepancy between the temperature and humidity of the air to hygienic standards.
Conclusion. The assessment of the students ' daily routine during distance learning showed the active use of electronic and digital means, an increase in the volume and time of the academic load, a change in the usual mode of educational tasks and the assimilation of their materials.

Молодежный инновационный вестник. 2021;10(S1):78-81
78-81

### THE RELATIONSHIP BETWEEN FUNCTIONAL STATES AND THE NATURE OF NUTRITION IN MEDICAL UNIVERSITY STUDENTS DURING DISTANCE EDUCATION

Popova M., Pobezhimova M.

#### Abstract

Relevance: compliance with the principles of food hygiene is the basis for the formation of a healthy lifestyle, as well as a factor that affects the mood, well-being and activity of a person.
Objective: to assess the dependence of the functional states of medical school students on the identified food preferences and the nature of nutrition during distance education.
Methods: general scientific, hygienic, sociological with the use of questionnaires, analytical.
Results: The food ration of students contains 7% less meat and dairy products compared to the recommended standards and increased by 7% due to vegetable products, which characterizes the lack of protein intake in the body of students. The levels of functional states of the body (well-being, activity, mood) do not exceed the average indicators and vary from 32.2 b. to 69.4 b. for activity indicators; from 35.8 b. to 66 b. for health indicators; from 37.4 b. to 67.4 b. for mood indicators. A significant strong negative correlation is observed between activity and predominant food intake and increased carbohydrate content.
Based on the obtained data, a system consisting of 7 recommendations was developed and aimed at forming the principles of healthy and proper nutrition.

Молодежный инновационный вестник. 2021;10(S1):82-85
82-85

### INFLUENCE OF ELECTROMAGNETIC RADIATION OF MOBILE PHONES ON THE PARAMETERS OF THE VISUAL ANALYZER

Popolitov A.S.

#### Abstract

Relevance. The human eye is the most complex organ in the human body after the brain. The role of vision is difficult to overestimate. As a means of cognition, it has reached the greatest development in humans, providing more than 90% of all information about the surrounding world. And in the conditions of distance learning, the eyes are subjected to a strong load from electronic devices.
The purpose of this work is to consider the contribution of the risk factor EMI MT in the formation of deviations in the work of the visual organ.
Materials and methods. The paper uses theoretical analysis and methods used when working with literature: bibliographic, abstracting, taking notes, and citation methods.

Молодежный инновационный вестник. 2021;10(S1):85-87
85-87

### ADAPTIVE POTENTIAL, THE STATE OF THE CARDIOVASCULAR SYSTEM AND THE EMOTIONAL HEALTH OF INFECTIOUS MEDICAL WORKERS

Pugacheva E.A., Bulygin Y.O., Fedortsov A.A.

#### Abstract

Relevance: due to the difficult epidemiological situation that has developed at the present time, almost all medical personnel are forced to be on high alert and work in a stressful mode due to a constant lack of conditions, as well as difficult working conditions.

Objective: To assess the unfavorable factors of working conditions, to analyze the physical health of medical workers, in particular, the state of their cardiovascular system (CVS), to test doctors for the presence of quality indicators of burnout (EB) and to find the relationship between these components.

Methods: Hypothetical-deductive method, comparison, probabilistic-statistical methods, generalization.

Results: The study involved 23 people (18 women, 5 men), in the following age groups: 20-30 years old - 2 (8.7%), 31-40 years old - 10 (43.5%), 41- 50 years - 4 (12.5%) and more than 50 years - 7 people (30.4%). According to the results of testing for emotional burnout, the following was found: non-developed EB - 4 people (17.4%), EB in the stage of formation - 10 (43.5%), formed burnout - 9 (39%). The following main outcome was revealed: 8 people (34.8%) have a satisfactory adaptive potential, and 15 (65.2%) have a reduced adaptive potential; 18 employees (78.3%) - signs of cardiovascular pathology, 5 doctors (21.7%) - without them.

Conclusion: this work is really unfavorable factors that determine the working conditions of doctors of the infectious corps and influence their physical and mental health. Some doctors have both disorders of adaptive development and signs of CVS diseases, and emotional burnout at the emerging or formed stages. In this regard, it is necessary to improve the quality of working conditions and ensure effective protection of the health of medical workers.

Молодежный инновационный вестник. 2021;10(S1):88-91
88-91

### FOOD QUALITY AND SAFETY IN THE REPUBLIC OF BASHKORTOSTAN

Teregulova Z., Nagimova E., Gafurova R., Oshibaev R.

#### Abstract

Today, foodborne diseases are of increasing concern worldwide due to the contamination of food raw materials with chemical and biological agents (WHO, 2015). It is known that 50% of human health is determined by lifestyle, including nutrition. The purpose of the study was to assess the quality and safety of food in the Republic of Bashkortostan for 2014-2019. The materials were data from the Rospotrebnadzor for the Republic of Bashkortostan, the Ufa Research Institute of Occupational Medicine and Human Ecology, and the Center for Hygiene and Epidemiology of the Republic of Belarus. Analytical, comparative and statistical methods were used. In the course of the analysis, the discrepancy between individual food products and the quality of microbiological and sanitary-chemical indicators was obtained. The specific weight of non-compliance with the requirements for microbiological indicators in 2018 was 4.07%, in 2019 – 4.92%. Percentage of antibiotics in food in 2015. it was 0.4%, which is more than in 2014. (0.08%) and 2013. (not identified). Positive tests for the falsification of dairy products were also found. On the part of sanitary and chemical indicators, the deviation from the established standards was 1.3%. The content of nitrates in fruit and vegetable products is also increased, but in recent years there has been a decrease in their content in food products. At the same time, pesticides, mycotoxins and nitrosamines were not detected in food products in 2014-2019, and heavy metals were not detected in 2019. Thus, at present, a certain proportion of food products in the Republic of Bashkortostan does not meet the quality and safety requirements in certain indicators.

Молодежный инновационный вестник. 2021;10(S1):91-93
91-93

### THE STUDY OF WATER QUALITY OF SOME BODIES OF WATER IN THE VORONEZH REGION IN THE ORGANOLEPTIC AND CHEMICAL CHARACTERISTICS

Ulianov I.

#### Abstract

Goal. The study was conducted in order to obtain data on the properties of some water bodies in the Voronezh Region and the possibility of using water from them as drinking water.
Materials and methods. Water samples from the Voronezh River, Don River, Voronezh reservoir and spring were collected and analyzed for their organoleptic and chemical properties.
Results. The absence of any smell was noted only in the sample of water from the spring, in the material from the Voronezh River and the Don River there was a fishy smell, from the reservoir – putrid. In the sample from the spring, turbidity was absent, in the samples from the Voronezh and Don rivers it was insignificant, in the sample from the reservoir – the most pronounced. The water saturation with mineral substances in terms of mineral sediment and hardness was the lowest in the sample from the Voronezh River, more pronounced in the sample from the spring, even stronger in the Don River and maximum in the reservoir. The value of the biological sediment was minimal in the material from the spring, its value gradually increased in the water samples from the Voronezh River, the Don River, with the highest level in the water sample from the reservoir.
Conclusion. The analysis of the obtained results allows us to conclude that according to the combination of organoleptic and chemical qualities, the most favorable for use is water from a spring.

Молодежный инновационный вестник. 2021;10(S1):94-96
94-96

### CHEMICAL COMPOSITION OF SYNTHETIC DETERGENTS AND THEIR EFFECT ON THE HUMAN BODY AND THE ENVIRONMENT

Khomyackova E.O.

#### Abstract

Synthetic detergents (CMC) play an important role in human life. Due to the wide distribution in the modern world of household chemicals and cosmetics and their usage in everyday life of a person, the issues of their safety and quality are especially relevant. The questionnaire was developed to determine consumer demand and awareness of the impact of SMS on human health and the environment. The survey was conducted in Google-form, in which 164 respondents took part. The survey revealed that the majority of respondents didn't study the composition of the purchased funds. More than half of the respondents aren't aware of potentially hazardous chemical components. Most of the respondents say that they often use CMC, don't change them and use their favorite companies. Also, 20 samples of synthetic detergents were selected and studied, of which: 5 samples of washing powders, 5 samples of dishwashing detergents, 5 samples of toothpastes and 5 samples of shampoos. The labeling and composition of 20 samples of synthetic detergents indicated on the package were studied. The samples were evaluated in accordance with the requirements of TR CU 009/2011 "On the safety of perfumery and cosmetic products", as well as in accordance with GOST 32479-2013 "Laundry detergents" and GOST 32478-2013 "Household chemical goods". ... Potentially hazardous ingredients have been identified, such as surfactants, phosphates, enzymes, optical brighteners, preservatives, fragrances, potential allergens, etc.

Молодежный инновационный вестник. 2021;10(S1):96-99
96-99

### The effect of the deficiency of the microelement iodine in the environment on the thyroid gland

Tcurkan A.A.

#### Abstract

Relevance. The deficiency of the trace element iodine in the environment is one of the most urgent medical and social problems, as it leads to the development of most thyroid pathologies.
The aim is to form a holistic view of the impact of the deficiency of the trace element iodine in the environment on the thyroid gland by assessing the incidence of thyroid pathology in the Voronezh region.
Materials and methods. The primary and general morbidity in thyroid pathology in the Voronezh region from 2013 to 2019 was studied on the basis of data from statistical form No. 12 and information from Voronezhstat. To study the dynamics of epidemiological indicators, we built a linear regression model, calculated the slope of the trend line (coefficient k), and used the Student's t-test to determine the significance of k: at the level of p<0.05. We used Microsoft Excel 2010 and Statistica 8.0.
Results. The results of the work allowed us to establish that the residents of the Voronezh region are most susceptible to endemic goiter and other forms of non-toxic goiter. The incidence of subclinical hypothyroidism and thyrotoxicosis at the level of average values in the Russian Federation. The average rate of primary morbidity in congenital iodine deficiency syndrome is lower than in the Russian Federation. Prolonged iodine deficiency in the diet of the population of the Voronezh Region affects all age groups, with children and adolescents remaining the most vulnerable.
Conclusion. The implemented regional measures for the prevention of iodine deficiency contribute to the reduction of morbidity in a number of pathologies, but do not solve the problem of complete elimination of iodine deficiency and elimination of iodine-deficient diseases. The analysis of the dynamics of epidemiological indicators of iodine deficiency diseases in our study shows that the prevention of iodine deficiency should be focused on the entire population, and not only on risk groups.

Молодежный инновационный вестник. 2021;10(S1):99-104
99-104

### QUANTITATIVE ASSESSMENT OF THE ACCUMULATION OF HEAVY ELEMENTS IN THE FRUITS OF PLANTS IN THE TERRITORIES OF HORTICULTURAL NON-PROFIT ASSOCIATIONS IN THE ZONE OF INFLUENCE OF THE AIRPORT AND THE ASSOCIATED HEALTH RISKS

Chernomor E.A., Zatsepina A.A.

#### Abstract

Annotation. Federal Law No. 135-FZ establishes requirements for the location of air airfields. They should be located in a suburban area, and the area around them should be demarcated in accordance with 7 zones. Directly in the 7th subzone, the construction of houses within a radius of 16 km is prohibited.
Goal:to assess the impact of anthropogenic factors on the contamination of food products with toxic metals in the territories of horticultural non-profit associations in the area of influence of the airport, to assess the associated risks to public health.
Methods: general scientific, hygienic, spectrophotometric, analytical.
Results: Depending on the type of plant fruit, the content of toxic elements took on different values. Toxic trace elements in the highest concentrations were found in rosehip (Fe-11.414 mg / kg, Zn-5.218 mg / kg, Cu-1.736 mg/kg), the lowest concentrations were found in apples (Si – 0.329 mg/kg, Zn – 0.231 mg/kg, Fe – 1.506 mg/kg). There were no significant differences between the content of toxic metals in the selected territories, the calculation was made using the average values.
The median values of non-carcinogenic risk for adults and children were 0.11 and 0.05 for copper, 0.0304 and 0.03 for lead, 0.005858 and 0.273 for cadmium, 0.012 and 0.03 for zinc, and 0.034 and 0.06 for iron, respectively. According to the 95th percentile, the non-carcinogenic risk for adults and children for copper is 0.24 and 0.11, for lead-0.0304 and 0.03, for cadmium-0.005858 and 0.273, for zinc – 0.05 and 0.07, for iron – 0.08 and 0.22, respectively. When assessing the total risk of non-carcinogenic risk, no excess of the permissible values was found, for the circulatory system the risk was 0.08, for biochemical parameters 0.043. The carcinogenic risk for cadmium and lead also did not exceed the safe values and amounted to 0.00142 and 0.00517, for Cd – 0.00182 and 0.10374, respectively.

Молодежный инновационный вестник. 2021;10(S1):104-107
104-107

### INFLUENCE OF FACTORS OF PRODUCTION ON STEEL FACTORY WORKERS

Yankovskaya D., Maslikov A.

#### Abstract

Relevance: in foundry, a large number of technological processes are used that serve as sources of harmful and hazardous production factors. In this regard, constant quantitative and qualitative monitoring of these factors is necessary, as well as regular preventive medical examinations of production workers.
Purpose: assessment of the compliance of the levels of harmful production factors with the current hygienic standards, determination of risk factors for the development of occupational pathology, development of a system of preventive measures.
Methods: to solve the set tasks, hygienic studies of the conditions and nature of labor of workers in the smelting shop, as well as workers of auxiliary units and services of the enterprise, were carried out The work was carried out using data from a special assessment of working conditions, the results of laboratory tests and measurements of harmful factors in the workplace. The analysis of occupational morbidity over the past 20 years has been carried out.
Results: a harmful production factor is present in almost all working places of workers in the smelting and auxiliary shops. According to the measurement results, most of the harmful factors do not meet hygiene standards. Annually, 1-6 cases of occupationally related diseases are detected at the surveyed enterprise.
Conclusion: according to the results, it is possible to trace the dependence of the manifestation of occupational pathology on the action of harmful production factors. It is necessary to introduce additional preventive measures at the enterprise, as well as establish additional control over the use of personal protective equipment.

Молодежный инновационный вестник. 2021;10(S1):107-110
107-110

## Внутренние болезни

### ANALYSIS OF THE EFFECTIVENESS OF APPLICATION OF THE ARTIFICIAL INTELLIGENCE PROGRAM IN THE ASSESSMENT OF FLUOROGRAMS

Abasov A.R., Bezborodov F.A., Klokova E.I.

#### Abstract

Annotation. Computerization and technical progress have not spared medicine either. More and more technologies are coming to help doctors who are loaded with a constant stream of patients. The use of one of them - artificial intelligence (AI), is currently the most discussed topic in radiation diagnostics. This article discusses the prospect of using AI in medical imaging. The authors, relying on the experience of last year's study at the Voronezh Regional Clinical Consultative and Diagnostic Center (VOKKDC), studied the capabilities of AI in structured analysis of chest fluorograms. The study was conducted during the first three weeks of January 2021. The study used an artificial intelligence program using deep learning algorithms based on a multi-level convolutional neural network. Artificial intelligence and qualified radiographers analyzed 50 fluorographic images provided to the authors of the VOKKDTS, with the condition that the images were divided into groups of "normal", "pathology" and "alarming". As a result of the study, the following data were obtained: 34% of fluorograms were marked as “normal”, 36% of fluorograms were marked as “pathology” and 30% of images were classified as “alarming”, which exactly coincides with the opinion of radiologists. Such a result should be regarded as successful. The study shows that today artificial intelligence, with deep learning algorithms, is a promising point in the development of modern radiation diagnostics.

Молодежный инновационный вестник. 2021;10(S1):111-113
111-113

### METHEMOGLOBINEMIA IN PATIENTS WITH CARDIOVASCULAR PATHOLOGY

Avan A.T., Zamanov A.A.

#### Abstract

Abstract

Relevance. The methemoglobinemias described in the literature are mainly of a toxic nature. There is no evidence of an increase in the concentration of methemoglobin (MetHb) in the blood due to any pathology.
Objective: to identify the risk of developing methemoglobinemia in patients with cardiovascular pathology.
Materials and methods. The whole blood of patients with diagnosed cardiovascular pathology was used. The concentration of methemoglobin and cholesterol was determined. The studies were conducted from October 2019 to October 2020.
Results. The blood of 110 people (women and men) was examined. It was found that patients have methemoglobinemia, which correlates with the concentration of cholesterol.
Conclusion: in patients with cardiovascular pathology, methemoglobinemia is detected, accompanied by an increased concentration of cholesterol.

Молодежный инновационный вестник. 2021;10(S1):113-115
113-115

### FEATURES OF COMPUTER TOMOGRAPHY FOR CORONAVIRUS INFECTION IN DIFFERENT POPULATIONS

Karmanchikova E.R., Silkin A.V.

#### Abstract

Relevance. A new type of coronavirus infection is rapidly spreading and is freely transmitted from person to person by airborne droplets and through household contact. This disease leads to serious consequences such as inflammation, fibrosis or sclerosis of the lung tissue, fever, and acute respiratory and cardiovascular failure. Computed tomography of the lungs is currently considered the main method for diagnosing coronavirus. This method of research is almost error-free and in the early stages shows the model and degree of lung damage.
Purpose. To study the frequency and dependence of the degree of affection of the manifestations of COVID-19 during CT on gender, age and place of residence. Pay attention to the results of the PCR test for coronavirus and to further confirm or refute this diagnosis using CT of the lungs.
Methods. A retrospective analysis of radiological and clinical
data from 30 patients with suspected coronavirus infection who underwent a multislice spiral computed tomography of the chest.
Results. After analyzing the data obtained, on the basis of X-ray symptoms, the main dependences and patterns of the frequency of occurrence and severity of X-ray symptoms on the age and gender of patients, as well as on environmental conditions (residents of the city and region) were identified. The results of the CT scan in the vast majority of cases confirmed the results of the PCR test for COVID-19.
Conclusion. In the clinic, in addition to determining the changes characteristic of coronavirus and assessing the degree of lung damage, the CT method allows differential diagnosis of pulmonary and extrapulmonary pathology in patients with concomitant diseases.

Молодежный инновационный вестник. 2021;10(S1):115-118
115-118

### MICROBIAL LANDSCAPE OF THE COLON OF HEALTHY STUDENTS AND WITH METABOLIC DISORDERS

Lilikina A., Kravchuk E., Chervinets Y.

#### Abstract

The high prevalence and severe complications make obesity one of the most serious health problems of the early 21st century.

Purpose of the study: To determine the relationship of metabolic disorders (MD) with the intestinal microbiome of young men.

Materials and methods: The microbiota of the large intestine of 34 students of the Tver State Medical University at the age from 18 to 22 years was studied in the period 2017-2019. The survey with voluntary informed consent was attended by 17 practically healthy young men and 17 students with MD.

Results: It was shown that during the microbiological analysis of feces from 34 students from different study groups, 19 genera of microorganisms were isolated. The prevalence of bacteria increased in obese students compared with the healthy group: Bacillus subtilis - by 18%, Lactobacillus spp. and Basteroides spp. - by 11%, but Enterocossus sрp decreased. - by 52%, Streptococcus spp. - by 19%, Peptostreptocoscus spp. - by 14%, Bifidobacterium spp. and Proteus vulgaris - by 9%. In students with underweight fecal matter, there was an increase in prevalence for Staphylococcus spp. - by 53%, E. coli - by 29%, Peptostreptocoscus spp. - by 19%, Microcossus spp. - by 11%, and a decrease - for Enterocossus spp. - by 25% and Lactobacillus spp. - by 16%, Streptococcus spp. - by 15%, Vacillus subtilis - by 12% and Klebsiella pneumoniae - by 10%.

Conclusion: The intestinal microbiota of students with MD was characterized by a 5-6-fold decrease in the frequency of occurrence of Bifidobacterium spp., In obese young men - by 3 times - Basteroides spp., In people with underweight, by 1.6 times - Сlostridium spp. However, Peptostreptococcus spp. and Pertococcus spp. were allocated 1.9-2.2 times more often in persons with MD in both groups.

Молодежный инновационный вестник. 2021;10(S1):118-121
118-121

### PREVALENCE AND MORPHOLOGICAL CHARACTERISTICS OF SKIN CANCER ON THE EXAMPLE OF ONE OF THE SUBJECTS OF THE RUSSIAN FEDERATION

Leifer O.V., Leifer E., Ivanov E.

#### Abstract

Skin cancer occupies one of the leading positions in the structure of oncological diseases both in Russia and around the world. In recent years, there has been a steady increase in the number of detected cases of skin cancer. This pathology is one of the socially significant problems. This article deals with the main issues of carcinogenesis of malignant neoplasms of the skin, their morphology and epidemiology on the example of the Novgorod region. Basal cell carcinoma accounts for the largest number of cases in the overall morbidity structure. This trend is typical both for the Novgorod region and for the whole world. Thus, according to the International Agency for Research on Cancer GLOBOCAN, by 2040 it is expected to increase the number of newly detected cases of skin cancer by 1.3 million, compared with the same value in 2018. (1.4 million). The problem of increasing the incidence of malignant neoplasms of the skin today is extremely relevant, which is due not only to the increase in the incidence, but also to the emergence of new methods that allow with high reliability and in the shortest possible time to make the correct diagnosis of the patient and effectively conduct his surgical treatment. The relevance of this topic is primarily due to the constant increase in the incidence of this pathology and the need for an interdisciplinary approach to solve this problem. In this study, the analysis of histological preparations was carried out on the basis of the pathology department of the oncology dispensary of Veliky Novgorod, in order to identify the dynamics and morphology of malignant skin neoplasms.

Молодежный инновационный вестник. 2021;10(S1):121-125
121-125

### RENAL DYSFUNCTION IN PATIENTS WITH AND WITHOUT MYOCARDIAL INFARCTION AND SARS-COV-2 INFECTION

Panasavets N., Karpovich Y.

#### Abstract

Violation of the functional state of the kidneys is an important pharmacological and socio-economic problem of modern society. Kidney dysfunction (DP) is associated with an increased risk of death from both cardiovascular and other causes [1]. This work was carried out on the basis of the US “Grodno Regional Clinical Cardiology Center”, where a retrospective analysis of the medical histories of 27 patients was carried out. The study examined the manifestations, consequences, and effects of myocardial infarction (MI) and SARS-Cov-2 infection on changes in renal function. The results of the study showed that more than 90% of the subjects have signs of impaired kidney function. Such comorbid patients need more thorough and long-term follow-up-especially at the outpatient stage. Also, all patients need nephroprotective therapy and correction of risk factors for chronic kidney disease (CKD). After all, an untimely start of therapy or an incorrect approach to it can lead to the development and rapid progression of CKD and, as a result, an unfavorable outcome

Молодежный инновационный вестник. 2021;10(S1):125-127
125-127

### ANALYSIS OF THE ACTIVITY OF THE HEALTH CENTER AND ITS FUNCTION IN THE PREVENTION OF CARDIOVASCULAR DISEASES

Pankratov V.S.

#### Abstract

Relevance: The health of the average resident of Russia is affected by various negative factors that increase the risk of developing many diseases, primarily cardiovascular. In this regard, in 2009-2010, Health Centers were established throughout Russia on the basis of health institutions, the main tasks of which are to promote a healthy lifestyle and prevent the incidence of diseases of the population.
Objective: To study the activities of the Health Center and to show its significant role in identifying risk factors for cardiovascular diseases.
Methods: The work was carried out on the basis of the Health Center of the "Voronezh polyclinic №10". To analyze the activities of the Health Center, a retrospective analysis of information from the reporting forms No. 68 ("Information about the activities of the Health Center") for 2017-2019 and the reporting forms "Medical Card of the Health Center" was performed on the basis of the computer program for 2019 for 100 randomly selected patients. Additionally, the SCORE 2019 scale was used to assess the risk of cardiovascular complications. Microsoft Office Excel was used to analyze the results of the study.
Results: The greatest number of risk factors was revealed during ophthalmological examination, bioimpedance measurement, and screening assessment of the level of psychophysiological and somatic health. In addition, compared to previous years, the number of detected cases with hypercholesterolemia, hyperglycemia, cardiac rhythm and conduction disorders, and ST segment abnormalities on ECG increased. Among the first applied in the health Center in 2019 prevail persons to hospitals at the place of attachment, on the 2nd place – the person who applied on their own, at the 3rd – person submitted after further examination. At the same time, 100% of persons referred from the employer, from the hospital and after medical examination were found to have risk factors. In the study group, the highest proportion of risk factors is observed in the age group of 50-79 years. The proportion of high and very high risk on the SCORE 2019 scale was found mainly in men. The predominant proportion of the Health Center population in 2019 (67%) is at low and moderate risk.
Conclusion: The results of the study allow us to clearly identify the problem of the morbidity of the younger generation and also the low incidence of medical treatment in male patients – the main contingent of the risk group for cardiovascular pathology. For a possible solution to these problems, it is recommended to increase the coverage of men of all ages, increase the motivation of young people for preventive examinations, as well as raise the interest of citizens in the topic of healthy lifestyle and teach them to take care of their health.

Молодежный инновационный вестник. 2021;10(S1):127-131
127-131

### PORTRAIT PAINTING AS AN OBJECT OF DIAGNOSTIC SEARCH

Pantyukhin D.V.

#### Abstract

Thanks to the accurate representation of sitters on canvases by realist artists, you can see various diseases. The analysis of 92 paintings by realist artists revealed the pathology of the bone system, skin, thyroid diseases, and breast cancer. Due to the impossibility of demonstrating the disease on the patient for ethical reasons or the rarity of the pathology, in addition to the method of curating patients, students can use the method of analyzing works of art to form diagnostic skills, and this method can also be used in distance learning.

Молодежный инновационный вестник. 2021;10(S1):132-134
132-134

### STUDY OF PREVALENCE OF CHRONIC SOMATIC DISEASES AND COMORBID PATHOLOGY AMONG PATIENTS WITH NEW CORONAVIRUS INFECTION

Rakhimova S., Suhoruchkina M.

#### Abstract

Relevance-The study of the structure of comorbid pathology in patients with COVID-19 is of great prognostic importance for doctors, new data in this area can help improve the management of patients with a large number of concomitant diseases.
Objective: to study the comorbid pathology of patients with a new coronavirus infection in the city of Voronezh, and its impact on the course and outcome of the disease.
Materials and methods-a retrospective analysis of 60 case histories of patients with an established diagnosis of a new coronavirus infection (COVID-19) was used. The clinical course of the infection was evaluated based on the following data: SpO2 in ambient air and with respiratory support, the degree of lung damage according to the results of computed tomography (CT), the maximum body temperature during the disease, the level of C-reactive protein (CRP) at admission and before discharge (in case of a fatal outcome – before death). To calculate the comorbidity indices and prognostic indicators of the risk of mortality during the disease, the Charlson system was used, and the structure of comorbidity was also determined.
Statistical data processing was performed using Microsoft Excel 2010 and Statistica 20.0 programs and using the Pearson test, differences between groups were considered significant at p<0.05. A logistic regression analysis was also performed using the step-by-step elimination method.
Results-the frequency of adverse clinical outcome increases significantly with the number of concomitant chronic diseases in the anamnesis. In the structure of comorbidity, the first places are occupied by diseases of cardiovascular diseases, hypertension, type 2 diabetes and obesity. The comorbidity index is a significant prognostic criterion for survival, allowing us to assess the clinical course of COVID-19 in a particular patient. Also, a decrease in the level of CRP has a prognostic value. A prognostic model was proposed for the management of patients with COVID-19, which allows us to evaluate their prognosis.
Conclusion-currently, information about the epidemiology, clinical features of the new coronavirus infection, its prevention and treatment remains limited. The tasks of rapid diagnosis, effective therapy and accurate prognosis of patients with COVID-19 are the main ones for public health, and further research related to the study of the causes that affect the severity of the clinical course of the disease may allow them to be solved.

Молодежный инновационный вестник. 2021;10(S1):134-137
134-137

### FEATURES OF THE NUTRITIONAL STATUS OF PATIENTS WITH CONGESTIVE HEART FAILURE

Skrizhalina E.E., Protsenko A.V., Riakhovskaia E.O.

#### Abstract

Relevance

Congestive heart failure is an outgoing cardiac disease. According to Russian epidemiological studies, the prevalence of CHF in the general population is 7%. The prevalence of pathology increases sharply in individuals. The functional activity of the elderly is affected by the nutritional status. The study examined the patterns of elderly patients with CHF.

Purpose

Cluster analysis to identify the most common phenotypes in patients with chronic heart failure.

Materials and methods:

- scales for assessing clinical status;

- anthropometry, calculation of body mass index (BMI);

- bioimpedance measurement with determination of body weight, percentage of fat, water, distribution of visceral fat, bone and muscle mass.

Statistical processing was carried out using the Statistica 20.0 software. K-means cluster analysis was performed

Results

The aim of the study was achieved: patients with CHF who took part in the study were divided into 4 clusters. It was revealed that the majority of patients with CHF have sarcopenic obesity.

Conclusion

In the analysis cluster analysis, the most common phenotypes of patients with CHF were identified, which must be taken into account when planning management tactics.

Молодежный инновационный вестник. 2021;10(S1):137-139
137-139

### EVALUATION OF THE PLEIOTROPIC EFFECTS OF ROSUVASTATIN IN PATIENTS WITH CORONARY HEART DISEASE: STABLE ANGINA PECTORIS II-III FC

Smakhtina A.M.

#### Abstract

Aim. To study the drug response in patients with coronary heart disease receiving statin therapy, taking into account morphometric parameters. Material and methods. The study included 84 patients with a diagnosis of ischemic heart disease: stable angina of functional classes II-III, receiving inpatient treatment in the Kursk City Clinical Hospital of Emergency Medical Care, who were prescribed rosuvastatin at a dosage of 5 mg, followed by an increase in the dose to 10 mg / day, if the blood lipid spectrum did not reach the target values. Blood lipid profile analysis and duplex ultrasound of the common carotid arteries were performed to measure the thickness of the intima-media complex (TIM). The study lasted 48 weeks. Results. A significant decrease in the maximum TIM was found regardless of the dose of rosuvastatin, and in the group of patients using 10 mg of rosuvastatin (group 2), the effect increased by 48 weeks. By week 24, there was a significant regression of the mean TIM in patients taking 5 mg of the drug (group 1). In group 2, the decrease in the mean TIM became significant only by week 48. Conclusion. The effectiveness of rosuvastatin in small doses (5 and 10 mg/day) as a drug that reduces the thickness of the intima-media complex in patients suffering from coronary heart disease has been proven.

Молодежный инновационный вестник. 2021;10(S1):140-142
140-142

### MRI AS RECOGNITION OF CORONAVIRUS INFECTION WITH A LOWER SHARE OF RADIATION FOR THE POPULATION UNDER COVID-19 PANDEMIC

Smolyaninov N., Petrov I.

#### Abstract

STRUCTURED ANNOTATION

Relevance. Include a safer and equally informative examination method, such as CT, in the diagnosis of coronavirus infection. To assess the role and place of MRI lung screening in the detection of pneumonia and patient routing.

Methods and Materials. CT scan of the chest cavity, MRI of the mediastinum with screening of the lungs, statistical analysis of the medical database. This work includes a retrospective analysis of 500 MRI examinations performed between 01.11.2020 and 15.12.2020. on the basis of more than 20 diagnostic centers of the federal network "MRT-Expert".

Results. When comparing the visual data of the control group (n = 25) with a positive PCR test in a single time interval (0-2 days), the fact of detecting MR changes coincided with CT changes in 76% of cases (n = 19) .

Conclusion. Based on the results obtained, an analysis of the capabilities of the MRI method in displaying pulmonary changes was carried out. We have recognized the method of MRI screening of the lungs as a possible alternative to computed tomography for dynamic control in conditions of a shortage of CT recording or the impossibility of performing it, and as a tool to reduce the collective effective radiation dose of the population.

Молодежный инновационный вестник. 2021;10(S1):142-143
142-143

### ERECTILE DYSFUNCTION AS AN INDICATOR OF THE PRESENCE OF CARDIOVASCULAR PATHOLOGY

Smolyannikova A.

#### Abstract

Numerous factors contribute to the development of erectile dysfunction: urological, mental, nervous, endocrine, as well as cardiological diseases. In this regard, the diagnosis and treatment of this pathology, especially developed against the background of diseases of the internal organs, require the participation of not only a urologist, but also other various specialists.
Objective: to study the relationship of erectile dysfunction as a predictor of cardiovascular pathology with dyslipidemia, for the timely detection and initiation of treatment of latent forms of CVD. The object of study: patients with disorders of erectile function.
Methods: collection of complaints and anamnesis, retrospective analysis of outpatient records (registration form 025 / y), ICEF-5 test questionnaire, SCORE test, lipidogram.
Results: the corresponding indicators were evaluated in the selected groups: the main group – patients with ED, the control group-patients who do not complain about erectile function, as a result of which the following conclusions were made:
1) patients of the main observation group have moderate to severe ED, due to high levels of total cholesterol and atherogenicity coefficient.
2) the inverse relationship between the indicators of the international index of erectile function and the indicators of total cholesterol, the coefficient of atherogenicity, the level of blood pressure was revealed.

Молодежный инновационный вестник. 2021;10(S1):143-145
143-145

### ASSESSMENT OF THE FUNCTIONAL STATUS AND CYTOKINE PROFILE OF PATIENTS WITH CHRONIC HEART FAILURE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Tokmachev R., Glavatskikh Y.

#### Abstract

The increase of life expectancy of both cardiovascular patients and people in general, has been accompanied by an increase in the proportion of patients with chronic heart failure (CHF). CHF decompensation plays a leading role, among the reasons of hospitalization in cardiology departments, especially among patients older than 65 years old. CHF patients are conceded to suffering from COPD, the percentage ratio is between 25 to 42%. The high comorbidity of CHF and COPD and the increased risk of adverse outcomes in such a combination of pathologies requires further study of the mechanisms of CHF progression, improvement of diagnostic methods and principles of treatment of this category of patients.

Linked to the identification of three categories of patients with CHF (with preserved, mid-range and reduced left ventricular ejection fraction (LVEF)) is particularly relevant to the study of the effect of systemic inflammation on the clinical flow, functional status and prognosis of patients with comorbide current COPD and CHF with different LVEF.
Methods: The study involved 240 patients aged 40-80 years diagnosed with ischemic CHF. According to the presence of COPD, the patients were divided into four subgroups: patients with CHF with preserved ejection fraction (CHFpEF) (n=69), patients with CHF with reduced ejection fraction (CHFrEF) (n=91), patients with COPD and CHFpEF (n=36), patients with COPD and CHFrEF (n=44). Since inclusion in the study, patients have been examined weekly by researchers to monitor the absence of symptoms of CHF decompensation and COPD exacerbation. After 12 weeks, the participants were examined. Laboratory methods of investigation included determination of serum levels of NT-proBNP, Nhs-CRP, IL-1β, IL-6, TNF-α. Tolerance of physical activity was determined by a complex of cardiorespiratory analysis, which included analysis of 6 minute walking distance (6MWD), and a monitoring system for patients with chronic heart failure.
Results: The average level of NT-proBNP in patients with CHFrEF (subgroup 2) 1171 within 191 ng/l was significantly higher than in patients with CHFpEF (subgroup 1) - 813 within 127 ng/l. The NT-proBNP blood serum level of patients with COPD and CHFrEF (in the fourth subgroup) was also higher than patients in the third subgroup with COPD and CHFpEF.
The level hs-CRP known as the biomarker of endogenous inflammatory processes in HFpEF patients was 3.7 within 0.62 mg/l, while in CHFrEF patients it was statistically less significant - 2.6 within 0.59 mg/l (p0.001). The level hs-CRP in the fourth subgroup (patients with COPD and CHFrEF) was 4.4 within 0.74 ng/L, which was also lower than the 4.9 within 0.85 ng/L patients in the third subgroup with COPD and HFpEF.
​The analysis of cytokine status indicators showed an increase in the level of proinflammatory cytokines in all subgroups studied, both in the isolated CHF and in the comorbide current CHF and COPD. The content of IL-1β, IL-6, TNF-αproved to be significantly higher in combined pathology.
A higher level of IL-1β, IL-6, TNF-α, hs-CRP in the CHFpEF and CHFpEF and COPD (subgroups 1 and 3) than in the reduced EF (subgroups 2 and 4) may reflect the significance of the contribution of systemic inflammation to the development and progression of HF.

