Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации8497Unclassified=ANTIAYPHILITIC AGENTS AND THEIR EFFECTIVENESSNefedovaDaria Sergeevna<p>student</p>nefedova_darya26@mail.ruhttps://orcid.org/0000-0002-8456-7607FrolovAlexsandr Yurevich<p>student</p>fr0low.4@yandex.ruhttps://orcid.org/0000-0002-7617-7852RazenkovIvan Andreevich<p>student</p>i.razenkov@bk.ruhttps://orcid.org/0000-0003-1941-9285KazaryanDiana Gurgenovna<p>young scientist</p>diankadiar@icloud.comhttps://orcid.org/0000-0002-2544-6610KotovaAlina Leonidovna<p>young scientist</p>a.l.kotova.vgmu@mail.ruhttps://orcid.org/0000-0003-0519-015XVoronezh State Medical University named after N.N. Burdenko2004202312S25615632102202323022023Copyright © 2023, Nefedova D.S., Frolov A.Y., Razenkov I.A., Kazaryan D.G., Kotova A.L.2023<p>Relevance:</p> <p>Syphilis is a disease that represents one of the serious problems of medicine, characterized by a rather high number of registered patients, difficulties in diagnosis and treatment. In this connection, consideration of drugs designed to treat syphilis and analysis of their effectiveness and side effects to identify the best drugs for this disease is of particular relevance.</p> <p>Objective:</p> <p>To study the mechanism of action and side effects of drugs against syphilis and to select from the studied drugs the most effective among those presented nowadays.</p> <p>Methods of the study:</p> <p>In the course of the study, 15 preparations of different derivatives were studied. Penicillin antibiotics (6 drugs) - benzylpenicillin potassium, sodium and novocaine salts, bicillins 1,3,5, cephalosporins (1 drug)- ceftriaxone (longacef),tetracyclines (2 drugs)- doxycycline, erythromycin, bismuth preparations (3 preparations)-biyoquinol, bismoverol, pentabismol, iodine-potassium iodide and arsenic preparations (3 preparations)-sulfarsfenamine, novarsenol, acetarsol. The study was conducted at the Voronezh State Medical University named after N.N. Burdenko. N.N. Burdenko Voronezh State Medical University". We evaluated such parameters as: individual tolerability of the drug, duration of action, spectrum of action, side effects and efficacy of use.</p> <p>Conclusion:</p> <p>Many antisyphilitic drugs have been shown to be effective on the basis of the data obtained in the study. Penicillin drugs and their derivatives are the drugs of primary choice in the therapy of syphilitic infection and are given first place among the prescriptions, but increasingly frequent cases of intolerance manifested as skin itching, allergic dermatitis, urticaria, sometimes anaphylactic shock. In this regard, the importance of broad-spectrum antibiotics, which have been shown to be sufficiently effective in their use, should not be overlooked.</p>syphilisdrugefficiencytreatmentсифилиспрепаратэффективностьлечение1.Методы лечения препаратами пенициллина больных вторичным сифилисом кожи и слизистых оболочек и их клиническая эффективность / Е.Ю. Сапешко, Котикова М.А.// Клиническая медицина. 2016. – №19. – С. 56-59.2.Эпидемиологические особенности сифилитической инфекции в настоящее время / Н.В.Баткаева // Практическая медицина. 2009– №3. – С. 84-93.3.Многотомное руководство по дермато-венерологии / Под ред. О.Н.Подвысоцкой. – М.: Мед.Книга, 1959. – т. 1, С.375.4.Большая Медицинская Энциклопедия (БМЭ) / Сифилис / Под редакцией Б.В.Петровского. – М.: Мед. Книга,1989. – 3-е издание.5.Сифилис: иллюстрированное руководство. / Под ред. Проф. В.И. Прохоренкова. – М.: Мед. Книга, 2002. – С.23-37.