Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации9391UnclassifiedThe possibility of correcting cognitive impairment with vitamin B12BurkaAngelina Andreyevna<p>3rd year student of the Pediatric Faculty of St. Petersburg State Pediatric Medical University</p>burkaangelina010203@gmail.comhttps://orcid.org/0009-0005-3309-7798LeshchenkoIuliia Alexandrovna<p>3rd year student of the Pediatric Faculty of St. Petersburg State Pediatric Medical University</p>juliialeshchenko007@gmail.comhttps://orcid.org/0009-0009-7909-8701MirzoyanAnna Norayrovna<p>3rd year student of the Pediatric Faculty of St. Petersburg State Pediatric Medical University</p>mirzoyananna@bk.ruhttps://orcid.org/0009-0004-2031-7723TadtayevaZara Grigorievna<p>Doctor of Medical Sciences, Professor of the Department of Pharmacology with a course in Clinical Pharmacology and Pharmacoeconomics at St. Petersburg State Pediatric Medical University</p>tadtaeva2003@mail.ruhttps://orcid.org/0000-0002-5809-1457St. Petersburg State Pediatric Medical University1904202413S15475471202202410052024Copyright © 2024, Burka A.A., Leshchenko I.A., Mirzoyan A.N., Tadtayeva Z.G.2024<p>Resume. In the Russian population, there have been practically no studies on the effect of vitamin B12 deficiency on cognitive functions. The relevance of the study is due to the increasing number of cognitive impairments and the tendency to rejuvenate diseases. One of the factors of cognitive decline is vitamin B12 deficiency. The purpose of this study is to find modern and timely opportunities to correct cognitive impairments that occur against the background of cyanocobalamin and folic acid deficiency by sharing these missing vitamins during treatment. Materials and methods. A search of literature sources was carried out in order to identify the possibility of correcting cognitive impairment with vitamin B12, as well as to identify the relationship between the level of cognitive impairment and vitamin B12 intake in respondents. Results. Three groups of respondents were identified, among which cognitive functions were assessed. The relationship of vitamin B12 and B9 deficiency with the level of cognitive impairment and lifestyle has been determined. Conclusions. The model of interaction of the metabolism of vitamins B12 and B9 in the human body, occurring in the folate cycle, has a complex effect on many processes in the body, including brain activity manifested by higher nervous activity (memory, attention, etc.). A relationship has been found about the effect of cyanocobalamin and folic acid on cognitive activity of the brain and psychogenic manifestation deficiency conditions of these vitamins, as well as the effect of bad habits, such as smoking, on the absorption of these vitamins and the depletion of their internal reserves in the body. The relationship between homocysteinemia and the metabolic processes of vitamin B12 and folic acid has been established through their joint interaction in the folate cycle, during which methionine is synthesized from homocysteine. Along with the development of the popularization of complex vitamin therapy in medical practice, this work proposes to place not only a significant emphasis on preventive and timely treatment with vitamin preparations, but also to highlight the problem of vitamin deficiencies among the population.</p>vitamin B12folic acidcognitive functionshomocysteinemiadeficiency conditionsvitamin therapyвитамин В12фолиевая кислотакогнитивные функциигомоцистеинемиядефицитные состояниявитаминотерапия1.Неврологические расстройства при дефиците витамина В12 / Ч. С. Павлов, И. В. Дамулин, Ю. О. Шульпекова, Е. А. Андреев // Терапевтический архив. – 2019. – Т. 91, № 4. – С. 122-129. – DOI 10.26442/00403660.2019.04.000116. – EDN ZERHZJ.2.Павленко, Л. В. Влияние дефицита витамина В12 на когнитивные функции / Л. В. Павленко // Наукосфера. – 2020. – № 12-1. – С. 48-53. – EDN XRCNIT.3.Факторы риска развития дефицита витамина В12 и его последствия / В. П. Вдовиченко, Г. М. Бронская, О. А. Борисенок, Т. А. Коршак // Медицинские новости. – 2019. – № 8(299). – С. 13-18. – EDN DGYYQW.4.Blasko I, Hinterberger M, Kemmler G, Jungwirth S, Krampla W, Leitha T, Heinz Tragl K, Fischer P. Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohort. J Nutr Health Aging. 2012 Aug;16(8):687-94. doi: 10.1007/s12603-012-0051-y. PMID: 23076510.