Conclusion: CHFpEF patients have higher levels of hs-CRP, pro-inflammatory cytokines compared to CHFrEF patients, reflecting a more pronounced subclinical inflammation and the importance of the immuno-inflammatory component’s contribution to the early stages of CHF. The combination of COPD and CHF amplifies systemic inflammation and myocardial remodeling processes, determined by the level of NT-proBNP, in comparison with the isolated flow of CHF. A negative impact of COPD on the functional status of CHF patients with different LVEF has been established, which is reflected by lower 6-minute walk test and 6MWD/6MWD(i) values and higher desaturation.

Молодежный инновационный вестник. 2021;10(S1):145-148
145-148

### ECHOCARDIOGRAPHY-DIAGNOSTICS OF THE CARDIOVASCULAR SYSTEM IN CORONAVIRUS INFECTION

Ulianov I., Kozmenko K.

#### Abstract

Relevance. For more than a year, the coronavirus pandemic continues to raise many questions in the scientific community. One of the issues is to identify the pathology of the cardiovascular system in COVID-19.
Goal. To identify possible pathologies of the cardiovascular system based on echocardiography data and to determine the frequency of occurrence among patients who have undergone COVID-19.
Materials and methods. On the basis of the Voronezh Regional Clinical Advisory and Diagnostic Center, the conclusions of the ultrasound of the heart of patients who underwent COVID - 19 were selected. A total of 48 studies were selected, all data were divided into three age groups of 16 materials each.
Results. No statistically significant changes were found in the groups of "elderly" and "young" patients. But in the" middle-aged " group, more striking patterns were determined: 17.5% of patients revealed foci of fibrosis on the valves of the heart valves.
Conclusion. According to the results of the study, the following conclusion can be made: in patients of the middle-aged group (mainly men) who have undergone COVID-19, foci of fibrin deposits on the valvular apparatus of the heart are detected. This may indicate the development of inflammatory processes in the cardiovascular system in COVID-19 .

Молодежный инновационный вестник. 2021;10(S1):148-149
148-149

### ANALYSIS OF THE INCIDENCE RATE OF CARDIOVASCULAR COMPLICATIONS COVID-19 DETECTED BY THE METHOD OF DAILY HOLTER MONITORING

Khandzhyan N., Grigorkin D., Kalinin K.

#### Abstract

ABSTRACT

The SARS-CoV-2 virus is capable of infecting not only the respiratory, but also other systems of the body. A particularly important task of public health is the timely diagnosis of known complications from the cardiovascular system, since CVS pathologies are one of the leading causes of death in the world. An informative method for diagnosing residual heart changes occurring in patients who have undergone COVID-19 during the period of convalescence is the Holter 24-hour monitoring (HM) method. An analysis of studies of 50 patients after suffering COVID-19 disease was carried out in order to identify the most common cardiovascular pathology.

PURPOSE: The purpose of this study is to identify the most frequent complications of COVID-19 from the cardiovascular system that occur in recovered patients during the period of convalescence using the Holter 24-hour monitoring method.

MATERIALS AND METHODS. This study was conducted on the basis of the AUZ VO "VOKKDTs" in the period from November 2020 to February 2021. The experiment included 50 patients, aged 20 to 74 years, of which 38 women and 12 men. The average age is 52. Compliance criteria were a history of COVID-19 disease, as well as complaints of cardiac dysfunction. The study used the Holter monitoring technique. HM is a type of electrocardiography, the technical and clinical capabilities of which allow obtaining continuous ECG recording in several leads [4]. The received data was stored on a solid-state medium and was decrypted by a special device. ECG registration was carried out while maintaining activity, therefore, each subject was recommended to keep a diary, which reflected the type of activity, physical and psycho-emotional stress, periods of sleep and wakefulness. For the study, an ECG monitor with the ability to record in 12 leads was used. Automatic analysis of the data obtained made it possible to calculate the heart rate, determine the onset of rhythm and conduction disturbances, classify them into ventricular, supraventricular, and pauses, and measure the displacement of the ST segment. The recommended ECG bases were used to detect QRS complexes and divide them into ventricular and supraventricular ones. The frequency of occurrence in the study group was calculated for each registered pathological change.

RESULTS.

The study demonstrates that in patients who have undergone COVID-19 disease during the recovery period, using the Holter monitoring method, the following pathological changes are detected: Ventricular extrasystole - in 50% Supraventricular extrasystole - in 34% Long QT syndrome - in 26% Sinus tachycardia - in 16 % Paroxysmal tachycardia - in 14% Mild sleep apnea - in 12% Tanzitorny AV block - in 6% Atrial fibrillation - in 6% Tanzitorny AV block - in 6% SA-blockade of the 2nd degree - in 4% Ventricular arrhythmia - in 4% PQ shortening syndrome - in 2% of subjects

DISCUSSION

As a result of the study, it was found out what pathologies can be detected in patients who have undergone COVID-19 during the period of convalescence. The most common extrasystoles are ventricular (detected in 50% of subjects) and supraventricular (detected in 34% of subjects), which indicates a possible tendency towards the formation of ectopic foci and electrical inhomogeneity of the heart muscle as a whole in patients who have undergone the disease. In addition, long QT syndrome was found in a quarter of the subjects. Representing a reflection on the electrocardiogram of a violation of the repolarization process, this pathological change is a risk factor for the development of such life-threatening conditions as sudden cardiac death and paroxysmal tachycardia.

CONCLUSION Thus, it was found that the disease COVID-19 can cause pathological changes in the heart muscle, which persist even during the period of convalescence. The most common are disturbances in electrical uniformity and cardiac repolarization. Holter monitoring is a reliable and preferred method for diagnosing these pathologies. Taking into account the information received, if a patient with COVID-19 has a history of complaints of cardiac abnormalities, it is advisable, assuming the possibility of developing the above syndromes, to recommend a consultation with a cardiologist followed by Holter monitoring for early detection of arrhythmic disorders and reducing the risk of sudden cardiac death.

Молодежный инновационный вестник. 2021;10(S1):149-151
149-151

### ESTIMATION OF THE NUMBER OF MAST CELLS AND MACROPHAGES IN INVASIVE EDGE AS ADDITIONAL COLORECTAL CANCER PREDICTION FACTOR

Kharchenko A., Pershina A.

#### Abstract

ANNOTATION
Statistical studies show that colorectal cancer (CRC) occupies one of the leading places among oncological diseases. The study of the tumor microenvironment is a trend in modern scientific oncomorphology. Namely, mast cells (MC) and macrophages (MF), as one of the most frequent representatives of the inflammatory microenvironment of the tumor, should be studied.

The aim of the study is to determine the density of distribution of MC and MF in the invasive edge of the tumor in case of colorectal cancer and to identify relationships with clinical and morphological factors in predicting the course of the tumor.

The article analyzes the data of patients with diagnosed colorectal cancer in the period from 2013 to 2018. MC and MF were detected on paraffin sections by immunohistochemistry using monoclonal mouse antibodies. Statistical processing was carried out using Microsoft Excel.

The results of the study showed that MC and MF are widely represented in the tumor microenvironment in the researched material. It was found that the number of MC in the invasive edge was more than 2 times higher in the group of patients with early death and without metastases to regional lymph nodes than the number of cells in the group of people with metastases. Also, in all groups, there was an increase in the number of MC in the invasive edge with a decrease in the degree of differentiation. The quantitative indices of mast cells differed the most in the groups with different degrees of tumor differentiation, which can be used in the assessment of tumor progression as an additional prognosis factor.

Молодежный инновационный вестник. 2021;10(S1):152-154
152-154

### LABORATORY DIAGNOSTICS FOR EVALUATING OF THE RISK OF DEVELOPING ATHEROSCLEROSIS IN PATIENTS FROM SOUTHERN AND CENTRAL FEDERAL DISTRICTS

Khoroshikh A., Mittova V., Maslov O., Ryazantsev S.

#### Abstract

Relevance: Atherosclerosis is one of the most widespread diseases of the cardiovascular diseases in the world. Cardiovascular disease associated with atherosclerosis are a global problem of modern medicine. But its timely diagnosis is often difficult.

The purpose of this study was the investigation of the indicators of lipid metabolism in patients of the Southern and Central Federal Districts

Materials and methods: The clinical study was carried out simultaneously, in the period from January to October 2019, the blood of 323 patients (235 women and 88 men) was examined, and their average age was 48 years. TC, LDL, HDL, apoA1, apoB, AIP and apoB/apoA1 ratio were analyzed.

Results: We revealed that 59.5% of patients have an increased level of TC/ The level of LDL and TG was increased in 61% and 15% of patients with increased TC level respectively. HDL was increased in 44.4% of women and in 63.8% of men with high cholesterol. In patients with normal TC level a decrease of HDL was observed in 62.6% of women and 90.2% of men. In 13.7% patients with normal total cholesterol levels, there was an increase in the level of apolipoproteins A1 to average values of 224 mg/dl. An increase in the atherogenic coefficient, as a result of a decrease in HDL, was found in 26% of patients with normal TC levels

Conclusion: The obtained data unambiguously show that men are more prone to atherosclerosis.

Молодежный инновационный вестник. 2021;10(S1):154-157
154-157

### APPLYING OF SPIROGRAPHY FOR COVID-19 PATIENTS' EXTERNAL RESPIRATION SYSTEM ESTIMATING (CLINICAL CASE REVIEW)

Malyugin D.A., Klyukin A.A., Taratuta R.V.

#### Abstract

Because of COVID-19 pandemic many people faced the need of external respiration system estimating in the rehabilitation period. Patients, who had a COVID-19 and complicated ARDS, have a tendency to decreasing of lung volumes and lungs' diffusion disorders. The target of our research is showing changes in external respiration system functioning, using analysis of spirography data, that were received in three different periods. The main method of our work is the analysis of spirograms and the comparison of indicators - VC, and also indicators that characterize airway patency - FVC and FEV1.

The results of our work are to reduce indicators during illness.The VC indicator was 42.9% and 49.5% of the required value, which is significantly below the norm.The parameters characterizing the patency of the airways also turned out to be below the proper values.The Tiffeneau index was 41.7% and 58.3%, while the proper value turned out to be 81%. In the rehabilitation period, there is a return to the normal VC, but at the same time, slight violations of the airway patency were revealed.

In conclusion, we found that the values of airway and air capacity of the respiratory system, such as VCL, FEV1 and Tiffno index in patients who had COVID-19, obtained by spirometry, can objectively indicate the degree of damage of the respiratory system

Молодежный инновационный вестник. 2021;10(S1):157-159
157-159

## Иммунология и инфекционные болезни

### FEATURES OF PREVENTION OF THE SPREAD OF A NEW CORONAVIRUS INFECTION

Aseeva A.S., Gyulakhmedova A.I.

#### Abstract

Relevance: It is determined by the fact that currently the scientific works of foreign and domestic researchers focus on several dozen types of viruses that are pathogenic to humans. Dangerous viral agents serve as a fundamental factor in the developed mechanisms of many socially-mediated diseases. These include inflammation of the lung tissue, inflammatory lesions of the heart muscle, and lesions of the upper and lower respiratory tract. From December 2019 to the present, new cases of infection with a new coronavirus infection have been reported. On March 11, the World Health Organization announced the start of the COVID-19 pandemic. Objective: to monitor the effectiveness of the implementation of preventive measures that prevent the transmission of the disease associated with the SARS-CoV-2 virus. Methods: In the course of the scientific work, the material was analyzed and the data of the regulatory and legal documentation regulating the procedure and algorithms were summarized

Молодежный инновационный вестник. 2021;10(S1):160-163
160-163

### IMPACT OF NOVEL CORONAVIRUS INFECTION ON THE TREATMENT OF CORONARY HEART DISEASE AND THE INCIDENCE OF CARDIOVASCULAR COMPLICATIONS

Babkin M.O., Kondrashova Y.А.

#### Abstract

Relevance. This study examines the effect of the moderate course of a new coronavirus infection on the patients' ischemic heart disease, and also analyzes the incidence of cardiovascular complications in the early postcovid period. The goal was to analyze the effectiveness of the use of standard therapy for ischemic heart disease in patients with an acute stage of a new coronavirus infection of moderate course and to identify the most common cardiovascular complications within the framework of the postcovid syndrome. Materials and methods. A group of 40 men, aged 47 to 65 years old, suffering from coronary heart disease and infected with a new coronavirus infection was selected. The method of general clinical examination, laboratory and instrumental diagnostics, statistical analysis of data were used. Results. It was found out
that a new coronavirus infection negatively affects the course of coronary heart disease, causing an increase in angina attacks, and also complicates therapy, since the objective effectiveness of anti-ischemic and lipid-lowering drugs in patients was lower than before infection. It also turned out that the system-wide influence of coronavirus also resonates within the framework of the postcovid syndrome - most often patients noted unstable blood pressure, frequent attacks of angina pectoris during habitual exercise, pronounced causeless tachycardia, and swelling of the extremities. Newly diagnosed arrhythmias and myocarditis appeared less frequently. Conclusion. The results of this study can be used to roughly predict the further management of patients and to conduct planned symptomatic therapy for the undesirable consequences of a new coronavirus infection.

Молодежный инновационный вестник. 2021;10(S1):163-166
163-166

### KNOWLEDGE ABOUT THE NEW CORONAVIRUS INFECTION AMONG STUDENTS OF VORONEZH UNIVERSITIES

Bakutina Y.Y., Gudcov V.M., Chertok E.D.

#### Abstract

The new coronavirus infection has made serious adjustments to the organization of public healthcare and preventive measures. The disease is characterized by a high degree of contagiousness, severe course and high mortality, especially in patients with concomitant chronic diseases. The aim of the work was to study the knowledge of students of Voronezh universities about the new coronavirus infection and their readiness to provide assistance to health care for patients. The study was performed with an anonymous survey of 266 students during the" first wave" of infection. According to the results of the survey the knowledge of Voronezh students about the new coronavirus infection is insufficient in terms of transmission routes, clinical manifestations, complications and possible treatment methods. Moreover medical students have insufficient knowledge about the main targets of the coronavirus and the risk factors for severe infection and serious complications development. Most students are aware of the milder course of the disease in children. Unfortunately less than half of the respondents are familiar with the federal guidelines according to the treatment of the disease. More than half of the students expressed their desire to help the health authorities in the treatment and prevention of infection. The authors consider that provide more information to students through Internet sites needs because this can be useful for more active student’s activities in the fight against coronavirus infection.

Молодежный инновационный вестник. 2021;10(S1):167-168
167-168

### FEATURES OF CHANGES IN THE INDICATORS OF THE GENERAL BLOOD TEST IN PATIENTS WITH CORONAVIRUS INFECTION IN DIFFERENT AGE GROUPS

Beskorovaeva A.V.

#### Abstract

This article presents data from the analysis of 68 medical records of patients diagnosed with "new coronavirus infection, COVID-19" and changes in general blood tests. The purpose of the study. To analyze the dynamics of the results of these studies blood count in patients with new coronavirus infection in different age groups and based on indicators of blood from the presence of comorbidities in each group. Materials and methods. For the study, data from 68 medical records of patients with COVID-19 were taken. The diagnosis of coronavirus infection in all patients was confirmed by the detection of COVID-19 virus RNA by PCR flushes from the nasopharynx, as well as by the results of CT examination of the chest organs. The results of the study. All patients were divided into four age groups. In the first group, elderly patients (60-74 years) - 37%, in the second group, middle-aged people (45-59 years) -33%, in the third group-young people (18-44 years) - 27%, and in the fourth group - 3% of elderly patients (75-90 years). In 55% of patients of the elderly group, various concomitant diseases were detected, in 25% of middle-aged patients, concomitant diseases were registered, they were also detected in 15% of hospitalized senile patients, 5% of patients with concomitant pathologies were young patients. Among all the examined patients, lymphocytopenia occurs in 80% of cases, thrombocytopenia in 9% of patients, leukocytopenia and changes in the level of ESR are observed in 5% of patients, leukocytosis-only in 1%.

Молодежный инновационный вестник. 2021;10(S1):168-171
168-171

### RISK FACTORS IN THE DEVELOPMENT OF ACUTE RESPIRATORY DISEASES AMONG STUDENTS OF VSMU IN AUTUMN-WINTER PERIOD 2020-2021

Kalashnikova P.M., Buksha M.S.

#### Abstract

Acute respiratory diseases are one of the leading infectious pathologies at the moment. Determination of risk factors in the development of respiratory diseases can qualitatively improve the prevention of diseases of this group. The research material is based on the results of an online survey of VSMU students. N.N. Burdenko, which includes questions on identifying health status, determining the frequency of respiratory diseases per year, the presence of chronic pathology, as well as those related to lifestyle. As a result, the leading risk factors for the development of acute respiratory diseases were identified.

Молодежный инновационный вестник. 2021;10(S1):171-173
171-173

### EPIDEMIOLOGICAL FEATURES OF MORBIDITY, METHODS OF CONTROL AND PREVENTION OF COVIND-2019

Vrakov Z., Yaglo V.

#### Abstract

Annotation.
Relevance: To date, people have witnessed three deadly pandemics in the twenty-first century associated with new coronaviruses: SARS, Middle East respiratory syndrome (MERS), and COVID-19. All of these viruses that cause acute respiratory tract infections are highly contagious in nature and cause high mortality. The newly emerging COVID-19 disease is a highly transmissible viral infection caused by another new zoonotic coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). SARS-COV-2 originated from bats that serve as an established reservoir. It is still unknown how the virus is transmitted from bats to humans, rapid transmission of the virus from person to person has been confirmed. The disease first appeared in Wuhan, China in December 2019 and quickly spread around the world infecting 48,539,872 people and causing 1,232,791 deaths in 215 countries, and at the moment the infection is still spreading. For effective methods of combating this infection, it is important to understand the source of the infection, the ways of transmission, how many people suffer from severe and mild forms, whether there are risk groups, whether immunity develops in a viral disease, and whether the fight really reduces the prevalence of the disease. All these questions are of interest to everyone.
Objective: To identify risk groups and study the spread of the disease among different age groups of individuals for effective prevention and control of coronavirus infection.
Methods: The analysis of the features of the distribution of coronavirus infection in the territory of the Voronezh region based on the data of statistical reporting forms was carried out.
Results: According to operational data, 60.071 cases of new coronavirus infection were registered in the Voronezh Region as of 05.02.2021. The incidence rate is 2580.57 cases per 100 thousand of the population. The percentage of diseased population groups: Children up to 1 year sick 0.15% of cases, Children aged 7 to 14 years have 3.2% of cases, Persons from 18 to 29 years sick in 10.1% of cases, Persons 30 to 49 years sick in 36.3% of cases, persons from 50 to 64 years in 30.6% of cases, Persons older than 65 years in 16.1% of cases. It can also be said that infection in the family hearth occurs in 34.3% of cases.
Conclusion: According to the above data, it can be concluded that the working class of people from 30 to 49 years old are more ill, to reduce the spread of coronavirus infection, a number of preventive measures must be observed: such as maintaining social distance, separating crowded groups, wearing masks in public places, etc. The infection is quite new, and therefore has not yet been fully studied.

Молодежный инновационный вестник. 2021;10(S1):173-175
173-175

### EPIDEMIOLOGICAL FEATURES OF NEONATAL SEPSIS IN THE RUSSIAN FEDERATION AND WORLD

Gomanova L.I., Sytaya J.S.

#### Abstract

Relevance. Neonatal sepsis is a systemic infection associated with inflammation and life-threatening organ dysfunction. It remains the leading cause of morbidity and mortality among newborns, especially in middle and low-income countries. According to modern data, more than 3 million newborns suffer from sepsis every year in the world. Neonatal sepsis is still difficult to diagnose due to its non-specific signs and symptoms. Health care-related infections (HAIs) and drug resistance remain important issues for sepsis.
Purpose. Summarize and analyze the epidemiological features of neonatal sepsis in the Russian Federation and the world, highlight the problems regarding sepsis in newborns.
Materials and methods. In the course of scientific work, the data of the State. reports on the sanitary and epidemiological well-being of the population of the Russian Federation for 2018-2019; data of statistical materials of Medico-demographic compilations of the Russian Federation for 2009-2018. Rosstat (table 4.85); and also summarized the data of scientific foreign and domestic literature of recent years from the Pubmed and eLibrary databases on the epidemiology of neonatal sepsis.
Results. Mortality from sepsis among newborns for the period from 2009 to 2015 in the Russian Federation had an upward trend, however, since 2016, there has been a downward trend. In 2009, 369 newborns died from bacterial sepsis (21.0 per 100 thousand live births), but in 2015, sepsis led to the death of 688 newborns (35.5 per 100 thousand live births). Then the number of newborns who died from sepsis began to decrease from 652 (34.5 per 100 thousand children born alive) in 2016 to 536 (33.4 per 100 thousand children born alive) in 2018.According to WHO, neonatal sepsis is the third largest the frequency of the cause of neonatal mortality. Globally, neonatal mortality has shown a declining trend over the past 20 years, from 50.6 per 1000 live births in 1998 to 28.9 per 1000 live births in 2017.
Conclusion. Neonatal sepsis remains an important public health problem, as it leads to severe consequences for newborns (multiple organ failure, distress syndrome, coma, mental retardation). Infectious diseases of the mother, unjustified use of antibacterial drugs, catheter-associated infections, premature birth, low birth weight are factors contributing to the development of neonatal sepsis. Modern epidemiological data prove that with proper preventive measures, these risk factors can be minimized, which will positively affect the quality of life of newborns.

Молодежный инновационный вестник. 2021;10(S1):175-178
175-178

### CLINICAL AND LABORATORY FEATURES OF THE NEW CORONAVIRUS INFECTION COVID-19 IN PATIENTS OF THE CITY OF VORONEZH AND THE VORONEZH REGION

Gorlov K.V., Narzieva M.

#### Abstract

Relevance: Currently, the relevance of the new coronavirus infection COVID-19 is not in doubt by most experts. The pandemic of the disease has been going on for 8 months, during this time more than 22 million cases of the disease have been identified, more than 780 thousand people have died.
Purpose: to study the clinical and laboratory features of COVID-19 in adults of the city of Voronezh and the Voronezh region, with mild and moderate forms of the disease. Materials and Methods: There were 42 patients with laboratory confirmed new coronavirus infection under observation.
Results: The patients' age ranged from 19 to 68 years, on average 35 [29; 40]. The asymptomatic course of infection occurred in 12.1% of patients, with the development of pneumonia, the disease proceeded in 47.6%. The disease began gradually with a slight deterioration of the condition, weakness, slight coughing and fever by 2-3 days of illness. Mostly the patients had subfebrile fever. Dry cough was observed in half of the patients, in a third there was a lesion of the upper respiratory tract. All patients recovered by 10 [8; 12] day from the first positive PCR test for SARS-CoV-2.
Conclusion: in most cases, the disease developed gradually with a slight deterioration in well-being, weakness, numbness and fever by 2-3 days of illness.

Молодежный инновационный вестник. 2021;10(S1):178-181
178-181

### ORGANIZATION FOR PROVIDING SPECIALIZED MEDICAL CARE TO INFECTIOUS PATIENTS DURING COMBAT OPERATIONS IN THE REPUBLIC OF AFGHANISTAN

Zakurdaev V.A., Buksha M.S.

#### Abstract

It's no secret that infectious diseases during military conflicts significantly influenced the number and nature of sanitary losses. Such highly dangerous diseases as dysentery, cholera, typhoid fever, plague sometimes even predetermined the outcome of military campaigns. The organization of the fight against infectious diseases is relevant not only in hot spots, but also in times of peace, therefore, in this work, the main historical, cartographic and photographic sources were analyzed, reflecting the experience of the medical service of the 40th Army, obtained during the Afghan war, and also was the importance of organizing various anti-epidemic measures has been proven.
Молодежный инновационный вестник. 2021;10(S1):181-182
181-182

### THE IMPACT OF A NEW CORONAVIRUS INFECTION ON THE PSYCHOLOGICAL STATE OF OUTPATIENT PATIENTS

Ivannikova I., Nasanovich T.

#### Abstract

Relevance: At the end of 2019, cases of SARS associated with a new coronavirus infection (hereinafter referred to as COVID-19) were reported in the Chinese province of Hubei, the city of Wuhan. Since March 11, 2020, WHO has announced that the COVID-19 outbreak has become a pandemic. In this situation, according to the WHO, depression has become one of the leading conditions of the population. This is influenced by a lot of factors: loss of work, lack of opportunity to see loved ones, fear for their own health.
Objective: To assess the indicators of the mental state of people with COVID-19, as well as to determine the attitude of parents to the child's illness with a new coronavirus infection. Materials and methods: To achieve this goal, we observed 74 COVID-19 patients, of which 38 were on outpatient treatment, as well as 36 foci of COVID-19 family infection, where children were infected. Respondents were asked to complete the Spielberger-Hanin questionnaire, the Hospital Anxiety and Depression Scale (HADS), and the DOBRO questionnaire.
Results: According to the results of the survey, it was found that in group 1, during the disease, more than 50% of the respondents had signs of subclinical depression, after recovery, this indicator decreased to 2.7%. Also, in the first group, there are high indicators of personal anxiety during the period of being on the sick list, and changes in situational anxiety did not significantly occur. In the second group, 63.8% of parents perceive themselves as responsible for the child's illness. In 58.3%, there is increased anxiety, while 69,4% formed hypnotease.
Conclusion: Thus, the current epidemiological situation, the disease of the new coronavirus infection COVID-19, certainly affects the psychological state of the population. There is an increase in the level of anxiety, the development of depression in the population. When a child is ill, parents often blame themselves for what happened, experience an increased level of anxiety, and as a result, form a protective mechanism in the form of hyponosognosia

Молодежный инновационный вестник. 2021;10(S1):182-185
182-185

### COVID-19 IN ANAMNESIS AS FACTOR PROVOKING HEARING LOSS

Korotkova O., Tvildiani T.A., Sorocina V.V.

#### Abstract

Aim: esteem of hearing ability in COVID-19 reconvalescents, finding out if it is decreased authentically and objectively

Materials and methods: Google-form survey, audiometry in the Android app, nasal endoscopy, interpretation and statistical analysis of results

Results: audiometry in group with subjective hearing decresion had shown that 17 of them (46%) had aberrations between 26-40 dB (1st degree of hearing loss), 20 participants (54%) had aberrations between 0-25 dB (normal). In the control group 4 patients had shown the result near the lowest normal (26-27 dB), so it was estimated as 1st degree of hearing loss. 33 patients had shown the normal result (0-25 dB). In specially divided group with postnasal drip syndrome (confirmed endoscopically) no hearing aberrations revealed.

Conclusion: this research reveals a correlation between COVID-19 in anamnesis and transitory hearing loss. Auditory and vestibular symptoms' combination gives us an opportunity to suppose a vestibulocochlear nerve affection in patients with COVID-19 in anamnesis.

Молодежный инновационный вестник. 2021;10(S1):185-188
185-188

### «MISCRODIAGNOSTIC CENTER» FOR PRIMARY DIAGNOSIS OF ACUTE VIRAL RESPIRATORY INFECTIONS (AVRI)

Moreplavtseva Y.D., Pushkarsky M.V.

#### Abstract

ABSTRACT

Relevance:

The idea of creating an electronic program "Microiagnostic Center for the Primary Diagnosis of Acute Viral Respiratory Infections" was caused by the rapid increase in the incidence of new coronavirus infection, the increased workload on primary care physicians, the need for remote monitoring of the health status of patients at home and providing the most effective and well-timed aid. The most difficult task in the current conditions is the early identification of patients with COVID-19, as it requires a differential diagnosis of AVRI with a different, non-coronavirus etiology, and the determination of the severity of the patient's condition.

Objective: The development of the electronic program "Microdiagnostic Center" for pre-medical primary differential etiological diagnostics of AVRI and for determination of the severity of the patient’s condition on the basis of remote questioning of the patient.

Materials and methods: For the clinical part of the electronic program and the development of the table of differential diagnostic manifestations of AVRI and COVID-19 at the Department of Pediatric Infectious Diseases, we analyzed the clinical features of the course of AVRI when observing 325 children with a laboratory-specified etiology of diseases (using the PCR method, respiratory screen of nasopharyngeal smears) at the age from 10 days to 14 years, hospitalized in the Children's Infectious Diseases Hospital in Voronezh in different years. Among these children: 85 were diagnosed with influenza, 36 had parainfluenza, 54 had respiratory syncytial (RS) infection, 38 had adenovirus infection, 56 had rhinovirus and 56 had new coronavirus infection, confirmed with the PCR method.

Results: A table of differential diagnostic manifestations of AVRI and COVID-19 was developed on the basis of the established clinical features of the course of these deseases. This table was later included in the clinical part of the electronic program "Microdiagnostic Center" for the primary differential etiological diagnosis of AVRI. The program consists of two applications: a server application adapted for all electronic devices based on remote patient questioning with the introduction of thermometry data and pulse oximetry data. The second application is the "alarm buttons". The two were developed by the students of Voronezh State Technological University (VSTU) and by the students of the pediatric faculty of Voronezh State Medical University (VSMU). The potential users of the program are patients, doctors of outpatient clinics, hospitals, and private centers. The completed work is planned to be tested on the admission department of the regional children's clinical hospital № 2.

Conclusion: In January 2021, the 3rd VSTU intensive of education and projects took place, where students presented their projects to clients and experts. The presented project "Microdiagnostic Center" was approved by the experts from both universities and recommended for further development. The management of VSMU and the project leaders were awarded with certificates. The new opportunities for joint work within the framework of the development of the National Technology Initiative of the “Holsnet” market segments appeared as a result of the fruitful work between Voronezh State Technological University and Voronezh State Medical University.

Молодежный инновационный вестник. 2021;10(S1):188-190
188-190

### DYNAMIC OF INCIDENCE WITH HELMINTHIASISES OF KURSK REGION POPULATION

Olovjannikov I.I., Adenle A., Esther C.C.

#### Abstract

The article presents a retrospective analysis of the values from the Department of the Federal Service for Supervision of Consumer Rights Protection and Population Welfare in the Kursk Region (Rospotrebnadzor) for 2014-2018 and reports of the Ministry of Health of the Russian Federation "On the state of health of the population and organization of health care based on the results of the activities of the executive authorities of the constituent entities of the Russian Federation » for the same time-period. An analysis of the incidence of some types of contact helminthiasis and geohelminthiasis among the population of the Kursk region of different age groups for the period 2014-2018 is presented and a comparison is made with the dynamics of the incidence of the same types of contact helminthiasis and geohelminthiasis in the Russian Federation for the specified period, taking into account the general dynamics of the disease with helminthic invasions for the previous years. Possible reasons for the revealed trends in the decrease in morbidity rates in the Kursk region in comparison with the average rates for the Russian Federation and neighboring regions in the groups of children and adults are analyzed. The role of different factors  in conducting preventive medical examinations both in reducing the overall incidence of contact and geohelminthiasis, and in its reduction by certain types of contact helminthiases and geohelminthiasis is discussed. The influence of the practice of classifying the foci of enterobiasis according to the percentage of infection on the decrease in the indicators of the general and relative incidence of enterobiasis in the Kursk region was evaluated.

Молодежный инновационный вестник. 2021;10(S1):190-193
190-193

### CLINICAL AND LABORATORY FEATURES OF CHRONIC VIRAL HEPATITIS C IN THE ELDERLY

Pavlova M.G.

#### Abstract

Annotation. Relevance. Over the past decades, developed countries have seen an increase in life expectancy, and, consequently, an increase in the number of people over 60 in the population structure. This leads to an increase in the frequency of age-related pathologies, in particular chronic viral hepatitis C (HCV), in the structure of morbidity at this age. Objective: to determine the clinical and laboratory features of the course of CVS in elderly patients. Materials and methods. A total of 274 patients with HCV of different ages (including 73 patients over 60 years of age) were examined, who underwent standard general clinical examination, serological examination for markers of viral hepatitis, liver ultrasound, PCR for HCV RNA with genotyping, liver fibroelastometry and viral load. Results. In the case of CVS, elderly patients were more likely to have general weakness, severity and/or pain in the right hypochondrium, and higher rates of fibrosis (F3-F4) compared to patients under 60 years of age. Markers of cholestasis, dysproteinemia, and significantly higher levels of viremia were more frequently detected. In contrast, older patients with HCV were less likely to have HCV genotype 3 compared to patients younger than 60 years of age. Conclusion. The identification of clinical and laboratory differences in the CVS clinic in elderly patients will help the clinician to better diagnose and treat this disease in old age, which becomes especially relevant in the era of radical therapy of CVS with direct antiviral drugs, since it allows including almost all elderly patients with CVS in the group of patients subject to highly effective and safe antiviral therapy.

Молодежный инновационный вестник. 2021;10(S1):193-196
193-196

### FEATURES OF THE COURSE OF IMPORTED DENGUE FEVER IN THE CENTRAL CHERNOZEM REGION

Polivoda B.V.

#### Abstract

Relevance. Over the past two decades, the number of cases of dengue fever (LD) has increased from 505,430 cases in 2000 to 4.2 million cases in 2019, according to WHO. At the same time, the global tourist flow is steadily growing: tropical countries account for up to 50 million tourists each year. The top three countries in terms of the number of reported cases include Thailand, Vietnam, and Indonesia. Since the registration of LD, 1,497 cases of the disease have been imported to the Russian Federation, among which the largest number falls on Moscow, St. Petersburg, the Novosibirsk Region and the Khabarovsk Territory. The absence of pathognomonic symptoms of the disease, the possibility of re-infection with another subtype of the virus with the development of hemorrhagic dengue, the presence of a vector in Russia makes LD relevant for analysis and study by practitioners of various profiles.
Objective: to study the epidemiological history, the main clinical syndromes and the results of laboratory examination of all cases of LD in Voronezh since its registration in Russia.
Materials and methods. Based on the materials of medical histories, 10 cases of dengue fever in Voronezh were analyzed. All patients were hospitalized in the Voronezh Regional Clinical Infectious Diseases Hospital (VOKIB) in 2010-2019 (n=10).
Results. When analyzing the medical records, it was found that all the patients returned from the countries endemic to South-East Asia on the eve of the disease. The clinical features of the disease were fever (100%), arthralgia and myalgia (90%), headache (90%), and gastrointestinal tract damage (40%). Generalized lymphadenopathy, bradycardia, and hypotension characteristic of LD were not detected in any patients. Small-spotted rash was observed in 90 % of cases at a later date in comparison with the literature data, catarrhal syndrome was in 70% of patients, splenomegaly - in 70%, hepatomegaly - in 90%. Small hematomas at the injection sites and a weakly positive "pinch" symptom, as mild manifestations of hemorrhagic syndrome, were detected in 40% of patients, and in 20% of cases were accompanied by a critical decrease in platelets of less than 50x106/l. The hemogram showed leukopenia (100%), relative monocytosis (90%), and thrombocytopenia (80%). In biochemical blood tests, ALT (60%) and AST (40%) increased by 2-8 times. The diagnosis was verified by the detection of dengue virus type 1 and type 2 RNA by PCR.
Conclusion. The course of LD in Voronezh in 2010-2019 was characterized mainly by typical clinical, epidemiological and laboratory symptoms described in the literature, but generalized lymphadenopathy, bradycardia and hypotension were not detected, and the rash occurred later in the disease. With a critical decrease in platelets, no bleeding was observed.

Молодежный инновационный вестник. 2021;10(S1):197-201
197-201

### CLINICAL AND EPIDEMIOLOGICAL FEATURES OF THE COURSE OF VIRAL HEPATITIS A IN CHILDREN IN THE VORONEZH REGION

Trishina S.D.

#### Abstract

Viral hepatitis A (HAV) is still the most common liver disease in humans.
Objective: in this study, we analyze the clinical and laboratory features of the course of HAV in children in Voronezh and the Voronezh region for the period from 2019 to 2020.
Methods: we analyzed 44 medical records of children diagnosed with acute HAV. The average age of the patients was 8.1±3.9 years. The diagnosis was established on the basis of clinical and laboratory studies conducted in accordance with the International Classification of Diseases of the tenth revision. In all patients, anti-HAV IgM was detected in the blood by enzyme immunoassay.
Results: in most patients, the disease was mild to moderate in severity. The pre-jaundice period in 78.5% of patients was mixed. The duration of the symptoms of intoxication was significantly different: in patients with mild HAV, it was 7.5±4.2 days, moderate 11.9±4.7 and severe 19.4±6.4 days. In most patients, the level of total bilirubin was 2.5 times higher than normal. The cytolysis parameters were increased by 6 times compared to the normal values. The symptom of cholestasis was detected in 100% of patients. Biochemical parameters of cholestasis were 2 times higher than normal.
Conclusions: HAV remains an urgent public health problem to date. The clinical picture is dominated by the cholestatic symptom.

