Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9810Conference ProceedingsStudy of the toxicity of the drug Rinoferon in immature ratsTatianaAnikanova Viktorovna<p>PhD student of the Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University</p>malorodova_tn@mail.ruhttps://orcid.org/0000-0002-8122-3382PokrovskayaTatyana Grigorievna<p>Doctor of Medical Sciences, Professor of the Department of Pharmacology and Clinical Pharmacology</p>pokrovskaia@bsu.edu.ruhttps://orcid.org/0000-0001-6802-5368Belgorod State National Research University Research Institute of Pharmacology of Living SystemsFederal State Autonomous Educational Institution of Higher Education "Belgorod State National Research University" Research Institute of Pharmacology of Living Systems1904202413S11992042102202428042024Copyright © 2024, Tatiana A.V., Pokrovskaya T.G.2024<p>Introduction. Acute respiratory infections occupy a leading place in the structure of infectious pathology in children. At the same time, in pediatric practice, a special place is occupied by genetically engineered interferon-2b, the safety and effectiveness of which is similar to endonasal use.</p> <p>The goal of this study is to study the toxic effects of the drug Rinoferon, dosed nasal spray, 500 IU/dose (Pharmstandard-Leksredstva OJSC, Russia) with repeated intranasal administration in two experimental doses to male and female immature rats for 14 days, followed by a 14-day withdrawal period introduction.</p> <p>The studies were carried out using visual, instrumental and laboratory monitoring of the condition of animals, modern methods for assessing the effect of drugs in accordance with the Guidelines for conducting preclinical studies of drugs under the general editorship of Doctor of Medical Sciences. A.N. Mironov and the rules of good laboratory practice GLP.</p> <p>It was found that the administration of the study drugs in the studied doses for 14 days did not have a significant effect on the body weight of the animals or their food consumption in comparison with the control group of rats. There was also no change in the general condition, qualitative and quantitative blood parameters and the functional state of the internal organs of rats in the experimental groups compared to the group of control animals receiving placebo. Macro- and microscopic examination of the internal organs and the site of drug administration revealed no signs of toxic manifestations caused by the administration of the study drugs. No pathological changes were observed in animals within 14 days after discontinuation of drug administration.</p>Interferontoxicological safetyrepeated administrationИнтерферонтоксикологическая безопасностьмногократное введение1.Попова, И. К. Подходы к терапии острых респираторных вирусных инфекций у детей на амбулаторном этапе / И. К. Попова, В. В. Коломацкая // Российский педиатрический журнал. – 2023. – Т. 23, № S1. – С. 39-40. – EDN JDESHU.2.Зайцева, С. В. Рациональный выбор антибактериальной терапии у детей с острыми респираторными инфекциями верхних дыхательных путей / С. В. Зайцева, О. В. Зайцева, Э. Э. Локшина // Медицинский совет. – 2023. – Т. 17, № 1. – С. 63-72. – DOI 10.21518/ms2023-004. – EDN KVTJKQ.3.Особенности микоплазменной инфекции органов дыхания в клинической практике / Р. А. Бонцевич, Т. Л. Субина, В. А. Винюков, А. А. Гаврилова // Consilium Medicum. – 2020. – Т. 22, № 3. – С. 40-45. – DOI 10.26442/20751753.2020.3.200081. – EDN LCXVDQ.4.Актуальные аспекты применения лекарственных препаратов на основе интерферонов в практике педиатра / И. М. Османов, Л. Н. Мазанкова, С. Н. Борзакова, А. В. Винокуров // Практика педиатра. – 2023. – № 1. – С. 51-61. – EDN LKAGVI.5.Руководство по проведению доклинических исследований лекарственных средств / Научный центр экспертизы средств медицинского применения Минздравсоцразвития России. Том Часть 1. – Москва : Гриф и К, 2012. – 944 с. – ISBN 978-5-8125-1466-3. – EDN SDEWMP.