Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9610UnclassifiedProspects of HBx-targeted therapy for hepatitis B virusSavelevaAnastasia A.<p>Student</p>a.a.savel1999@gmail.comhttps://orcid.org/0009-0009-4997-4045AstudinEgor S.<p>Student</p>astudin-egor.ru@yandex.ruhttps://orcid.org/0009-0002-6890-5634AlexanyanAregnazan M.<p>Student</p>nazeli2003live@gmail.comhttps://orcid.org/0009-0004-2229-0798RusanovskyVladimir V.<p>Doctor of Medical Sciences, Professor of the Department of Pharmacology with a course in Clinical Pharmacology and Pharmacoeconomics</p>rusvv2058@mail.ruhttps://orcid.org/0000-0002-0432-7946St. Petersburg State Pediatric Medical University1904202413S15655681402202429042024Copyright © 2024, Saveleva A.A., Astudin E.S., Alexanyan A.M., Rusanovsky V.V.2024<p><em>Introduction. The incidence of viral hepatitis B is a pressing issue in healthcare, prompting the need for new approaches to disease therapy. The question remains open regarding the development of new treatment strategies. Objective. To analyze contemporary data on the molecular mechanisms of viral hepatitis B pathogenesis and promising directions in antiviral therapy. Materials and methods. Literature search and analysis were conducted on platforms such as Elibrary, PubMed, CyberLeninka, and Scopus to identify the latest research results in the field of viral hepatitis B pathogenesis and key perspectives in antiviral therapy. Results. The data on the mechanisms of HBx protein functioning in viral hepatitis B have been obtained. Three promising directions in antiviral therapy aimed at reducing HBx protein production or limiting its activity were identified: nitazoxanide - a drug inhibiting the interaction of HBx with host cell proteins, which is important for the pathogenesis of viral hepatitis; dicoumarol - a substance promoting HBx degradation; monoclonal antibodies against HBx. Conclusions. HBx protein is the most important link in the pathogenesis of viral hepatitis B. Antiviral HBx-targeted therapy is potentially effective in the treatment of acute and chronic forms of viral hepatitis B and requires further studies.</em></p>viral hepatitis BHBx antigennitazoxanidedicoumarolmonoclonal antibodiesвирусный гепатит ВHBx антигеннитазоксаниддикумаринмоноклональные антитела1.Hsu YC, Huang DQ, Nguyen MH. Global burden of hepatitis B virus: current status, missed opportunities and a call for action. Nat Rev Gastroenterol Hepatol. 2023 Aug;20(8):524-537. doi: 10.1038/s41575-023-00760-92.Динамика заболеваемости вирусными гепатитами населения Российской Федерации в 2015-2021 гг / Ю. В. Михайлова, А. В. Громов, Е. Л. Аверьянова, С. А. Стерликов // Современные проблемы здравоохранения и медицинской статистики. – 2022. – № 4. – С. 269-297. – DOI 10.24412/2312-2935-2022-4-269-297. – EDN DVYSXB.3.Tsukuda S., Watashi K. Hepatitis B virus biology and life cycle //Antiviral research. – 2020. – Т. 182. – С. 104925. doi:10.1016/j.antiviral.2020.1049254.Schollmeier A., Glitscher M., Hildt E. Relevance of HBx for Hepatitis B Virus-Associated Pathogenesis //International Journal of Molecular Sciences. – 2023. – Т. 24. – №. 5. – С. 4964. doi.org/10.3390/ijms240549645.Schollmeier A., Glitscher M., Hildt E. Relevance of HBx for Hepatitis B Virus-Associated Pathogenesis //International Journal of Molecular Sciences. – 2023. – Т. 24. – №. 5. – С. 4964. doi:10.3390/ijms240549646.Sekiba K., Otsuka M., Ohno M., Yamagami M., Kishikawa T., Suzuki T., Ishibashi R., Seimiya T., Tanaka .E, Koike K. Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction. Cell Mol Gastroenterol Hepatol. 2019;7(2):297-312. doi: 10.1016/j.jcmgh.2018.10.010.7.Rossignol J.F., Bréchot C. A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B. Hepatol Commun. 2019 Mar 29;3(6):744-747. doi: 10.1002/hep4.1339.8.Cheng ST, Hu JL, Ren JH, Yu HB, Zhong S, Wai Wong VK, Kwan Law BY, Chen WX, Xu HM, Zhang ZZ, Cai XF, Hu Y, Zhang WL, Long QX, Ren F, Zhou HZ, Huang AL, Chen J. Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx. J Hepatol. 2021 Mar;74(3):522-534. doi: 10.1016/j.jhep.2020.09.019.9.Zhang JF, Xiong HL, Cao JL, Wang SJ, Guo XR, Lin BY, Zhang Y, Zhao JH, Wang YB, Zhang TY, Yuan Q, Zhang J, Xia NS. A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway. Theranostics. 2018 Jan 1;8(2):549-562. doi: 10.7150/thno.20047.