Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9819Conference ProceedingsAnalysis of microflora resistance in children with phlegmonous appendicitisRepinaMaria Dmitrievnarepina-repina-m02@yandex.ruhttps://orcid.org/0009-0004-0286-1477BarkalovaEkaterina Andreevnakatya.barkalova2001@maill.ruhttps://orcid.org/0009-0000-2008-9389ZhdanovaOlga Alexandrovna<p>Doctor of Medical Sciences, Associate Professor, Professor of the Department of Clinical Pharmacology</p>olga.vr9@yandex.ruhttps://orcid.org/0000-0002-3917-0395NazarievaNonna Alexevna<p>Assistant of the Department of Clinical Pharmacology</p>nonazar@yandex.ruVoroneg State Medical University named after N. N. BurdenkoVoronezh State Medical University named after N. N. Burdenko1904202413S12232262102202428042024Copyright © 2024, Repina M.D., Barkalova E.A., Zhdanova O.A., Nazarieva N.A.2024<p>Introduction. The irrational use of antibiotics in the treatment of acute phlegmonous appendicitis leads to ineffective therapy and various complications. The purpose of the work. Assessment of the dynamics of the level of resistance of the isolated microflora in children with acute phlegmonous appendicitis with a 14-year interval. Materials and methods. The article analyzes 105 results of microbial seeding and their antibiotic resistance obtained from patients aged 1 to 17 years hospitalized in Regional Children's Clinical Hospital No. 2 with a diagnosis of Acute phlegmonous appendicitis in 2007 and 2021. The results of the study. A review of the results on antibiotic resistance showed that Gram-positive bacteria, namely Staph. epidermidis, have a high level of resistance to erythromycin. Most gram-negative bacteria are resistant to ampicillin. E.coli strains (ESBL) also show resistance to amoxiclav, cefotaxime and ceftriaxone. Conclusions. The main bacterium often secreted remains E.coli, the seeding of which has increased from 45% to 52% over the past 14 years. There has been a change in the varieties of microorganisms secreted Ps. aeruginosa became the cause of acute phlegmonous appendicitis in 2021. A large number of bacteria appeared, which began to produce broad-spectrum -lactamases. The conducted antibacterial therapy should be prescribed taking into account the expected microflora and corrected in accordance with the results of bacteriological sowing of effusion from the abdominal cavity.</p>childrenacute appendicitisantibioticsresistance of microorganismsдетиострый аппендицитантибиотикирезистентность микроорганизмов1.Федеральные клинические рекомендации «Острый аппендицит у детей» / В. М. Розинов, А. Ю. Разумовский, А. Ф. Дронов [и др.] -2013.2.Chong Y, Shimoda S, Shimono N. Current epidemiology, genetic evolution and clinical impact of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Infect Genet Evol. 2018;61:185-188. https://doi.org/10.1016/j.meegid.2018.04.0053.Theodorou CM, Stokes SC, Hegazi MS, Brown EG, Saadai P. Is Pseudomonas infection associated with worse outcomes in pediatric perforated appendicitis? J Pediatr Surg. 2021;56(10):1826-1830.4.https://doi.org/10.1016/j.jpedsurg.2020.10.031