Молодежный инновационный вестник

2415-7805

Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации

9905

Conference Proceedings

Comparison of the effectiveness of delayed motherhood programs in different age groups of patients

Lavrukhina

Maria

maria.alexandrovna05@mail.ruhttps://orcid.org/0009-0007-6568-1598Kasyanova

Galina Viktorovna

Candidate of Medical Sciencesmaria.alexandrovna05@mail.ru

Pirogov Russian National Research Medical University (RNRMU), Moscow, Russian Federation

27122024

1327071

28032024

17062024

2024

Abstract. Introduction. The number of women exercising childbearing function in older reproductive age is growing [1]. Age is one of the unmodifiable factors of oocyte aging, a process in which 2 main mechanisms are distinguished: a decrease in the expression of the gene encoding the enzyme DNA topoisomerase [2], which leads to impaired chromosome condensation, chromatid separation and torsion stress relief; and oxidative stress [3], realized by a decrease in melatonin and an increase in tumor necrosis factor alpha (TNF-alpha) in follicular fluid [4]. Both mechanisms lead to embryo aneuploidy. The goal of this study is a preservation of genetically high-quality material in women in delayed motherhood programs. Materials and methods. The outcomes of in vitro fertilization (IVF) programs in 156 patients of reproductive age were analyzed. A total of 797 embryos were obtained. A retrospective study of the dependence of the quantity and quality of 797 embryos on the age of patients in the department of infertility treatment and IVF of the Lapino Clinical Hospital for 2022 was conducted. Results. Statistical analysis showed an inverse average relationship between the age of patients and the number of embryos received; an inverse strong relationship between the age of patients and the proportion of euploid embryos; a significant decrease in the proportion of euploid embryos in patients aged 35 years and older and a uniform decrease in the ratio of euploid embryos to the total of embryos in subsequent age groups. Methods for improving the outcomes of delayed motherhood programs are proposed. Conclusions. The higher the patient's age, the worse the yield in terms of the number and quality of embryos, especially euploid ones. It is necessary to inform women about the influence of the age factor on reducing the chance of obtaining a genetically healthy embryo (even in assisted reproductive technology (ART) programs) and about the greater effectiveness of delayed motherhood programs for cryopreservation of oocytes at a younger age. Keywords: infertility; delayed motherhood; female age factor; euploid embryos; oocyte aging

infertilitydelayed motherhoodfemale age factoreuploid embryosoocyte aging

бесплодиеотсроченное материнствоженский возрастной факторэуплоидные эмбрионыстарение ооцита

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4. Liu Y.X., Zhang Y., Li Y.Y., Liu X.M., Wang X.X., Zhang C.L., et al. Regulation of follicular development and differentiation by intraovarian factors and endocrine hormones. Front Biosci (Landmark Ed). 2019; 24 (5): 983993. DOI: 10.2741/4763.

5. Адамян Л.В., Елагин В.В., Пивазян Л.Г., Исаева С.Г. Преимплантационное генетическое тестирование в гинекологии — быть или не быть? Проблемы репродукции. 2023;29(3):16 24.

Adamyan LV, Elagin VV, Pivazyan LG, Isaeva SG. Pre-implantation genetic testing (PGT) in gynecology — to be or not to be? Russian Journal of Human Reproduction. 2023;29(3):16 24. (In Russ.)

https://doi.org/10.17116/repro20232903116