Молодежный инновационный вестник. 2021;10(S1):201-203
201-203

### FIGHT AGAINST INFECTIOUS DISEASES IN THE BASSR DURING THE GREAT PATRIOTIC WAR

Famutdinova A.I., Dautbaev D.G.

#### Abstract

The Great Patriotic War led to a massive movement of the population, large human casualties and economic losses. This required the implementation of active measures in the fight against infectious diseases not only in the front-line regions, but also in the republics remote from the hostilities, where trains with the wounded, refugees, and factories were going from the west. Despite this, the BASSR health care system did not allow the development of epidemic diseases, including through specialized methods of prevention. The study of these measures will make it possible to find out the contribution of Bashkortostan doctors to the struggle for the life and health of the population of the BASSR.

Молодежный инновационный вестник. 2021;10(S1):203-206
203-206

### QUESTIONS OF REHABILITATION IN THE NEW CORONAVIRUS INFECTIONS (COVID-19)

Khasanov A.

#### Abstract

Молодежный инновационный вестник. 2021;10(S1):206-209
206-209

### ANALYSIS OF CLINICAL MANIFESTATIONS OF HFRS FOR THE PERIOD 2017-2019. ON THE TERRITORY OF THE VORONEZH REGION

Hripushin N.

#### Abstract

Relevance. The Voronezh region is a natural focus of HFRS, which ensures the epidemiological and clinical significance of this pathology.
Purpose. Analysis of the features of clinical manifestations of hemorrhagic fever with renal syndrome in the Voronezh region in 2017 and 2019.
Materials and methods. A comparative analysis of clinical data, general clinical laboratory studies in patients of two groups: the first group - 23 patients with HFRS in 2017 and 42 patients with HFRS in 2019.
Results. The analysis of the clinical picture of hemorrhagic fever with renal syndrome in 2017 and 2019 was carried out and the prevalence of intoxication, edema, pain syndromes, signs of oliguria in the development of HFRS in patients in 2019 was revealed.
Conclusion. The leading clinical manifestations of HFRS in 2019 in the Voronezh region are intoxication, pain, edema syndromes, as well as oliguria, at the same time, a decrease in the incidence of such important symptoms of HFRS as hemorrhagic manifestations, visual impairment, dry mouth was noted. These features of the clinic should be taken into account when making a diagnosis at the outpatient stage.
Keywords. Hemorrhagic fever with renal syndrome, clinical features, hemorrhagic syndrome, myalgia, intoxication.

Молодежный инновационный вестник. 2021;10(S1):209-211
209-211

## Клиническая фармакология и фармакоэкономика

### NEW ANTIVIRAL DRUGS: COMPARATIVE CHARACTERISTICS, MECHANISM OF ACTION

Abramyan A.A.

#### Abstract

Relevance. About 50 million cases of infectious diseases are recorded annually in Russia, of which up to 90% are SARS. They pose a great danger to persons with immunodeficiencies, chronic diseases of the bronchopulmonary and cardiovascular systems, as well as to children.

The research objective. To study the mechanisms of action, the main pharmacological effects, the main indications, contraindications and the main side effects of modern antiviral agents.

Methods. During the scientific work the material of the state register of medicines, the latest versions of the official recommendations of the Ministry of Health of the Russian Federation on the treatment of viral infections was analyzed and data on the range of pharmaceutical products, the pharmacological characteristics of new antivirals were summarized.

Results. Currently a large number of different antiviral drugs are presented on the pharmaceutical market, which differ in the mechanism of action, indications, features of use in different age groups of the population and different effectiveness in the treatment of viral infections.

Conclusion. In recent years separate antiviral drugs have appeared that have a certain selectivity against virus-infected cells and suppress the replicative cycle of the virus, while not damaging the cells of the "host."

Молодежный инновационный вестник. 2021;10(S1):212-214
212-214

### ETIOLOGICAL STRUCTURE OF ACUTE POISONING IN ADOLESCENTS OF THE VORONEZH REGION IN 2016-2019

Arustamyan A.A., Karpushkina E.S.

#### Abstract

In pediatric practice, the most common reasons for seeking medical attention and hospitalization in intensive care units include poisoning with poisons and drugs.

The purpose of the study: to determine the structure, characteristics and frequency of acute poisoning among adolescents in the Voronezh region.

Methods: the study was conducted retrospectively based on the analysis of medical records for 2016-2019. In total, 50 medical records of children aged 11-17 years were analyzed, including 26 boys.

Results: drug poisoning was observed in 27 people (54%), narcotic and psychotropic substances – in 11 children (22%), alcohol – in 4 adolescents (8%), the rest – animal bites, carbon monoxide poisoning. Poisoning in adolescents, in most cases, was intentional, among the drugs were dominated by anxiolytics, neuroleptics, analgesics and combinations of drugs. Most of the children were admitted with moderate to severe poisoning. In all cases, a favorable outcome of treatment was observed.

Conclusions: in order to reduce cases of poisoning, it is necessary to increase individual control over adolescents, strengthen the quality of work of psychologists in educational organizations and sanitary and educational work in educational institutions.

Молодежный инновационный вестник. 2021;10(S1):214-217
214-217

### COMPARISON OF THE FEATURES OF THE USE OF DRUGS FOR THE PURPOSE OF SELF-MEDICATION BY MEDICAL STUDENTS OF SENIOR AND JUNIOR COURSES

Kiyaev A.B., Voluyko P.A., Zhirnova S.V.

#### Abstract

Summary:

Relevance. According to the definition of the World Health Organization (WHO), self-medication is the use of drugs by a consumer to treat disorders and symptoms recognized by itself. Every year, there is an increasing trend towards self-medication in the world, which is associated with an increase in the level of education of the population in the field of health care, lack of time, as well as the mass prevalence of various types of advertising.

Research objective. Perform a comparative analysis of the prevalence and features of the use of medicines without the appointment of a doctor by medical students of junior and senior courses of study of the Medical Academy named after S. I. Georgievsky.

Materials and methods. The study was conducted using the online questionnaire method, which was attended by 360 respondents who are students of senior and junior courses of study of the Medical Academy named after S. I. Georgievsky. A survey of students using multiple response options made it possible to assess the frequency of drug use for self-treatment, as well as the level of awareness of respondents about the possible risks of self-use of drugs.

Conclusion. Self-medication is common among medical students in both junior and senior courses. However, among students of different age categories, there are a number of features in treatment approaches. At the same time, respondents demonstrate a responsible attitude to health, understanding all the risks associated with the independent use of medicines.

Молодежный инновационный вестник. 2021;10(S1):217-219
217-219

### FEATURES OF THE CLINICAL COURSE AND PHARMACOTHERAPY OF PNEUMONIA CAUSED BY A NEW CORONAVIRUS INFECTION

Korchagina S.A., Dubrovskiy A.A., Batishcheva G.A.

#### Abstract

Relevance. The pandemic of coronavirus infection COVID-19 has become a global problem of the healthcare system in 2020. Analysis of the actual practice of choosing drugs for the treatment of pneumonia caused by coronavirus infection, depending on the clinical course and laboratory control indicators, is of current importance.

Goal. Evaluation of clinical and laboratory parameters to determine the severity of the condition and the choice of pharmacotherapy in patients with pneumonia caused by COVID-19.

Methods. The object of the study was 100 patients hospitalized with coronavirus infection in the BUZ VO "Voronezh City Clinical Hospital No. 2 named after K.V. Fedyaevsky "in 2020. Taking into account the duration of hospitalization, three groups were formed: group 1 (n = 37) hospitalization for 4-10 days, group 2 (n = 59) - hospitalization for 11-14 days, group 3 (n = 10) - patients with hospitalization ≥15 days who received treatment in the ICU due to the severity of the condition.

Results. Taking into account the volume of lung lesions according to computed tomography, patients with severe pneumonia made up 100% with CT 3 (group 3, n = 10), 25% (group 2, n = 59) and 15% (1- i group, n = 37), respectively. Patients admitted to the ICU also had low oxygen saturation indicators - 91 ± 1.9%. The level of lymphocytes significantly decreased as the condition worsened and amounted to 24.5 ± 8.4% for the 1st group, 18.7 ± 6.6% in the 2nd group, and 11 ± 2.2% in the 3rd group. % (p <0.05). Among biochemical parameters, the most informative was the level of C-reactive protein. The control of fibrinogen made it possible to determine an increase in its concentration in all three groups, in groups 1 and 2 these changes were moderate - 4.7 ± 0.8 g/l and 4.7 ± 0.9 g/l, in group 3 - exceeding the upper limit of the norm by more than 1.5 times - 6.4 ± 0.4 g/l (p <0.05). The ferritin value in patients with coronavirus infection was 2-3 times higher than normal values, while in the 1st group its value was 600 ± 125 ng/ml, in the 1st group 534 ± 199 ng/ml, in the 3rd group ferritin> 3000 ng/ml (p <0.0015). The dosage regimen of drugs depended on the severity of the patient's condition. A distinctive feature of the pharmacotherapy of patients with a severe course of the disease was the long-term administration of dexamethasone intravenously at 24-32 mg/day.

Conclusion. The diagnostic significance of clinical and instrumental data and laboratory parameters is associated with the severity of the course of coronavirus infection. This is important for determining the conditions for the provision of medical care, the choice of a pharmacotherapy regimen, and the duration of hospitalization.

Молодежный инновационный вестник. 2021;10(S1):219-223
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### PHARMACOECONOMIC ASPECTS OF BRONCHIAL ASTHMA TREATMENT

Korchagina S.A., Matyashova A.I., Gridnev N.S., Novik O.I., Batishcheva G.A.

#### Abstract

Relevance. The prevalence of bronchial asthma (BA) in the world reaches 300 million patients, accounting for 6.9% among adults. In clinical guidelines, the main criterion for the effectiveness of BA pharmacotherapy is symptom control with a decrease in the frequency of exacerbation of the disease. The search for clinically significant BA phenotypes is a promising tool for optimizing the pharmacotherapy of the disease in order to increase its effectiveness and reduce treatment costs. It seems promising to study the modes of pharmacotherapy of bronchial asthma taking into account phenotypic heterogeneity in order to calculate pharmacoeconomic indicators to increase the effectiveness of treatment.

Purpose. On the basis of a comprehensive pharmacoeconomic study, substantiate drug provision for patients suffering from bronchial asthma, taking into account the phenotype of the disease.

Materials and methods. The object of the study was 570 patients hospitalized in the pulmonary department of the ChUZ "Clinical Hospital" Russian Railways Medicine ", Voronezh". During the collection of material, 570 records of patients hospitalized with BA exacerbation were filled in. When analyzing the costs of therapy, ABC-VEN-analysis, frequency analysis, the method of “cost minimization” were used. Statistical processing of the results was carried out using Microsoft Excel (2010). The chi-square test and Fisher's exact test were used to assess the statistical significance of the differences. Differences were assessed as significant at p <0.05.

Results. In patients with bronchial asthma, a pharmacoeconomic assessment of therapy for exacerbation of the disease was carried out. Differences in the cost of one bed-day in patient groups were determined by a combination of drugs that included basic treatment (ICS / LABA) and additional therapy (mucolytics, short-acting beta-agonists, systemic glucocorticosteroids), the intake of which depended on the clinical course of the disease. The costs of BA pharmacotherapy depended on the disease phenotype (allergic BA, non-allergic BA, “late onset” BA, BA in obese patients). The study found that the cost of treatment increased by 17-20% in patients with a mixed BA phenotype. The results of the study showed that the formation of drug supply for BA patients should take into account the list of medical prescriptions, and the cost of the pharmacotherapy performed depends on the phenotype of the disease.

Conclusion. The obtained data make it possible to formulate the formulary of the pulmonary department in patients with asthma. This is necessary for planning budgetary funds for financing the therapy of BA exacerbation at the stage of hospital treatment. The continuation of the study is the development of a program for calculating the individual cost of pharmacotherapy depending on the severity of the disease, the duration of inpatient treatment, and the nature of concomitant pathology.

Молодежный инновационный вестник. 2021;10(S1):223-226
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### BIOSENSORS BASED ON NATURAL LUMINESCENT BACTERIA FOR ANALYSIS OF ECOTOXICITY OF DRUGS

Samolyuk V., Katsev A.M.

#### Abstract

Annotation. The ecotoxicity of five medicinal substances: ammonia, niketamide, procaine + sulfocamphoric acid (PS), ketorolac, iron (III) polymaltose hydroxide were analyzed. These drugs are considered as a part of frequently consumed groups of drugs, among them are respiratory stimulants (ammonia, cordiamine, sulfocamphokaine), a non-steroidal anti-inflammatory drug (ketans), an antianemic agent (ferrumlek). The ecotoxicity of each of the mentioned substances was studied on luminous bacteria Photobacterium leiognathi Sh1: toxicity indexes (IT) of various doses of drugs, their effective concentrations as indicators of acute and chronic toxicity (ЭК50О и ЭК50Х). For ammonia, niketamide, PS, ketorolac and iron (III) polymaltose hydroxide, the following ЭК50О values were observed after 15 minutes of incubation with Photobacterium leiognathi Sh1 w - 0.220, 0.612, 0.392, 0.076, and 0.297 mg / ml. After 30 minutes, there was a decrease in ЭК50О by an average of 1% and by another 1% after 60 minutes from the 30-minute value for four drugs. The action of ammonia after 15 minutes led to a complete decrease of luminescence of the P. leiognathi Sh1 strain. After determining EK50O, EK50X was established, having the following values: 0.554 mg / ml - for niketamide, 0.236 mg / ml - for PS, 0.066 mg / ml - for ketorolac and 0.277 mg / ml - for iron (III) polymaltose hydroxide. IT was for: ammonia - 100%, niketamide - 95.93%, PS - 63.47%, ketorolac - 90% and iron (III) polymaltose hydroxide - 82.41%, such values allowed us to identify them as a “highly toxic " group. The obtained results showed that the bioluminescence of the used biosensor test strain decreases under the influence of different classes of drugs. The available literature data make it possible to interpret the quantitative characteristics of inhibition of bacterial luminescence as indicators of ecotoxicity.

Key words: luminescent biosensors, Photobacterium leiognathi Sh1, pharmaceutical pollutants, ecotoxicity parameters.

Молодежный инновационный вестник. 2021;10(S1):227-229
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### THE USE OF MONOCLONAL ANTIBODIES IN THE TREATMENT OF NEW CORONAVIRUS INFECTION

Sorokina V.V., Leonov S.

#### Abstract

The new coronavirus infection, which rapidly swept the whole world,hasbecome a real test for all of humanity. For the first time in several centuries, people are faced with a problem of this magnitude.It touched literally every inhabitant of our planet. Now, the future of not only Russia, but the entire world as a whole depends on how effective they will find a solution to this scourge.
The aim of this study is to consider monoclonal antibodies as cytokine storm antagonists in the treatment of new coronavirus infection.
In this study, the following methods were applied:
• Review of publications on studies of the ICAT application
• Analysis of literature on the research topic
• Processing of statistical data
• Assessment of clinical cases
• Comparative analysis of MCAT drugs, their compliance with the set goal
One of the major achievements of medicine is the invention and use in clinical practice of monoclonal antibodies - inhibitors of interleukin-6, which have shown high efficacy in the treatment of immunoinflammatory rheumatic diseases, and in recent months - in the treatment of cytokine "storm", including COVID-19 ... Many of the MCATs are already being used to treat new infections, while others are in the process of being tested. Along with the effectiveness of inhibiting IL-6 in patients with a severe course of the new coronavirus infection, it is necessary to continue the search for solutions to the issues of immunopathology and pharmacotherapy of this disease.
The pandemic of the new coronavirus infection has proved to be a real threat to all inhabitants of the Earth. There is an urgent need for antiviral drugs, as well as for immune drugs for the prevention and treatment of COVID-19, while the therapy strategy should be basedon the effect on the virus and the human immune system in order to weaken the processes of inflammation in the lungs and prevent the development of acute respiratory distress syndrome.
Молодежный инновационный вестник. 2021;10(S1):229-232
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### MEDICINAL PLANTS OF THE BOTANICAL GARDEN VSMU NAMED AFTER N.N. BURDENKO ACCUMULATING MICROELEMENTS

Fedortsov A.A., Dautova R.R.

#### Abstract

Relevance: This article describes the types of medicinal plants growing in the botanical garden of VSMU named after N.N. Burdenko, which are a source of essential microelements. The systematic belonging of the studied species is indicated, information on the content of various minerals in plants is given, and medicinal properties are listed.

Оbjective: The purpose of this study was to study medicinal plants of the Botanical Garden of the Voronezh State Medical University named after N.N.Burdenko, which accumulate trace elements.

Methods: The study used methods such as determining the taxonomy of a plant, analyzing scientific literature, studying herbarized material.

Results: In the course of the work, 16 species of medicinal plants of the Botanical Garden of N.N. Burdenko, which are sources of the most important minerals necessary for the normal functioning of the human body. The investigated species are included in many medicines and preparations and have been used in scientific medicine for a long time.

Conclusion: Medicinal species of the Botanical Garden of Voronezh State Medical University named after N.N.Burdenko, accumulating trace elements, belong to 5 families of the Angiosperms department. In the vegetative organs and fruits of these species, microelements such as copper, zinc, manganese are mainly accumulated.

Молодежный инновационный вестник. 2021;10(S1):232-236
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### THERAPY OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC PAIN SYNDROME ASSOCIATED WITH DORSOPATHY

Khodarina Y.V., Kartashova E.S., Margulis M.E.

#### Abstract

Relevance: Dorsopathy is one of the most common pathologies in clinical practice in middle-aged and elderly people. With age, the proportion of patients with chronic back pain syndrome increases. At the same time, the risk of developing arterial hypertension (AH) increases, especially with the appointment of NSAIDs. The treatment of this comorbid pathology is rather complicated, therefore, both monotherapy and combined therapy of hypertension are used in clinical practice.
Aim: to determine the features of the treatment of arterial hypertension in patients with chronic pain syndrome associated with dorsopathy in real clinical practice.
Materials and methods: retrospective analysis of history. diseases 85 patients hospitalized in the neurological department of the ChUZ Clinical Hospital "Russian Railways Medicine" in the city of Voronezh "in 2019-2020. The criterion for inclusion in the sample was the presence of comorbidity in the patient: arterial hypertension (AH) and chronic pain syndrome (CHD) against the background of dorsopathy. For each patient, an individual pharmacotherapy chart was compiled indicating the dosage regimen, duration of taking drugs for the treatment of hypertension and chronic heart failure.
Results: monotherapy for the treatment of hypertension was observed in 32.2% of patients, with most patients in this group taking ACE inhibitors. Combination therapy of two antihypertensive drugs was in 38.7% of patients, among whom a combination of a thiazide diuretic (TD) and an ACE inhibitor (ACE inhibitor) was noted in half of the cases. Pharmacotherapy of three antihypertensive drugs was taken by 29.1% of patients, in whom the most common combination of beta-blockers (BAB), TD and ACE inhibitors. Among the observed group of patients with AH and CHD, the prescription of calcium channel blockers (CCBs) was established only in 3.5% of patients.
Conclusion: the analysis of the treatment of hypertension in patients with CHD against the background of dorsopathy showed that combined antihypertensive therapy is most often prescribed in real clinical practice. which was noted in 67.8% of patients. In the case of prescribing a combination of two drugs, the most frequent was the use of TD + ACE inhibitors, with the appointment of three antihypertensive drugs - BAB + TD + ACE inhibitors. With monotherapy, established in 32.2% of cases, ACE inhibitors were the drugs of choice. The prescription of CCBs was established only in 3.5% of patients, which indicates a limited intake of drugs of this group in real clinical practice with frequent administration of ACE inhibitors both in monotherapy and as part of combined pharmacotherapy.

Молодежный инновационный вестник. 2021;10(S1):236-239
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### THE RESEARCH OF UNDESIRABLE ADVERSE REACTIONS TO DRUGS FROM THE GROUP OF FLUOROQUINOLONES

Khodarina Y.V., Musaeva M.M.

#### Abstract

Relevance: Fluoroquinolones can cause undesirable side effects (NPR) that are not detected in pre-registration clinical trials. The analysis of notifications of an adverse reaction or the absence of a therapeutic effect of a drug by pharmacovigilance authorities contributes to the establishment of these NPR data.
Aim: to evaluate the adverse adverse reactions that occurred in patients when using drugs of the fluoroquinolone group for pharmacotherapy.
Materials and methods: a retrospective analysis of 95 notifications about the occurrence of NPR for the use of drugs from the group of fluoroquinolones in clinical practice sent by medical organizations of the Voronezh Region to the Regional Center for Monitoring the Safety of Medicines (RCMBLS) for 2018 - 2020 was carried out.
Results: Every year, more than half of the NPR notifications are for antimicrobial drugs, with NPR for drugs from the fluoroquinolone group (FCH) accounting for an eighth of the total number of NPR for all medicines. Most often, NPR is detected in the form of a hepatotoxic effect and skin allergic reactions, less often-bronchospasm, hemorrhagic rashes, hypotension, etc. The number of dose-dependent NPS prevails over the number of dose-independent NPS.
Conclusion: The steady increase in the use of FH contributes to better detection of NPR. Today, more than half of the identified adverse reactions are due to antimicrobial drugs. Hepatotoxic effect and skin allergic reactions are the most frequent NPR when taking FH, the least frequent include bronchospasm, hemorrhagic rashes, hypotension, etc.

Молодежный инновационный вестник. 2021;10(S1):239-241
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### CHARACTERISTICS OF HUMORAL IMMUNITY INDICATORS IN VIRAL INFECTIONS

Chechekina D.

#### Abstract

The relevance of the problem. To date, there is already solidly proven knowledge about the structure and functions of the immune system. It is well known that the immune system is the only collective organ in the human body, consisting of central (bone marrow and thymus gland, or thymus) and peripheral organs (spleen, lymph nodes, all the lymphoid tissue of the mucous membrane and lymphocytes) [1, 2]. In the protection of the body from pathogens, two systems of immunological protection take part – the reactions of innate (natural) and acquired (adaptive) immunity. The modern concept of anti-infective immunity, formulated by the American researcher Charles Genway, is that the division of the immunological response into innate and acquired is based on two types of receptors for recognizing "one's own" and "someone else's", which are possessed by phagocytes and lymphocytes, and in accordance with this — two types of recognition of pathogens [3, 4]. These receptors perform the same task of recognizing foreign (pathogenic) material, but they are arranged differently and interact with different molecular structures of pathogens, which are patterns or antigenic epitopes [5]. In contrast to the highly specific recognition of antigenic epitopes performed by lymphocytes using

T-and B-cell receptors, phagocytes recognize highly conserved molecular patterns characteristic of large groups of microorganisms. Immunoglobulins are present in the blood in two main states: one part of the molecules is dissolved in the blood plasma, the other part is sorbed on the surface of the blood cells. There is a dynamic equilibrium between them [6, 7].
The purpose of the study. To study the indicators of humoral immunity in specific viral infections
Materials and methods of research. Groups of patients with herpes simplex (PG), chickenpox (VO), herpes zoster (OG) and infectious mononucleosis (MI) who were on inpatient treatment were examined. Diagnosis of PG, HE, OG, and MI was carried out on the basis of clinical, epidemiological, and laboratory data. The secretion of lymphocytes from peripheral blood was performed in the gradient density fillarray. Using a combined rosette formation with sheep erythrocytes and zymosan conjugated complement, B-lymphocytes were tested. The results of the determination of B-lymphocytes were expressed by the relative values in % of the number of circulating lymphocytes and the absolute content in 1 liter of blood.
Results and discussions. The results of the determination of the content of immunoglobulins dissolved in plasma in patients with high potential for chronization (HPV) and acute viral hepatitis B (OVD) are presented below. As follows from the results, the content of immunoglobulin A (IGA) in patients with OVD significantly exceeded the content of immunoglobulins of this class of healthy patients.

Молодежный инновационный вестник. 2021;10(S1):241-243
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### PHARMACOLOGY- ECONOMIC FEATURES OF DRUG PROVISION TO THE RHEUMATOLOGIC DEPARTMENT OF THE REPUBLICAN CLINICAL HOSPITAL

Sheikhmambetova L.N.

#### Abstract

Summary.

Diseases of the musculoskeletal system including joint damage are among the most common reasons for patients seeking doctor’s advice. The prevalence of rheumatic diseases (RD) in general population ranges from 9, 8 % to 33, 2 %. The purpose of the study is to assess the expenditure of material resources allocated for drug provision of the Rheumatologic Department of the State Budgetary Institution of Health Care of the Republic of Crimea “Republican Clinical Hospital named after N.A. Semashko (SBIH RC “Semashko RBC”) for the period from June 2018 to May 2020.

Materials and Methods.

The materials of the study are the data of statistical records of the financial means expenditures on the purchase of drugs for the Rheumatologic Department of SBIH RC “N.A. Semashko RBC” (city of Simferopol). Based on the facts obtained, a pharmacology-economic assessment of the budgetary funds expenditures was carried out by means of ABC/VEN analysis.

Results and discussion.

The total expenditures on the purchase of drugs for provision of the Rheumatologic Department of the Clinical Hospital amounted to 5 308 775,23 rubles with the list of medical products admitted to the Department including 50 names of drugs. The ABC analyses revealed that 80 % of the budgetary funds (A class) were spent on 4 drugs included into the standards of pharmacotherapy of rheumatic diseases, according to VEN analysis all of these drugs were classified as those referred to V category (vitally important).

Conclusion.

The results obtained testify to the high efficiency of the implementation of the state program of drug provision to the Rheumatologic Department of the State Budgetary Institution of Health Care of the Republic of Crimea “Republican Clinical Hospital named after N.A. Semashko (SBIH RC “N.A. Semashko RBC”).

Молодежный инновационный вестник. 2021;10(S1):244-247
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## Морфология

### ANALYSIS OF THE EFFECTIVENESS OF SPERMATOGENESIS IN SABLES OF DIFFERENT AGES

Ulianov I.

#### Abstract

Relevance. Sable is one of the most valuable fur-bearing animals. The determination of the spermatogenic activity of the testis is important when planning the breeding of sables. The most objective data on this issue can be obtained from the quantitative study of spermatogenic cells in animals of different ages.
Goal. To determine the effectiveness of spermatogenesis in sables of different ages.
Materials and methods. The material was obtained from 14 sexually mature individuals, the first group of which (7 individuals) - at the age of 3 years, and the second (7 individuals) -7 years. In the obtained preparations, in 50 convoluted seminal tubules for each animal, spermatocytes were counted in the zygotene, pachytene, and spermatid round (early) stages. To determine the effectiveness of spermatogenesis, a formula was used in which the number of pachytic spermatocytes is N, the number of spermatids is N1, and the theoretically possible number of spermatids is N2 (Nx4). Spermatogenesis efficiency= N1 x 100: N2.
Results. It was found that the efficiency of spermatogenesis in sables at the age of 3 years is 80.9%. In individuals aged 7 years, the efficiency of spermatogenesis was 64.7%.
Conclusion. Based on the results obtained, it can be concluded that the effectiveness of spermatogenesis and the level of sexual activity of the testis in sables at the age of three years is higher than in seven-year-olds. These data allow us to recommend using it for breeding younger sables.

Молодежный инновационный вестник. 2021;10(S1):248-249
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## Неврология

### SOMATIC EXTRUSION AND RISK FACTORS AS FORMOFORMING COMPONENTS OF POST-STROKE DEPRESSION AND ANXIETY IN PATIENTS WITH CMV

Arzhanykh Y., Zolotukhin V.

1428 / 5000

## Результаты перевода

Relevance. Stroke is one of the most common diseases of the nervous system, which is often complicated by the development of anxiety-depressive disorders. Purpose. To assess the incidence and features of the course of depressive disorders in patients with stroke, as well as their relationship with somatic burden. Methods. Retrospective analysis of 40 case histories of patients with stroke, questionnaires using questionnaires: Hospital Anxiety and Depression Scale (HADS), Toronto Alexithymic Scale, TAS-26. Results. Depressive disorders of varying severity were detected in more than 70% of the examined patients with stroke. The severity of functional impairment after stroke directly affects the risk of developing post-stroke anxiety-depressive disorders. Females are more likely to develop depression and anxiety. The overwhelming majority of patients had ischemic strokes in 45% - in the right carotid system, in 35% - in the left carotid system, and in 20% - in the vertebrobasilar system. In 18% of patients, strokes were repeated. Among patients after ischemic stroke and acute myocardial infarction, the proportion of persons with moderate and severe levels of depression was higher. Conclusion. Post-stroke anxiety-depressive disorders negatively affect the rate of recovery of neurological functions and significantly reduce the survival rate of patients with acute cerebrovascular accidents.
Молодежный инновационный вестник. 2021;10(S1):250-253
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### ACUTE SYMPTOMATIC EPILEPTIC SEIZURES IN PATIENTS WITH IMPAIRED CEREBRAL CIRCULATION

Ayubova L.R., Kaliushko A.V.

#### Abstract

Background: Epileptic seizures arise from a 3.0—13.8% of patients with recent acute violation of cerebral circulation. In patients over 60 years of age, stroke is the most common cause of seizures.[1] The relevance of this issue is directly related to mortality among patients who have symptomatic seizures in the acute period of stroke. It was noted that the mortality rate among them is 3 to 10 times higher compared to patients with unprovoked seizures. [2]
Objective: to study the EEG manifestations of acute symptomatic convulsive seizures in patients with acute cerebrovascular accident in the acute period; to study the influence of various factors on the occurrence of seizures and to determine the prognosis.
Materials and methods: analysis of medical records, systematization and grouping of the information received, calculation of the percentage ratio in each study group.
Results: All patients, depending on the changes in the EEG, were divided into 4 groups: with detected epileptiform activity, with the presence of slow-wave activity, with a combination of slowing and epileptiform activity, without pathological changes in the EEG. Within each group, subgroups are identified by age, gender, stroke subtype, and the pool of affected arteries. The analysis of cases of favorable and unfavorable outcomes was also carried out. Most often, fatal cases were observed when the localization of epileptiform activity and deceleration coincided, when the localization of the focus of ischemia and slow-wave activity coincided, with diffuse deceleration, as well as when the focus of ischemia and the localization of epileptiform activity coincided.

Conclusion:In patients with impaired cerebral circulation, acute symptomatic epileptic seizures with EEG registration of epileptiform activity in combination with a slowdown or the presence of only epileptiform activity have a high percentage of mortality and are an unfavorable sign.

Молодежный инновационный вестник. 2021;10(S1):253-256
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### DIFFICULTIES IN EARLY REHABILITATION OF THE PATIENT THE RECOVERY PERIOD OF A CEREBRAL INFARCTION AGAINST THE BACKGROUND OF A POSTPONED CORONAVIRUS INFECTION

Bedirov M.D.

#### Abstract

Relevance. The current situation in world medicine is due to the struggle

with a new coronavirus infection and its complications. Models of the pathogenetic effect of coronavirus 2 acute respiratory syndrome (SARS-CoV-2) in the new coronavirus infection 2019 (COVID-19) on the brain indicate the possibility of both direct and indirect damage. Stroke or acute cerebrovascular accidents are the most common cause of disability and death worldwide. Stroke is also one of the most common complications of a new coronavirus infection from

nervous system.

Purpose. To study the features of the course of ischemic stroke and the features of rehabilitation in the early recovery period in patients with COVID-19 disease

Methods. The analysis of a patient with stroke by ischemic type, developed against the background of bacterial

viral pneumonia of mild severity in a patient with COVID-19.

Results. Treatment, methods and

the results of early rehabilitation, as well as the prognosis of the disease.

Conclusion. The considered case of a complicated course

a new coronavirus infection with the development of ischemic stroke,

proved the effectiveness of the successive management of the patient in

specialized centers for the treatment of COVID-19 and acute cerebrovascular accidents and high economic efficiency, the social significance of intensive multi-vector treatment and rehabilitation from the very

onset of the disease

Молодежный инновационный вестник. 2021;10(S1):257-260
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### TENSION HEADACHE, CLINICAL MANIFESTATIONS AND IMPACT ON THE QUALITY OF LIFE OF STUDENTS OF THE BURDENKO STATE MEDICAL UNIVERSITY

Zemlyankina I.N.

#### Abstract

Tension headache (THa) is the most common type of primary headache.  The prevalence of THa in the world is 42% [1]. Its appearance is caused by various reasons. 1) Tension of the muscles of the shoulder girdle, neck (prolonged stay in a monotonous or non-physiological position). Tension of the scalp causes vasospasm which increased pain. 2) Stressful situations in which the tone of the muscles increases. 3) Sleep disturbance, as a result of which the central nervous system (CNS) does not have time to fully recover. There are clinical types of tension-type headache: episodic (ETHa), chronic (CTHa). ETHa lasts from 30 minutes to a week. CTHa can be daily and non-stop, occurs at least 15 days a month for more than 3 months [2]. They are squeezing - "helmet of a neurasthenic" ("helmet of a Beard"). The pain is usually diffuse,  bilateral, and does not increase with physical exertion. Pain can be transient/permanent, with tension in the occipital region, the back of the neck, and in the shoulders.

The aim of this research work: is to identify the approximate number of students of the Faculty of General Medicine studying at the Burdenko State Medical University, who note the signs of ETHa or CTHa, to determine whether these headaches affect their academic performance and ability to work.

Methods: The data for the statistic analysis were obtained using the questionnaire method. The Guseynovs questionnaire (T.Y Guseynov is the research at the State Scientific Center for Laser Medicine of the Ministry of Health of the Russian Federation) was used to recognizing the approximate type of headache. Students were asked questions: 1) do you think that pain affects your academic performance/ability to work? 2) are you capable of purposeful productive activities? 3) is your academic performance / ability to work getting worse/better?

Results: Above 170 people participated in the survey (145 had THa).

Conclusions: THa occupies a leading place among cephalgias in the surveyed students, with their ability to learn/work is not impaired, the quality of life (QoL) doesnt suffer.

Молодежный инновационный вестник. 2021;10(S1):261-263
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### HOW TO PUT INTO PRACTICE MODERN APPROACHES TO THROMBOLYSIS AGAINST THE BACKGROUND OF A SEVERE COURSE OF ARTERIAL HYPERTENSION

Elizarova T.S., Dmitrii K.V.

#### Abstract

Relevance. Ischemic stroke accounts for 85% of all. Currently, there are theories of the "therapeutic window" and the theory of the "ischemic cascade" [1,5]. In most cases, a stroke is disabling; only 10-13% of patients return to their previous life.
Purpose of the study. To evaluate the ways of implementing modern approaches to thrombolysis against the background of severe course of arterial hypertension (AH).
Materials and methods. We examined a 58-year-old woman with a diagnosis of lacunar ischemic stroke in the basin of the right middle cerebral artery, syndrome of left-sided hemiparesis, dysarthria. Were identified (CT) small cysts in both hemispheres of the brain (GM), mainly in the parietal lobes, and the absence of clear boundaries between the gray and white matter of the GM without clear focal signs of hypodensity. Testing was performed according to standard methods - NIHSS 17 points, Glasgow Coma Scale (GCS) 15 points, Rehabilitation Routing Scale (SRM) 5 points, Rivermead Index (IR) 0 points. The treatment was carried out in accordance with the Russian clinical guidelines for the management of patients with IS. Duplex ultrasound scanning of the brachiocephalic arteries revealed signs of atherosclerotic lesions of the great vessels at the extracranial level and stenosis of the left common carotid artery in the area of ​​the bulb (50%). ECHO-KG reveals intact left ventricular function without signs of myocardial hypertrophy. After the transfer of the patient to the department, drug therapy and a rehabilitation plan were developed.
Results. Standard techniques were repeated - NIHSS 9 points GCS -15 points, SRM-3 points, IR 10 points. The results of the second stage were regression of hemiparesis and left hemiparesis, mild dysarthria, independent movement; NIHSS 5 points, GCS 15 points, SRM 1 point IR - 13 points. The patient continued to have minor limitations in self-care.
Output. With a timely visit to a doctor, the use of the drug alteplase, control of blood pressure, with the observance of the thrombolytic therapy protocol, one can observe good and stable results of the treatment of IS, which shows the effectiveness and appropriateness of the systemic thrombolysis technique.

