Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9759Conference ProceedingsA case of meconium peritonitis in a newborn child with cystic fibrosisAlekseevaAnastasia Vasilevnams-ava@mail.ruhttps://orcid.org/0000-0002-4391-094XDemidovaRimma Aleksandrovnams-ava@mail.ruKashirskayaElena Igorevna<p>Doctor of Medical Sciences, Associate Professor</p>ms-ava@mail.ruAstrakhan State Medical UniversityFederal State Budgetary Educational Institution of the Federal State Medical University of Astrakhan1904202413S13143172002202413052024Copyright © 2024, Alekseeva A.V., Demidova R.A., Kashirskaya E.I.2024<p><em>Introduction. Meconium ileus is one of the manifestations of cystic fibrosis and is characterized by intestinal obstruction with viscous meconium, which often leads to the development of perforation and peritonitis. Goal. To show the features of the course, diagnosis and therapy of meconium peritonitis in a newborn child with cystic fibrosis. Materials and methods. The medical history of a patient with cystic fibrosis. Results. During a routine ultrasound examination at the 33rd week of pregnancy, the intrauterine child showed signs of colon obstruction and meconium peritonitis. Surgical treatment of peritonitis was performed on the 1st day after birth. From day 1, the child is on a ventilator. On the 8th day of life, the child showed signs of intrahepatic cholestasis with direct hyperbilirubinemia (up to 100 mmol / l). On the 10th day of the child's life, a negative blood test result for IRT was obtained (21.6 ng/ml with a norm of 70 ng/ml). On the 21st and 23rd days of life, sweat tests were performed, the results of which revealed high levels of chlorides of sweat fluid (112 mmol/l in both samples, the norm is 30-59 mmol/l). The diagnosis of cystic fibrosis was established, dornase alpha (2.5 mg / day) was added to therapy. Conclusions. Meconium ileus is one of the specific intestinal manifestations of cystic fibrosis and is often complicated by intestinal perforation of an intrauterine child with the development of peritonitis. Children with meconium ileus need sweat tests regardless of the results of neonatal screening.</em></p>meconium ileusmeconium peritonitisnewborncystic fibrosisмекониевый илеусмекониевый перитонитноворожденныймуковисцидоз1.1. Игнатьев Е. М., Караваева С. А., Котин А. Н., и др. Об опыте хирургического лечения мекониевого перитонита. Научные ведомости БелГУ. Серия: Медицина. Фармация. 2012; 123 (4).2.2. Zangheri G., Andreani M., Ciriello E. et al. Fetal intra-abdominal calcification from meconium peritonitis: sonographic predictors of postnatal surgery // Prenat. Diagn.—2007.—№ 27.—P. 960–963.3.3. Об опыте хирургического лечения мекониевого перитонита / Е. М. Игнатьев, С. А. Караваева, А. Н. Котин [и др.] // Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. – 2012. – № 4(123). – С. 42-46. – EDN RMUBJP.4.4. Ping L.M., Rajadurai V.S., Saffari S.E., Chandran S. Meconium Peritonitis: Correlation of Antenatal Diagnosis and Postnatal Outcome — An Institutional Experience over 10 Years. Fetal Diagn. Ther. 2017; 42: 57–62. doi:10.1159/000449380