Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации8157UnclassifiedCOMPARATIVE ANALYSIS OF THE MICROFLORA FROM THE TONSILS IN OTORHINOLARYNGOLOGICAL PATIENTS AND PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH CHRONIC TONSILLITISKorotkovaOlga Mikhailovnastarship.souyz@gmail.comhttps://orcid.org/0000-0002-5412-1508Voronezh State Medical University named after N.N. Burdenko2004202312S21831843001202328032023Copyright © 2023, Korotkova O.M.2023<p>Relevance: in patients with diabetes mellitus, infectious diseases, including lesions of the upper respiratory tract, are quite common. It is known that in patients with diabetes mellitus, the damage to the upper respiratory tract is up to 50%, therefore, the relevance of this problem is not disputed.<br />Purpose: to analyze the composition and characteristics of the microflora from the tonsils in otorhinolaryngological patients with chronic tonsillitis and patients suffering from type II diabetes mellitus with chronic tonsillitis.<br />Materials and methods: a retrospective comparative analysis of the results of cultures for microflora (pharyngeal swabs) was carried out in patients with chronic tonsillitis and type II diabetes mellitus complicated by chronic tonsillitis. All patients were treated in the otorhinolaryngological and endocrinological departments of the BUZ VO VOKB No. 1. The sample consisted of 28 patients in each group (with and without diabetes).<br />Results: In otorhinolaryngological patients with chronic tonsillitis, mixed microflora (Staphyllococcus aureus, streptococci, Neisseria, etc.) was most often sown - 40.5%. Staphylococcus aureus was found in 22.1% of cases. And in patients with chronic tonsillitis complicated by type II diabetes mellitus in 12 (43%) patients, Staphyllococcus aureus was isolated in combination with saprophytic microflora (Streptococcus viridans, Streptococcus epidermidis, etc.). Four (14%) patients were diagnosed with Haemophillius influenzae. 3 (11%) patients had Klebsiella pneumoniae, 3 (11%) patients had Staphylococcus epidermidis, and 1 (4%) patient had Escherichia coli. In addition, Candida albicans were cultured in 5 (18%) patients.<br />Conclusion: Based on the study, it can be concluded that the microflora from the tonsils in patients with type II diabetes mellitus in chronic tonsillitis is the most aggressive, which indicates a decrease in immunological reactivity in these patients. In addition, the prevalence of Staphyllococcus aureus and its high antibiotic resistance are noteworthy. Antibiotic resistance has also been found in Escherichia coli and even in Staphylococcus epidermidis.</p>Diabeteschronic tonsillitismicroflora of the oropharynxENT diseasesСахарный диабетхронический тонзиллитмикрофлора ротоглоткиЛОР-болезни1.Дедов И.И., Шестакова М.В., Викулова О.К., Железнякова А.В., Исаков М.А. Эпидемиологические характеристики сахарного диабета в Российской Федерации: клинико-статистический анализ по данным регистра сахарного диабета на 01.01.2021. Сахарный диабет. 2021;24(3):204-221. [Dedov I.I., Shestakova M.V., Vikulova O.K., Zheleznyakova A.V., Isakov M.А. Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021. Diabetes mellitus. 2021;24(3):204-221.]2.Бирюкова Е.В., Гуров А.В., Юшкина М.А. Сахарный диабет и гнойно-воспалительные заболевания ЛОР-органов. Сахарный диабет. 2012;15(2):54-59. [Biryukova E.V., Gurov A.V., Yushkina M.A. Diabetes mellitus and pyoinflammatory diseases of ENT organs. Diabetes mellitus. 2012;15(2):54-59. ]3.Крюков А.И., Аксенова А.В., Захарова А.Ф., Чумаков П.Л., Жук Л.Г. / Особенности эпидемиологии хронического тонзиллита в современных условиях оказания специализированной ЛОР-помощи // Вестник оториноларингологии. - 2013. - N 13. - С. 4-7. [A.I. Kryukov, A.V. Aksenova, A.F. Zakharova, P.L. Chumakov, L.G. Zhuk. / Peculiarities of epidemiology of chronic tonsillitis under current conditions of providing specialized aid to the patients presenting with ENT diseases // Vestnik Otorhinolaringologii. - 2013. - N 13. - p. 4-7.]4.Гофман В.В. Патогенетическое обоснование способов лечения больных хроническим тонзиллитом: дис. ... докт. мед. наук: 14.01.03. – Федеральное государственное бюджетное военное образовательное учреждение высшего профессионального образования «Военно-медицинская академия имени С. М. Кирова» Министерства обороны РФ, Санкт-Петербург, 2014 - 277 с. [Hofman V. V. Patogenetic explanation of the treatment of patients with chronic tonsillitis: dis. ... MD: 14.01.03. – Military Medical Academy named after S. M. Kirov, Saint Petersburg, 2014 - 277 p.]