Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации8160STUDYING THE INFLUENCE OF ALOE EXTRACT ON VESSELS OF THE MICROCIRCULATORY BED IN SKIN WOUND HEALINGEnenkovNikita Vasilevichenenckow2013@yandex.ruhttps://orcid.org/0000-0001-7430-9359Ryazan State Medical University named after Academician I.P. Pavlova2004202312S22262283001202321022023Copyright © 2023, Enenkov N.V.2023<p><em>Relevance. Currently, various stimulators of skin wound regeneration are being actively studied, among which aloe extract is of interest. Literature data show that this compound enhances angiogenesis, however, this effect is little studied in relation to a skin wound.</em></p> <p><em>Purpose: to study the effect of aloe extract on the vessels of the microvasculature during skin wound healing.</em></p> <p><em>Materials and methods. The study was performed on 18 guinea pigs. Animals were modeled with a 20x20 mm wound. After euthanasia, material was taken for histological examination on days 7, 14, and 21. Then, histological sections were made and stained with hematoxylin-eosin. Ten fields of vision were evaluated at a magnification of 400, the total number of vessels and their average area were determined. Statistical data processing was carried out using the Mann-Whitney test at р˂0.05.</em></p> <p><em>Results. It was found that on the 7th day there were no statistically significant differences. On day 14, in the group using aloe extract, the total number of vessels was 7.79% more than in the control group (p˂0.05). There is also a statistically significant increase in the average vascular area in the aloe extract group versus the control group by 91%. On the 21st day of experimental skin wound healing, it was found that the total number of vessels in the microcirculatory bed under the conditions of using aloe extract was 88.24% more than with spontaneous wound healing (р˂0.05). The mean vascular area is also larger in the aloe extract group by 14.29% than in the control group (p˂0.05).</em></p> <p><em>Conclusion. Morphological analysis of the vessels of the skin wound showed that aloe extract has an effect on the processes of angiogenesis, as evidenced by an increased number of blood vessels on all days of the experiment.</em></p>angiogenesisaloe extractskin woundmicrocirculatory bedmorphometryангиогенезэкстракт алоэкожная ранамикроциркуляторное русломорфометрия1.Wilkinson, Holly N, and Matthew J Hardman. “Wound healing: cellular mechanisms and pathological outcomes.” Open biology vol. 10,9 (2020): 200223. doi:10.1098/rsob.2002232.Reinke J. M., Sorg H. Wound Repair and Regeneration // Eur. Surg. Res. 2012. Vol 49. P. 35–43.3.Hekmatpou, Davood et al. “The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review.” Iranian journal of medical sciences vol. 44,1 (2019): 1-9.4.Abdel Hamid AAM and Soliman MFM. Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study. J Histol Histopathol. 2015; 2:3. doi:10.7243/2055-091X-2-35.Rodriguez Rodriguez E, Darias Martin J and Diaz Romero C. Aloe vera as a functional ingredient in foods. Crit Rev Food Sci Nutr. 2010; 50:305-26.6.Jittapiromsak N, Sahawat D, Banlunara W, Sangvanich P and Thunyakitpisal P. Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Tissue Eng Part A. 2010; 16: 1997-2006.7.Davis RH, Donato JJ, Hartman GM and Haas RC. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc. 1994; 84:77-81.