Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации8906USE OF HYDROGEN WATER IN THE TREATMENT OF EXPERIMENTAL WOUNDSZaharovaSofia Sergeevnazakharova-sofya@inbox.ruhttps://orcid.org/0000-0002-1468-4779MikhailovNikolai Olegovichn.o.mikhailov@gmail.comhttps://orcid.org/0000-0002-1710-205XKonovalovPavel Andreevichdr.kon68@gmail.comhttps://orcid.org/0000-0002-6178-1205Voronezh State Medical University named after N.N. Burdenko2912202312217202304202304052023Copyright © 2023, Zaharova S.S., Mikhailov N.O., Konovalov P.A.2023<p>Relevance. Soft tissue defects are diagnosed annually in 5.5 million patients worldwide. Wound suppuration is the cause of half of the cases of patients seeking surgical care in the Russian Federation.<br />Purpose. Improvement of wound process relief results due to application of hydrogen water in complex treatment of experimental wounds.<br />Materials and methods. Studies were conducted in 2 blocks. Block I studies were conducted in 150 rats with aseptic wounds in 5 study groups: 3 control and 2 main ones. The 1st control group was animals without treatment. In the 2nd and 3rd control groups, applications and hydropressive sanitization of the wound surface were performed using 0.9% sodium chloride solution, in the 1st and 2nd main groups - 0.9% sodium chloride solution enriched with molecular hydrogen. Block II studies were conducted in 150 rats with purulent wounds in 4 study groups: 2 main and 2 control groups. No treatment was performed in Control Group 1. Hydropressive wound sanitization of 0.9% sodium chloride solution was performed in the 2nd control group. In the 2nd and 3rd main groups - applications and hydropressive treatment of the wound surface with 0.9% sodium chloride solution enriched with molecular hydrogen, respectively.<br />Results. In all experimental groups where hydrogen water was applied, an acceleration in the timing of the relief of inflammation symptoms was observed, including a decrease in hyperemia and edema in the damaged area. The reduction of inflammation and wound healing in the experimental groups, compared with the 1st control, occurred most efficiently.<br />Conclusion. Application of hydrogen water in the treatment of purulent soft tissue wounds accelerated the duration of the 1st and 2nd phases of the wound process by an average of 1.1-1.7 and 1.1-1.3 times, respectively, compared with the data obtained in the 1st control group. Applications with hydrogen water in the treatment of clean wounds demonstrated better treatment indicators compared to control groups and 2 experimental ones, due to the anti-inflammatory and antioxidant properties of H₂ water. Hydropressive treatment with H₂ water (2 trial groups) showed better results in the treatment of purulent wounds, compared with application and treatment with 0.9% of NaCl p-rum, due to better wound cleaning during GIS. The use of hydrogen water in the experiment showed in the treatment of "pure" soft tissue wounds the highest activity of reparative processes. In the treatment of purulent wounds - faster relief of swelling, acceleration of the formation of fibrin and collagen, epidermis and restoration of muscle tissue. 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