Молодежный инновационный вестник. 2021;10(S1):263-264
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Kuslivaya A.V.

## Исходный текст

Relevance. Stroke is a state medical and social problem, therefore, effective measures aimed at preventing stroke are extremely important. Cerebral stroke is a polyetiological and heterogeneous pathological process that requires an individual approach to stroke prevention.
Objective. To assess the possibility of using phenotyping of acute cerebrovascular accident (ACVA) according to the ASCOD gradation with an assessment of treatment compliance to identify the most significant risk factors and develop effective individual primary and secondary prevention of cerebral stroke in certain groups of patients.

Methods. The object of the study was 48 patients of working age with acute cerebrovascular accidents who were hospitalized in the department for patients with cerebrovascular accidents at the State Healthcare Institution VOKB No. 1 in Voronezh from 1.10.2019 to 20.04.2020. In retrospective analysis, a list of criteria for stroke risk factors was used. For patients with stroke, special phenotyping was used. The ASCOD system includes: A - atherosclerosis; S - disease of small vessels; C - heart disease; O - other reasons: D - dissection of arteries and allows assessing the contribution of various etiological factors and pathogenetic mechanisms to the onset and development of stroke. Compliance was assessed using the MMAS-8 scale (Morisky-Green). Results. The study involved 48 patients, 76% of them were men, 23% were women. The average age of the patients included in the study was 45-46 years. Among the examined patients, 10 were on treatment with a diagnosis of hemorrhagic stroke (HI), 38 - with a diagnosis of ischemic stroke (IS). Among patients with IS, the atherothrombotic subtype was identified in 20 patients (54%); cardioembolic subtype - in 4 patients (12%); lacunar subtype - in 14 patients (34%). With the help of clinical examination and ASCOD, the subtypes of IS were verified in the following ratio: atherothrombotic - 10 patients; cardioembolic - 4 patients; lacunar - 10 patients, other etiology elucidated - 2 patients, unexplained etiology - 12 patients. When phenotyping - 28 out of 38 patients with ACVA had at least one main identified factor in the development of an ischemic event. Using ASCOD and clinical examination, basic risk factors were identified : in 14 patients (39%) - two or more risk factors, in 40 (83%) - 4 or more risk factors out of 11 indicators of the generally accepted list. Of the frequently detected factors, it was possible to note the lack of blood pressure control - 40 patients (83%) and dyslipidemia with stenosis of the brachiocephalic arteries (BCA) - 24 patients (50%). According to the Moriska scale, 2 patients (4%) had high adherence to treatment, average - 6 patients (12.5%), low –24 patients (50%). A number of patients failed to assess adherence, because these patients were not examined for a long time (except for preventive examinations) and did not receive appointments.

Discussion. Taking into account the results of the study, it is possible to offer personal prevention of stroke in cases of insufficient blood pressure control and dyslipidemia with BCA stenoses, the basis of which will be correct antihypertensive therapy and adherence to it, as well as the identification of the severity of BCA dyslipidemia and stenosis with the appointment of adequate lipid-lowering therapy and possible surgical treatment.

Conclusion. An individual strategy for the prevention of stroke should include the timely identification of risk factors for stroke, correction of modifiable risk factors, dynamic monitoring of patients with a burdened hereditary history and / or those who have had cerebral stroke with the appointment of correct therapy and compliance to it. In order to identify the most significant risk factors and develop effective individual primary and secondary prevention of cerebral stroke during outpatient and inpatient treatment of patients with cerebrovascular diseases, it is advisable to use ACVA phenotyping according to ASCOD gradation with an assessment of treatment compliance.
Молодежный инновационный вестник. 2021;10(S1):265-267
265-267

### THERAPY OF PSYCHOMOTOR DISORDERS IN PATIENTS WITH ALZHEIMER'S DISEASE

Kutashov D.V.

#### Abstract

Relevance: At the moment, there is a clear trend of increasing the incidence of AD, which makes the problem of treating this pathology one of the most important tasks of modern neurology and psychiatry

Objective: To review the literature on the treatment of agitation and aggressive behavior in patients with AD.

Materials and methods: A search was conducted for articles in the PubMed database published from 1996 to 2020. using the keywords: "Alzheimer's disease", "dementia" and "agitation", "aggression", "neuropsychiatric symptoms".

Results: A review of 53 publications showed that both medicinal and non-medicinal methods can be used for the treatment of agitation and aggression. Regarding the pharmacotherapy of agitation in AD, according to the RCT data, it was noted that antipsychotic drugs have moderate benefits, but adverse effects limit their use.

Conclusion: There is an increase in the evidence base for the use of both pharmacological and non-pharmacological methods of treating agitation and aggression in AD. Non-pharmacological methods of therapy should be used as the first line and combined with the use of drugs, which is necessary in the absolute majority of cases.

Молодежный инновационный вестник. 2021;10(S1):267-268
267-268

### NEURONAL SUBSTRATES OF FORMATION AND POTENTIAL TREATMENTS FOR LEVODOPA-INDUCED DYSKINESIA IN PARKINSON'S DISEASE

Kutashov V.A., Vostrikova K.V.

#### Abstract

Relevance: Today, one of the main drugs for the treatment of Parkinson's disease is levodopa. Prolonged treatment leads to so-called dyskinesia. In this regard, at the moment, this problem continues to be relevant.

Objective: To evaluate possible clinical features, neuronal substrates of formation, as well as psychopharmacological and surgical methods of treatment of DVL.

Materials and methods: The studies for this review were selected from the PubMed and PsychINFO databases using the keywords "deep brain stimulation", "dopamine"," levodopa-induced dyskinesia", "Parkinson's disease".

Results: The most common symptoms of DVL were chorea and dystonia. It was found that the use of continuous infusion of levodopa was successful in the treatment of patients with severe PD and there was no risk of an increase in the formation of dyskinesia compared to oral therapy with levodopa.

Conclusion: DVL is a common side effect of PD treatment with dopamine. With parenteral administration of levodopa (including subcutaneous, intramuscular, and intravenous administration), there is a lower probability of DVL.

Молодежный инновационный вестник. 2021;10(S1):268-269
268-269

### HOMOCYSTEINE IS A FACTOR IN THE DEVELOPMENT OF DEMENTIA

Medvedeva M.

#### Abstract

Homocysteine (Hcis) is a sulfur-containing non-protein amino acid. Hcis is a member of the group of endogenous thiols that provide the redox balance of cells. Endogenous thiols can exhibit both pro-and antioxidant properties, depending on their physiological state. Hcis, formed in the methylation reaction of methionine, has neurotoxic properties. Normally, the level of homocysteine in the blood should not exceed 7 mmol/l. It was noted that when the level of Hcis is more than 11.9 mmol/l, the risk of damage to the white matter of the brain is tripled, and an increase in the level of Hcis more than 14 mmol / l doubles the risk of developing Alzheimer's disease. The causes of hyperhomocysteinemia are defects in the structure of genes encoding the necessary enzymes for the neutralization of homocysteine, smoking, taking certain medications, thyroid diseases and metabolic disorders, as well as, most often present in elderly patients, a deficiency of B vitamins (folic acid, B12, B6). The hippocampus is particularly sensitive to the effects of homocysteine. Molecular damage to the nerve cells of the brain structure responsible for the processes of memory formation is accompanied by various cognitive disorders that are prone to progression. The neurotoxicity of homocysteine is due to several mechanisms: on the one hand, the formation of endothelial dysfunction, leading to hypoperfusion of neurons, on the other hand, a direct effect on the nerve cell in the form of oxidative stress, which results in cellular apoptosis.

Молодежный инновационный вестник. 2021;10(S1):270-273
270-273

### FACTORS THAT INCREASE THE RISK OF EATING DISORDERS IN GIRLS DURING THE COVID-19 PANDEMIC

Mudrakova T.A.

#### Abstract

Relevance. Due to the recent emergence of a new coronavirus infection, the problem of the COVID-19 pandemic on the incidence of mental illness has not been sufficiently studied. In particular, it is not known whether there is an association between the pandemic and the risk of developing eating disorders (ED) in girls. This study investigated the psychosocial factors of a pandemic that increase the risk of RCC. Purpose. To identify the factors that increase the risk of ED in girls 17-23 years old. Materials and methods. The study was conducted in the period November 2020 - January 2021. To use psychosocial risk factors for ED, a compiled questionnaire was used, including the main risks and a food preference test (Eating Behavior Test, EAT-26). The sample consisted of 386 girls aged 17-23. The analysis of the obtained data was carried out in Microsoft Excel 2010 and by manual method. The principle of rank scaling was used. Results. During the COVID-19 pandemic, the overall risk of ED in girls increased by 3.8% compared with the results of the 2018 study [2]. Girls who are diagnosed with new chronic diseases during a pandemic have a 21.3% higher risk of ED than girls without new pathologies. One in five girls who leave home in a pandemic once a week is found to be at risk of ED. The respondents who began to go to such places less often had a 10.6% higher risk of ED than those who began to go to such places less often. The following factors did not significantly affect the risk of ED: financial situation, feelings of social constraints. Girls with reduced work / study load have a 7.9% higher risk of ED than girls with increased workload. The most unfavorable in terms of the risk of ED is the “food addiction” method of dealing with turnout stress (the risk of ED is 19%). Conclusion. The risk of ED is increased by psychosocial factors: detection of new chronic diseases during a pandemic, the frequency of leaving the house once a week, the frequency of visits to social services corresponds. use, reduce the load, eat more food, as a method of dealing with stress

Молодежный инновационный вестник. 2021;10(S1):273-275
273-275

### ANALYSIS OF THE ANXIETY AND DEPRESSION IN THE WORKING POPULATION DURING THE NEW INFECTION OF CORONAVIRUS

Nomokonova E., Ponomareva D.A.

#### Abstract

Relevance: In 2020, WHO announced the beginning of a pandemic of a new coronavirus infection. This led to the introduction of new measures to limit its spread around the world. Each person was affected in one way or another by the consequences of the pandemic (changes in work schedules, economic costs and, accordingly, financial instability, the occurrence of the disease in friends and relatives, the introduction of a mask regime, etc.).
Objective: The objective of this study was to try to trace trends in the level and structure of anxiety and depression over time (before the announcement of the self-isolation regime, during the first and second waves of coronavirus), to identify factors that can influence these processes, as well as the impact of anxiety on compliance with COVID-19 prevention measures.
Methods: For this purpose, an online survey was conducted (the sample size was 69 people), the results were processed by statistical methods and compared with data in similar, but larger studies for different time periods.
Results, conclusion: During the analysis of the data obtained, the percentage of people with increased anxiety/depression was determined, compared with similar indicators for an earlier period, and the main factors that can lead to adaptation disorders (the appearance of increased anxiety and depression) were identified.

Молодежный инновационный вестник. 2021;10(S1):276-280
276-280

### MIGRAINE IN CHILDREN OF THE CITY OF BARNAUL

Reshetnikov A.

#### Abstract

The article presents a description of a migraine attack, prevalence in the Altai Territory, the main provoking factors and problems of primary diagnosis in pediatrics

Молодежный инновационный вестник. 2021;10(S1):280-282
280-282

### KEY FEATURES OF THE DIAGNOSIS AND TREATMENT OF HEREDITARY NEUROPATHIES. CLINICAL CASE REVIEW

Khodarina Y.V.

#### Abstract

Relevance: Hereditary motor-sensory neuropathies (NMSN) are a broad heterogeneous group of diseases of the peripheral nervous system, which are characterized by genetic determinism, different types of inheritance and polymorphism of phenotypic manifestations. The prevalence of NMSN varies from 5 to 40 cases per 10,000 people. In the Russian Federation, it is an average of 5.64 cases per 10,000 population. NMSN is characterized by the rapid development of complications - joint contractures, pronounced amyotrophy, movement disorders, which, in the absence of effective therapy for the primary disease, entail a noticeable decrease in the quality of life and early disability.

Aim: To study the features of the course, diagnosis and therapy of hereditary Charcot-Marie-Toute neuropathy in clinical practice.

Materials and methods: Current clinical studies on Charcot-Marie-Toute disease, its diagnosis and treatment are analyzed. A patient of the neurological department of the VOKB No. 1 suffering from hereditary Charcot-Marie-Toute neuropathy (NNSMT) was examined.

Results: The pathological process in NNSMT affects the distal parts of the extremities and is manifested by their weakness, hypo-or areflexia, loss of deep and superficial sensitivity. The article presents a clinical case of a patient suffering from NNSMT. A three-stage diagnosis of the disease was performed: neurological examination of the patient, electroneuromyography and molecular genetic analysis of the pathology.

Conclusion: The symptoms of hereditary neuropathies consist of peripheral tetraparesis and hypo-or atrophy of the muscles of the distal extremities. The lack of effective treatment leads to complications of the disease: muscle contractures and pronounced amyotrophy, and, consequently, leads to a progressive decrease in the quality of life and early disability of the patient.

Молодежный инновационный вестник. 2021;10(S1):282-285
282-285

### KINESIOTAPING IN THE COMPLEX THERAPY OF MIGRAINE

Tarasova A., Khomyakova A.

#### Abstract

Relevance. Migraine is a disease that significantly affects the working capacity of patients and the quality of life. Migraines affect from 15% to 25% of the population of developed countries (the share of chronic migraines reaches 0.8-2.8%).
Goal. To evaluate the effectiveness of kinesiotaping in patients with migraine to correct the established myofascial pain syndrome.
Methods. We examined 40 women with a diagnosis of migraine and conducted functional testing, including a palpation study of the trapezius muscle and an assessment of the amplitude of movement of the cervical spine in lateroflexia. To influence the pain points of the trapezius muscle, the kinesiotaping technique was used
Results. In 40 patients, when testing the muscles of the cervical spine with palpation before taping, myofascial pain syndrome was established in the form of pain points in the area of the trapezius muscles, in addition, 16 patients showed pain points of the belt muscle and a restriction of the amplitude of movements in the cervical spine with lateroflexia. After applying the technique of muscle correction by kinesiotaping, in all 40 patients by palpation, there was no tension in the area of all myofascial segments, trapezius muscle, 16 patients noted a decrease in pain density in the area of the lower pain point of the belt muscle. There was an increase in the amplitude of movements in the cervical spine in lateroflexia. There were significant differences in the severity of headache on the "VAS" scale under the influence of kinesiotaping[1,2].
Discussion. Knowing about the comorbidity of migraines and myofascial pain syndrome (MBS), the role of MBS in the chronization of migraines and the correction of muscle dysfunction is an important task in the treatment of migraines along with classical approaches. Myofascial pain points in patients with migraine provoke reflected pain from certain painful seals, spreading to the cranial zones, thereby activating the trigeminovascular system[1,4]. This leads to the development of allodynia, associated with low efficacy of drugs.
Conclusion. The method of kinesiotaping has shown its effectiveness in the prevention of pain attacks.
We consider it advisable to use kinesiotaping as a method of therapy for migraines.

Молодежный инновационный вестник. 2021;10(S1):285-287
285-287

## Управление в здравоохранении

### ASSOCIATION OF SUPRAVENTRICULAR CARDIAC ARRHYTHMIAS WITH ANTHROPOMETRIC CHARACTERISTICS OF PATIENTS

Vlasenkova A.A.

#### Abstract

Relevance. Atrial fibrillation (AF) is the most common cardiac arrhythmia, which is a growing public health problem in populations around the world. In addition to being an independent risk factor for stroke, AF is associated with a higher risk of heart failure and death. At the same time, the risk factors for AF have not been sufficiently studied.
Objective: To conduct a comparative analysis of the anthropometric characteristics of patients with the presence and absence of supraventricular arrhythmias.
Methods: Assessment of anthropometric parameters (height, body weight) of patients. Analysis of medical records of 72 patients (36 patients with AF and 36 patients without supraventricular arrhythmias) in a cardiology hospital. The results of standard ECG and daily ECG monitoring were evaluated.
Results:
The average height of patients with AF was significantly higher than in those with sinus rhythm (178±7.79 cm and 169±8.63 cm, p<0.05). At the same time, there were no statistical differences in the BMI value.
Conclusion: The anthropometric features of patients with atrial fibrillation, consisting in a higher growth compared to those without supraventricular arrhythmias, were established. In this regard, it seems appropriate to use such a simple and easily determined indicator as human height when assessing the risk of developing AF.

Молодежный инновационный вестник. 2021;10(S1):288-290
288-290

### REASONS AND FACTORS OF THE PREVALENCE OF SELF-MEDICATION AMONG THE POPULATION OF THE REPUBLIC OF TATARSTAN

Gafurova C.

#### Abstract

Relevance. A large proportion of the population is engaged in self-medication, and it can lead to negative consequences such as complications of diseases and a decrease in the effectiveness of drugs. If we know the reasons for the spread of self-medication, we can better regulate it, and it will help to reduce this negative consequences.
This study was conducted in order to clarify the causes and factors of the spread of self-medication.Materials and methods. 105 respondents from the Republic of Tatarstan took part in an anonymous online survey.Results. We identified some reasons of the prevalence of self-medication among the population of the Republic of Tatarstan: violation of the rules for selling prescription drugs, insufficient literacy of the population in matters of self-medication, problems with the availability of medicine. This article discusses the factors that people rely on when choosing a method of treatment, as well as the methods of self-medication that are used by the population. We found out the reasons for the reluctance to go to a medical institution such as long queues, inability to register, absence of a doctor, lack of time and disrespectful attitude of medical workers.We found out that a fifth of the population turned to self-medication because the treatment prescribed by the doctor did not help. The satisfaction of the population with the quality of services provided in hospitals and satisfaction with self-treatment were assessed. The level of awareness of the negative consequences of self-medication was not high enough, about 40% of respondents assumed that there were no negative consequences of self-medication. The level of public confidence in medical personnel turned out to be high in the Republic of Tatarstan - 90%. However, there was less confidence in drug treatment - only half of the respondents consider them more effective than traditional drugs.Conclusion. Considering that it is necessary to resolve the problem of the self-medication spreading, medicine should be more accessible and high quality, also we need to increase the level of literacy of the population, and one of such ways is the transition to the concept of responsible self-medication.


Молодежный инновационный вестник. 2021;10(S1):291-293
291-293

### APPLICATION OF LEAN MANUFACTURING METHODS IN POLYCLINICS OF THE VORONEZH REGION

Goleva Y., Fedosova E.

#### Abstract

Primary health care is the most important part of health care, since this is the initial and final stage of examination and treatment of about 80% of patients. However, nowadays the tendency is disappointing: most patients are not satisfied with the level and usefulness of primary health care services.
The purpose of this study is to assess the level of implementation of the project "Lean Polyclinic" in the Voronezh region specifically in the Budgetary healthcare facilities of the Voronezh region "Liski Regional Hospital". In the course of this work, the information contained in the passport and the plan of the project "Lean Polyclinic"; presentations of the Russian Ministry of Health; the documentation of the Budgetary healthcare facilities of the Voronezh region "Liski Regional Hospital" were studied and analyzed; a social survey was conducted among 350 residents of the city of Liski in order to find out satisfaction with the provision of primary health care in the Budgetary healthcare facilities of the Voronezh region "Liski Regional Hospital".
The set of the appropriate modifications in the organization of the work of the clinic was formulated according to the volume and list of medical services performed, as an institution that provides primary health care.
By the year 2020 Liski Regional Hospital, within the framework of the regional project "A new model of a medical organization providing primary health care", had carried out a number of activities to transform the level and quality of medical care by establishing processes and minimizing losses, creating an atmosphere of comfort for patients and employees.
Thus, using the illustrative example of the Liski Regional Hospital, one can see how exactly the project "Lean Polyclinic" allows to reform the process of providing primary health care to the population.

Молодежный инновационный вестник. 2021;10(S1):293-297
293-297

### PYOTR SEMYONOVICH BABKIN IS A NEUROLOGIST WHO FIRST DESCRIBED A NUMBER OF REFLEXES IN NEWBORNS

#### Abstract

The purpose of this work is to study the biography, scientific achievements, role and significance of Pyotr Semyonovich Babkin for the medicine of the city of Voronezh and the Voronezh region.

The relevance of the study lies in the merits that were studied by the outstanding scientist P. S. Babkin. As the head of the Department of Neurology of the Voronezh Medical University named after N. N. Burdenko, he made a significant contribution to science. The scientist is known as the discoverer of the palmar-oral reflex, which is still widely used in neonatology and pediatrics.

Research objectives: to analyze and summarize the merits of Pyotr Semyonovich Babkin, to study the archival data of his family, the museum of the N. N. Burdenko VSMU, as well as to systematize the information obtained.

Materials and methods: in this work, the historical research method (historical and archival developments) was used, based on the study of information from the museum of the N. N. VSMU. Burdenko (historical and graphic study of literature).

Results: Babkin's research on some physiological and evolutionary aspects of childbirth in women, the state of the fetus during these periods, as well as on the neurophysiology of newborns was fundamental and has no analogues in the domestic and foreign literature. Together with Irina Petrovna Babkina in 1987, Pyotr Semyonovich discovered and described intranatal fetal hibernation. He also studied the phenomenon of autoanalgesia in women in labor and adaptation in the early postnatal period of the mother and newborn. Babkin opened a fundamentally new direction in neonatal neurology-the study of the influence of fetal presentation during pregnancy and childbirth on the features of the neurological status of the born child.

Conclusions: Babkin made a huge contribution to the development of neurology as a science not only in our university, but also around the world. He was an amazingly efficient person, a talented scientist, an experienced doctor, and a sensitive and responsive teacher.

Молодежный инновационный вестник. 2021;10(S1):297-299
297-299

### REFLECTION OF NATURAL DISASTERS OF A HYDROLOGICAL NATURE IN THE VISUAL ARTS

Zakurdaev V.A., Buksha M.S.

#### Abstract

At all times, the minds of outstanding professional artists have been concerned with the problems of natural disasters. The talents of thinkers and masters of the brush found themselves in art, in particular in painting. The artists did not ignore the theme of hydrological hazards, which are some kind of event that arose as a result of certain hydrological processes under the influence of various factors of a natural or man-made nature, affecting people, animals, plants, infrastructure and the environment in general.
Молодежный инновационный вестник. 2021;10(S1):299-301
299-301

### THE DEATH RATE OF THE POPULATION OF THE IRKUTSK REGION FROM TUBERCULOSIS

Kalennikova A., Pukhlyak A.

#### Abstract

The situation of tuberculosis (hereinafter referred to as TB) in the Irkutsk region has been and remains difficult, due to many features of the region, including the HIV epidemic. The aim of the work was to characterize the situation of mortality of the population of the Irkutsk region from TB. The official data of Rosstat were used, dynamic and comparative analyses were used, and rating positions were determined among 85 subjects of the Russian Federation. According to the results of the work, the mortality rate of the population of the Irkutsk region from TB for 2012-2019 decreased by 64.2 %, but still exceeds the national figure by 2.5 times (2019). In comparison with the data for the Russian Federation, excess indicators are recorded in all gender and age groups, starting from 20 years. The highest mortality rates from tuberculosis were recorded in the age groups of men and women 55-59, 80-84 years, and men 75-79 years. During the analyzed period, the rating position of the Irkutsk region in terms of mortality from tuberculosis, although it improved from 2nd to 10th place, but the region is still among the top 10 disadvantaged regions of the Russian Federation.

Молодежный инновационный вестник. 2021;10(S1):301-302
301-302

### ALTERNATIVE MEDICINE TODAY

Mamedova E., Volocii D.

#### Abstract

STRUCTURED ANNOTATION Actuality. The study is devoted to the popular problem of popularizing alternative medicine.Goal. To study the relevance of alternative medicine today, to analyze the special literature on methods of diagnosis and treatment of alternative medicine, to identify the age group that adheres to the methods of alternative medicine, to analyze the features of alternative medicine.Methods. In the course of the study, the following methods were used: analytical, statistical, empirical, as well as methods of induction, deduction, abstraction, analysis and synthesis. In the course of the work, the results of scientists ' research published in periodicals, as well as the materials of scientific and practical conferences were used. A survey of 300 respondents was conducted, revealing their attitude to alternative medicine.Results. In the course of the study, it was possible to identify the main principles of alternative medicine, to determine the percentage of the main problems on the topic of concern to respondents of different age categories.Conclusion. Alternative medicine today is of reasonable interest to both specialists and ordinary people. Most of the respondents are familiar with such a concept as alternative medicine. About 20% of respondents in their lives resorted to alternative medicine methods, however, considering traditional medicine more effective and safe.

Молодежный инновационный вестник. 2021;10(S1):302-304
302-304

### M. V. LOMONOSOV'S DISCOVERIES IN THE FIELD OF ETIOLOGY OF DISEASES AS THE BASIS OF ETIOTROPIC THERAPY AND DISEASE PREVENTION

Buraeva M., Nishenko V., Buraeva M.

#### Abstract

The article contains a study of the discoveries of Mikhail Lomonosov in the field of etiology of diseases, his study of the causes of various diseases. On the basis of the conclusions made by the scientist, the connection between the formation of modern principles of treatment and prevention of diseases is established. Namely, inflammatory, infectious and mental diseases. Mikhail Lomonosov, as a specialist in all fields of science, made a huge contribution to the formation of practical aspects of medicine in all its branches. His proposed methods of treatment and prevention have proven and undeniable effectiveness, as they are based on long-term observations and studies. The relevance lies in the fact that the therapy of all diseases today is also based on the evidence and features of the etiology and pathogenesis of diseases. This is the basis of etiotropic therapy, methods of prevention, as well as partially pathogenetic treatment. Therefore, the methods of therapy and prevention put forward by Lomonosov are basic, according to the principle of which modern medicine is being improved. The conclusions made in the article testify to the genius of Mikhail Lomonosov and confirm that the history of medicine is rich in various examples and prerequisites for the formation of well-known and relevant principles of practical medicine of the 21st century.

Молодежный инновационный вестник. 2021;10(S1):304-306
304-306

### THE ROLE OF LABOR ACTIVITY CARRIED OUT IN MEDICAL ORGANIZATIONS AS MEDICAL PERSONNEL IN THE FORMATION OF CLINICAL THINKING IN RESPONDENTS STUDYING AT THE BURDENKO STATE MEDICAL UNIVERSITY

Ovcharova M.S., Gudkov V.M.

#### Abstract

Relevance
The year 2020 has made serious adjustments to the organization and implementation of educational programs in educational institutions of our country, medical universities are no exception. The main problem during this period was the lack of opportunities to gain knowledge, skills and practical skills through direct contact with the patient during student curations.
Goal:
To identify and justify the importance of work experience in the positions of medical personnel in the formation of clinical thinking in respondents studying at the Burdenko VSMU»
Materials and methods:
The following research methods were used: an Internet questionnaire consisting of 20 questions with suggested and free answers, referencing, and analysis. The objects of the study were students of the 1st-6th year and residents studying at the Burdenko State Medical University, and simultaneously working in medical organizations as medical staff.
Results:
Among 75 respondents, 30 people are students of the 5th-6th year, 24 people are residents, the rest are students of the 1st-4th year.
The work experience of 31 people is less than six months, 27 people-more than 1 year, 15 people-from six months to a year.
More than half of them work in the positions of secondary medical staff, 23 people - in the medical position, 12 people-junior medical staff.
Most of the students surveyed noted that their knowledge in the field of medicine has expanded during their work in medical organizations, and there is also an incentive to study new material.
49 people note the negative impact of distance learning on obtaining the necessary medical knowledge and the formation of practical skills and abilities.
Almost half of the respondents experience emotional lability after employment in a medical organization.
The majority of the participants said that classes have to be skipped 1-3 times a week, depending on many factors, but the work in the health care center did not affect the current academic performance.
According to 70 people, working in a medical organization as medical personnel contributes to the formation and development of their clinical thinking.
Conclusion:
In the course of the study, data were obtained that working as medical staff in medical organizations had a twofold effect on the probability of forming clinical thinking in future specialists. The negative aspect is the inability to obtain the necessary medical knowledge, skills, and skills. Positive – there was a motivation to study new material, to be involved in the educational process, which in the future, undoubtedly, can have a beneficial effect on the formation of their creative professional clinical thinking.

Молодежный инновационный вестник. 2021;10(S1):306-310
306-310

### ORGANIZATION OF EMERGENCY CARE FOR PATIENTS WITH CORONAVIRUS INFECTION ON THE EXAMPLE OF THE WORK OF THE HEALTHCARE INSTITUTION OF HIGHER EDUCATION OF THE VORONEZH REGIONAL CLINICAL CENTER FOR DISASTER MEDICINE

#### Abstract

Relevance: The family of coronaviruses circulates around the world every year and causes seasonal SARS, but since 2002, a new strain has been identified that can cause cases of SARS. In March 2020, WHO declared a pandemic associated with a new coronavirus infection. All healthcare forces are deployed to fight COVID-19. The All-Russian Disaster Medicine Service at all levels of the organization has undergone changes in its work.
Purpose: To analyze the provision of emergency care by the QUZ VO VOKCMK during the epidemic spread of a new coronavirus infection. Study the number of COVID-19 employees infected and the causes of infection. Suggest measures to prevent contamination in the workplace.
Materials and methods: Study of temporary guidelines for the prevention, diagnosis and treatment of new coronavirus infection. Visit to the KUZ VO VOKTsMK, study of the documentation and scope of work of the center from April to November 2020.
Research results: The main direction of work of the KUZ VO VOKTsMK during a pandemic is interhospital evacuation from the regional hospitals of Borisoglebsk, Kalach, Rossosh, Pavlovsk, Bobrov, Ostrogozhsk, Liski to the BUZ VOKB No. 1, after - in the emergency hospital No. 1, 8, 10 4 brigades are on duty every day, 2 of which are resuscitation and 2 ambulance brigades. Until April 2020, the average number of control room calls per month was 70-100, with the spread of the new coronavirus infection, this number increased to 150-200. As of November 2020, 40% of employees had been ill with COVID-19 in a mild to moderate form.
Conclusion: During the second wave of the new coronavirus infection, more people fell ill in the Voronezh region than in the first. To date, the load on the QUZ VO VOKTsMK is gradually decreasing, this is due to the mass immunization of citizens with the vaccine "GAM-COVID-VAK, Sputnik V" and the formation of the immune layer of the population due to the transferred disease.

Молодежный инновационный вестник. 2021;10(S1):310-313
310-313

### TO THE 100TH ANNIVERSARY OF THE DISCOVERY OF EMBRYONIC INDUCTION: HANS SPEEMAN

Silkin A.V., Klyukin A.A.

#### Abstract

Relevance. 2021 marks exactly 100 years since the discovery of the phenomenon of embryonic induction. This phenomenon was discovered in 1921 by the German embryologist Hans Spemann and his student Hilda Mangold in a series of experiments to study the properties of the chordomesoderm material [1].
Purpose. Get acquainted with the history of the discovery of this phenomenon and the biography of the German embryologist, Nobel Prize laureate, professor of zoology G. Spemann.
Methods. Review and study of the literature on this topic. Study of materials from the archives of the university. Consolidation of information from historical sources about the life of Hans Spemann and the phenomenon he discovered.
Results. Spemann had a great influence on the development of such an important science today as embryology. The methods that he developed and the questions posed to the scientist determined the ways for the further development of embryology in the first half of the last century. Hans Spemann was able to demonstrate that in the course of embryonic induction, certain interactions of the parts of the embryo take place, and the influence of one of these elements regulates the development of the second, which triggers a series of morphogenetic processes. As a result of all these processes, the tissue, which is able to perceive the induction effect and respond to it, becomes predetermined for a specific type of development. Spemann's experiments pushed him to formulate specific questions about causal interactions between clear, unquestionable processes of formation of certain cell groups. His work laid the foundation for the current doctrine of the development of the embryo. A year after receiving the Nobel Prize, his famous work "Embryonic Development and Induction" was published, where he summarized most of his writings. This book to this day is the foundation that determines the further development paths of such a section of modern biology as developmental biology.
Conclusion. Knowledge of biographical information about scientists known to the whole world is an integral step in preparing medical students for their future professional activities.

Молодежный инновационный вестник. 2021;10(S1):313-316
313-316

### NUTRIENTY_LIPIDNOI__PRIRODY_V_RATSIONE_STUDENTOV

Tiunina A., Badanova A., Drobenko A.

#### Abstract

Goal. To find out the quantitative and qualitative composition of the lipid-based nutrients in the diet of our medical university students. Compare the results with the regulatory documents.

Object and methods of research. To achieve this goal, a survey was conducted in 2020 of 35 first-year students of the Faculty of Pharmacy of the Burdenko State Medical University. Among the respondents there were 10 boys and 25 girls.

Results and discussion. Based on the survey results, the following average values of the main indicators were calculated and obtained.

The amount of fat in the daily diet was 55 g and 20 g for boys and girls, respectively. Weight of vegetable fats: 9 g for girls and 10 g for boys. Animal fat mass: 11g for girls and 45g for boys. At the same time, fat accounts for 33.2% of the energy value of the daily diet in boys and 12.6% in girls.

According to the normative documents [2], the diet of students (age: 18-29 years, the first group of labor intensity, male and female, respectively) should contain 81 and 67 g of fat for boys and girls, respectively. With the daily energy expenditure of boys (2450 kcal) and girls (2000 kcal) for all students, fat should account for 30% of the kcal.

The results show that the amount of fat in the daily diet of young men corresponds to the norm, and in girls it is lower than the standard indicators. This can negatively affect their health and performance. Such a lack of fat can lead to a lack of fat-soluble biologically active substances, such as terpenoids and carotenoids [6]. These substances affect the metabolic processes and their determination may be the task of our further research.

In young men, the content of animal fats is much higher than the content of vegetable fats. Lipids of animal origin can not only have a high melting point and a solid aggregate state, but can also contain saturated fatty acids with a long chain having from twenty or more carbon atoms. Such animal fats include pork, beef, lamb, and a number of others. High intake of saturated fatty acids is the most important risk factor for cardiovascular diseases, obesity, diabetes, and other pathologies. In food products of plant origin, lecithin is mainly found (its composition includes the vitamin-like substance choline, as well as kefalin [1-5]).

Conclusion. Thus, the nutrients of the lipid nature play an important role in human life. Lipids are widely distributed in nature and are an integral part of every cell in every biological system. To maintain normal health, it is necessary to adhere to the general rules of rational nutrition and consumption of fats of both vegetable and animal origin.

Молодежный инновационный вестник. 2021;10(S1):316-317
316-317

### THE SANITARY STATE OF THE BASSR DURING THE GREAT PATRIOTIC WAR

Famutdinova A.I., Dautbaev D.G.

#### Abstract

During the Great Patriotic War (WWII) as a result of bloody battles, a massive movement of the population was formed. Wounded soldiers, the local population, prisoners of war of the Wehrmacht were transported from west to east, which contributed to the development of massive infectious diseases. In the Bashkir Autonomous Soviet Socialist Republic (BASSR) there were more than 53 evacuation hospitals, many transported industrial enterprises and a large number of refugees. At the same time, the sanitary state of the republic was already in a deplorable state at the beginning of the war. Because of this, a large-scale sanitary and anti-epidemic work was carried out here, which consisted in improving the sanitary organization of the population, evacuation evacuation hospitals, transport hubs. An admission and triage hospital No. 3127 was created, which contributed to the fight against carriers of various infectious diseases, and carried out routing of the incoming wounded. At the same time, the sanitary provision in the evacuation hospitals was very weak. There was a shortage of water, amenities, and hygiene supplies. Bedbugs and lice were found in many evacuation hospitals. Many methods were used to improve the sanitary state of the republic. The establishment of hygienic services for the population, epidemiological intelligence, immunoprophylaxis of the population was carried out, and the isolation of patients was carried out. To combat infections, sanitary detachments and brigades were created, the work of sanitary and epidemiological stations was organized, special attention was paid to their interaction with other medical organizations (hospitals, dispensaries, etc.) Despite the effect of these measures and the end of the war, infectious diseases are still significant undermined the health of the inhabitants of the republic, therefore, sanitary and anti-epidemic measures in 1945 were strengthened, they were carried out both massively, covering the majority of the population, and point-wise, to detect and eliminate foci of infectious diseases.

Молодежный инновационный вестник. 2021;10(S1):317-321
317-321

### HISTORY OF THE PHILADELPHIA CHROMOSOME DESCRIPTION IN PATIENTS WITH CHRONIC MYELOCYTIC LEUKEMIA

Haprova I.O., Sakharova D.A.

