Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9409Conference ProceedingsThe COVID-19 pandemic and the consequences of its impact on men’s reproductive healthBubnovaAnastasiia Mikhailovna<p>student</p>nasbubnowa@yandex.ruhttps://orcid.org/0000-0002-0830-1137StaryninaDarya Владимировна<p>student</p>starynina.darya@mail.ruhttps://orcid.org/0009-0002-6634-3236RozhnovaTatyana Mikhailovna<p>Phd, Assistant Professor of Medical Genetics Department</p>stm-i@yandex.ruhttps://orcid.org/0000-0002-3323-5303First Moscow State Medical University named after I.M. Sechenov1904202413S155561202202402052024Copyright © 2024, Bubnova A.M., Starynina D.В., Rozhnova T.M.2024<p>Introduction. The COVID-19 pandemic has had a huge impact on population health. Despite the large amount of research on this problem, a number of open questions remain, including those related to male reproductive health. The presented thesis briefly summarizes the data on the impact of COVID-19 on male reproductive function. Male infertility is not only a medical and biological problem, but also a social issue that requires modern solutions, as well as special attention when married couples are planning the birth of a child. The goal of this study is to review the mechanisms and prognostic significance of the effect of COVID-19 on the male reproductive system. Materials and methods. Keyword searches were carried out in the following databases: PubMed, MEDLINE and elibrary. The thesis included studies reflecting the impact of COVID-19 factors on male reproductive health. Results. The main symptom of COVID-19 is an increase in body temperature, which, according to research, significantly escalates sperm aneuploid. As a result, it has an adverse effect on spermatogenesis and causes sperm DNA breakage. COVID-19 also causes oxidative stress, during which the formation of reactive oxygen species (ROS) rises, causing lipid peroxidation in the sperm membrane. The effect described above can induce apoptosis, disrupt the differentiation of spermatogenic cells and the course of steroidogenesis. Temperature and oxidative stress are interrelated processes, since the first provokes the occurrence and may even enhance the second one. Temperature, by provoking oxidative stress, potentially affects the level of heavy metals involved in redox cycles, where free radicals are formed. Knowing the points of application of the pathogenetic mechanisms that was described above, a field is created for further applied research and the development of therapeutic strategies and measures for the prevention of disorders of male reproductive function.</p>COVID-19reproductive healthspermatogenesisinfertilitytemperatureoxidative stressCOVID-19репродуктивное здоровьесперматогенезбесплодиетемператураоксидативный стресс1.Медведев, И. Н. Реактивность сенсорных зон головного мозга в процессе познавательной деятельности у лиц пожилого возраста / И. Н. Медведев, Н. А. Никишина // Успехи геронтологии. – 2010. – Т. 23, № 3. – С. 421–423. – EDN MTXNCZ.2.Анализ предпочтений студентов-медиков и практикующих врачей в части способов получения учебной информации в период изучения ими в медвузе дисциплины "гистология, эмбриология, цитология" / А. В. Иванов, С. Н. Радионов, А. В. Прусаченко [и др.] // Морфология – науке и практической медицине: Сборник научных трудов, посвященный 100-летию ВГМУ им. Н.Н. Бурденко, Воронеж, 21 апреля 2018 года / Под редакцией. И. Э. Есауленко. – Воронеж: Издательско-полиграфический центр "Научная книга", 2018. – С. 100–106. ISBN 978-5-901202-50-03.Черемошкина, Л. В. Эффективность и нейропсихологические аспекты мнемических способностей активных киберигроков / Л. В. Черемошкина, Н. А. Никишина // Вестник Российского гуманитарного научного фонда. – 2008. – № 3(52). – С. 176–183. – EDN UDZQCN.4.Эффективность мнемических способностей и время реакции геймеров / Л. В. Черемошкина, Н. А. Никишина, А. Е. Харитонов // Вопросы психологии. – 2009. – № 5. – С. 84–92. – EDN NBMMDN.