Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9948Conference ProceedingsVitamin D receptor gene rs1544410 polymorphism and autoimmune thyroiditis in womenValigunYanina Sergeevna<p>Assistant of the Department of Transplantation and Clinical Laboratory Diagnostics</p>valigun.kdl@mail.ruhttps://orcid.org/0009-0009-4364-1995Donetsk State Medical University named after M. Gorky2712202413219201004202412062024Copyright © 2024, Valigun Y.S.2024<p><em>Introduction. Genetic factors play an important role in the development of autoimmune thyroiditis (AIT). Polymorphisms of the vitamin D gene (VDR) may be pathogenetically significant in this disease. Target. To study the genetic polymorphism rs1544410 of the VDR gene among women with autoimmune thyroiditis. Materials and methods. We examined 373 women whose age indicators (Me [Q1-Q3]) were 49 [35-62] years. Detection of VDR gene polymorphism (rs1544410) was carried out using the polymerase chain reaction method in real time. Statistical analysis of the results was carried out using the Medstat statistical software package. Results. Analysis of molecular genetic studies showed that the genotype frequencies of the studied polymorphism corresponded to the HardyWeinberg law and did not differ from the expected values (p0.05). There was no association between polymorphic variants of the VDR gene and AIT in a group of postmenopausal women. However, among women of reproductive age, AIT showed an association with the GG genotype (p = 0.043) and the G allele (p = 0.041) of the rs1544410 polymorphism. Conclusions. The results obtained indicate that the presence of the G allele and the GG genotype of the rs1544410 polymorphism of the VDR gene increases the likelihood of autoimmune thyroid disease in women of reproductive age.</em></p>womenpolymorphismvitamin Dautoimmune thyroiditisженщиныполиморфизмвитамин Dаутоиммунный тиреоидит1.Игнатенко, Т.С., Распространенность аутоиммунного тиреоидита среди женщин различного возраста / Т. С. Игнатенко, Э. А. Майлян, Г.Д. Капанадзе // Университетская клиника. – 2021. – № 2. – С. 44-50.2.Gao, X.R. Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease / X.R. Gao, Y.G. Yu // Int J Endocrinol. – ¬2018. – Vol. 2018. – Р. 2846943. doi: 10.1155/2018/2846943.