#### Abstract

Advances in the treatment of chronic myelocytic leukemia (CML) have paralleled advances in understanding the pathogenesis of the disease. More than 60 years ago, Peter Nowell and David Hungerford discovered the "small acrocentric chromosome"in cultured cells of CML patients. Subsequent studies confirmed their observations and studies were continued. The method of differential chromosome coloring allowed us to clarify the features of the mutation. The molecular basis of this event was determined, and the chimeric gene BCR-ABL1 was discovered. The development and introduction of tyrosine kinase inhibitors (imatinib)improved the prognosis of patients with chronic CML.

Goal. To study the stages of describing the balanced reciprocal translocation t (9; 22) (q34;q11.2) in patients with CML and subsequent events that contribute to a significant improvement in the prognosis.

Methods. Systematization and generalization of the literature devoted to the studied issue. The search for literary sources (in Russian) was conducted in the scientific electronic library e-library.

Results. The main stages of studying one of the chromosomal mutations, which, according to statistics, is detected in 95% of patients with CML, are analyzed. Drugs have been developed, the effect of which, when taken for many years, leads to its disappearance and long-term clinical and hematological remission.

Conclusion. Familiarity with the history of the study of the etiology and pathogenesis of one of the hemoblastoses, which occurs mainly in adults of working age, is an important component in the training of a specialist. Moreover, the data on this topic is not fully presented in the modern educational literature.

Молодежный инновационный вестник. 2021;10(S1):321-323
321-323

### TO THE QUESTION ABOUT TELEMEDICINE

Chernykh V.

#### Abstract

Relevance: The study is devoted to the increasingly popular topic of the use of remote sensing technologies in treatment.
Purpose. To study the relevance of the problem of remote treatment, to analyze the special literature on the topic of specific cases of application of technologies in the process of diagnosis and treatment. Determine the percentage of people who trust telemedicine among students of leading medical universities.
Methods: During the research were used: analytical, statistical, empirical methods, as well as methods of induction, deduction, abstraction, analysis and synthesis. A survey of 2,500 respondents was conducted, as a result of which the attitude towards distance treatment was revealed.
Conclusion: At this stage of development, telemedicine is rather suspicious, 75% of the participants consider the use of remote forms of treatment as quackery. Practicing doctors also faced telemedicine in the minority, 87.8% have never worked in this area.


Молодежный инновационный вестник. 2021;10(S1):323-325
323-325

### ABOUT THE LIFE AND SCIENTIFIC ACTIVITY IN THE POST-WAR YEARS OF THE EMPLOYEE OF THE DEPARTMENT OF BIOLOGY OF THE BURDENKO VSMU, PROFESSOR E. I. POKROVSKAYA

Chibisova T.A.

#### Abstract

Relevance. The participation of E. I. Pokrovskaya in the formation of the department and one of the areas of biology in the post-war years had a significant impact on science and history. The results of her experimental work on the study of the development cycles of arthropods (ticks) were carried out together with other employees of the department and allowed us to establish the role of the latter in the transmission of pathogens of many infectious diseases.
Goal. Turning to the materials of the library archives, to highlight the life and study the scientific heritage of the first head of the Department of Biology after the end of the war, Professor E. I. Pokrovskaya.
Methods. When performing the work, the general scientific method of research was used.
Results. In the course of data analysis, results were obtained that are of general scientific significance. The results of the scientific works of Professor Pokrovskaya helped to develop methods of prevention in the fight against vectors of protozoal and infectious human diseases.
Conclusion. The study of aspects of the biography and scientific works of the department's employees plays an important role in the professional and personal development of medical university students.

Молодежный инновационный вестник. 2021;10(S1):325-327
325-327

### The ATTITUDE of REPRESENTATIVES of the WEAKER SEX To the HEALTHY WAY OF LIFE

Shapkarina K.A., Romahova A.A., Turalieva A.I.

#### Abstract

Health as value takes rather high seat in hierarchy of individual values of people. The information on a current condition of the health is a resistant indispensability for acceptance of duly measures of preventive maintenance and correction of a way of life. Especially it concerns women, whose level of desease remains high to this day, that often connect with realization of their gender role. Objective of research was studying opinion of the women who have addressed in the Center of health, concerning the health and its factors defining. The questionnaire has been developed for achievement of an object in view from 25 questions, sociological and statistical methods were applied. To results of research have shown, that women addressed in the Center of health consider a condition of the health satisfactory. However, health besides a heredity also is influenced with a way of life, a conditions of life. Our participants of questioning in overwhelming majority do not smoke and do not take alcohol (or drink on holidays), eat is triple hot food, material and living conditions consider good. The greater fraction is necessary on healthy women with what, probably, and it is connected low обращаемость in the Center of health. The high percent of the female population has expressed an indispensability in preventive maintenance, that once again emphasizes their close attitude to the health.

Молодежный инновационный вестник. 2021;10(S1):328-331
328-331

### PUBLIC HEALTH AT THE PRESENT STAGE: FAMILY INSTITUTE THROUGH THE EYES OF THE FACULTY OF PEDIATRICS

Shcherbakova V.A., Kiyatkina O.I.

#### Abstract

Relevance. Currently, as stated in the research literature, there is a rejection of the old, traditional (patriarchal) model of the family, where the head is a man. In such a model, there is a special hierarchical sequence of "father - mother - children". Today's young families are undergoing a transition from the old model to a newer, "transitional" one, in which completely different values are embedded. In this model, the equality of all family members prevails, and the importance of the personal opinions of each of them, even children, is noted. On the other hand, it cannot be said that human relations themselves have undergone some changes - this is not the case. People are still susceptible to feelings, still love their parents, partner, children. The modern family model has brought only a more pronounced emotional component and mutual support for each other.

Goal. To study the attitude to the family, family life of different age groups of the pediatric faculty.

Methods: statistical analysis, descriptive, also using the Google Form platform, 1800 students of the Faculty of Pediatrics, as well as 150 young medical specialists, were interviewed. During the oral survey, the opinions of 50 teachers and faculty members were obtained.

Results. In the course of the study, the opinions of various age and professional groups (students, specialists and teachers) were obtained and analyzed. However, there is a similarity in the views of the majority of respondents, regardless of age and other social factors.

Conclusion. In the modern world, nothing stands still, and the institution of the family is also changing. Many people are increasingly abandoning the traditional way of life of the family in the direction of greater equality in the distribution of family responsibilities and the upbringing of children. But, despite this, many things remain important and unchanged, such as the meaning and importance of official marriage.

Молодежный инновационный вестник. 2021;10(S1):331-334
331-334

### FROM THE HISTORY OF THE DEPARTMENT BIOLOGY VSMU THEM N.N. BURDENKO: PETER KONSTANTINOVICH KUZNETSOV ㅤ

Chayka S.

#### Abstract

STRUCTURED ANNOTATION

Relevance. In 2020 ㅤ the Department of Biology ㅤ VSMU named after N.N. ㅤ Burdenko turned 90 ㅤ years old. Taking into account the significance of this event, it is necessary to ㅤ remember such an employee К as Petr Kuznetsov ㅤ Konstantinovich, who made a great contribution to a the development of acarology in ㅤ Voronezh region. His деятельность scientific activity was ㅤ devoted to the study of life ㅤ cycles of blood-sucking arthropods ㅤ and the establishment of their ㅤ role in the transfer of ㅤ pathogens of especially dangerous ㅤ vector-borne diseases [1]. ㅤ
Purpose. Using the materials ㅤ of the library fund, to get acquainted ㅤ with the history of life ㅤ and scientific activities ㅤ of one of the first ㅤ employees of the Department of Biology, ㅤ Ph.D. Kuznetsova P.K. ㅤ
Methods. In the work ㅤ the general scientific method was used ㅤ research. ㅤ
Results. The acquired data ㅤ are of great importance ㅤ for biology. The analysis of ㅤ scientific works of Peter ㅤ Konstantinovich made it possible to study ㅤ ticks as carriers of об especially dangerous transmissible diseases in humans. ㅤ
Conclusion. On the basis of ㅤ the information provided about нике an employee of the Department of Biology, ㅤ it was possible to evaluate ㅤ his contribution to ㅤ the development of acarology, which ㅤ allowed subsequent generations ㅤ to continue studying in ㅤ this area. ㅤ

Молодежный инновационный вестник. 2021;10(S1):334-336
334-336

## Педиатрия

### CLINICAL CASE OF A NEW CORONAVIRUS INFECTION WITH MULTISYSTEM INFLAMMATORY SYNDROME IN A CHILD

Bobrova E.

#### Abstract

The pandemic of the new coronavirus infection COVID-19, declared by the WHO in March 2020, is an emergency for humanity. In most cases, it is not severe in children, but cases of severe multisystem inflammation associated with COVID-19 have been described that require intensive therapy. Risk factors for severe multisystem inflammation in children have not yet been studied. Therapy of such patients includes the appointment of oxygen therapy, anticoagulants, glucorticosteroids (pulse therapy), interleukin inhibitors, high-dose intravenous immunoglobulins, antibiotics in case of suspected bacterial infection. The article describes and analyzes the critical form of COVID-19 infection-a multisystem inflammatory syndrome in a 12-year-old child with a premorbid background-grade 2 obesity of a constitutionally exogenous nature.The critical form of infection manifested more than three weeks after a mild course of COVID-19 and a prolonged replication of the SARS-CoV-2 virus for 21 days. The disease required the use of respiratory support, the appointment of high doses of glucocorticosteroids, anticoagulants and combined antibacterial therapy. The clinical example presented in the article demonstrates the severe course of a new coronavirus infection COVID-19 with the development of a multisystem inflammatory syndrome in a child with a burdened premorbid background – grade 2 obesity.

Молодежный инновационный вестник. 2021;10(S1):337-340
337-340

### SCREENING OPPORTUNITIES FOR IRON DEFICIENCY IN CHILDREN WITH ALLERGIC DISEASES

Gudkov V.M., Bakutina Y.Y., Chertok E.

#### Abstract

The main cause of anemia in childhood is iron deficiency. However, the diagnosis of iron deficiency anemia is usually made only when changes in the hemogram are detected, and the initial stages of iron deficiency in the form of sideropenic syndrome remain unrecognized, and the correction of iron deficiency is not administrated. Iron deficiency leads to decrease in immune protection and the development of frequent respiratory diseases, which are a trigger factor for the occurrence of exacerbations of respiratory allergic diseases (asthma, allergic rhinitis). The aim of our work is to identify early signs of iron deficiency in allergic children. This study included outpatient records and a survey of parents of 139 children with various allergic diseases (asthma, allergic rhinitis, atopic dermatitis). According to the results of the survey signs of sideropenic syndrome were detected in 76.2% of children. Frequent respiratory diseases were observed in 62.4% of children, who were characterized by prolonged subfebrility (up to 7-10 days), prolonged cough and runny nose. In most children, the level of hemoglobin was normal, but a decrease in the mean corpuscular volume of red blood cells was registered, which is a reliable sign of an iron deficiency. We can recommend to pay the attention of pediatricians to thorough collection of anamnesis and analysis of the hemogram in order to detect sideropenic syndrome and timely administrate of iron replacement therapy.

Молодежный инновационный вестник. 2021;10(S1):340-342
340-342

### FEATURES OF THE COURSE OF NOROVIRUS INFECTION IN CHILDREN

Zolotukhin V., Arzhanykh Y.

#### Abstract

Relevance: Norovirus infection is one of the most common causes of acute intestinal infections (AEI) in children, which is characterized by damage to the gastrointestinal tract. The similarity of the clinical picture of norovirus infection with other AEI often causes difficulties in making the correct diagnosis.
Purpose: To study the structure of norovirus infection, prevalence, features of the clinical and epidemiological course, to evaluate the data of laboratory research methods, both with monoinfection and with developed complications.
Materials and methods: A retrospective analysis of all case histories of children with AEI in the period from October 2019 to October 2020 was carried out on the basis of the CSTO No. 2. Norovirus infection was diagnosed in only 19 cases during the year.
Discussions: The structure of norovirus infection was mainly represented by gastroenteritis in 79.0% of cases, gastritis in 21.0% of cases. A general increase in CRP was observed in 47.4% of the surveyed. The average CRP value was 38.04 mg / L. In 100% of cases, leukocytosis was with a shift of the leukocyte count to the left. The mean leukocytosis values ​​were 14.8 * 〖10〗 ^ 9 / l. The most common course of norovirus infection of moderate severity was detected in 84.2%, and a severe course was diagnosed in 15.8%. A severe course was mainly associated with acute mesenteric adenitis in 21.0% of cases, with reactive pancreatitis in 15.8% of cases and with the addition of a bacterial infection and the detection of pathological E. coli. - 15.8%. Mixed infection (norovirus + rotavirus) was detected in 10.5% of cases.
Results: Leukocytosis with a shift of the leukocyte formula to the left, as well as an increase in the level of C-reactive protein in the presence of certain symptoms, can be considered reliable signs of norovirus infection.
Conclusion: In mixed infections (norovirus + rotavirus), in addition to the standard changes inherent in intestinal infections, there is also an increase in the level of AsAt and AlAt, which is reliably absent in other combined pathologies.

Молодежный инновационный вестник. 2021;10(S1):342-344
342-344

### ANALYSIS OF THE STRUCTURE AND PREVALENCE OF THYROID DISEASES IN CHILDREN WITH OVERWEIGHT AND EXOGENOUS CONSTITUTIONAL OBESITY AMONG PATIENTS OF THE VORONEZH CHILDREN'S CLINICAL HOSPITAL

Kirguev G.A.

#### Abstract

Relevance: The growing rates of obesity, the relationship between thyroid hormones and adipocyte secretion products, the endemicity of the Voronezh region for iodine deficiency necessitates a study of the incidence of thyroid pathology in overweight and obese children.
Purpose: To analyze the structure and prevalence of thyroid diseases in children with overweight and exogenous constitutional obesity.
Materials and methods: Retrospective analysis of case histories of patients at the Voronezh Children's Clinical Hospital for the period January 2019 - November 2020, hospitalized with a diagnosis of "Obesity due to excessive intake of energy resources" (ICD-X: E66.0) and identification among them patients with thyroid pathology.
Results: We analyzed 106 case histories of overweight children or diagnosed with exogenous constitutional obesity. Among them, 61 (57.5%) are boys and 45 (42.5%) are girls. The presence of thyroid pathology was revealed in 46 children (43.4%): in 24 (52.2%) boys and 22 (47.8%) girls. In the study group, the following nosological structure of thyroid diseases was revealed: diffuse non-toxic goiter is determined in 24 (52.2%) children, subclinical hypothyroidism in 17 (37%) children, clinical hypothyroidism in 4 (8.7%) children, suffers from autoimmune thyroiditis 1 child (2.1%)
Conclusion: The revealed high incidence of thyroid pathology (43.4% of all studied patients) among the studied patients indicates the need to assess the thyroid status in children and adolescents with overweight and obesity.

Молодежный инновационный вестник. 2021;10(S1):344-347
344-347

### DIGITAL PHONOCARDIOGRAPHY IN THE DIAGNOSIS OF THE OPEN DUCTUS ARTERIOSUS IN PREMATURE NEWBORNS

Mudrov A.

#### Abstract

Relevance: The clinical significance of the open ductus arteriosus (OAP) and the degree of its influence on the physiological development of the child remain the subject of constant debate in pediatrics and neonatology. Changes in central hemodynamics affect the cerebral blood flow and are in the perinatal period one of the main causes of neonatal mortality, as well as severe outcomes from the central nervous system.
Objective: To evaluate the possibilities of using digital phonocardiography in the diagnosis of the ductus arteriosus in premature newborns based on the analysis of heart tones.
Materials and methods. 60 premature newborns who were treated in the department of congenital heart defects were examined. All newborns underwent phonocardiography (FKG) using the HeartDop hardware and software package (portable doppler and software for mobile communication systems). As a conditional "gold standard", an echocardiographic study was used, conducted by a newborn on the eve of phonocardiography using a SIEMENS ACUSON NX3 ELITE device. Ultrasound signs of hemodynamically insignificant open ductus arteriosus (OAP) had 90% (54/60), hemodynamically significant OAP (GZOAP) had 10% (6/60) of newborns. The study in these groups performed a comparison of numerical analysis FKG characterizing the cardiac and the gap between the first and second tone.
Results. When comparing the parameters of FKG in groups of children with hemodynamically insignificant and hemodynamically significant OAP at the first point of auscultation, there were no statistically significant differences in the parameters characterizing the first and second heart tones, and the intervals between them. Meanwhile, the application of equation discriminant analysis including the parameters of the correlation energy of the first and second tones of the energy of the first tone and the total weighted energy in the interval between the first and second tones of the energy of the second tone and the total weighted energy gap between the first and the second tones, allows you to effectively assess the existence of hemodynamic disturbances: the sensitivity of the developed method is 60% and the specificity 80%.
Conclusions. Isolated assessment of phonocardiography parameters in most cases does not reveal significant differences in hemodynamics. Meanwhile, the use of discriminant analysis makes it possible to increase the effectiveness of the diagnosis of hemodynamically significant disorders, which will optimize the management tactics of premature newborns with OAP in hospital and at home.
Prior to the study, the voluntary informed consent of the legal representatives was obtained.
The authors declare that there is no conflict of interest.

Молодежный инновационный вестник. 2021;10(S1):347-351
347-351

### FUNCTIONAL DISEASES OF THE GASTROINTESTINAL TRACT (GIT) IN CHILDREN IN VORONEZH

Panina O.V., Razuvaeva Y.Y., Kolomatskaya V.V., Ulyanova L.V.

#### Abstract

The article deals with the issues of functional gastrointestinal disorders, which are one of the main problems of modern pediatrics and gastroenterology. The frequency of functional diseases of the gastrointestinal tract in children is steadily increasing every year. Despite the fact that this pathology is not associated with an organic lesion of the gastrointestinal tract and, as a rule, does not lead to serious consequences in the future, it significantly reduces the quality of life of the patient and his parents. When analyzing the data of the questionnaire for parents on the detection of functional disorders of the gastrointestinal tract in children aged 0 months to 3 years 11 months, developed by the Russian Society of Pediatric Gastroenterologists, Hepatologists and Nutritionists, taking into account the recommendations of ESPGHAN, the following data were obtained: functional diseases of the gastrointestinal tract in children of G. Voronezh is a common pathology and occurs in 2/3 of cases, in children under one year in most cases (83.3%), two or more functional pathologies of the gastrointestinal tract are detected and the most frequent violation is infant colic, in the age category of children from one to 3 years in 100% of cases, only one pathology is observed and the most common disease is functional constipation.

Молодежный инновационный вестник. 2021;10(S1):351-353
351-353

## Сестринское дело

### ТЕМА «ВЛИЯНИЕ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ COVID-19 НА СЕРДЕЧНО-СОСУДИСТУЮ СИСТЕМУ»

Boldireva S.Y.

#### Abstract

СТРУКТУРИРОВАННАЯ АНННОТАЦИЯ

Новый возбудитель инфекции SARS-CoV-2, вызывающий COVID-19, относится к группе инфекций, поражающих верхние дыхательные пути. Тем немее все чаще учеными отмечается и иная опасность - негативное воздействие вируса на сердечно-сосудистую систему, вызывая серьезные осложнения (инфаркт миокарда, аритмии и т.д.).

В статье рассматривается влияние новой коронавирусной инфекции на сердечно-сосудистую систему, а также развитие осложнений, с которыми сталкиваются пациенты после перенесенной инфекции, имеющие в анамнезе сердечно-сосудистые патологии и пациенты, не имеющие данные патологии ранее. Рассмотрены современные подходы по профилактике и методы реабилитации после перенесенной новой короновирусной инфекции COVID-19.

После проведения профилактических бесед все недочеты были устранены, дана теоретическая база о заболевании и рекомендации по профилактике и реабилитации в восстановительный период.

Актуальность

В настоящем времени тема влияния COVID-19 на сердечно-сосудистую систему считается очень важной и актуальной. Главной проблемой здравоохранения во многих государствах все еще остаются болезни сердечно-сосудистой системы, нередко являющиеся причинами инвалидности и смертности, занимают основное место в мире.

По словам главного внештатного кардиолога Минздрава Евгения Шляхто, пандемия привела к увеличению заболеваемости и смертности от сердечно-сосудистых патологий, существенно оказала влияние, особенно на группы населения с факторами риска. По словам специалиста, у заразившихся пациентов, имеющих в анамнезе сердечно-сосудистые патологии, риск тяжелого течения заболевания и летального исхода выше в 2,5 раза.  По данным департамента здравоохранения Москвы, свыше 83% всех умерших от ковида (основная причина смерти) из них 53% имели сопутствующие заболевания, а наиболее часто встречаются болезни сердечно-сосудистой системы (67%).

Пациенты, переболевшие новой коронавирусной инфекцией, сталкиваются с серьезными проблемами такими как приступы удушья, «перебои» в работе сердца, одышка, отеки нижних конечностей, повышенная склонность к тромбозам, приводящая к инсультам, инфарктам, легочной эмболии.

Кардиолог исследовательского института скрининга (США) систематизировал знания в октябре 2020 г. и отразил в статье журнала Science часто встречаемые осложнения, вызываемые COVID-19 - это миокардит, аритмии, острая и хроническая сердечная недостаточность, а также ограниченный некроз кардиомиоцитов.

Ученые определили, что белки SАRS-CoV-2 поражают клетки эндотелия стенок сосудов, вызывая повышенную коагуляцию и воспаление, а также влияют на проницаемость сосудов.

Изменения в эндотелии связаны с рядом факторов:

-прямым воздействием на клетки внутренней поверхности сосудов, вызывающих эндотелиальную дисфункцию;

-лизисом клеток;

-отторжением человеческого ангиотензин-превращающего фермента вирусными белками.

Цель

Увеличение информированности о воздействии коронавирусной инфекции на сердечно-сосудистую систему и исследование методов профилактики и реабилитации после перенесенного заболевания для улучшения качества жизни пациентов.

Результаты

Я принимала непосредственное участие в подборе материала для анкетирования и разработке рекомендаций по профилактике сердечно-сосудистых заболеваний в виде буклета. Обучала технике измерения артериального давления, пульса, дыхательной гимнастики, правилам здорового питания и принципам физической нагрузки. Больше всего было задействовано пациентов в возрасте 50-65 лет с преобладанием женского пола.

По результатам анкетирования пациентов, были выявлены следующие результаты: 80% (56 человек) имели сердечно-сосудистую патологию до пандемии, а у 20% (14 человек) выявлены нарушения со стороны сердечно-сосудистой системы после перенесенной инфекции COVID-19.

По окончанию каждой беседы был проведен опрос, чтобы понять, на сколько хорошо пациенты усвоили полученный материал. Беседа с каждым пациентом проходила в течение месяца. Исходя из этого, я сделала вывод о том, что из 70 пациентов (100%) спустя месяц у 14 человек, у которых впервые были выявлены нарушения со стороны сердечно-сосудистой системы (3 человека с нарушением ритма, 5 человек с синусовой тахикардией и 6 человек с эпизодами повышения артериального давления и тахикардией), клиническая картина болезни полностью исчезла. Из оставшихся 80% пациентов, которые ранее имели патологии со стороны ССС: ишемическую болезнь сердца, гипертоническую болезнь, у 37 человек были отмечены улучшения (одышка стала менее выраженной, стабилизировались показатели АД и пульса).

Благодаря разработанным рекомендациям пациенты повысили свои знания о сердечно-сосудистых патологиях, влиянии ковида на сердечно-сосудистую систему, факторах риска, осложнениях и способах их устранения, приобрели практические навыки.

Обсуждение

Во время выполнения данной работы мной были замечены следующие преимущества подобных бесед:

1) Была создана атмосфера, которая помогла пациентам побороть страх перед новой инфекцией и возникшими осложнениями.

2) В обсуждении были придуманы принципы и приемы для коррекции образа жизни.

3) Эффективность данных бесед повышается в основном за счет обмена знаниями и опытом между пациентами и специалистами.

На мой взгляд недостатков в подобных беседах нет. Мы – медики таким образом повышаем уровень необходимых знаний у пациентов о заболевании и возможных осложнениях, вызывая чувство ответственности к своему здоровью.

Заключение

В ходе моей исследовательской работы:

- проанализировано состояние здоровья пациентов после перенесенной COVID – инфекции в поликлинике г. Липецка;

-  выделены часто встречающиеся осложнения;

- даны рекомендации по питанию, профилактике и реабиллитации в восстановительный период;

- отработаны практические навыки по измерению АД и пульса;

- разработаны методические рекомендации в виде буклета по профилактике осложнений со стороны сердечно-сосудистой системы  в восстановительный период.

P.s. Если своевременно и правильно проводить соответствующие профилактические мероприятия (ежедневный контроль за показаниями АД и пульса, соблюдение режима и рациона питания, отказ от вредных привычек, занятия физической активностью), то можно добиться уменьшения количества больных, страдающих заболеваниями сердечно-сосудистой системы. А также необходимо соблюдать меры безопасности в период пандемии (ношение масок и перчаток, соблюдение дистанции, не посещать общественные места скопления людей), все это позволит избежать серьезных осложнений, особенно у лиц с сердечно-сосудистой патологией.

Молодежный инновационный вестник. 2021;10(S1):354-357
354-357

### TO THE QUESTION OF THE EFFECT OF THE WORD ON HUMAN HEALTH AND WELL-BEING

Kartashov I.A., Oreshkin V.Y.

#### Abstract

STRUCTURED ANNOTATION

Actuality. A person constantly utters some words, hears and interprets the speech of other people. Their semantic orientation and the tone of the narrative are not indifferent to the speaker and the listener. The word is a powerful source of positive or negative information that can influence the well-being and mood of an individual, and therefore his feelings, quality of life, and health.

Objective: to study the impact of words on human health and well-being

Materials and methods. Materials: printed sources and Internet resources, developed questionnaire. Methods – survey, search, analytical, descriptive, statistical processing of the results obtained.

Results. The influence of the word on a person is considered on the examples of the activities of well-known representatives of literature, medicine, science, and the Orthodox Church. The scientific facts of the negative impact of the separation of children and their mothers, the influence of words on the germination of seeds, and the structure of water are presented. The origin of abusive and abusive words, their influence on the human body, their vital activity is considered. There is a reference to the legal framework. The developed questionnaire about mate was used to identify the attitude of young people to bad language.

Conclusion. Medical professionals, when faced with psychosomatic pathology, with diseases that develop as a result of stress, negative emotions, should be aware of the importance of proper communication and behavior of people. Modern future doctors choose a classic, literary style of communication.

Молодежный инновационный вестник. 2021;10(S1):357-360
357-360

### THE MAIN DIRECTIONS OF PREVENTIVE WORK OF THE DISTRICT MEDICAL NURSE OF THE CHILDREN'S POLYCLINIC

Koryukina E.

#### Abstract

The child population is the most vulnerable part of society, therefore, the relevance of preventive work in this age group is great. It is important to convey to parents / guardians the basic principles of organizing life and life, feeding, preventing hypovitaminosis and other vital aspects of caring for children.
Therefore, the purpose of the work is to study the main directions of the preventive work of the district nurse of the children's clinic.
The study was carried out by a questionnaire method, in 2020 on the basis of the city polyclinic No. 1 in Voronezh. 80 people participated in the survey.
As the survey has shown, almost all parents are undergoing preventive work for certain diseases. The issue of rational nutrition remains relevant in 70% of cases at home visits, the problems of the motor regime and the organization of children's leisure are less urgent. Preventive work with children in the first years of life and their parents by nurses is carried out at a high level, an individual approach is clearly traced during patronage, there is a high loyalty of parents to nurses and literacy of nurses in the application of aspects of medical ethics and deontology. However, attention is drawn to the insufficient regularity of nursing patronages for children under one year old, which was noted by a quarter of the parents surveyed.
The survey showed that the district nurse regularly visits children at home, participating in the organization and control of proper child care. The nurse plays a key role in correcting the care of infants in their first year of life. The tasks of the nurse's work include helping the mother in organizing the correct regime and rational feeding, preventing rickets, anemia, childhood infections, monitoring the physical and neuropsychic development of the child, health, family education, etc. According to the survey results, the majority of parents were satisfied with the work of the nurses conducting patronage.

Молодежный инновационный вестник. 2021;10(S1):361-365
361-365

### THE OLDER GENERATION AS AN OBJECT OF GENDER AND SOCIAL STEREOTYPES IN THE ACTIVITIES OF SECONDARY MEDICAL PERSONNEL

Kyran D.

#### Abstract

The article raises the issues of gender and social stereotypes in the activities of nursing staff, examines the attitude of nurses to the elderly from the position of differentiation of preferred choice.

Молодежный инновационный вестник. 2021;10(S1):365-369
365-369

## Стоматология

### THE USE OF A CAST BASE IN REMOVABLE PROSTHETICS

Antonyan R.

#### Abstract

IV. STRUCTURED ABSTRACT

In orthopedic dentistry, removable dentures are widely used, designed to replace the dentition of different lengths, as well as to restore the functions of chewing and speech. For the manufacture of removable dentures with a cast base, noble alloys have become more widely used, since due to their good thermal conductivity, it is possible to maintain the perception of cool and hot at a significant level. [1] The article deals with the use of cast basis in removable prosthetics. Advantages regarding plastic-based prostheses. Considerable attention is paid to research and experiments. The article also describes the materials from which prostheses are manufactured with cast basis. These include alloys of noble and base metals. Precious metals are attributed to: gold, silver, platinum. To the ignoble - iron, lead, etc. There are such alloys as cobalt-chromium, silver-palladium alloys, etc. Currently, titanium alloys have gained popularity. Their most important advantage is their excellent biocompatibility with the human body

VII. Goal

Justification for the use of modern cast bases in the clinic of orthopedic dentistry for the production of removable dentures.

VIII. Materials and methods.

Alloy of gold AU 900 blanks.
STRUCTURE: 90% gold, 4% silver, 6% copper.
PROPERTIES: melting point 1063°C. The alloy is characterized by ductility, easy to machine under pressure (stamping, forging). The gold alloy is made in the form of a disk. The alloy is easily erased. Therefore, when manufacturing stamped crowns from the inside, solder is poured on the chewing surface or cutting edge. They are available in the form of disks and blocks.
Gold alloy of 750 samples.
COMPOSITION: gold-75%, silver and copper-8%, platinum-9%.
PROPERTIES: Platinum gives this alloy elasticity and reduces shrinkage during casting.
Silver-palladium alloys have a higher melting point - 1100-1200 C. Their physical and mechanical properties are similar to gold alloys of gold. The corrosion resistance is lower. Alloys are ductile and malleable. Soldered with gold solder.
Alloy Pd-250.
COMPOSITION: silver-75.1%, palladium-24.5%, some alloying metals (zinc, copper, gold).
Alloy Pd-190.
Alloy Pd-150. Reduced the amount of palladium to 14.5%, increased the amount of silver.
Base metal alloys:
COMPOSITION: carbon-1.1%; nickel-9%; chromium-18%; manganese-2%, titanium-0.35%, silicon-1%, the rest-iron.
STRUCTURE: carbon-0.2%, 9% nickel, chromium-18%, manganese-2%, titanium-1%, silicon-1%, the rest-iron.
* STEEL GRADE 25X18N102. COMPOSITION: carbon-0.25%, nickel-10%, chromium-18%, 2.0% manganese, silicon-1.8%, the rest-iron.

Cobalt-chromium alloy.
STRUCTURE:
• cobalt - 66-67%, the basis of the alloy, solid, durable and lightweight metal.
* chromium - 26-30%, to increase corrosion resistance.
* nickel - 3-5%, increases ductility, ductility, viscosity, improves the technological properties of the alloy.
* molybdenum - 4-5. 5%, increases the strength of the alloy.
* manganese-0.5%, increases the strength, quality of casting, lowers the melting point, helps to remove toxic sulfur compounds from the alloy.
* carbon - 0.2%, reduces the melting point and improves the fluidity of the alloy.
* silicon-0.5%, improves the quality of castings, increases the fluidity of the alloy.
• iron - 0,5%, increases fluidity, improves the quality of castings.
Properties of KHS-dental alloy:
It is characterized by good physical and mechanical properties, low density. The melting point is 1458C. The alloy is resistant to abrasion and retains its mirror-like luster for a long time. [3]

Titanium alloys. In dentistry, both pure (99.5%) and its alloys are used. Its mechanical characteristics are no worse than those of some noble alloys used for dental purposes. The titanium coating forms a resistant oxide film, thanks to which it is resistant to corrosion and biologically compatible with the soft tissues of the human oral cavity.
For the manufacture of removable dentures with cast bases, metals and their alloys are used. Such materials include alloys of noble (to a greater extent) and base (cobalt-chromium alloys) metals. But despite this, they continue to be used because of their excellent biocompatibility with the human body. Gold-based alloys are strong, withstand heavy chewing loads, have an antibacterial effect, do not cause an allergic reaction, darkening and inflammation of the gums. They are not subject to corrosion, do not react with saliva, do not cause intoxication. In its pure form, gold is not used because of its softness and is therefore used exclusively with additives.[4]
Cobalt-chromium alloys (CCS) were used in general orthopedics for prosthetics of large joints, and from there came to dental prosthetics. The advantage of these prostheses is high strength, rare cases of individual intolerance, and cost-effectiveness. The disadvantage is the need to turn the teeth (their service life is reduced), as well as the overload of the supporting nodes, which sometimes leads to the destruction of their periodontal. The melting point of CCS is slightly less than 1500°C. The alloy is suitable for casting complex structures in terms of configuration, although it creates some difficulties in manufacturing. According to the "price-quality" parameter, cobalt-chromium alloys are considered one of the best dental materials for prosthetic frames. They are characterized by the following properties: high biocompatibility with oral tissues. In rare cases, individual intolerance to individual components, such as nickel, may be observed. Good physical and mechanical properties (strength, corrosion resistance, high wear resistance). Satisfactory properties of injection molding. They are inferior to nickel-chromium alloys, but if the technology is followed, they can cast accurate, but at the same time openwork designs. Economical (cheaper than gold and zirconium dioxide).
Titanium has taken its rightful place among modern materials. With an increase in allergic reactions to various alloys and metal alloys used in medicine and dentistry, titanium is considered as the main alternative. Titanium has attracted the attention of orthopedists due to its remarkable biocompatibility and good stability. High biocompatibility is determined by the ability of titanium to form a protective oxide layer on its own surface in a fraction of a second, so that it does not release free metal ions that are ready to cause pathological processes around the implant or prosthesis. At the moment, titanium gives us the ability to use only 1 metal in the oral cavity. We can make almost any design. There are no chemical interactions between the various elements of the prostheses, but the tissues around the prosthesis remain independent of metal ions.[5]

Titanium is a pure chemical element, a metal; it has the ability, while in the body, to be inert for a long period; in dental prosthetic equipment, pure titanium is used in 4 gradations (from T1 to T4); hardness, depending on the gradation, from 140 to 250 units.
As long-term practical activity has shown, having numerous positive properties, metals have every chance to have negative effects in the tissue of the prosthetic bed and the body as a whole.[6,7] Factors of metal intolerance in the rarest cases are considered: mechanical trauma of the oral mucosa with removable dentures, exposure to the oral mucosa with bacteria that are present in the plaque of the prostheses, allergic and toxic-chemical effects of substances that make up the prostheses, internal organ disease, hormonal disorders, psychogenic factors. An important obstacle to the entry of allergens, toxic elements, bacteria and their waste products into the human body is the epithelium, in this case, mechanical trauma of the mucous membrane is one of the main factors of intolerance to removable dentures .[8] The epithelium is subjected to mechanical trauma, under the influence of a wide range of temperatures, fluctuations in PH values, and exposure to irritating and damaging factors. It is known that the basis of the removable prosthesis should clearly reproduce the microrelief of the mucous membrane of the tissues of the prosthetic bed. But, in the course of metal casting, its linear-volume changes inevitably occur due to shrinkage. There are discrepancies between the relief of the base of the prosthesis and the relief of the tissues of the prosthetic bed [9].
Thus, research data from Russian and foreign sources of literature suggests that a large range of basic materials is used today, which are subject to high requirements for quality, comfort, and high aesthetics. It is necessary to emphasize that such materials must have high hygienic properties, the characteristics of which have a great influence on the operational properties.

