Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9442Conference ProceedingsAssessment of the risk of developing anemia during surgical modeling of additional respiratory resistance in ratsSpesivtsevaNatalia Nikolaevna<p>Lecturer of the Department of Pathophysiology</p>n.spesivtseva@mail.ruFedinaElena Olegovnalena.fedina.2002@mail.ruRud-PanarinVladimir Vladimirovich<p>студент 3 курса стоматологического факультета</p>rudpanvladimir@gmail.comDenisukAnna Viacheslavovna<p>3rd year student of the Faculty of Dentistry</p>anutka.ddd5@gmail.comPovarovaAlisa Olegovnapovarova.2003@mail.ruRyazan State Medical University named after akad.I.P.PavlovaRyazan State Medical University named after Academician I.P. Pavlov1904202413S13053081302202410042024Copyright © 2024, Spesivtseva N.N., Fedina E.O., Rud-Panarin V.V., Denisuk A.V., Povarova A.O.2024<p><em>The need to use personal respiratory protection equipment, as well as an increase in the number of patients with airway obstruction, makes the study of the effect of additional respiratory resistance (АRS) on the body one of the key problems. To study the adaptation processes formed in the body under the influence of airflow restriction, it is necessary to use experimental models that make it possible to study various adaptive and pathological processes, including in the blood system. </em><em>Complete blood count </em><em>(СВС) data make it possible to determine the risk of anemia during operational modeling of АRS. Goal. To determine the effect of the development of АRS on the development of anemia. Materials and methods. The study involved 20 animals. They were randomly divided into 4 groups of 5 rats each. All animals except the control group underwent tracheal ligation surgery with restricted airflow. The frequency of respiratory movements, weight were determined in animals, and blood was taken for general analysis. Results. Against the background of the tracheal ligation operation in animals, there are no violations of the parameters of red blood, except for the indicator of erythrocyte anisocytosis, which returns to normal by 12 days after ligation, which may indicate minor blood loss during surgery. Conclusions. The indicators of red blood change slightly, the ligation operation does not lead to blood loss in animals, there are no signs of anemia on days 6 and 12.</em></p>additional respiratory resistanceanemiaanimalsexperimentдополнительное респираторное сопротивлениеанемияживотныеэксперимент1.Спесивцева, Н.Н. Влияние дополнительного респираторного сопротивления на показатели частоты сердечных сокращений и дыхания у крыс / Н.Н. Спесивцева // Сборник докладов IX всероссийской научной конференции с международным участием молодых специалистов, аспирантов, ординаторов «Инновационные технологии в медицине: взгляд молодого специалиста». – 2023. – С.114-116. - EDN: NDODAS2.Бяловский, Ю.Ю. Условный дыхательный рефлекс на увеличенное сопротивление дыханию как экспериментальная модель адаптивной деятельности / Ю.Ю. Бяловский // Российский медико биологический вестник имени академика И.П.Павлова. – 2012 - №2. – С. – 77. - EDN: PBHYUH3.Glynos C, Toumpanakis D, Loverdos K, Karavana V, Zhou Z, Magkou C, Dettoraki M, Perlikos F, Pavlidou A, Kotsikoris V, Topouzis S, Theocharis SE, Brouckaert P, Giannis A, Papapetropoulos A, Vassilakopoulos T. Guanylyl cyclase activation reverses resistive breathing-induced lung injury and inflammation. Am J Respir Cell Mol Biol. 2015 Jun;52(6):762-71. doi: 10.1165/rcmb.2014-0092OC. PMID: 25353067