Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9953Conference ProceedingsChallenges and breakthroughs in the treatment and prevention of herpes infections associated with herpes simplex virus types 1 and 2LaptevNikita Evgenievich<p>student</p>apodicktey@mail.ruhttps://orcid.org/0009-0006-6438-0657LaptevaAnna Vladislavovnane.av.la@mail.ruhttps://orcid.org/0009-0009-4854-3876Ryazan State Medical University2712202413272731204202415062024Copyright © 2024, Laptev N.E., Lapteva A.V.2024<p>Introduction. Herpetic infections (HI) in the 21st century represent a serious problem for the system of health care organization, there is a huge increase in morbidity and mortality, according to WHO, morbidity reaches 50%, the mortality rate from severe forms of the disease is increasing, in this regard, the task of research of modern points of application of forces to counteract herpetic infections associated with herpes simplex viruses types 1 and 2 has been set. The aim of the study is to formulate the problems of the current position of herpetic infections in the general series of infectious diseases. Methods. Domestic and foreign literature from 2014 to 2023 was analyzed, and the main points of the problematic were presented, which are planned to be influenced by the outcome of subsequent studies. Results. The following aspects were highlighted: almost complete monopoly of acyclovir, i.e. absence of the fact of using other antiviral drugs against herpetic infections, also small number of appropriate drugs, absence of highly effective drugs for treatment of GI caused by multidrug-resistant strains, absence of quality drugs for newborns and sick pregnant women, absence of vaccine for GI. Conclusions. Although work in these areas is partially underway, it is necessary to bring together this information, so that in the future it will be possible to comprehensively approach to the solution of the problems, as well as point studies to eliminate certain problems. The paper presents a brief comprehensive characterization of these problems to provide a theoretical basis for further implementation of certain studies.</p>herpetic infectionsherpes simplex virus types 1 and 2HPVHPV vaccinetreatment of herpetic infections.герпетические инфекциивирус простого герпеса 1 и 2 типовВПГвакцина от ВПГлечение герпетических инфекций.1.1.Molero García JM, Moreno Guillén S, Rodríguez-Artalejo FJ, Ruiz-Galiana J, Cantón R, De Lucas Ramos P, García-Botella A, García-Lledó A, Hernández-Sampelayo T, Gómez-Pavón J, González Del Castillo J, Martín-Delgado MC, Martín Sánchez FJ, Martínez-Sellés M, Bouza E. Status of Herpes Zoster and Herpes Zoster Vaccines in 2023: A position paper. Rev Esp Quimioter. 2023 Jun;36(3):223-235. DOI: 10.37201/req/004.2023.2.2.Samies NL, James SH. Prevention and treatment of neonatal herpes simplex virus infection. Antiviral Res. 2020 Apr;176:104721. DOI: 10.1016/j.antiviral.2020.104721.3.3.Majewska A, Mlynarczyk-Bonikowska B. 40 Years after the Registration of Acyclovir: Do We Need New Anti-Herpetic Drugs? Int J Mol Sci. 2022 Mar 22;23(7):3431. DOI: 10.3390/ijms23073431.