Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации8450UnclassifiedDEVELOPMENT OF NEW GLUE FOR SEALING SURGICAL ANASTOMOSES. SELECTION OF CHEMICAL COMPONENTS IN EXPERIMENTS ON CADAVER AND FRESH ORGANOCOMPLEXESTursunovaNazirakhon D.nazira.tursunova2002@gmail.comhttps://orcid.org/0009-0004-6022-4249AbdukhalikovaAltynay AbdullajonovnaAltynayabdukhalikova02@gmail.comhttps://orcid.org/0000-0001-7439-9614Voronezh State Medical University named after N.N. Burdenko2912202312227311502202315042023Copyright © 2023, Tursunova N.D., Abdukhalikova A.A.2023<p>Relevance. Intra - and postoperative bleeding is one of the most frequent complications when performing complex surgical interventions. One of the alternative methods of stopping bleeding is the use of surgical adhesives. The properties of currently existing surgical adhesives do not fully meet all the requirements imposed on them, which creates prerequisites for the development of new products in order to improve the effectiveness of surgical interventions.<br />Goal. Development of an original biological adhesive for sealing surgical anastomosis.<br />Materials and methods. A study on the development of a new surgical adhesive for sealing surgical anastomosis was conducted at the Department of Specialized Surgical Disciplines of the N.N. Burdenko VSMU. Databases of medical literature and patents have been analyzed, functional evaluation of various surgical adhesives and their components has been carried out, physico-chemical properties of adhesives in a chemical laboratory have been evaluated.<br />Results. The components of surgical glue were selected: a solution of CA 40% and DEE 10%.<br />Conclusions. The selected adhesive formulation ensures the tightness of the surgical suture anastomosis. It is necessary to refine the modes of using surgical glue on biological tissues. To assess the effectiveness and safety, it is necessary to conduct a series of long-term experiments on animals.</p>surgical gluesealingalbuminglutaraldehydediglycidyl ether of ethylene glycolхирургический клейгерметизацияальбуминглутаральдегиддиглицидиловый эфир этиленгликоля1.Абасов М.М., Солнцова Н.В., Ковбатенко О.М. Результаты экспериментального применения новой гемостатической композиции в кардиохирургии. Тезисы доклада 10-ого всероссийского съезда сердечно-сосудистых хирургов. Бюллетень НЦ ССХ. 2004; 11 (5): 369.2.Бокерия. Л. А., Межнева В. В., Муратов Р. М., Костава В. Т., Серов Р. А. Новый желатино-резорциновый биологический клей «Биоклей-ЛАБ» для профилактики кровотечений при оперативных вмешательствах. «Тромбоз, гемостаз и реология». 2002; 4 (1): 39-42.3.Демина Н. Б., Чернова Л. В., Козлова Ж. М. Применение клеевых композиций в хирургии. Журнал им. Н.И. Пирогова. 2019; 3 (1): 129-134.4.Baykal A., Yorgancı K., Sokmensuer C., Hamaloglu E., Renda N., Sayek I. An experimental study of the adhesive potential of different meshes, European Journal of Surgery, Volume 166, Issue 6, July 2000, Pages 490–494. DOI: 10.1080/110241500750008826.5.Burks, S., & Spotnitz, W. Safety and usability of hemostats, sealants, and adhesives. AORN journal. 2014; 100 (2): 160–176. Burks, Sandra, and William Spotnitz. “Safety and usability of hemostats, sealants, and adhesives.” AORN journal vol. 100,2 (2014): 160-76. DOI:10.1016/j.aorn.2014.01.026.6.Chao, H. H., & Torchiana, D. F. BioGlue: albumin/glutaraldehyde sealant in cardiac surgery. Journal of cardiac surgery. 2003; 18 (6): 500–503. DOI: 10.1046/j.0886-0440.2003.00304.x.7.Passage, J., Jalali, H., Tam, R. K., Harrocks, S., & O'Brien, M. F. BioGlue Surgical Adhesive--an appraisal of its indications in cardiac surgery. The Annals of thoracic surgery. 2002; 74 (2): 432–437. DOI:10.1016/s0003-4975(02)03689-5.8.Spotnit W.D. Surgical Tissue Adhesives: New Additions to the Surgical Armamentarium. Journal of Long-Term Effects of Medical Implants: 13 (5): 385-387. DOI:10.1615/JLongTermEffMedImplants.v13.i5.30.9.Vakalopoulos KA, Daams F, Wu Z, Timmermans L, Jeekel JJ, Kleinrensink GJ, van der Ham A, Lange JF. Tissue adhesives in gastrointestinal anastomosis: a systematic review. J Surg Res. 2013 Apr; 180 (2): 290-300. DOI: 10.1016/j.jss.2012.12.043.