Молодежный инновационный вестник

2415-7805

Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации

8309

Unclassified

FEATURES OF THE CLINICAL COURSE OF SYSTEMIC LUPUS ERYTHEMATOSUS IN MALE PATIENTS

Valiulin

Rashid Ildarovich

rashidvaliulin@gmail.comhttps://orcid.org/0000-0001-5608-9321Ibragimova

Lola Murotovna

ibragimovalola3112@gmail.comhttps://orcid.org/0000-0002-1645-5232Khasanova

Mekhrangiz Shukratovna

xasanova.m.sh01@gmail.comhttps://orcid.org/0000-0001-5898-248X

Tashkent Medical AcademyTashkent medical academy

20042023

12S2101102

13022023

02042023

2023

Annotation: systemic lupus erythematosus (SLE) is a systemic connective tissue disease of an autoimmune nature, which leads to immunoinflammatory damage to internal organs, and sometimes to death. According to the epidemiological study (USA, 19992016, n = 45 million people), in patients with SLE (n = 95 thousand, 0,21%), heart damage was recorded much more often than in the control group: rhythm disturbances and conduction - in 22% and 6%, coronary artery disease - in 13% and 4%, significant valve damage - in 11% and 2%, myocardial infarction (MI) - in 6% and 2%, pulmonary hypertension - in 2,2% and 0,2%, HF in 1,0% and 0,2% of patients, respectively. In addition, the male gender is a risk factor for the development of cardiovascular diseases. In men, the risk of developing coronary heart disease (CHD) is about 3 times higher than in women of the same age with the same level of cholesterol. Purpose: to study the features of the course of SLE in male patients and complications from the cardiovascular system (CVS). Methods: for the study were studied the medical histories of 35 men with SLE who were treated inpatient at the Cardiorheumatology Department of the Tashkent Medical Academy Clinic from 2017 to the current year. The results of their therapeutic examination and diagnostic measures were analyzed. To compare the data about male patients complications, a group of female patients was collected. Results: the classic risk factor for the development of cardiovascular diseases (arterial hypertension) was more often observed in older age groups of patients, but it also occurred in almost 50% of cases in young patients. Hypoxic changes in the myocardium were present in more than half of the men. It was also noted that cardiovascular lesions: valvular defects, aseptic necrosis of the femoral head, Raynaud's syndrome, stroke and heart attack, which were not observed or were rare in the female comparison group, were often observed in men. Conclusion: male gender is one of the risk factors for developing cardiovascular diseases, which is even more aggravated when the patients have complications are caused by systemic disease. According to our study, it was possible to determine that men are more difficult to tolerate the disease and they can expect more serious damage to the cardiovascular system.

systemic lupus erythematosusmencomplicationscoursecardiovascular system

системная красная волчанкамужчиныосложнениятечениесердечно-сосудистая система

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Аршинов АВ, Левшин НЮ, Маслова ИГ. Сердечно-сосудистые осложнения при системной красной волчанке: механизмы ускоренного развития атеросклероза, диагностика, возможности коррекции. Научно-практическая ревматология. 2017;55(3):304-310

Клюквина Н.Г. Системная красная волчанка у мужчин: клинические ситуации и литературные данные. РМЖ. 2014;28:2068

Клюквина Н.Г., Ведерникова Е.А., Ломанова Г.В. Особенности системной красной волчанки у мужчин: описание случаев и данные литературы. Современная ревматология. 2013;(4):26–32