Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9728Adrenal neuroblastoma in the first year of lifeMatrosEkaterina Sergeevna<p>5th year student of the pediatric faculty</p>kate@matros.ushttps://orcid.org/0000-0003-4377-632XAksenovAnton Olegovich<p>5th year student of the pediatric faculty</p>ton.ov@yandex.ruhttps://orcid.org/0009-0009-2529-6374DeminaSofia Alexandrovna<p>5th year student of the pediatric faculty</p>sofademina19@gmail.comhttps://orcid.org/0009-0004-8370-7198LarinaLiubov Evgenievna<p>candidate of medicine, associate professor of department of childhood diseases propaedeutics in pediatrics faculty at Pirogov Russian National Research Medical University</p>yaginia@gmail.comhttps://orcid.org/0000-0002-0735-7139Pirogov Russian National Research Medical University1904202413S13393412002202410052024Copyright © 2024, Matros E.S., Aksenov A.O., Demina S.A., Larina L.E.2024<p>Introduction. Neuroblastoma (NB) is a malignant extracranial solid tumor of the pediatric population. It can be localized in sympathetic parts of the nervous system and adrenal glands. It occurs sporadically but may be associated with a family history. Treatment tactics of this disease are different, depending on localization, stage and severity. Objective. To describe a patient with accidentally detected NB of the left adrenal gland. Materials and methods. Analysis of the patient's medical history, domestic and foreign literature on the subject of the article. Results. We present a clinical case of accidental detection of adrenal NB in a child of the first year of life who was taken to the hospital with anemia and suspected urinary tract infection. Complex diagnostics made it possible to establish the diagnosis. The child needs thorough examination, specialist consultations, selection of therapy and determination of further management tactics. Conclusion. Risk determination based on a combination of instrumental and laboratory diagnostic methods is no less important than early diagnosis of NB. To date, the search for new methods and schemes of treatment remains relevant due to its high share in the structure of pediatric mortality from oncologic diseases.</p>neuroblastomaurinary tract infectionanemiaclinical casechildrenнейробластомаинфекция мочевыводящих путейанемияклинический случайдети1.Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):83-103. https://doi.org/10.3322/caac.212192.Matthay KK, Maris JM, Schleiermacher G, et al. Neuroblastoma. Nat Rev Dis Primers. 2016; 2:16078. Published 2016 Nov 10. https://doi.org/10.1038/nrdp.2016.783.Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010;362(23):2202-2211. https://doi.org/10.1056/NEJMra08045774.Matthay KK, Maris JM, Schleiermacher G, et al. Neuroblastoma. Nat Rev Dis Primers. 2016; 2:16078. Published 2016 Nov 10. https://doi.org/10.1038/nrdp.2016.785.Chung C, Boterberg T, Lucas J, et al. Neuroblastoma. Pediatr Blood Cancer. 2021;68 Suppl 2(Suppl 2):e28473. https://doi.org/10.1002/pbc.284736.Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science. 1984;224(4653):1121-1124. https://doi.org/10.1126/science.67191377.Perri P, Ponzoni M, Corrias MV, Ceccherini I, Candiani S, Bachetti T. A Focus on Regulatory Networks Linking MicroRNAs, Transcription Factors and Target Genes in Neuroblastoma. Cancers (Basel). 2021;13(21):5528. Published 2021 Nov 3. https://doi.org/10.3390/cancers132155288.Ponzoni M, Bachetti T, Corrias MV, et al. Recent advances in the developmental origin of neuroblastoma: an overview. J Exp Clin Cancer Res. 2022;41(1):92. Published 2022 Mar 11. https://doi.org/10.1186/s13046-022-02281-w