IX. Results.

The patient with a plate prosthesis does not fully feel the taste of food and temperature changes, since the base of the structure is covered by the mucous membrane of the hard palate. And, consequently, the area of receptors that respond to external stimuli decreases. Dentures with a metal base differ from plate dentures and have their own advantages. The patient feels less foreign body in the mouth, because the metal base is thinner than the plastic one. The perception of cold and hot food is preserved due to the fact that the metal base has good thermal conductivity. The metal-based prosthesis is suitable for patients with allergies to acrylic and plastic.
One of the main reasons for choosing metal is the frequent failure of the prosthesis with a plastic base. Over time, it ceases to withstand the chewing load and breaks into two parts.
Any prostheses in the mouth affect the mucous membrane and disrupt the process of salivation. In patients with a metal base, dry mouth is less common than in patients with a plastic prosthesis.
Also, inflammation of the mucous membrane of the upper jaw with a metal prosthesis is less common than with a plastic one.
For oral hygiene, it is better to have a prosthesis with a metal base. Its surface is smooth, unlike plastic, so the plaque on it does not settle much. And on a metal base, this will be more noticeable, so the patient will have to carefully monitor the quality of cleaning.[10]
It can be summarized that prostheses with a cast base are preferable to plastic ones. Patients with such prostheses feel more confident and do not have additional costs for the repair of the prosthesis.

X. Discussion

The advantages of choosing a cast base for the production of food products are shown by the following properties: :
* precise fit and secure fixation in the oral cavity ;
* quick habituation and the possibility of constant wear (even during a night's sleep );
* uniformity of the base material, lack of hygroscopicity, non-susceptibility to food color and absorption of foreign substances;
* the strength of the prostheses and the rational distribution of mechanical loads when placed only on one side of the jaw;
• maintaining the temperature sensitivity;
* biochemical equality of oral fluid.[11,12,13]
XI. Conclusion

Thus, prostheses with a cast base have a higher chewing efficiency, they can be used for allergies to acrylic plastics, with an increased gag reflex, repeated fractures of plastic bases, low clinical crowns. This all allows the orthopedic dentist to use removable dentures with a cast base.

Молодежный инновационный вестник. 2021;10(S1):370-373
370-373

### ETHICS AND DEONTOLOGY IN THE SPECIALTY "ORTHOPEDIC DENTISTRY" QUALIFICATION «DENTAL TECHNICIAN»

Barysheva G.

#### Abstract

Relevance: medical deontology is studied in sufficient detail in higher and secondary specialized educational institutions at those faculties and departments, after which specialists are in constant business contacts with patients, their relatives and with each other.

The purpose of the work is to improve the quality of professional activity, taking into account ethical and deontological principles.. The scientific literature devoted to the moral and ethical component of the dental technician profession is quite small. This is due to the relatively recent emergence of this specialty as an independent profession, not related to the dentist, as well as the lack of need for constant communication between the dental technician and the patient. All this proves that ethics and deontology in the profession of a dental technician are given insufficient attention in modern conditions.

Materials and methods: the subject of this study is the teaching of the duty and moral foundations of the work and behavior of a medical specialist qualified as a dental technician by studying the field of activity of a dental technician, systematizing general cultural and professional competencies for the formation of key modern ethical and deontological principles at all stages of the manufacture of orthopedic structures.

Results: it was found that dental technicians, who do not have the right to manipulate the oral cavity, rarely contact patients, but this does not exempt them from strict compliance with the principles of deontology when performing functional duties. The more competent and experienced the technician, the more often he is invited to the doctor's office in order to consult how best to solve a particular problem of a technical and aesthetic nature. The treatment of specialists to each other should be polite, ethical, and the whole conversation is aimed at making a decision in favor of the patient.

Conclusion: everyone working in the laboratory, having a permanent individual place in the technical laboratory, should plan the work during the day in such a way as to reduce the queue for collective places in specialized premises, without allowing a clash of interests. The better the microclimate in the dental laboratory, the more meaningful, interesting, and desirable the work activity.

Молодежный инновационный вестник. 2021;10(S1):373-377
373-377

### PROTEOLYTIC ACTIVITY OF ANTISEPTICS USED IN MEDICAL ROOT CANAL TREATMENT

Bayazova O.A., Nurmotov N.S.

#### Abstract

ANNOTATION

Endodontic therapy consists of medical and mechanical root canal treatment. This is rather a challenge for a dentist who has to work practically blindfolded. Irrigation of root canals is one of the main steps in endodontic therapy. Medical treatment destroys the infection in the root end opening. This is a tooth-saving measure taken to prevent complications and secondary infections.

Purpose. The purpose of this research is to compare and analyze proteolytic activity of antiseptics used for irrigation of root canals.

Methods. The determination of proteolytic activity required research methods as follows: theoretic, empirical and mathematical.

Outcome. Pieces of chicken breast of the same weight (initial wight) were fully submerged in antiseptics, earlier selected for the test. 24 hours later the chicken breasts were taken out and their weight was compared with the initial weight. Having done some necessary calculations we determined the proteolytic activity of the antiseptics.

Conclusion. The research shows that Belodez has the highest proteolytic activity, while Chlorhexidine has the lowest

Молодежный инновационный вестник. 2021;10(S1):378-379
378-379

### MODERN TRENDS IN THE MANUFACTURE OF POST DESIGNS OF DENTURES FROM VARIOUS MATERIALS

Burlo A.

#### Abstract

STRUCTURED ANNOTATION
Delayed treatment of teeth with a damaged crown and a violation of its integrity can develop morphological problems in the structure of the dentition, which lead to dysfunction in the dentition. The longer the pathology develops, the more difficult it is to recover. There are many ways to eliminate teeth defects. But, with the complete destruction of the crown of the tooth, the particular problem of restoring the structure of the dentition motivates to search for the most effective restorative procedures.
One of the criteria in solving this question is the preservation of the roots of the teeth, suitable for prosthetics, excluding atrophy of the alveolar processes, the formation of pathologies and deformities of the dentition. The presence of a root is an important factor in the restoration of a decayed tooth. To recreate teeth, the most reliable and demanded cast stump pin tabs are used.
Purpose: to study and systematize the use of modern nail designs of dentures from various materials.
Materials and methods: 1. to give a comparative characteristic of existing in clinical practice post orthopedic structures made of various materials used to restore complete or partial destruction of hard tissues of the dental crown. 2. To systematize the methods of manufacturing various types of post orthopedic structures depending on the conditions in the oral cavity and to display the peculiarities of working with each technique. 3. To identify the most optimal in all characteristics type of pin orthopedic structures used in clinical practice to restore significant destruction of the coronal part of the teeth, and the method of its manufacture.
Results: 1. Comparative characteristics of existing in clinical practice post orthopedic structures showed the importance of using modern post designs of dental prostheses from various materials in orthopedic dentistry. 2. Systematization of methods for the manufacture of various types of post orthopedic structures depending on the conditions in the oral cavity showed a wide range of applications and the choice of post designs depending on the individual characteristics of the human oral cavity. Stump post inlays created in the oral cavity using standard posts are made in one step and have high-quality aesthetic properties. Cast pin structures made using individual modeling on a model in a laboratory are characterized by the best strength properties both for fracture and for abrasion. 3. It was possible to reveal that cast stump pin inlays are the most optimal in all characteristics type of pin orthopedic structures used in clinical practice to restore significant destruction of the coronal part of the teeth, and the method of its manufacture.
Conclusion: in recent years, the use of modern pin designs of dental prostheses from various materials is increasingly being introduced into dental practice, as a result, the availability of these methods is increasing.

Молодежный инновационный вестник. 2021;10(S1):379-382
379-382

### RULES OF ASEPSIS, ANTISEPTICS AND SANEPID-REGIME IN THE DENTAL LABORATORY

Evsikova P.

#### Abstract

On the territory of the Russian Federation, the number of HIV-infected persons increases annually. So for 2017, 1,200,000 people with HIV infection were registered. However, according to the international medical institutes, WHO and the international organization UNAIDS, the number of infected people is almost 2 times higher.Thus, according to UNAIDS [2011], for every officially confirmed case, there may be 10-15 unconfirmed cases [2]. According to the laws of the Russian Federation, a dentist cannot refuse admission to a person with a confirmed HIV infection [F3-38 of 30.03.1995]. However, the patient has the legal right not to disclose their diagnosis. This puts the dentist at a certain risk [1]. Therefore, prevention of transmission of nosocomial infection and proper sterilization is important in this matter.

Молодежный инновационный вестник. 2021;10(S1):383-386
383-386

### COMPARATIVE CHARACTERISTICS OF MODERN THERMOPLASTIC MATERIALS BASIC MATERIALS

Kibartas Y.

#### Abstract

The provision of high-quality dental care, the result of which is the functional usefulness, aesthetics and durability of the use of a dental prosthesis is impossible without a thorough approach to the study of the properties of the main materials used in dentistry. Most of the bases of removable dentures today are made of acrylic plastics, which consist of a polymer powder and a monomer liquid. During their mixing and further polymerization, errors often occur, which lead to undesirable consequences. In addition, the quality requirements for the main chemical components of modern polymers are constantly increasing. Thermoplastics are currently one of the most used basic materials for the manufacture of dentures in the clinic of orthopedic dentistry. They are aesthetic, hypoallergenic, and easy to use. Like other materials, they have their own positive and negative properties. Therefore, it is necessary to compare the properties of these materials for the manufacture of dentures and identify the most suitable for a particular clinical case. The research paper presents a comparative analysis of the properties of modern thermoplastics for removable prosthetics used in orthopedic dentistry.

Молодежный инновационный вестник. 2021;10(S1):386-389
386-389

### THE ADVANTAGE OF ENDOGENOUS DRUGS OVER EXOGENOUS IN TREATMENT CARIES

Kireeva A., Ippolitov Y.

#### Abstract

Despite the widespread use of high technology, the prevalence and intensity of dental caries remains high. Currently, there is insufficient information on the effectiveness of endogenous methods of caries prevention. This was the reason for this study.

Молодежный инновационный вестник. 2021;10(S1):389-390
389-390

### ERRORS IN THE MANUFACTURE OF METAL-CERAMIC PROSTHESES. CAUSES AND WAYS TO ELIMINATE THEM

Kuzmina O.E.

#### Abstract

Relevance: in modern orthopedic dentistry, the production of metal-ceramic dentures is almost an everyday practice of a dentist and a dentist. Unfortunately, we have to state the fact that metal-ceramic crowns and bridges are not perfect structures, despite the use of modern structural and auxiliary materials, high technical and instrumental capabilities of orthopedic dentistry and dental production

The aim of the work is to assess possible errors in the manufacture of metal-ceramic prostheses to improve the quality of orthopedic treatment.

Materials and methods: systematization of the causes, errors and complications at the technological stages of the manufacture of metal-ceramic restorations and the study of methods for their elimination.

Results: after studying the clinical and laboratory stages of manufacturing metal-ceramic structures, the main types of errors were identified, which were divided into clinical, laboratory and errors at the casting stages. The subject of this study was a detailed study of technological errors. We have identified the causes of errors at each laboratory stage of manufacturing and provided recommendations for their prevention and methods of elimination. It is revealed that the most common defects are identified at the stages of modeling and casting the frame, as well as at the stages of applying and firing ceramic masses.

Conclusion: the resulting errors and complications dramatically reduce the time of use of metal-ceramic structures, affect the dissatisfaction of patients with the quality of orthopedic treatment, provoke conflicts and proceedings, and most importantly, dramatically reduce the quality of dental health and human life.

Молодежный инновационный вестник. 2021;10(S1):390-395
390-395

### FEATURES OF THE LABORATORY STAGES OF MANUFACTURING A REMOVABLE PROSTHESIS FROM THERMOPLASTIC MATERIALS

Kumskova D.

#### Abstract

In orthopedic dentistry, removable and non-removable denture structures are widely used, which serve to replace defects in the dentition of various lengths and restore the functions of chewing and speech.
At the present stage of development of orthopedic dentistry, the requirements for basic materials have increased, the quality of which, to a large extent, determines the functional value of removable dentures. Currently, the market is saturated with a huge variety of basic materials of various quality and technological characteristics.
Recently, technologies for manufacturing removable and non-removable structures made of thermoplastics, which are characterized by the absence of a residual monomer, have appeared on the Russian dental market. They do not contain toxic or allergenic additives, have high biocompatibility and the ability to remember shapes. A high degree of plasticity, accuracy in the manufacture, a wide color gamut to empower and partial removable dentures, splinting, manufacturing immediat-dentures, periodontal prosthesis, tires-dentures and enhance their aesthetic qualities.
Purpose: to justify the use of modern polymer materials in the clinic of orthopedic dentistry for the manufacture of removable dentures.
Materials and methods:
1. To study the main properties of modern dental thermoplastic materials made of nylon used in the clinic of orthopedic dentistry.
2. Improve the laboratory stages of manufacturing removable nylon prosthetics.
Results: 1. To analyze the use of thermoplastic materials used in prosthetic dentistry for bases removable laminar dentures; 2. To study bioinertness polymers for medical purposes; 3. Find out what quality bases removable laminar dentures affects the tissues of the prosthetic bed, the microflora of the oral cavity and durability of the denture; 5.To identify that nylon is the most optimal performance on all kind of thermoplastic materials used in prosthetic dentistry to restore chewing function.
Conclusion: Thermoplastic polymer materials for dental use based on nylon:
- do not contain a residual monomer, which means that they do not subsequently cause a toxic and allergic reaction to the human body as a whole, that is, they have biocompatibility;
- have increased strength;
- have elasticity, shape memory, stability;
- have good aesthetic characteristics;
Thus, as the experience of using these materials has shown, a number of positive properties of thermoplastics allow dentists to expand the indications for the manufacture of many orthopedic structures in the treatment of partial tooth loss, complicated by dental deformities and periodontal diseases.

Молодежный инновационный вестник. 2021;10(S1):395-399
395-399

### MODERN ASPECTS OF THE USE OF ZIRCONIUM DIOXIDE IN ORTHOPEDIC DENTISTRY

Litvinova A.K.

#### Abstract

Relevance When it comes to zirconium oxide, first of all, we mean tetragonal polycrystalline zirconium oxide, partially stabilized by yttrium oxide. It is a high-tech ceramic material that is successfully used in orthopedic dentistry for the manufacture of almost all types of restorations. First, zirconium is processed chemically, and then zirconium blanks are formed from it mechanically. There is a wide variety of manufacturers and types of this ceramic. Available in blocks of various sizes. For their coloring, special dyes are used.

Objective: to study the main aspects of the use of zirconium dioxide in the practice of dental technicians at the present stage to improve the effectiveness of orthopedic treatment with fixed structures.

Materials and methods: a modern structural material - ceramics based on zirconium dioxide-was chosen as the research material. We have analyzed the domestic and foreign literature on the features of the use of zirconium dioxide in dental practice, systematized the advantages and disadvantages of zirconium dioxide in orthopedic dentistry. The clinical and laboratory stages of manufacturing a single crown are studied, the most significant technological principles in the manufacture of orthopedic structures based on zirconium dioxide are determined by the example of manufacturing a single crown on a tooth.

Results: the study identified the advantages of this material, the main of which are its strength and aesthetic characteristics, and the main disadvantage is the large material costs for the production of orthopedic structures and implants from it. But at present, there is already a tendency to reduce the cost of products made of zirconium dioxide. It was determined that zirconium has a strength similar to metals, so theoretically this material can be the material of choice in the future and replace the metal frames of prostheses, as well as all-metal structures.

Conclusion: it is proved that a number of requirements are imposed on modern dental materials and zirconium dioxide meets them, so it is a promising material with a wide range of applications

Молодежный инновационный вестник. 2021;10(S1):400-402
400-402

### METAL-CERAMIC - REVIEW OF MANUFACTURING TECHNOLOGIES AND COMPARATIVE CHARACTERISTICS

Lyukshted A.R.

#### Abstract

The main goals of modern dentistry are to ensure the most complete restoration of the integrity of the teeth and dentition, to achieve maximum functionality, biocompatibility and aesthetics, as well as to meet the requirements of patients and doctors. Today, in orthopedic dentistry, many different structures of dentures are used to restore the lost functions of the dental system. Each type of prosthesis sufficiently meets the requirements of prosthetics, but the most popular method is the use of metal-ceramic structures, which are currently the most reliable. Metalloceramics are non-removable dentures, which are a metal frame covered with a layer of ceramic mass. Despite the relatively long period of use for stomatology, this type of prosthesis is rapidly improving and there is a huge variety of materials and equipment on the modern market, and all of them meet high requirements. The technology of manufacturing metal-ceramic products is not very complex, however, it still requires the necessary skills from the doctor and technician, precise compliance with the technological stages, concentration and accuracy, as well as specialized equipment, tools and materials. This article is devoted to the review of manufacturing stages and comparative characteristics of the properties of materials used in production.
Молодежный инновационный вестник. 2021;10(S1):402-408
402-408

### METHODOLOGICAL FOUNDATIONS OF 3D TECHNOLOGIES IN ORTHOPEDIC DENTISTRY

Potseluev M.R.

#### Abstract

STRUCTURED ANNOTATION
The development of the scientific and technological revolution allows us to use and implement advanced 3D computer-aided design technologies, both in the daily lives of people and in the field of orthopedic dentistry.
Purpose: to study and systematize the possibilities of using modern digital technologies in dental production.
Materials and methods: 1. To analyze the literature on the use of computer technologies in dentistry. 2. To systematize the main types of digital technologies in the modern practice of a dental technician. 3. Analyze the advantages and prospects of various areas of digital technologies in dental production.
Results: 1. The analysis of the literature has shown the importance of using 3D technologies in orthopedic dentistry. 2. The modern practice of a dental technician is implemented using a number of digital technology segments: tomographs, which can be used to plan treatment; scanners, which are necessary for obtaining digital models of the jaws; 3D printers and milling machines, which create inlays, crowns and other orthopedic structures, and monitors help us to visualize the stages of modeling. 3. Digital technologies have a number of advantages compared to traditional methods of prosthodontics: the process of making dentures is fully automated and reduces the involvement of the human operator to a minimum; ready dentures fully take into account the purely individual anatomical structure of the patient's mouth; it is possible to accept or e-mail orders for the manufacture of dental prostheses, easily restore lost or damaged dentures; the productivity of the dental prosthetic laboratory increases while reducing the time for manufacturing and installing prostheses.
Conclusion: In recent years, digital technologies have been gradually introduced into dental practice in connection with the development of 3D technologies, as a result, the availability of these methods and equipment is increasing.

Молодежный инновационный вестник. 2021;10(S1):408-412
408-412

### TREATMENT OR REMOVAL OF A WISDOM TOOTH

Serikova M.G., Popova A.M.

#### Abstract

This article shows the possibility of diagnosis and a comprehensive approach to the treatment or removal of wisdom teeth. We are aware of the peculiarities of the treatment and removal of teeth in the Soviet period. The procedure for removing wisdom teeth, medical treatment of complications is described.

Молодежный инновационный вестник. 2021;10(S1):413-416
413-416

### PERSONAL METHOD OF ORAL HYGIENE FOR DIFFERENT TYPES OF ORTHODONTIC INTERVENTION

Ovsyannikova E.V., Popova V.S.

#### Abstract

Currently, anomalies associated with the development of the dentoalveolar system are widespread, more than half of these patients need orthodontic treatment. Orthodontic devices contain retention elements in their design, due to which the hygienic condition of the oral cavity and the dentition itself deteriorates. This, in turn, entails various dental diseases. The intensity of damage to the tooth and periodontal tissues against the background of anomalies of the dentoalveolar system depends on the consistent and correct implementation of personalized hygiene procedures. Thus, the problem of prevention of dental diseases in the presence of dental anomalies in orthodontic treatment and the development of individual effective hygiene measures of the oral cavity in the treatment of various orthodontic devices is an urgent problem of dentistry.
The goal is to develop personal methods of oral hygiene in orthodontic treatment and to study their effectiveness.
In the course of the study, patients with removable orthodontic plates aged 8 to 14 years and patients with non-removable braces aged 20-35 years were examined. The study was conducted before the selection and preparation of recommendations for individual oral care, 14 days, 1 month after the proposed detailed recommendations.
Prior to the development and application of individual measures in patients with removable orthodontic apparatus and fixed orthodontic structures, it was found that the Fedorov-Volodkina hygiene index and the RNR hygiene index were insufficient and indicated poor oral hygiene. This proves that the standard care provided by patients on their own is not sufficient to achieve a positive result in hygienic oral care.
Individual preventive measures were developed and proposed for each patient undergoing orthodontic treatment.
The evaluation of the effectiveness of the developed measures was carried out after 14 days, 1 month. An improvement in the quality of oral hygiene was revealed by visual inspection and evaluation of hygiene indices, which indicated positive dynamics and good oral hygiene.
Based on the results of the study, we can conclude that the actual effect of hygiene procedures can be achieved only as a result of an absolutely personal approach to each patient. At the same time, reduce the risk of periodontal diseases and dental caries during orthodontic treatment.

Молодежный инновационный вестник. 2021;10(S1):416-419
416-419

### PROSTHETICS ON IMPLANTS IN AN AESTHETICALLY SIGNIFICANT AREA

Ryabikina D.A.

#### Abstract

At the moment in the development of dentistry, the restoration of anterior teeth is of great importance, since they affect the function, anatomy and aesthetics of the dentition. This research paper presents an algorithm for prosthetics on single implants in an aesthetically significant area. The aesthetically significant area is the area that is visible with a wide smile. Replacement of a tooth in the anterior region depends on white (restoration itself) and pink (adjacent gingiva) aesthetics. This article describes the results of the research using both theoretical (work with educational and scientific literature) and empirical (conversation) methods. The object of the study was middle-aged people with loss of anterior teeth. Issues such as the expediency of using aesthetic materials in an aesthetically significant area - metal-free ceramics (zirconium dioxide and lithium disilicate) and various types of fixation; choice of treatment tactics depending on the biotype of the patient's gums. Attention is paid to the assessment of the placement of the implant and the choice of the abutment, the importance of adhering to all clinical stages in a certain sequence and the installation of a provisional prosthesis to form the correct contour of the eruption and the gingival margin. Prosthetics on implants have high durability, excellent aesthetic and functional results.

Молодежный инновационный вестник. 2021;10(S1):419-422
419-422

### OPTIMIZATION OF THE CHOICE OF THE LOCKING SYSTEM OF FIXATION IN CLASP PROSTHETICS

Sinitсyna A.P.

#### Abstract

STRUCTURED ANNOTATION
One of the unique prostheses that can restore the lost teeth of the upper and lower dentition is a clasp prosthesis, which is a combined method of transferring the chewing load through the teeth to the periodontal tissues and soft tissues covering the toothless alveolar processes. In various clinical situations in the oral cavity of patients, it can be difficult to create the right design of the denture, to choose the right fixing elements that meet both the needs of patients according to aesthetics and functional effectiveness.

Objective: To optimize the effectiveness of treatment of patients with dentition defects using a clasp prosthesis with a locking system of fixation, by analyzing the features of the functioning and design of various types of lock fasteners.

Materials and methods: 1. To review the literature on the use of various types of clasp prostheses in patients with dentition defects. 2. To give a comparative description and systematize the locking systems of fixation in clasp prosthetics. 3. To identify the most optimal type of lock system of fixation in clasp prosthetics for all the characteristics of orthopedic practice.

Results: 1. The review of literature revealed the importance of a full range of diagnostic and treatment procedures in the oral cavity of patients with different defects of dentition, and careful clinical and laboratory planning structures partial denture with a locking mechanism in each clinical case individually, to produce a high quality prosthetic.
2. Comparative characteristics of existing in clinical practice lock fasteners for clasp prosthetics showed significant advantages of various lock systems of the company "Bredent", depending on the clinical situation in the patient's oral cavity, compared with the designs of other manufacturers
3. Practical experience of prosthetics of extended defects of dentition has shown the best quality results in the manufacture and use of patients with clasp prostheses with lock fasteners of the company " Bredent»

Conclusion: After analyzing the literature and systematizing the data, it was found that Bredent lock fasteners can be used in the manufacture of a clasp prosthesis in almost any clinical situation with end and included defects of the dentition. They are aesthetic, functional and easy to use.

Молодежный инновационный вестник. 2021;10(S1):422-426
422-426

### CAD / CAM TECHNOLOGIES AS A FULL-FLEDGED TOOL IN THE DAILY PRACTICE OF A DENTAL TECHNICIAN: AN OVERVIEW OF MODERN CAPABILITIES

Snegireva V., Guriev K.

#### Abstract

In the daily practice of a dental technician, the specialist faces various difficulties when performing technical work on the prosthetics of the dentition. Orthopedic dentistry is a dynamically developing vector of dental science. New methods of prosthetics, as well as modern materials are used. In difficult conditions of prosthetics, where previously the only indication for the patient was prosthetics with a removable plate prosthesis, now work on implants is widely used [1]. To perform such work, a dental technician requires a high level of skill, professionalism and experience. Such work is multi-stage and requires a large resource of time for their implementation. Digital technologies in dentistry are developing with positive dynamics. One of the areas of digital technologies in dentistry is CAD/CAM systems. The capabilities of CAD/CAM systems, as well as the artificial intelligence of the software environment, constantly open up new opportunities for the implementation of various projects by milling, stereolithagrophic printing. Digital impressions obtained by intra-oral scanners are characterized by detail and clarity, as well as the process of obtaining them causes less discomfort in the patient, especially if the patient has a pronounced gag reflex. The 3D scan result is ready to be sent to the laboratory immediately. [2].

Молодежный инновационный вестник. 2021;10(S1):426-429
426-429

### ULTRAMINI. COMPARATIVE CHARACTERISTICS OF MODERN METHODS OF RESTORATION OF THE ANTERIOR GROUP OF TEETH

Utrobina I.I., Kibartas Y.S.

#### Abstract

The study and comparison of methods of restoration of the anterior group of teeth are important components for improving the provision of high-quality dental care and aesthetics.
Ultramini are an innovative method of aesthetic restorations. They are very thin dental linings made of ceramic, and have a thickness of up to 0.3 mm. Ultramini used in adjusting the color and shape of teeth, and for the protection of the front teeth.
The predecessor of ultranarrow was veneers and lumineers. At the first stages of using veneers, specialists applied a layer-by-layer reflective filling material to the surface of the tooth, which was previously subjected to preparation.
Subsequently, the pads were made whole, the need for deep preparation of the tooth was reduced to a minimum. Such independent dental plates became known as lumineers. But they had one big drawback - they were patented in the United States. As a result, they had a very high cost.
It lumineers served as an example for creating high-quality domestic analogue of ultranarrow.

Молодежный инновационный вестник. 2021;10(S1):429-431
429-431

### APPLICATION OF OSTEOPLASTIC MATERIALS IN ALVEOLAR BONE DESTRUCTIVE PROCESS IN SURGICAL DENTISTRY

Kharitonov I.D., Moiseeva N.

#### Abstract

Actuality. According to statistics, diseases of the maxillofacial region, accompanied by alveolar bone destructive processes, occupy a leading place in the structure of maxillofacial defects, therefore, along with the modern surgical methods, the rationale approach for choosing optimal bone-plastic materials becomes relevant.
Aim. Study of the composition and properties of osteoplastic materials used in bone-destructive changes of the maxillofacial region.
Materials and methods. The composition and properties of three groups of the most common osteoplastic materials, indications and contraindications to use, as well as methods of their using were studied.
Results. The advantages of xenogenic materials are the absence of restrictions on the amount used, good osteoconductivity, and the absence of immunological reactions of the recipient. Disadvantages include the possible manifestation of an allergic reaction and infection. Among the advantages of allogeneic materials are their high osteoinductive potential, but their disadvantages are: biological incompatibility of tissues, possible manifestation of an allergic reaction, infection. Synthetic materials have advantages: there is no necessity to take bone tissue, the likelihood of infection is excluded. The main disadvantage of the group of materials is the lack of osteoinductive properties.
Conclusion. Thus, the rationale for the use of a particular bone-plastic material depending on various clinical situations by doctors and dentists-surgeons may be due to the presented systematic review and comparative characteristics of osteoplastic materials.

Молодежный инновационный вестник. 2021;10(S1):431-436
431-436

### DYNAMICS OF THE OPTICAL DENSITY OF THE JAW BONE TISSUE IN PATIENTS WITH BISPHOSPHONATE OSTEONECROSIS

Shelegova I.

#### Abstract

Early diagnosis of bisphosphonate osteonecrosis of the jaws in cancer patients is critical to prevent excessive bone loss. The development of a method for early diagnosis of bisphosphonate osteonecrosis based on measuring the optical density of bone tissue is promising. Purpose: to investigate the dynamics of the optical density of the jaw bone tissue in patients with bisphosphonate osteonecrosis. Materials and methods. A retrospective analysis of the medical histories of oncological patients was carried out; for a detailed study, a group of 6 patients with a confirmed diagnosis « bisphosphonate osteonecrosis» of the mandibles while taking zoledronic acid (n = 6) was selected. In these patients, the optical density in the mandibles was determined in dynamics: before the start of therapy and after 4-24 months of therapy with zoledronic acid. Research results. On the affected side in the lateral part of the mandibles, all patients showed a decrease in the average optical density by 6.65 - 409.7 HU. Conclusions: the results of this study may indicate that in patients 1-3 months before the appearance of clinical and radiological signs of bisphosphonate osteonecrosis, a decrease in the average optical density in the mandibles is observed.

Молодежный инновационный вестник. 2021;10(S1):436-438
436-438

### SETTING ARTIFICIAL TEETH IN REMOVABLE PROSTHETICS-FROM THE COMPLETE ABSENCE OF TEETH TO THE SUPPORT OF PROSTHESES ON IMPLANTS

Yugai R.A.

#### Abstract

Currently, orthopedic treatment of patients with complete absence of teeth (complete adentia) is a rather complex process, because it is necessary to make a prosthesis that will not only function correctly, but also have high aesthetic qualities. To do this, you must take into account all the anatomical features of the oral cavity.
The majority of patients with complete absence of teeth who went to the dentist have a significant atrophy of the alveolar ridge, and therefore a disturbed interalveolar height, which greatly complicates the placement of artificial teeth during the manufacture of the prosthesis.
In modern orthopedic dentistry, many methods of setting artificial teeth are known. All of them have certain advantages and disadvantages. And it is impossible to single out the best method, because each patient's oral conditions are purely individual. In the manufacture of prosthetic dental technician must take into account the atrophy of the alveolar ridges, jaw relation, the number of existing natural teeth, the location of the incisive papilla, the height of the lower section of the face, as the temporomandibular joint, the flexibility of the mucous membrane, the presence of exostosis, allergic reactions to the material of which the prosthesis will be made and a lot more. Thus, in each clinical case, a certain method of setting artificial teeth will be effective.

Молодежный инновационный вестник. 2021;10(S1):438-442
438-442

## Фармация

### STUDY OF THE ANALGESIC ACTIVITY OF NEW SULFUR-CONTAINING DI- AND TETRAHYDROPYRIDINE DERIVATIVES IN THE OROFACIAL TRIGEMINAL PAIN TEST

Bibik E.Y., Samokish A.A., Venidikova V., Krivokolysko D.S., Pankov A.A., Frolov K.A., Dotsenko V.V., Krivokolysko S.G.

#### Abstract

This article is a search for new modern drugs for pain control. We selected di- and tetrahydropyridines for pharmacocorrection of pain syndrome. Determination of analgesic activity was carried out in the orofascial trigeminal pain test.

Молодежный инновационный вестник. 2021;10(S1):443-446
443-446

### SEARCH FOR NEW ANALYZES - OCUSS ON SULFUR-CONTAINING DI- AND TETRAHYDROPYRIDINES

Samokish A., Venidiktova Y.

#### Abstract

The article presents screening studies of 5 samples of sulfur-containing di - and tetrahydropyridines synthesized on the basis of the NIL "Himex" in the test of orofascial trigemenal pain by subcutaneous injection of 0.1 ml of 5% formalin solution into the vibrissae region of white male rats. The most pronounced analgesic activity at a dose of 5 mg/kg is shown by the following compounds with ciphers as-262, do2-138, and fo2-079, which are more effective than analgin at late follow-up.

Молодежный инновационный вестник. 2021;10(S1):446-448
446-448

### ASSESSMENT OF THE QUALITY OF PHARMACEUTICAL ADVICE TO VISITORS IN RETAIL PHARMACIES OF THE REPUBLIC OF BELARUS

Korol Y.

#### Abstract

Introduction. In connection with the introduction of the new edition of the Good Pharmacy Practice in the Republic of Belarus, it is necessary to develop practical approaches to the organization of pharmaceutical consulting in retail pharmacies. Purpose. Assess the quality of pharmaceutical advice in retail pharmacies and propose approaches to organizing pharmaceutical advice, taking into account changes in Good Pharmacy.
Practice Materials and methods. The study was conducted on the basis of private and state-owned pharmacies in the city of Minsk from December 2020 to February 2021 by the method of photo timing. Using the Microsoft Excel program, the mean values ​​and boundaries of the confidence interval of service time were calculated when patients were sold to patients with a different number of over-the-counter (for product and problematic issues) and prescription drugs.
Results. The service time for visitors to pharmacies naturally increases with an increase in the number of dispensed drugs. Most of the time is spent when selling one drug if there is a doctor's prescription for it, a little less when selling an OTC drug for a problematic issue, and much less when selling a request for one OTC drug. Assessment of the quality of counseling showed that it is best carried out in case of a problematic issue, however, even in this case, the pharmacy employee does not always inform about the method of using the purchased drug.
Conclusion. To improve the quality of counseling in retail pharmacies of the Republic of Belarus, it is proposed to introduce the position of a clinical pharmacist, to increase the level of knowledge of pharmaceutical workers in this area, and to develop standard operating procedures for pharmaceutical counseling of pharmacy visitors if they have specific health problems.

Молодежный инновационный вестник. 2021;10(S1):448-452
448-452

### ANALYSIS OF THE EXPERIENCE OF THE USE OF ENTEROSORBENTS BY THE POPULATION

#### Abstract

The relevance of this work is determined by the constant changes and innovations taking place in the global pharmaceutical industry. Since the expansion of the drug markets and the increase in the range of products is inevitable, it is important to know which enterosorbents are preferable for patients – old, time-tested and experienced positions, or new market items.
The purpose of the work is to study the experience of using enterosorbents by the population.
Materials and methods. The survey of people from different professional fields was conducted using Google Forms. The following indicators were taken into account: the effectiveness assessment, the frequency and method of use, the prevalence of various names and dosage forms. The respondents also had to answer the question whether they had taken combined enterosorbents and enterosorbents in combination with other drugs and dietary supplements.
Results. 310 people took part in the survey. According to the results of the survey, the most effective, recognizable and used enterosorbents were determined, taking into account the type of dosage form.
Conclusion. According to the results of the study, the absolute majority of respondents used carbon enterosorbents, in particular activated carbon in the classic tablet form due to its long stay on the market, affordability and wide prevalence among the population.

Молодежный инновационный вестник. 2021;10(S1):452-456
452-456

### DISPOSAL OF MEDICINAL PRODUCTS. CHEMICAL DESTRUCTION OF CARVEDILOL AND LOSARTAN

Sazonenka K.

#### Abstract

Relevance. Currently, the disposal and neutralization of pharmaceutical waste is most often carried out by thermal methods, but the use of such methods has a number of disadvantages, the most significant of which is the release of dioxins-substances that can have a negative impact on the human body, including the development of cancer.
Goal. Development and proof of the effectiveness of methods of chemical disposal of medicines on the example of carvedilol and losartan with the help of available reagents, followed by verification of the effectiveness of the destruction of medicinal substances. Evaluation of the toxicity of the products of the neutralization of drugs in silico.
Materials and methods. The structure of the obtained products was determined using the method of Raman spectroscopy.
For the decomposition of medicines, chemical reagents are necessary:
– hydrobromic acid 5% and hydrobromic acid 5%%;
– Fenton reagent (FeSO4 solution 5% + H2O2 solution 33%).
Assessment of the toxicity of starting substances and products of degradation reactions – Toxicity Estimation Software Tool.
Results. During the toxicity analysis, it was revealed that the semi-annual concentration of carvedilol hydrolysis products increased by 15-166055 times. The hydroxylation of losartan reduces the toxicity of the reaction products by 1.8-2.4 times.
Conclusion. The use of the method of chemical neutralization of the active substance can become a new way of safe disposal of medicines. The main difficulty lies in the rational choice of reagents for the destruction of medicinal substances, so that the chemical reaction proceeds under conditions close to normal, without the use of high-tech and expensive equipment.
The proposed methods of destruction of medicines are significantly safer than high-temperature incineration, the rejection of complex equipment and the reduction of energy costs will optimize and simplify the process of disposal of pharmaceutical waste and expired medicines.

