Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации8329UnclassifiedTHE PHENOMENON OF ARBORIZATION OF THE CERVICAL MUCOSE IN WOMEN CARRIERS OF THE HUMAN PAPILLOMA VIRUSGorushkinaElena S.<p>4th course student of faculty of General Medicine</p>goruskinaalt@mail.ruhttps://orcid.org/0000-0003-4813-8466KulikovaEkaterina V.<p>4th course student of faculty of General Medicine</p>katydigit@gmail.comhttps://orcid.org/0000-0003-3805-1826MarkinDmitry A.<p>5th course student of faculty of General Medicine</p>9amda132@mail.ruhttps://orcid.org/0000-0003-0232-1409N.N. Burdenko Voronezh state medical university2004202312S212141302202325032023Copyright © 2023, Gorushkina E.S., Kulikova E.V., Markin D.A.2023<p>Relevance. Achievements in research aimed at finding the etiological factor of malignant neoplasms make it possible to develop new preventive measures, create targeted therapy and reduce the mortality rate from this pathology. In Russia, one of the most common pathologies in women is cervical cancer. Pathology is associated with the carriage of the human papillomavirus, which creates the preconditions for early detection of infection and the organization of preventive measures to prevent its spread.</p> <p>Purpose of the study: using a general morphological analysis, tachymetric and crystalloscopic research methods, to identify differences in the manifestation of the phenomenon of arborization during persistence in the body of the human papillomavirus.</p> <p>Materials and methods: 100 native dried samples of cervical mucus were used for the study, 75 of which were taken from women with confirmed carriage of the human papillomavirus. Survey microscopy using a research microscope ZEISS Axio Imager.A2, processing of statistical data in the software packages STATISTICA (StatSoft Russia 4.0) and Microsoft Office Excel 2010.</p> <p>Results. A change in the structure of the epithelium, especially in the area of the external cervical os, leads to a violation of its function. The cervical mucus secreted by these cells is a glycoprotein that changes its physicochemical properties depending on the concentration of estrogens. The discovery of new manifestations of the phenomenon of arborization in native dried samples of female carriers of the human papillomavirus will allow the development of a new accessible diagnostic technique.</p>phenomenon of arborizationhuman papillomaviruscervical cancercervical mucuspreventionфеномен арборизациивирус папилломы человекарак шейки маткицервикальная слизьпрофилактика1.Sravani AB, Ghate V, Lewis S. Human papillomavirus infection, cervical cancer and the less explored role of trace elements. Biol Trace Elem Res. 2023 Mar;201(3):1026-1050. doi: 10.1007/s12011-022-03226-2. Epub 2022 Apr 25. PMID: 35467267; PMCID: PMC9898429.2.Роговская С.И., Михеева И.В., Шипулина О.Ю., Минкина Г.Н., Подзолкова Н.М., Радзинский В.Е., Шипулин Г.А. Распространенность папилломавирусной инфекции в России // Эпидемиология и вакцинопрофилактика. 2012. №1 (62). [Электронный ресурс] URL: https://cyberleninka.ru/article/n/rasprostranennost-papillomavirusnoy-infektsii-v-rossii (дата обращения: 12.12.2022)3.World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem [Электронный ресурс] URL: https://www.who.int/publications/i/item/9789240014107 (дата обращения: 01.12.2022)4.Curlin M, Bursac D. Cervical mucus: from biochemical structure to clinical implications. Front Biosci (Schol Ed). 2013 Jan 1;5(2):507-15. doi: 10.2741/s386. PMID: 23277065.5.Bernardi S, Rinaudo A, Marini P. Cervical mucus characteristics and hormonal status at insemination of Holstein cows. Iran J Vet Res. 2016 Winter;17(1):45-9. PMID: 27656229; PMCID: PMC4898020.6.Tsiligianni Th, Amiridis G, Dovolou E, Menegatos I, Chadio S, Rizos D, Gutierrez-Adan A. Association between physical properties of cervical mucus and ovulation rate in superovulated cows. Can. J. Vet. Res. 2011; 75:248–253.