Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9903Conference ProceedingsStudy of the influence of auxiliary substances in the development of dietary supplement of butyric acidBarkovskayaEkaterinaeb448335@gmail.comhttps://orcid.org/0009-0004-9042-3898DubovskayaNatalyadubovskaya_n@pimunn.nethttps://orcid.org/0000-0002-2110-5317VolkovAlexandervolkov_a@pimunn.nethttps://orcid.org/0000-0002-8245-0739Privolzhsky Research Medical University2712202413217193103202412062024Copyright © 2024, Barkovskaya E., Dubovskaya N., Volkov .2024<p class="5-" style="text-align: justify;"><span lang="EN-US">Introduction. Irritable bowel syndrome (IBS) is a common gastrointestinal (GI) disorder in developed countries, with morbidity ranging from 20% to 50% of people aged 25-50 years. One of the reasons for this problem is the lack of universal methods of symptomatic and pathogenetic treatment. Objective. Development of technology for obtaining an oral delivery form of butyric acid and selection of necessary auxiliary substances for replenishing the deficiency of the active substance in the large intestine. Materials and methods. A literature search was performed to determine the role and functions of the use of butyric acid and its salt sodium butyrate in GI diseases. A delivery form using wet granulation method was developed. Results. Literature review determined the effect of butyric acid in the treatment of GI disorders elucidated its ability to restore cell metabolism and normal intestinal microflora, which is used in various disorders. Several formulations have been obtained. The presence of the natural polymer sodium alginate provided modification of the release due to its swelling and formation of pores through which the active component was released. The composition without the polymer component did not possess prolonged release, it was immediately destroyed when exposed to the acidic environment of the stomach. Conclusions. As a result of the conducted researches the influence of auxiliary substances changing solubility, disintegrability, strength during tablet preparation was determined. The qualitative and quantitative composition was developed and selected, and the technology of obtaining an oral delivery form of butyric acid with prolonged release was worked out.</span></p>butyric acidmetabioticenteric soluble formdisintegrationanalysisмасляная кислотаметабиотиккишечнорастворимая формараспадаемостьанализ[Косюра С.Д.Применение масляной кислоты и инулины в практике гастроэнтеролога / Г. Г. Тотолян,][И. Г. Федоров,М.А. Чичкина [и др.] // Фундаментальная медицина.–2015.–№3.–URL: https://cyberleninka.ru/article/n/primenenie-maslyanoy-kisloty-i-inulina-v-praktike-gastroenterologa][Ситкин С.И. Дисбиоз кишечника при язвенном колите и целиакии и его терапевтическая коррекция с помощью масляной кислоты в комбинации с инулином / С. Я. Вахитов, Е. И. Ткаченко, Л. С. Орешко [и др.] // Экспериментальная клиническая гастроэнтерология. – 2017. – С. 8-9.][Левченко С.В. Эффективность масляной кислоты и инулина у больных синдромом раздраженного кишечника: результаты многоцентрового исследования / И.А. Комиссаренко, А.А. Голохвастова, Е.В. Мороз][[и др.] //Медицинский науяно-практический журнал. – 2018. – № 2.– URL: https://www.lvrach.ru/2018/02/15436911]