Молодежный инновационный вестник. 2021;10(S1):456-459
456-459

### THE POSSIBILITY OF USING DIGITAL COLORYMETRY IN THE ANALYSIS OF SOLUTION SULFACYLI-NATRI

Khandanyan A.M., Ushakova A.V.

#### Abstract

Relevance: The problem of ensuring the quality and authenticity of pharmaceutical products is currently the most important task. To implement control in this area, complex analytical equipment has been developed and manufactured, the cost of which makes it inaccessible to most laboratories. Сonsequently, the development of cost-effective, but sufficiently effective methods of pharmaceutical analysis is a relevant task.

Objective: to substantiate the possibility of using a colorimetric approach for the quantitative determination of the content of substances in a solution that can enter into precipitation reactions.

Methods and materials: To register an analytical signal, it is possible to use any digital device that allows you to register an image (a camera, a web camera, a scanner with a slide adapter, a smartphone). In this work, we used an iPhone 7 with a 13Mp camera. To standardize the lighting conditions, the shooting was carried out in a light-tight camera, the inner surface of which was painted black. The resulting images were analyzed using a standard computer program for image processing Adobe Photoshop. The chromaticity of the images was evaluated using the RGB, HSB, and Lab color models. A solution of sodium sulfacyl was chosen as the object of the study.Results: It was shown that the intensities of individual color channels exhibit a linear dependence on the drug content in the solution, and with a high degree of approximation. These dependencies can be used as calibration data to determine the drug content in the analyzed solution.

Conclusion: This approach allows for quantitative analysis in a wide range of concentrations. This method is characterized by its cost-effectiveness, accessibility, expressiveness and does not require a special tool base, since it uses conventional digital devices and standard software packages.

Молодежный инновационный вестник. 2021;10(S1):459-462
459-462

## Физиологические механизмы адаптации в норме и патологии

### COMPARATIVE ANALYSIS OF FOCAL AND GENERALIZED FORMS OF EPILEPSY IN CHILDREN

Verbickaya V., Buchneva K.

#### Abstract

Relevance: Currently, 5 million people are diagnosed with epilepsy every year, and in the next 15-20 years, only a doubling of the incidence is expected. But along with this, the variety of clinical manifestations, the mechanisms of epileptogenesis and the diagnosis of epilepsy remain among the most complex problems of clinical neurology.
Objective: to conduct a comparative analysis of certain aspects of the diagnosis, clinical course and drug therapy of focal and generalized forms of epilepsy.
Materials and methods: 30 medical records of children with different forms of epilepsy were analyzed. Patients aged from 5 to 18 years, male and female, were under observation. All children underwent video-EEG monitoring according to standard methods in the state of wakefulness and during sleep, the neurological status was examined, magnetic resonance imaging (MRI) of the brain was performed, the anamnesis of life and the anamnesis of the disease were analyzed. The patients were divided into two groups: Group I consisted of patients with a diagnosis of generalized epilepsy; Group II included patients with focal epilepsy. We compared the results of the above-described studies in two groups, on the basis of which conclusions were drawn.
Results: 1. With a generalized form -46.7%. The average age of onset of the disease is 3-4 years. 64% of children have a perinatal diagnosis without special features, 79% of children develop by age. In 85.7% of the patients, no pathologies were detected during the assessment of the neurological status. In most patients, no changes were observed during MRI. EEG-study in the inter-stage period in half of the patients within the normal range. Generalized peak-wave activity with a frequency of 3 Hz and higher is characteristic.
2. Patients with focal epilepsy – 53.3%. The average age is 10-11 years, the average age of onset of the disease is 7 years. The onset of seizures more often occurred during wakefulness. Perinatal history without specific features in 63% of cases, 56% of children with focal epilepsy develop by age. In 63% of patients, brain MRI revealed epileptically significant structural changes. 46% of patients were prescribed monotherapy-valproates, and 31% of patients were prescribed a combination of valproates and levetiracetam. As a result of antiepileptic therapy, remission was achieved in 92% of cases.
Conclusion: various forms of epilepsy have not only clinical specifics, but also neurophysiological features. Based on this, it is necessary to look for the possibility of a comprehensive approach to the assessment of epilepsy and its forms.

Молодежный инновационный вестник. 2021;10(S1):489-493
489-493

### MODULATING EFFECTS OF BIPOLAR GALVANIC STIMULATION ON HUMAN POSTURAL STABILITY

Zheltukhina A., Mukhametova E., Mileckova A.

#### Abstract

Goal. The response to bipolar galvanic stimulation in humans involves mutual changes in the activity of the muscles of the trunk and limbs on both sides, which leads to a lateral oscillation of the body to the anode electrode. The aim of the study was to determine the effect of the modulating effects of bipolar galvanic stimulation on postural stability in humans.
Methods. The study involved students of Kazan (Volga Region) Federal University in the number of 8 people. Each subject was explained the contraindications, the purpose of the study, the methodology and the main stages. The postural stability of the subject was evaluated on the stabilographic platform "Stabilan" produced by ZAO OKB "RITM", Russia, with the appropriate software. Bilateral bipolar galvanic stimulation was performed using a UK-made Digitimer DS 5 stimulator, as well as two skin electrodes. The stimulation was performed using two self-adhesive rectangular silver chloride electrodes, 2 cm2 in diameter, located in parallel, in a single line above the mastoid processes of the temporal bones behind the ears of the subject.
Results. In all samples of the experiment with galvanic stimulation, there were changes in the average values of such indicators as the quality of the equilibrium function during and after stimulation, namely, its increase, a decrease in the linear average velocity of the center of pressure of the feet, the indicator of which decreases with postural stability, a decrease in the area of the CD of the ellipse, also indicating postural stability.
Conclusions. Bipolar galvanic stimulation in conditionally healthy individuals positively affected postural stability in a test with closed eyes in a stand on a soft surface.

Молодежный инновационный вестник. 2021;10(S1):493-496
493-496

### BODY WEIGHT PROBLEMS IN THE MODERN WORLD: ON THE ISSUE OF DIFFERENCES IN SELF-ESTEEM OF WEIGHT AMONG MEN AND WOMEN

Tikhomirova A.P., Tikhomirov V.R., Dzen N.V.

#### Abstract

Relevance. Currently, the problem of obesity has become quite widespread. According to the World Health Organization from 1980 to 2018. the number of obese people around the world has almost doubled and continues to grow. Unfortunately, obesity is not only an external cosmetic defect, but also entails many diseases, such as type 2 diabetes mellitus, arterial hypertension, atherosclerosis, some types of malignant tumors, reproductive disorders, diseases of the gastrointestinal tract, etc. musculoskeletal system. It is worth mentioning such pathology as anorexia, which is a serious medical problem, a disease for the treatment of which it is necessary to work with both a psychologist and other qualified specialists.
Purpose. Study of the characteristics of self-assessment of body weight among men and women.
Materials and methods. To study self-esteem, a survey of 250 people was conducted, men accounted for 29.20% (n = 73), women - 70.80% (n = 177). The average age is 23.5 ± 10.3 years. Based on the answers to the question: "How do you assess your body weight?" in accordance with the proposed answer options, 4 groups were selected for research. For the objectivity of self-assessment of the respondents' body weight, the Quetelet Index was used. Statistical data processing was carried out on the Microsoft Excel platform
Results. To the question: "How do you assess your body weight?", Men in 65.70% of cases attributed their weight to normal, 20.55% to excess, 6.85% found it difficult to answer and 6.85% thought they were obese. Among women, 61.02% rated their weight as normal, 32.20% as excess, 2.82% as obesity, and 3.96% found it difficult to estimate. Subsequently, all groups were analyzed using the Quetelet Index for the correspondence of their self-assessment to the actual body weight.
Conclusion. The study revealed differences in self-reported weight among men and women. Women tend to overestimate their weight more, while men are more objective in their self-esteem.

Молодежный инновационный вестник. 2021;10(S1):496-499
496-499

### PASSPORT AND BIOLOGICAL AGE OF STUDENTS: A COMPARATIVE ANALYSIS

Korolenko A., Рazhetnykh T.

#### Abstract

The article deals with the problem of preserving and strengthening the health of students. According to the results of many studies, in recent years, there has been a tendency towards a decrease in the level of health and their physical activity among students. There are many methods for assessing health status, such as the method for determining biological age.
The purpose of the study is to compare the passport and biological age of students. Materials and methods. The study was carried out on the basis of the Lipetsk Medical College. 53 students of I-IV courses of the specialty General Medicine took part in the research. To determine biological age, the following research methods were used: testing; questioning, observation method; method of generalization, method of synthesis and analysis. Results and conclusion. It was found that compared to senior courses, students of I-II courses, biological age exceeds the passport. The analysis of the research results revealed that the majority of students of the I-IV courses had poor static coordination, decreased attention and reaction speed, as well as a decrease in breath holding during exhalation. Based on the results of the study, a memo was developed for students with recommendations on how to reduce their biological age.

Молодежный инновационный вестник. 2021;10(S1):499-501
499-501

## Физическая культура и медицинская реабилитация

### ASSESSMENT OF THE EFFECTIVENESS OF APPLICATION OF THE REHABILITATION METHODS OF BIOLOGICAL FEEDBACK AND INNOVATIVE PROGRAM «KORVIT» IN CHILDREN WITH CEREBRAL PALSY ON THE BASIS OF THE REHABILITATION CENTER «SAIL OF HOPE»

Glavatskikh Y., Buchneva K.A., Utochkina L.A.

#### Abstract

Every year, the incidence of paediatric cerebral palsy is gradually increasing. The use of rehabilitation techniques in a comprehensive treatment programme helps to restore the impaired motor functions of such patients, to develop more domestic skills and to improve their quality of life. Today it is very important to prove the relevance and necessity of comprehensive modern rehabilitation programmes using innovative rehabilitation methods.
Goal: To compare the effectiveness of the application of rehabilitation biological feedback methods and innovation program «Korvit» in sick children with cerebral palsy in Voronezh Oblast Rehabilitation Center «Sail of Hope» with a group that was treated according to the standard methods of the centre.

The survey included 60 children with cerebral palsy who were undergoing rehabilitation at the Voronezh Regional Centre «Sail of Hope». All of the children with this disease were assessed on specialized scales: Ashworth, RAMN Scientific Centre's and Orgogozo. The results of the above rehabilitation programmes were subsequently analysed and their effectiveness evaluated.
The control group underwent rehabilitation according to the standard program, which included: therapy gymnastics classes, underwater stretching, classical massage, Stand Machine classes, decimeter therapy. In comparison groups 2 and 3, in addition to applying standard rehabilitation methods, biological feedback sessions were applied with electromyogram and innovation program «Corvit». The results of the course were evaluated on the above scale.

Based on the results of the specialized scale questionnaire, the following conclusions were drawn:
There has been a significant improvement in motor functions;
Expanding and developing new domestic skills;
A significant increase in the psychosomatic status of those patients who were engaged in, besides standard methods, biological feedback sessions and innovation program «Corvit».

Taking into account the different orientation and complexity of rehabilitation methods of the developed program, in groups comparing children with cerebral palsy there was a reliable increase in motor activity, the development of new domestic skills and skills, as well as a more pronounced improvement in well-being.

Молодежный инновационный вестник. 2021;10(S1):463-466
463-466

### SPORTS HEART. PHYSIOLOGICAL DEMONSTRATION OF CARDIOMETRY IN ATHLETS AND UNTRAINED GROUP OF PEOPLE

Dorokhov A., Stanislav P.

#### Abstract

This article discusses the main differences between the "athletic heart" and the heart of an untrained person. The purpose of the work was to conduct an experiment to identify the final indicators, with the help of which it is possible to draw a conclusion about the autonomic function of the heart in the subject and his behavior under stress. We analyzed the data obtained from 28 subjects, students of VSMU named after N. N. Burdenko of different ages. The need for a deeper, more laborious and knowledge-intensive measurement to obtain the most extensive indicators is revealed. As a result, as expected, there was a difference in indicators between the groups of subjects, it is possible to correct the loads in the future.

Молодежный инновационный вестник. 2021;10(S1):466-469
466-469

### INFLUENCE OF A COMPLEX OF JUMPING EXERCISES ON THE VERTICAL JUMP HEIGHT OF VOLLEYBALL STUDENTS

Zubareva E.K.

#### Abstract

Relevance: the jump is a basic movement in volleyball, used both in attack and defense, the height of the jump is one of the key characteristics that affect the effectiveness of game actions. Jump plays an important role in the game at the net, with timely and technical execution of this element, it is possible to level the difference in height between players and compete with higher opponents. A well-designed training plan will increase the strength of the legs, the elasticity of the muscles, and hone the moment of repulsion and landing.

Objective: to experimentally substantiate the effect of a set of jumping exercises on the height of a vertical jump in students engaged in volleyball.

Methods:

1) We conducted a study in which volleyball players of 18-22 years old studying at the Burdenko State University took part.

2) The object of the study is the process of developing the jumping ability of volleyball students.

3) Before and after the course of exercises, tests were conducted to determine the current performance.

4) The study was conducted from September 2020 to February 2021.

5) An improvement in the vertical jump performance of the experimental group of students was expected.

6) The study was conducted using a set of exercises to increase the vertical jump.

Results: the study involved 12 volleyball students, divided into 2 groups: control and experimental, 6 people each, with approximately the same values of the jump height in the initial test. When repeated measurement, there is a significant increase in the jump height indicators in the participants in the experimental group. In the control group, positive results are also observed.

Conclusion: according to the results of the study, it was noted that a significant part of volleyball players, taken in the form of experimental and control groups, showed a high result in the tests for the height of the jump. When re-testing after a systematic exercise program experimental group at the height increase vertical jump, there is visible progress in the performance of vertical jump, in comparison with students in the control group.

Молодежный инновационный вестник. 2021;10(S1):469-471
469-471

### THE EFFECT OF CIRCUIT TRAINING ON THE CARDIOVASCULAR SYSTEM AND THE RATE OF RECOVERY IN STUDENTS OF THE MAIN HEALTH GROUP

Sonnova K.A., Kotlina E.Y.

#### Abstract

Relevance: At present, such a form of organization of the educational and training process as circuit training is gaining more and more popularity. This is due to the wide scope of its application, as well as the ease of movement and the small amount of time spent. All of the above is just an excellent option for students who are always loaded with educational material and limited in time.

Purpose: To assess the state of the cardiovascular system and the speed of recovery of students of the Faculty of Dentistry of V.G. N.N. Burdenko, systematically engaged in circuit training.

Methods:
• Research, which was attended by students of VSMU them. N.N.Burdenko.
• The object of the study is the level of physical development of third-year students of the Faculty of Dentistry, who regularly engage in circular training.
• Assessment of indicators of the cardiovascular system (measurement of blood pressure and heart rate) at rest using Letunov's test after the first, second and third loads.
• Recording results with the help of self-control diaries during individual lessons with this system.

Results: Using a comparative analysis of the indicators of the cardiovascular system, it was revealed that at the start of the study, 17% of students had a hypertensive type of reaction, 33% had a hypotonic type of reaction, and 50% had a normotonic type of reaction. After completing this methodology, the percentage of students with a hypertensive type of reaction decreased to 14%, and with a hypotonic type of reaction to 21%. It is observed that the recovery time decreased and the heart rate indicators after exercise approached the baseline.

Conclusion: After completing the complex of circular training, a positive effect on the health of students was observed. We can safely say that conducting classes using the circular training method is an excellent way to strengthen the cardiovascular system and develop basic physical qualities while using the minimum amount of time.

Молодежный инновационный вестник. 2021;10(S1):471-474
471-474

### DYNAMICS OF RESISTANCE TO HYPOXIA IN GIRLS 20-25 YEARS OLD ENGAGED IN FITNESS

Levchenko L.E., Neliubina D.A.

#### Abstract

Relevance: in the current situation around the world – the Covid-19 coronavirus pandemic, the problem of resistance to hypoxia occupies one of the central places. Certain issues of the body's resistance to hypoxia are quite important for people of different age groups and athletes of different sports.

Objective: To assess the dynamics of the body's resistance to hypoxia in girls 20-25 years old engaged in fitness.

Methods: two groups of girls of the specified age category took part in the study, which was conducted in the premises of the fitness center of the city of Voronezh. The authors conducted the Stange test and the Genchi test for all subjects twice: at the beginning of the study and at the end. It was revealed that the body's resistance to hypoxia depends not only on the athlete's physical fitness, but also on other factors.

Results: The study showed that for the most part, all girls engaged in fitness have a fairly high type of reaction of the body to resistance to hypoxia.

Молодежный инновационный вестник. 2021;10(S1):474-478
474-478

### A COMPARATIVE ANALYSIS OF THE GENERAL PHYSICAL TRAINING OF PUPILS AT THE 20 WUSHU YOUTH SPORTS SCHOOL DURING THE PANDEMIC

Ivanova P.E., Pogorelov M.D., Frolov A.Y.

#### Abstract

Relevance: In moving to a distance-based training format, it is important to understand how effective training will be without the coach’s constant control, and how home-based constraints will affect the final outcome

Objective: To determine the dynamics of physical performance of athletes after the transition to a distance training format.

Research methods: 30 athletes - 15 young men and 15 young women - took part in the general physical training tournament «Shaolin Tiger» in November 2019 and May 2020. The autumn tournament was held at the sports school after 3.5 months of training, spring tournament was held at home, athletes sent videos of their results. The criteria for evaluating the results of a study are the development of physical qualities (muscle strength of the hands, thighs, abdominal press, coordination capacity, speed and flexibility).

Results: in 4 types of test exercises, more than half of the athletes worsened their results, no athlete increased all their physical performance during distance training. In only three exercises more than 50% of athletes - boys - had improved results. The same pattern was observed in girls: in three types of control exercise, more than half of the female athletes improved their physical performance, and none of the female athletes improved on each indicator. Conclusion: The distance training system did not show any progress in the physical performance of athletes owing to the lack of equipment for the quality of exercises and the lower level of motivation compared to face-to-face training

Молодежный инновационный вестник. 2021;10(S1):478-480
478-480

### DYNAMICS OF CHANGES IN THE INDICATORS OF THE FUNCTIONAL STATE OF THE AUTONOMIC NERVOUS SYSTEM IN VOLLEYBALL ATHLETES

Sazina R.G., Beschetnova M.V.

#### Abstract

Objective. The monitoring and evaluation of indicators of the functional state of volleyball players.
Methods. The study was conducted at VSMU’s Department of Physical Education and Medical Rehabilitation. 10 male volleyball players from a professional team took part in the experimental part over the course of 5 months. Simultaneously, as planned, a series of assessments was conducted, and the data was analyzed.
Results. The research revealed changes related to the state of the vegetative nervous system. Due to the abundance and the variety of experiments an objective assessment of the human body’s reaction was possible.
Conclusions. As a conclusion, the research has enabled the assessment of the state of the vegetative nervous system of the athletes. Most have proved to be within the norm. Thus, fitness level and health status should both be taken into account when it comes to the development of the training routine for an athlete.

Молодежный инновационный вестник. 2021;10(S1):481-484
481-484

### THE DEVELOPMENT OF JUMPING ABILITY IMPACT ASSESSMENT OF DIFFERENTIAL EXERCISES IN THE PREPARATION OF BASKETBALL PLAYERS

Khoroshikh A., Byvaltseva A.

#### Abstract

Relevance. The development of jumping ability in athletes of various types of sports is important. Especially it is among youths 15-16 years old who play basketball.

Purpose. Determine the degree of influence of differentiated exercises on the level of development of speed-strength and coordination abilities. This will be an indicator of jumping ability.

Methods. The study was on base of the sports school of the Olympic reserve number 9 in the city of Voronezh. Sportsmen of the youth basketball  team of the city of Voronezh took part in the experiment. There are a composition of 15 people aged 15-16 years. The author proposed a complex of differentiated exercises with overcoming weight of own body aimed at the development of jumping ability.

Results. The study showed an improvement of degree jumping ability when they are using a complex of differentiated exercises. Dynamic exercises were effective for the development of jumping ability.

Conclusion. These exercises can be recommended for use in the training process for basketball players to develop jumping ability.

Молодежный инновационный вестник. 2021;10(S1):484-486
484-486

### THE INFLUENCE OF CLASSES IN SPORTS SECTIONS ON STRESS RESISTANCE AND ANXIETY AMONG MEDICAL STUDENTS

Yudina M.A., Sorokina V.V.

#### Abstract

Relevance: Students of a medical school during the academic period are often exposed to stress, may be in a state close to neuroses, especially during the session. To increase stress resistance, concentration of attention, the ability to switch from one type of activity to another, classes in sports sections help students. Key words: resistance to stress, test, students, psychotype, sport. Purpose: The purpose of this study is to compare the indicators of the level of anxiety, speed of attention switching, concentration, stress resistance among students - athletes and among students who are not involved in sports sections. Materials and methods: To achieve this goal, the following methods were used: a literature review on the topic, questionnaires using the Eysenck and Khanin-Spielberger test, Gorbov-Schulte tables, statistical analysis. Results: In each group there are people with a fairly stable psyche and people who are prone to neuroses. Most of the subjects in the group of athletes are sanguine, and students who do not go in for sports are choleric. The concentration test showed that it was higher among athletes than among representatives of the non-sports group. But anxiety in the sports group turned out to be higher than in the non-sports group, both situational and personal. Conclusion: Based on the above, we can conclude that the most stress-resistant are people who regularly play sports. At the same time, each psychotype requires its own approach when conducting the training process. Such features must be taken into account when conducting training. Therefore, it is important to pay attention not only to physical, tactical training, but also psychological.

Молодежный инновационный вестник. 2021;10(S1):486-488
486-488

## Философия и религиоведение в XXI веке

### FILOSOFI AND MEDICAL EDUCATION

Begenjova O.

#### Abstract

Filosofi

Молодежный инновационный вестник. 2021;10(S1):502-505
502-505

### SANCTITY. THE PHENOMENON OF HOLINESS

Kukhno N.

#### Abstract

The article provides an analysis of the historically established concepts of holiness. In the modern world, people are constantly looking for the origins of various incidents, including the origin of concepts. The culture of the present time constantly turns its attention to the foundations of the religious, linguistic, national, moral, ethical, and spiritual. Each of these aspects is directed to finding and understanding the only thing that is important for all of humanity – the search for oneself, faith, holiness, and a single universally accepted Law. A person constantly hears the word "saint", but does he know its true meaning? This article examines the various points of contact that the thinkers of their time explain. Also here you can analyze a brief analysis of some statements, which in the future will give an understanding of the integrity of the issue under study. The words of Russian and foreign philosophers and thinkers serve as epithets for discussion. The phenomenon of sanctity, inherent not only in people, but also in other objects of research, is mentioned in the article. Such a deep understanding of religion of one of the fundamental spiritual phenomena suggests the need to study the sanctity from a scientific point of view and on specific examples of local history.

Молодежный инновационный вестник. 2021;10(S1):505-508
505-508

## Формирование профессиональной компетенции средствами иностранных языков

### AUGMENTED REALITY TECHNOLOGY IN THE STUDY OF ANATOMY IN ENGLISH

Arutyunyan L.

#### Abstract

This article discusses the possibility of using augmented reality technology in the study of normal human anatomy in the intermediary language. The project “Augmented reality technology in the study of anatomy in English” is proposed, the purpose of which is to optimize and improve the educational process of medical students by visualizing 3D objects using augmented reality technology. The author defines the technology of augmented reality (AR), considering its advantages as an educational tool in the study of anatomy in the context of distance learning. It should also be noted that the application can be used both for distance learning and for independent work of students in traditional full-time education.

Молодежный инновационный вестник. 2021;10(S1):509-511
509-511

### SYNONYMY AND METAPHORIZATION IN GREEK-LATIN DENTAL TERMINOLOGY

Kryuchkov A., Panyuk D., Dovlatov N.

#### Abstract

erminology, as part of the lexical system of a language, although it has a number of features, nevertheless, obeys general trends in the dynamics of this language, in which such processes as synonymy and metaphorization play an important role. There is a lack of research in this area, and the dentist, as well as any doctor, must be deeply versed in their professional terminology. Purpose: to consider the causes of synonyms and metaphors in the dental nomenclature on the example of terms with Greek and Latin origin. Materials and methods: the study was carried out using express analysis of scientific texts on the specified topic from the Google Scholar database, and the information obtained was processed by methods of linguistic description and analysis of dictionary definitions. Results: in the analysis of dental nomenclature identifies seven major sources of synonymy in the Greco-Latin terminology, among which are important to use as intra - and

Молодежный инновационный вестник. 2021;10(S1):511-515
511-515

### A HEALTHY LIFESTYLE AS A FUNDAMENTAL FACTOR OF LIFE EXPECTANCY

#### Abstract

Abstract.

Relevance. For many years people have inquired life expectancy, its features and opportunities of increasing. There are many assumptions about the structure of developing and researching of this topic. The article is devoted to the one of the most important problem of the 2020 generation, its influence on human life and his future.

The research objective. The aim of this article is to learn more about harmful effects of unhealthy mode of life on human health.  This topic is of particular interest to those of who is going to become a doctor or who takes care of their health. The beneficial effect of healthy lifestyle on the «quality of life» and life expectancy is discussed in the article.

Methods. The design of the research is observational and historical study.

Results. According to the studies, not lots of adults meet the criteria for a healthy lifestyle, but today more and more young man aged between 18-24 get involved in this type of problem. Various areas of medicine began to conduct research in the field of attempts to solve problems associated with old and senile age.

Conclusion. The investigation has proven that most cases of accelerated aging and premature death are related to an unhealthy mode of life: living in areas with a polluted environment, all kinds of harmful habits for the body, lack of proper nutrition, and prolonged stressful situations.

Молодежный инновационный вестник. 2021;10(S1):515-517
515-517

### CASE METHOD IN FOREIGN LANGUAGE CLASSES AT A MEDICAL UNIVERSITY IN THE CONTEXT OF DISTANCE LEARNING: A MULTIDISCIPLINARY APPROACH

Tcurkan A.A.

#### Abstract

Relevance. The most important task of a medical university - training of highly qualified health care professionals- is currently closely related to the professionally oriented study of a foreign language. The case method, originally developed for non-linguistic disciplines, has found its place in language teaching, in particular English for Specific Purposes (ESP), being considered a source of more effective and motivating language teaching methodologies. It is noted that the use of the case method in the study of foreign languages ​​(FL) contributes to the development of not only linguistic and communicative, but also professional competencies of future healthcare workers, improves the ability to analyze the situation, evaluate alternatives, and make the best solution to the problem.
The aim of the study is to create an English lesson that goes beyond the scope of the compulsory curriculum, based on an actual problem situation from clinical practice using the case method.
Methods: scientific-methodical literature analysis, heuristic method (selection and analysis of clinical and linguistic material), linguistic method, contextological analysis method.
Results. There was developed a lesson with elements of a role playon the problem "Iodine deficiency diseases of the thyroid gland - a medical and social problem", which appears to be an "end-to-end interdepartmental distance" case. The created case simulated the work of a doctor as much as possible and brought students closer to practical activity.
Conclusion. The introduction of case technologies in the process of teaching foreign language at a medical university in the context of distance learning simulates conditions as close as possible to real ones and contributes to the development of professionally oriented competencies in medical students.

--

Молодежный инновационный вестник. 2021;10(S1):517-520
517-520

### THE ROLE OF THE STUDENT SCIENCE CLUB OF THE CHAIR OF FOREIGN LANGUAGES IN THE DEVELOPMENT OF THE PROFESSIONAL COMPETENCE OF FUTURE MEDICINE SPECIALISTS

Яковенко Д.А., Рыбина А.Д.

#### Abstract

Abstract.

Relevance. The research reveals the important role of the student science club of the Chair of Foreign Languages of VSMU in the formation of the professional competence of the future physician. The article discusses the main duties of the supervisors of the student science club, examines the main scientific directions of the student science club of the Chair.

The research objective. The aim of this article is to learn about the work of the Student Scientific Club of the Department of Foreign Languages of Voronezh State Medical University. The main steps of the work of the Student Scientific Club and the main achievements are discussed in the article.

Methods. The design of research is observational and historical study.

Results. The members of the club take an active part in the work of the Student Scientific Society of VSMU named after N.N. Burdenko. The presentations at scientific conferences and research works have repeatedly brought prizes; the results of scientific research are regularly published in medical periodicals. The student scientific club of the Department holds eight meetings annually. Participants of the student scientific club of the Department of Foreign Languages take part in round tables and international meetings.

Conclusion. During their work at the Student Scientific Club of the Chair of Foreign Languages students master the methods of research activities that allow them to identify and analyze the most pressing problems associated with the organization, management and practice of, as well as organize and collect scientific information, conduct its analysis to solve the scientific problem in the most acceptable and successful way.

Молодежный инновационный вестник. 2021;10(S1):520-522
520-522

### THE INFLUENCE OF THE LATIN LANGUAGE ON THE FORMATION OF MEDICAL TERMINOLOGY

Shaleev A.Y., Mazin V.A., Agapova I.V.

#### Abstract

Purpose of the work: to convey to medical students and new generations of specialists the expediency of studying and applying Latin and Greek in everyday practice, to explain the importance of the ability to draw up medical prescriptions and exchange information with colleagues, based on the knowledge gained, to emphasize the essential importance of the ability to correctly formulate diagnoses and indications.

Research methods: a thorough analysis of confirmed historical findings and references, recommendations and manuals, including scientific works on medical ethics, reflecting the rational use of Latin and Greek terminology in the practice of the attending physician.

Results: we identified the relationship of the Latin language with medical applied subjects, we made sure from personal experience that the study of the Latin language is an integral part in the training of specialists of the highest and intermediate category, it simplifies the understanding of voluminous professional information and the access to its transmission, but leaves ignorant persons in the dark medical secrets.

Conclusion: Summing up, our research group came to the conclusion that medicine and Latin are inextricably linked and go hand in hand, even after many centuries of coexistence. It would be correct to note the fact that the knowledge of a physician who does not speak Latin is at least incomplete.

Молодежный инновационный вестник. 2021;10(S1):522-525
522-525

Arzhanykh Y.

1161 / 5000

## Результаты перевода

Relevance. Tuberculosis is a widespread infectious disease that is often associated with viral hepatitis and HIV infection. Goal. To assess the impact of various combinations of coinfections (TB + HIV + GV), (TB + HIV), (TB + GV) on the clinical manifestation of tuberculosis. Methods. Russian and foreign literature was studied and systematized, as well as studies on the topic presented over the past 5 years were analyzed. Results. The use of complex treatment with anti-tuberculosis and ARVT in patients (HIV + TB ± GV) is not accompanied by the development of hepatotoxic reactions. In patients in the group (TB + HIV + VH), the content of gamma globulin was significantly higher than in patients in other groups (TB; TB + HIV; TB + VH). In the early stages of HIV infection is manifested by involvement in the inflammatory process of the intrathoracic lymph nodes (IHLN). The course of TB in the late stages of HIV infection tends to generalize the process, affecting not only the respiratory system, but also other body systems. Conclusion. Additional measures are needed to optimize the prevention, detection and treatment of tuberculosis associated with HIV and viral hepatitis.
Молодежный инновационный вестник. 2021;10(S1):526-528
526-528

### INFLUENCE OF PULMONARY TUBERCULOSIS ON PREGNANCY AND OUTCOME

Arzhanykh Y., Tarasova A., Zolotukhin V.

#### Abstract

RELEVANCE. Tuberculosis during pregnancy, childbirth and the postpartum period can threaten with serious consequences, among which it is worth noting a twofold increase in the risk of premature birth, intrauterine growth retardation, as well as an increase in perinatal mortality.
TARGET. To assess the clinical and epidemiological features of the course of pulmonary tuberculosis in pregnant women; to study the possible complications of pregnancy in women with pulmonary tuberculosis; to assess the effect of pulmonary tuberculosis of a pregnant woman on fetal health.
MATERIALS AND METHODS. Russian and foreign literature was studied and systematized, as well as studies on the topic presented over the past 5 years were analyzed.
RESULTS. Pulmonary tuberculosis, which occurs during pregnancy and in the postpartum period, often begins acutely and is characterized by a less favorable course. In the first trimester, the diagnosis of pulmonary tuberculosis in pregnant women is often difficult because many of the symptoms are nonspecific and may be present during a normal pregnancy. The effectiveness of treatment for pregnant women is much lower, which is associated with hormonal changes in the body of a pregnant woman and manifests itself in the progression of a specific process after childbirth and artificial termination of pregnancy.
CONCLUSION. In the first trimester of pregnancy, the initial manifestations of tuberculosis, caused by moderate intoxication, can be masked by signs of early toxicosis. In the second half of pregnancy and in the last weeks of pregnancy, pulmonary tuberculosis, despite pronounced morphological changes in the lungs, often proceeds without pronounced clinical symptoms. Pregnancy against the background of pulmonary tuberculosis can be complicated by the development of anemia of an autoimmune nature caused by hemolytic anemia syndrome.

Молодежный инновационный вестник. 2021;10(S1):528-531
528-531

### THE EFFECT OF THE THYROID GLAND ON THE COURSE OF TUBERCULOSIS

Bakutina Y.Y.

#### Abstract

Relevance
One of the underestimated causes that affect the course of tuberculosis may be a violation of the functioning of the thyroid gland.
Goal
To study the features of detection and course of pulmonary tuberculosis in patients with thyroid diseases.
Materials and methods
We analyzed patients with newly diagnosed pulmonary tuberculosis who were treated and examined in the day hospital of the Voronezh Regional Clinical Tuberculosis Dispensary named after N. S. Pokhvisneva from September 2019 to the present. Of all identified patients with pulmonary tuberculosis during this period, 64 medical histories were studied without data personalization.
Results
In the analysis of the complaints at admission to the TB hospital Kuz "Voronezh regional clinical TB dispensary them. N. S. Pohvistnevo established that in the 1st group complaints of General weakness showed 18 (56,25%) patients, the increase in body temperature to subfebrile night, 16 (50%), and loss of appetite – 22 (68,75%), and weight loss – 15 (46,9%), night sweats – 22 (68,75%). In the 2nd (control) group, complaints of general weakness were made by 12 (37.5%) patients, for an increase in body temperature to subfebrile figures in the evening-11 (34.4%), for a decrease in appetite – 16 (50.0%), for weight loss – 11 (34.4%), night sweats – 12 (37.5%). In the course of the study, no adverse reactions or complaints of patients were noted.

Conclusion
Thus, tuberculosis in patients with thyroid pathology is detected more often when submitting complaints to medical and preventive institutions.

Молодежный инновационный вестник. 2021;10(S1):531-533
531-533

### COMPARATIVE ANALYSIS OF PSYCHOEMOTIONAL STATUS IN PATIENTS WITH TUBERCULOSIS, TAKING INTO ACCOUNT GENDER CHARACTERISTICS

Martyshova O.S., Korchagina S.A., Petrova N.S.

#### Abstract

Relevance. Tuberculosis is an infectious disease widespread in the world, known not only for its direct effect on the affected organs, but also for its traumatic effect on a person, due to which his mental activity can change. It is relevant to conduct a comparative analysis of the psychoemotional status, taking into account the gender of the patient, since each gender has its own characteristics of changes in the mental and cognitive spheres.

Goal. The aim of the study was to assess the psychoemotional status in patients with pulmonary tuberculosis and further conduct a comparative analysis of the data obtained, taking into account gender.

Materials and methods. Study of scientific literature on the peculiarities of psychoemotional status in patients diagnosed with pulmonary tuberculosis; conducting a survey using A.I. Serdyuk among 72 patients who received treatment at the KUZ VO "VOKPT named after N.S. Pohvisnevoy ", building 2, in the period 2019-2020.

Results. In the course of a comparative analysis of the results obtained, it was revealed that a significant number of examined patients (40.27%) felt weakness and weakness, while there were no significant differences in gender (46.43% of women out of 28 people; 36.37% of men in 44 people). Relationships in the family were complicated by tuberculosis in almost a third of males (27.28%); however, women had to limit themselves to various types of pleasures to a greater extent (35.71%). An absolute minority of the respondents (1.38% of the total number of patients) noted the deterioration of relationships at work. A decrease in the amount of free time was observed mainly in males (43.19%). The disease restricts career growth in a significant number of patients (in women (60.72%) to a greater extent than in men (43.18%)). Unpleasant changes in appearance are noted mainly by women - 60.72%. The formation of a feeling of inferiority due to tuberculosis is observed in an equal number of women (17.86%) and men (18.18%), as well as the emergence of restrictions in communication with people (25% among persons of each sex). The disease causes significant material damage to 1/3 of men (29.55%) and 2/3 of women (64.29%). Thus, gender in the study of the psychoemotional status of patients with tuberculosis plays a significant role in the spheres of life identified in the second, third, fifth, seventh and tenth questions of A.I. Serdyuk.

Conclusion. Any chronic somatic disease affects the patient's social position, changes the usual way of life and the circle of interests of the patient. That is why tuberculosis patients need high-quality psychological care, and the approach to treatment should take into account gender.

Молодежный инновационный вестник. 2021;10(S1):533-537
533-537

### MEDICAL AND SOCIAL FACTORS OF TUBERCULOSIS DEVELOPMENT IN THE ENVIRONMENT OF INTERNAL LABOR MIGRATION

Kharkovskaya E.

#### Abstract

Relevance. Tuberculosis, being a socially determined disease associated with unsatisfactory sanitary and hygienic and socio-economic conditions, most acutely raises questions about the impact on the health of both internal labor migrants themselves and their families.
Goal. To identify medical and social risk factors for the development of tuberculosis of interregional labor migrants.
Methods. Analysis of 27 internal labor migrants who passed the survey. The questions focused on the assessment of such aspects as: gender, age, family status, awareness of tuberculosis prevention, assessment of the presence of risk factors for tuberculosis in domestic labor migrants.
Results. Most of the internal labor migrants are men of working age (from 22 to 47 years). The following groups of risks of tuberculosis development in internal labor migrants are identified, such as: socio-economic (financial instability, group living – 88.8%, increased stress load, eating disorders, work and rest – 89%), medical-social (problems in obtaining medical care – 46.3%), family-educational (breaking family ties for a long period of time – 77.8%).
Conclusion.
There are a number of organizational problems of preserving the health of migration groups. Including the lack of a well-established system of prevention and control over the passage of a fluorographic examination among migrant workers, so 25.92% of respondents undergo a fluorographic examination less than once a year.
According to the survey, the awareness of labor migrants about the prevention of tuberculosis infection is at a fairly high level, but they do not always have the opportunity to follow these recommendations.

Молодежный инновационный вестник. 2021;10(S1):537-540
537-540

### THE LEVEL OF ANXIETY AND PSYCHOLOGICAL CHARACTERISTICS OF THE ATTITUDE TO THE DISEASE OF PATIENTS WITH A NEW CORONAVIRUS INFECTION

Khmyz I., Semikolenova V.

#### Abstract

Relevance. The problem of mental assessment of patients with different levels of anxiety is very relevant, because in many cases, the effectiveness of treatment depends on the mental mood of the person. Therefore, the determination of the level of anxiety plays an incomparable role in the management of patients [1].
Goal. To conduct a comparative analysis of the level of situational and personal anxiety in patients with a new coronavirus infection complicated by pneumonia with the volume of lung lesions CT1 and CT2.
Methods. A survey of 50 patients with coronavirus infection complicated by pneumonia with lung lesions CT1 and CT2 was conducted using the Spielberger-Hanin questionnaire.
Results. Differences in the level of anxiety, and, accordingly, in the attitude to their disease, were revealed in patients with different degrees of lung damage to CT1 and CT2.
Conclusion. Regularities of formation of the picture of the disease, and various types of psychological response on disease combined in the clinic with the specific features of the mental state of patients, the nature of the response to it, the success of treatment and, as a result, the outcome.

Молодежный инновационный вестник. 2021;10(S1):540-545
540-545

### FEATURES OF THE COURSE AND THERAPY OF HIV-ASSOCIATED TUBERCULOUS MENINGITIS

Khodarina Y.V., Kudrina D.S.

#### Abstract

Relevance. Tuberculosis is a severe, widespread infectious disease that kills more than 4,000 people every day. More often it affects the lungs, however, other localization of the pathological process, for example, damage to the central nervous system, is not excluded. Tuberculous meningitis is characterized by inflammation of the meninges with the development of predominantly cerebral symptoms. Mortality ranges from 16 to 55%. Damage to the central nervous system in people infected with mycobacteria is more common in HIV-associated tuberculosis. Over the past 3 years, the number of HIV-infected people in Russia has increased 1.6 times, which could not but affect the increase in the incidence of TM. Expansion of diagnostic capabilities does not help to timely detect tuberculous meningitis due to atypical clinical picture and laboratory data, which leads to an untimely diagnosis and a decrease in the effectiveness of treatment.

Aim. To study the features of the course and principles of treatment of tuberculous meningitis in patients with HIV infection and its influence on the outcome of TM.

Materials and methods. We analyzed current research, foreign and Russian literature for the period 2017-2021. on the topic presented.

Results. HIV-associated tuberculous meningitis is characterized by the absence of headache and lesions of cranial nerves, the onset of the disease is usually gradual. Often, patients have a pronounced impairment of consciousness and multiple organisms of the pathological process. CSF examination reveals normocytosis or very high pleocytosis, the level of glucose in the cerebrospinal fluid is significantly reduced, mycobacteria are rarely found. It is also important to treat HIV-associated TM, the choice of chemotherapy regimen (RCT). Between a quarter and half of HIV + tuberculosis coinfected patients suffer from multidrug resistance (MDR). This is the basis for choosing RCT II, ​​which implies the use of not only basic, but also reserve chemotherapy drugs. Since HIV infection is associated with immunodeficiency conditions, a combination of anti-TB drugs and antiretroviral therapy is necessary, but the latter should be started 2-8 weeks after starting anti-tuberculosis drugs.

Discussion. Immunosuppressive processes occurring in patients with HIV infection give rise to the development of atypical forms of TM and, accordingly, a variety of clinical and laboratory picture, which leads to untimely diagnosis of the disease. Immunodeficiency states that occur in HIV-positive patients can significantly reduce the effectiveness of PTT, which requires adjustments of the drugs themselves and their doses of appropriate RHT and prescribing in combination with antiretroviral therapy.

Conclusion. HIV-associated tuberculous meningitis is an urgent problem that requires special attention and further careful study. It has an atypical course for this form, which complicates timely diagnosis, requires a serious and careful approach to the selection of a combination of drugs for chemotherapy and antiretroviral therapy, and, unfortunately, often leads to the death of patients.

Молодежный инновационный вестник. 2021;10(S1):545-547
545-547

## Medicine without frontiers

### THE COMPARATIVE ANALYSIS OF FUNCTIONAL INDICES IN PATIENTS WITH OSTEOARTHRITIS AND COMORBID OBESITY

Абакумова С.А., Korneev R.V.

#### Abstract

Objectives: assessment of knee joints in patients with osteoarthritis and obesity

Methods: The study included 40 patients with osteoarthritis in the age group from 45 to 65 years, 80% women and 20% men.  The patients were divided into 2 groups.  In the first group of patients, in addition to OA, concomitant obesity was diagnosed.  In group 2, patients suffered from osteoarthritis

Results: The result of the analysis was that the people who were included in the second group differed significantly from patients with OA and concomitant obesity.

Conclusion: in patients with OA and without comorbid obesity, there was an increase in the functional activity of the knee joints and a decrease in pain according to the VAS, compared with patients with OA and concomitant obesity.

Молодежный инновационный вестник. 2021;10(S1):548-548
548-548

### ENDOSCOPIC REMOVAL OF BENIGN TUMORS OF THE TRACHEOBRONCHIAL TREE

Акуленок Е.В., Панкова Д.И.

#### Abstract

Endoscopic treatment of patients with benign tumour of the trachea and bronchi has become widespread. It is characterized by the speed of access to pathological formations and a relatively low risk and complications during manipulations with the improvement of minimally invasive methods. The aim of the study is to compare the results of treatment for similar clinical cases of benign tumors of the tracheobronchial tree, determining the presence of recurrent growth and the frequency of complications of the intervention. The study of the endoscopic removal of 9 cases of benign tumors of the tracheobronchial tree was performed in the department of endoscopy of the Smolensk Regional Clinical Hospital. On the based of the primary examination of patients, the tactics of treatment and the selection of anesthesia were determined, taking into account possible intraoperative complications on an individual basis. The choice of technique was based on the histological conclusion and video bronchoscopy materials. 66% of the tumors were removed by loop electroexcision. Among the methods of anesthesia, local lidocaine solution prevailed in 88%. The lumen of the airways was restored in 100% with the maintenance of adequate ventilation in thegroupof patients. Recurrent growth and inflammation patterns were not detected in all 9 patients during the control of the tumor removal zone. The study showed good results with a competently applied endoscopic technique for treating patients with benign tumours of airways.

Молодежный инновационный вестник. 2021;10(S1):548-551
548-551

### ASSESSMENT OF THE QUALITY OF INTRAOPERATIVE ANALGESIA IN CONDITIONS OF MIXED AND COMBINED ANESTHESIA IN PATIENTS THORACOCERVICAL PROFILE

Маничева Ю.С.

#### Abstract

The qualitative choice of anesthesia affects not only the effectiveness of intraoperative analgesia, but also the patient's condition and quality of life during the entire intraoperative and postoperative period. The aim of the work was to identify the features of combined and combined anesthesia in surgical interventions of the thoracic profile. The first group consisted of patients (n=17), whose surgical intervention was accompanied by combined anesthesia, and patients of the second group (n=23) - under combined anesthesia. The following parameters were evaluated: blood pressure, heart rate, volume of infusion therapy, additional administration of vasopressors, additional doses of analgesics. The induction was carried out with fentanyl 5 mg / kg, propofol 2 mg / kg, rocuronium 0.6 mg / kg. Maintenance anesthesia was performed with sevoflurane up to 1.1 MAC. Also, when using combined anesthesia, ropivacaine 0.75% - 10.0 ml was used. Statistical analysis was performed by the STATISTICA 10.0 software. The study did not reveal statistically significant differences in analgesic intraoperative protection in both methods of analgesia. Both methods provide an adequate and high-quality level of intraoperative protection, and also do not have a significant negative impact on the course of the intraoperative and early postoperative periods.

Молодежный инновационный вестник. 2021;10(S1):551-552
551-552

### ESTIMATION OF THE NUMBER OF MAST CELLS AND MACROPHAGES IN INVASIVE EDGE AS ADDITIONAL COLORECTAL CANCER PREDICTION FACTOR

Pershina A.E., Kharchenko A.A.

#### Abstract

Statistical studies show that colorectal cancer (CRC) occupies one of the leading places among oncological diseases. The study of the tumor microenvironment is a trend in modern scientific oncomorphology. Namely, mast cells (MCs) and macrophages (MFs), as one of the most frequent representatives of the inflammatory microenvironment of the tumor, should be studied.

The aim of the study is to determine the density of distribution of MCs and MFs in the invasive edge of the tumor in case of colorectal cancer and to identify relationships with clinical and morphological factors in predicting the course of the tumor.

The article analyzes the data of patients with diagnosed colorectal cancer in the period from 2013 to 2018. MCs and MFs were detected on paraffin sections by immunohistochemistry using monoclonal mouse antibodies. Statistical processing was carried out using Microsoft Excel.

The results of the study showed that MCs and MFs are widely represented in the tumor microenvironment in the researched material. It was found that the number of MCs in the invasive edge was more than 2 times higher in the group of patients with early death and without metastases to regional lymph nodes than the number of cells in the group of people with metastases. Also, in all groups, there was an increase in the number of MCs in the invasive edge with a decrease in the degree of differentiation. The quantitative indices of mast cells differed the most in the groups with different degrees of tumor differentiation, which can be used in the assessment of tumor progression as an additional prognosis factor.

Молодежный инновационный вестник. 2021;10(S1):552-554
552-554

### ASSESSMENT OF THE FUNCTIONAL STATUS AND CYTOKINE PROFILE OF PATIENTS WITH CHRONIC HEART FAILURE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Tokmachev R., Glavatskikh Y.

#### Abstract

The increase of life expectancy of both cardiovascular patients and people in general, has been accompanied by an increase in the proportion of patients with chronic heart failure (CHF). CHF decompensation plays a leading role, among the reasons of hospitalization in cardiology departments, especially among patients older than 65 years old. CHF patients are conceded to suffering from COPD, the percentage ratio is between 25 to 42 %. The high comorbidity of CHF and COPD and the increased risk of adverse outcomes in such a combination of pathologies requires further study of the mechanisms of CHF progression, improvement of diagnostic methods and principles of treatment of this category of patients.

Linked to the identification of three categories of patients with CHF (with preserved, mid-range and reduced left ventricular ejection fraction (LVEF)) is particularly relevant to the study of the effect of systemic inflammation on the clinical flow, functional status and prognosis of patients with comorbide current COPD and CHF with different LVEF.
Methods: The study involved 240 patients aged 40-80 years diagnosed with ischemic CHF. According to the presence of COPD, the patients were divided into four subgroups: patients with CHF with preserved ejection fraction (CHFpEF) (n=69), patients with CHF with reduced ejection fraction (CHFrEF) (n=91), patients with COPD and CHFpEF (n=36), patients with COPD and CHFrEF (n=44). Since inclusion in the study, patients have been examined weekly by researchers to monitor the absence of symptoms of CHF decompensation and COPD exacerbation. After 12 weeks, the participants were examined (clinical, laboratory and instrumental methods). Laboratory methods of investigation included determination of serum levels of NT-proBNP, Nhs-CRP, IL-1β, IL-6, TNF-α. Tolerance of physical activity was determined by a complex of cardiorespiratory analysis, which included analysis of 6 minute walking distance (6MWD), and a monitoring system for patients with chronic heart failure.
Results: The average level of NT-proBNP in patients with CHFrEF (subgroup 2) 1171 within 191 ng/l was significantly higher than in patients with CHFpEF (subgroup 1) - 813 within 127 ng/l. The NT-proBNP blood serum level of patients with COPD and CHFrEF (in the fourth subgroup) was also higher than patients in the third subgroup with COPD and CHFpEF.
The level hs-CRP known as the biomarker of endogenous inflammatory processes in HFpEF patients was 3.7 within 0.62 mg/l, while in CHFrEF patients it was statistically less significant - 2.6 within 0.59 mg/l (p0.001). The level hs-CRP in the fourth subgroup (patients with COPD and CHFrEF) was 4.4 within 0.74 ng/L, which was also lower than the 4.9 within 0.85 ng/L patients in the third subgroup with COPD and HFpEF.
​The analysis of cytokine status indicators showed an increase in the level of proinflammatory cytokines in all subgroups studied, both in the isolated CHF and in the comorbide current CHF and COPD. The content of IL-1β, IL-6, TNF-αproved to be significantly higher in combined pathology.
A higher level of IL-1β, IL-6, TNF-α, hs-CRP in the CHFpEF and CHFpEF and COPD (subgroups 1 and 3) than in the reduced EF (subgroups 2 and 4) may reflect the significance of the contribution of systemic inflammation to the development and progression of HF.

Conclusion: CHFpEF patients have higher levels of hs-CRP, pro-inflammatory cytokines compared to CHFrEF patients, reflecting a more pronounced subclinical inflammation and the importance of the immuno-inflammatory component’s contribution to the early stages of CHF. The combination of COPD and CHF amplifies systemic inflammation and myocardial remodeling processes, determined by the level of NT-proBNP, in comparison with the isolated flow of CHF. A negative impact of COPD on the functional status of CHF patients with different LVEF has been established, which is reflected by lower 6-minute walk test and 6MWD/6MWD(i) values and higher desaturation.

Молодежный инновационный вестник. 2021;10(S1):554-557
554-557

### ENLIGHTENMENTS OF THE SPIRIT OF GREAT MEDICINE TO THE IMPROVEMENT OF MEDICAL ETHICS OF CONTEMPORARY MEDICAL STUDENTS

Chen Z.

#### Abstract

Abstract: "Big doctor" is a synonym for doctors with both integrity and ability. "Spirit" can be understood as a belief, so the promotion of medical ethics of medical students is an indispensable link in today's medical college education, conducive to medical students to establish a correct career outlook, but also conducive to the construction of high-quality medical talent team. Starting from the spirit of big medicine, transforming spirit into theory to guide study reflects that it is necessary to combine the spirit of big medicine with the education and teaching of medical professional courses. This paper combines the spirit of big medicine to explore the necessity and path of improving the cultivation of medical ethics of medical students and gets some enlightenment.

Молодежный инновационный вестник. 2021;10(S1):557-559
557-559

### A NANO-LOADED GEL SYSTEM FOR IMPROVING BCG EFFICACY OF BLADDER CANCER BY MEDIATING MACROPHAGE POLARIZATION

Chen J., Guo P., Wang L., Xu W.

#### Abstract

Молодежный инновационный вестник. 2021;10(S1):559-562
559-562

### PROGNOSTIC INFLAMMATORY INDEX PREDICTS THE PROGNOSIS OF PATIENTS WITH COLORECTAL CANCER: BASED ON A LARGE CHINESE RETROSPECTIVE COHORT

Fu J., Zhang L., Li D., Huang H., Tian T., Liu Y., Liu Y., Zhang Y., Xu J., Meng S., Jia C., Sun S., Li X., Zhao L., Zhang D., Kang L., Gao L., Zheng T., Liu Y., Zhao Y.

#### Abstract

Relevance: Host inflammation is a critical component of tumor progression and its status can be indicated by peripheral blood cell counts.

The research objective: We aimed to construct a comprehensively prognostic inflammatory index (PII) based on preoperative peripheral blood cell counts and further evaluate its prognostic value for patients with colorectal cancer (CRC).

Methods: A total of 4154 patients with stage II and III CRC were included in this study. The PII was constructed by integrating all the peripheral blood cell counts associated with prognosis. Cox analyses were performed to evaluate the association between PII and overall survival (OS) and disease-free survival (DFS) of patients with CRC.

Results: In the cohort, multivariate Cox analyses indicated that high OS-PII (>4.27) was significantly associated with worse OS (HR: 1.330, 95% CI: 1.189-1.489, p<0.001); and high DFS-PII (>4.47) was also significantly associated with worse DFS (HR: 1.366, 95% CI: 1.206-1.548, p<0.001). The nomograms achieved good accuracy in predicting both OS and DFS, with a C-index of 0.718 and 0.700. Time-dependent ROC analyses showed that both OS-PII and DFS-PII have a stable prognostic performance at various follow-up times. The prognostic value of tumor-node-metastasis staging could be enhanced by combiningby combining it with either OS-PII or DFS-PII.

Conclusion: We demonstrated that PIIs are independent prognostic predictors for CRC patients, and the nomograms based on PIIs can be recommended for personalized survival prediction of patients with CRC.

Молодежный инновационный вестник. 2021;10(S1):562-564
562-564

### ANTIBACTERIAL PROPERTIES OF ZINC COATING PREPARED BY MICRO ARC OXIDATION ON PURE TITANIUM

Li Y.

#### Abstract

Relevance:Among dental implant materials, titanium is a metal material that can be directly combined with biological tissue, which has excellent fatigue resistance and toughness. However, due to its poor biological activity and no obvious antibacterial property, it is easy to cause surgery failure, so it is necessary to carry out surface modification. Zinc is an important trace element in human body. It can accelerate bone calcification and reduce fracture healing time. At the same time, zinc also has antibacterial properties, which can reduce the accumulation of bacteria and reduce the failure rate of implant surgery.

Objective:Prepare different concentrations of zinc-containing coatings on pure titanium by micro-arc oxidation, and compare the surface morphology, element distribution, phase composition and antibacterial propertie.

methods:Five groups including No Zn-containing(N-Zn), low Zn-containing(L-Zn), medium Zn-containing(M-Zn), high Zn-containing (H-Zn) were prepared with micro-arc oxidation on titanium surface and machined commercial pure titanium(CP) was usedas control group. SEM and EDS were used to observe the surface morphology and element distribution.XRD was used to determine the phase composition. Antibacterial properties of Escherichia coli and Staphylococcus aureus on samples surface were appraised by the paster method.

Results:Scanning electron microscopy showed that the surface pore size of the specimens became smaller and more uniform as the zinc concentration increased; the energy spectrometer showed that the content of O, P, Ca, Na, Si, and Zn was relatively small in the region of the micro-arc discharge pores. The results of X-ray diffractometry showed that anatase TiO2 (Anatase) and rutile TiO2 (Rutile) were formed on the surface of the coating, and the coating method experiment showed that there was a statistically significant difference between the groups (P <0.05).

Conclusion:The zinc ion coating prepared by the micro-arc oxidation method can improve the biological activity and antibacterial property of the material, and the antibacterial property increases with the increase of the zinc content.

Молодежный инновационный вестник. 2021;10(S1):564-566
564-566

### THE PSYCHOLOGICAL STATUS OF CHINESE FRONTLINE HEALTHCARE WORKERS DURING THE EARLY STAGE OF THE COVID-19 OUTBREAK

Qi X., Qunhong W., Xin Z., Jiahui W.

#### Abstract

Introduction: In December 2019, a coronavirus, COVID-19 emerged in Wuhan, China and escalated domestically and internationally into an unprecedented outbreak with a frightening transmission speed, exposing frontline health care workers (HCWs) to a hasty war without being fully equipped and protected.

Objective: This study examines the prevalence of peritraumatic distress, burnout among frontline COVID-19 HCWs in China during the early stage of the COVID-19 outbreak.

Methods: A cross-sectional survey through self-administered questionnaires was conducted on February 18, and March 4, 2020, after the outbreak. PTSD was assessed using the PTSD self-rating scale (PTSD-SS). Burnout was measured using a 22-item Maslach Burnout Inventory (MBI).

Results: 676(58.1%) of HCWs met the PTSD criteria. 48.6% suffered burnout. 417[35.9%] self-reported physical and mental exhaustion and 666[57.3%] emotional exhaustion (MBI scale-measured).

Conclusion: Chinese frontline HCWs demonstrated a severe prevalence of PTSD, peritraumatic distress, and burnout during the outbreak. Hence, the need to establish comprehensive psychological intervention for HCWs, globally.

Молодежный инновационный вестник. 2021;10(S1):566-568
566-568

### MIR-103 INHIBITING CARDIAC HYPERTROPHY THROUGH INACTIVATION OF MYOCARDIAL CELL AUTOPHAGY VIA TARGETING TRPV3 CHANNEL IN RAT HEARTS

Ren J.

#### Abstract

Relevance: The sudy provide a new idea for the therapy of pathological cardiac hypertrophy.

the research objective: Cardiac hypertrophy is a common pathological change frequently accompanied by chronic hypertension and myocardial infarction. Nevertheless, the pathophysiological mechanisms of cardiac hypertrophy have never been elucidated.

Methods: The protein expression was detected by western blot. The cell surface area was detected by Immunofluorescence staining. The relationship between miR-103 and TRPV3 was detected by luciferase reporter gene assay.

Results: TRPV3 protein, cardiac hypertrophy marker proteins (BNP and β-MHC) and autophagy associated proteins (Beclin-1 and LC3-II) were up-regulated, as well as,

miR-103 expression and autophagy associated proteins (p62) were down-regulated in cardiac hypertrophy models in vivo and in vitro respectively. Further results indicated that silencing TRPV3 or forcing overexpression of miR-103 could dramatically inhibit cell surface area, relative fluorescence intensity of Ca2+ signal and the expressions of BNP, β-MHC, Beclin-1 and LC3-II, but promote p62 expression. Moreover, TRPV3 protein was decreased in neonatal rat ventricular myocyte transfected with miR-103, but increased by AMO-103. Co-transfection of the miR-103 with the luciferase reporter vector into HEK293 cells caused a sharp decrease in luciferase activity compared with transfection of the luciferase vector alone. The miR-103-induced depression of luciferase activity was rescued by an AMO-103.

Conclusion: MiR-103 could attenuate cardiomyocyte hypertrophy partly by reducing cardiac autophagy activity through the targeted inhibition of TRPV3 signalling in the pressure-overloaded rat.

Молодежный инновационный вестник. 2021;10(S1):568-570
568-570

### DOWNREGULATION OF MIR-200A PROTECTS CARDIOMYOCYTE AGAINST APOPTOSIS

Wanga Y., Jiang Y., Sun X., Shen X., Wang H., Dong C., Lu B., Yan Y., Lu Y., Fasaeb M., Liu B., Bai Y.

#### Abstract

Brief summary: Acute myocardial infarction (AMI) is a major clinical manifestation of ischemic heart disease and represents a significant cause of morbidity and mortality. However, key regulators in the pathogenesis of ischemic heart disease remain controversial.

The present study was designed to investigate the involvement of miR-200a and its related mechanism in AMI.

Methods: Left coronary artery (LCA) ligation was conducted to induce an AMI mouse model. The infarct size was measured by TTC staining. H2O2 was used to induce an AMI model in vitro. miR-200a mimics, anti-miR-200a antisense oligodeoxyribonucleotides (AMO-200a), as well as corresponding negative controls were transfected into cardiomyocytes to observe the eﬀect of miR-200a. Flow cytometry was used to detect cell apoptosis. Realtime PCR, immunoﬂuorescence and western blot assays were used to evaluate gene expression at RNA or protein levels, respectively.

Results: Apoptosis was activated in AMI models. The expression of miR-200a was upregulated both in the periinfarcted region of mice myocardium and H2O2-treated cardiomyocytes. The co-administration of AMO-200a decreased the number of apoptosis cells and altered the expression of apoptosis related proteins. Interestingly, bioinformatics analysis results revealed that miR-200a could bind to the 3′-untranslated regions (3’-UTR) of Fus mRNA. In addition, the expression of Fus was downregulated in the AMI mouse models and in H2O2-treated cardiomyocytes. The alteration of miR-200a negatively regulated Fus expression in cardiomyocytes. Also, the protective eﬀect of AMO-200a was observed through its regulation of Fus.

Conclusion: MiR-200a-dependent apoptosis signaling pathway plays an important role in the pathogenesis of AMI injury and could be an exciting potential therapeutic target.

Молодежный инновационный вестник. 2021;10(S1):570-572
570-572

### APPLICATION PROSPECT OF THREE-DIMENSIONAL RECONSTRUCTION SYSTEM OF MALE PELVIC FLOOR IN MEDICAL IMAGING UNDERGRADUATE TEACHING

Wang A.

#### Abstract

The three-dimensional reconstruction system of the male pelvic floor can fully mobilize the students' vision and touch, and transform the plane schematic diagram and knowledge points on the blackboard and slide into three-dimensional intuitive model, which makes the students deeply impressed and can "apply what they have learned" to their future clinical career. It is a new and innovative teaching mode . The purpose is to put forward feasible practical ideas for the application of the three-dimensional reconstruction system of male pelvic floor in the teaching of medical imaging undergraduate, and to prospect its application in the teaching of medical imaging undergraduate.

Молодежный инновационный вестник. 2021;10(S1):572-576
572-576

### THE PSYCHOLOGICAL IMPACTS OF COVID-19 ON PEOPLE WITH MENTAL DISORDERS IN CHINA: A CROSS-SECTIONAL STUDY

Wang W., Zhang S., Wang X., Zhang Z., Qu P., Li X., Zhou Y.

#### Abstract

Background: The psychological impacts of COVID-19 on people with mental disorders in China is unclear.

Methods: A cross-sectional study was designed, and 284 individuals with mental disorders were selected from the Third Hospital of Daqing and the First Psychiatric Specialist Hospital of BaiYuPao, Harbin. Stress, anxiety, depression, resilience, and individuals’ perceptions of the epidemic and disease relapse were measured. Univariate and multiple regression analyses were used to identify the factors influencing stress, anxiety and depression.

Results: Only 13.03% of the individuals thought they were at risk of COVID-19 infection. The mean level of stress was 17.94 (SD: 5.12). The prevalence of anxiety was 64.08% (38.38% with mild anxiety, 19.01% with moderate anxiety and 6.69% with serve anxiety). The prevalence of depression was 67.61% (53.88% with a tendency towards depression and 10.56% at risk for depression). The duration of illness was correlated with anxiety and depression. The perceived risk of COVID-19 infection and education level were significant factors for stress. Resilience and perceived possibility of relapse were significant factors for stress, anxiety and depression. There was no difference in the levels of stress, anxiety and depression among individuals in general hospital, rehabilitation hospital and home.

Conclusion: Individuals with mental illness should be given sufficient support and attention due to their perception of having a limited risk of COVID-19 infection and high levels of stress, anxiety, and depression. More targeted relapse prevention strategies should be identified to address the psychological impacts of COVID-19 among people with mental disorders.

Молодежный инновационный вестник. 2021;10(S1):576-578
576-578

### THE RELATIONSHIP BETWEEN THE LIFESTYLE OF THE RESIDENTS RESIDING IN FLUOROSIS ENDEMIC AREAS AND ADULT SKELETAL FLUOROSIS

Ye Q., Liu G., Li Q.

#### Abstract

The relationship between fluorosis and the lifestyle of adult residents of areas in which fluoros is is endemic was evaluated. A cross-sectional and case-control analysis was performed to study 289 villagers living in fluorosis endemic areas who drank the local water. Subjects were divided into skeletal fluorosis and non-skeletal fluorosis groups according to whether they were afflicted with skeletal fluorosis. A semi-quantitative food frequency questionnaire, homemade lifestyle questionnaires, and general characteristics were analyzed. The factors that affected the occurrence of skeletal fluorosis were determined by generalized estimating equations. Our results showed that protective factors against skeletal fluorosis included drinking boiled water, storing water in a ceramic tank, and ingesting fruits, vitamin A,thiamine, and folic acid. Risk factors for skeletal fluorosis were overweight status and obesity, drinking tea, drinking water without storage, and ingestion of oils, fats, and phosphorus. Our results demonstrate that skeletal fluorosis has a close relationship with lifestyle.

Молодежный инновационный вестник. 2021;10(S1):579-582
579-582

### IGG FC BINDING PROTEIN (FCGBP) IS DOWN-REGULATED IN METASTATIC LESIONS AND PREDICTS SURVIVAL IN METASTATIC COLORECTAL CANCER PATIENTS

Yuan Z.

#### Abstract

Background

Liver is the most frequent metastatic spread sites for CRC patients and these patients have much poorer prognosis compared to those without metastasis. Previous studies have shown that IgG Fc binding protein (FCGBP) plays important roles in tumorigenesis, progression and prognosis, but the role in colorectal cancer metastasis remains unclear.

Purpose

In this study, we are aimed to explore the significance of FCGBP in liver metastatic CRC (LMCRC) patients.

Methods

We analyzed the expression of FCGBP RNA between CRC primary samples and liver metastatic samples in GEO database and The Cancer Genomic Atlas (TCGA). Next, we assessed the expression of FCGBP protein in 135 paired of primary CRC (PC) samples and liver metastasis of CRC (LMCRC) samples respectively. At last, we explored the relationship between the expression features and clinicopathological characteristics.

Results

The expression data of FCGBP was obtained from Gene Expression Omnibus (GEO) and TCGA database, FCGBP RNA expression was evaluated between primary lesions (PC) and liver metastatic lesion (LM). FCGBP RNA was down-regulated in PC and LM, and especially lower in LM (p<0.001). Next, the expression of FCGBP protein was evaluated by immunohistochemistry array in 135 paired primary tumor tissue and metastatic tissue. We also found FCGBP protein was down-regulated in primary lesion and metastatic lesion, especially in metastatic lesion. According to immunohistochemistry score (SI), each cohort was divided into FCGBP-positive (SI=4-12) and FCGBP-negative (SI=0-3) group. In both groups, the level of CEA (PC group, 3.880 vs 77.049, p<0.001; LM group, 3.890 vs 14.239, p=0.008) and CA19-9 (PC group, 8.610 vs 111.700, p<0.001; LM group, 7.660 vs 19.380, p=0.037) was lower than those in FCGBP-negative group. FCGBP-positive in LM cohort was an independent risk factor both in OS (HR 1.573, 95% Cl [1.017-2.433], p=0.042) and DFS (HR 1.869, 95% Cl [1.256-2.781], p=0.002).

Conclusion

This study has found the relationship between FCGBP and clinical information of LMCRC patients and FCGBP expression was decreased with disease development. The expression of FCGBP in liver metastasis is associated with the OS and PFS. Our works illustrate that FCGBP can be a promising prognostic factor for LMCRC.

Молодежный инновационный вестник. 2021;10(S1):582-585
582-585

### THE PROBLEM OF THE ELDERLY PROTECTION IN THE ELDERLY CARE INSTITUTIONS DURING COVID-19 PANDEMIC

Zhang H., Yang C., Yin M., Qu P.

#### Abstract

In early 2020, COVID-19 pandemic spread rapidly around the world. Globally, as of February 6, 2021, there have been 104,790,123 confirmed cases of COVID-19, including 2,285,048 deaths, reported to WHO. Among them, the morbidity and mortality of the elderly account for a large proportion, so the elderly care institutions have become the most severely hit. Elderly care institutions around the world face great challenges in protecting the elderly. Based on the characteristics of the elderly, this article explores the protection of elderly care institutions, and suggestion on the health management, closed-off management and improvement of elderly care mode in public health emergencies.

Молодежный инновационный вестник. 2021;10(S1):585-587
585-587

### AKKERMANSIA MUCINIPHILA PREVENTS COLD-RELATED ATRIAL FIBRILLATION BY THE MODULATION OF TMA/TMAO PATHWAY

Zhang Y., Li Y.

#### Abstract

Relevans of the brief summary: Cold exposure is one of the most important risk factors for atrial fibrillation (AF). Gut microbiota has been reported to be associated with AF. However, the role and pathogenesis of gut microbiota in cold-related AF remain poorly understood.

The research objective of the brief summary: To reveal the role and pathogenesis of gut microbiota in cold related atrial fibrillation.

Methods of the brief summary: Various techniques including 16S rRNA gene sequencing, fecal microbiota transplantation, and electrophysiological examination were used to determine whether gut microbiota dysbiosis promotes cold-related AF. Metabonomics were performed to investigate changes in fecal TMA and plasma TMAO during cold exposure. To identify the special microbiota responsible for cold-related AF, we evaluated the correlation between results of 16S rRNA and metabolomics. In addition, single-bacterial intervention experiments were conducted and clinical relevance was verificated among human subjects.

Results of the brief summary: We found that cold exposure induced AF by altering the composition and metabolism of microbiota, including the decrease of Akkermansia muciniphila(A. muciniphila) and increase in TMA and TMAO. TMAO promotes atrial remodeling and AF. Moreover, supplement with A. muciniphila virtually completely protected rats from cold-related AF by inhibiting the production of TMA. More importantly, the clinical relevance between A. muciniphila and cold-relatd AF has been confirmed in the population.

Conclusion of the brief summary: These findings demonstrate a novel causal role of aberrant gut microbiota and metabolites in contributing to the pathogenesis of cold-related AF, which raised the exciting possibility of selectively targeting microbiota and microbial metabolites as a potential therapeutic strategy for cold-related AF.

Молодежный инновационный вестник. 2021;10(S1):587-589
587-589

### RESEARCH PROGRESS ON SEPARATION AND PURIFICATION OF EXTRACELLULAR VESICLES

Zhao Y.

#### Abstract

Extracellular vesicles (EVs) are small vesicles with membrane structure released by cells. They play an important role in the pathogenesis, diagnosis and treatment of many diseases, such as tumor, nervous system, metabolic disorders and so on. They are one of the most rapidly developing research directions in the field of life science in recent years. The separation and capture of EVs from complex body fluid samples is the premise of medical research and clinical diagnosis based on EVs. However, there is no unified standard for the separation and purification of EVs so far. The existing separation and purification technologies have their own advantages and disadvantages, which restricts the continuous development of EVs in the biomedical field. This paper reviews the research progress of EVs separation and purification methods in recent years, and compares the efficiency, applicability, advantages and disadvantages of each technology, so as to provide reference for the future research based on EVs.

Молодежный инновационный вестник. 2021;10(S1):589-593
589-593

## БЕРЕЧЬ И РАЗВИВАТЬ БЛАГОРОДНЫЕ ТРАДИЦИИ МЕДИЦИНЫ»: ВЫДАЮЩИЕСЯ ВРАЧИ РОССИИ

### The Botkin Medical Dynasty

Bykovskiy A.

#### Abstract

The article briefly analyzes the Botkin medical dynasty, presents the main achievements and areas of work, and also reflects information about the living representatives of the dynasty.

Молодежный инновационный вестник. 2021;10(S1):