Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7945UnclassifiedCOMPARATIVE EVALUATION OF THE OTOTOXICITY OF CISPLATIN AND CARBOPLATIN IN THE EXPERIMENTBakhadirovaIroda Bakhadirovna<p>Free Applicant of the Department of Otorhinolaryngology</p>iroda-bakh@yandex.ruhttps://orcid.org/0000-0003-2860-6103ArtikovaDilfuza Turdaliyevna<p>PhD, assistent otolaryngology department</p>lor-tashiuv@mail.ruhttps://orcid.org/0000-0002-9223-4677Center for the Development of Professional Qualifications of Medical WorkersСenter for the development of professional qualifications of medical workers2912202312212140502202323022023Copyright © 2023, Bakhadirova I.B., Artikova D.T.2023<p>Relevance: Platinum-based chemotherapeutic drugs are widely used in the treatment of malignancies. Representatives of this group of drugs such as cisplatin and carboplatin have side effects such as nephrotoxicity, myelosuppression, neurotoxicity and ototoxicity. Ototoxicity is manifested by unilateral or bilateral hearing loss, which can be accompanied by tinnitus. Hearing damage depends on the dose and cumulative capacity of the drug. In experimental animal models, cisplatin was found to lead to the death of external and internal hair cells. Carboplatin is an analogue of cisplatin, the mechanism of action is similar to cisplatin, but the side effects of carboplatin are less pronounced.<br />Objective of the study: To evaluate the ototoxic effect of platinum-containing chemotherapy drugs in laboratory rats using objective methods of hearing examination.<br />Study materials and methods: A series of experiments were conducted on 30 laboratory rats of albinos weighing 190gr to 210 gr. Laboratory animals were divided into three groups, which were given three courses of chemotherapy. Before and after the chemotherapy course, laboratory animals underwent functional hearing examination.<br />Results: After a series of experiments, it was found that cisplatin was administered in a group of animals at therapeutic doses, and an increase in hearing thresholds was noted. The studies performed in laboratory rats treated with carboplatin did not differ significantly from the control group treated with saline.<br />Conclusion: After a series of experiments, our results show that there is a difference in the manifestation of ototoxicity of chemoperapes containing platinum.</p>ototoxicitychemotherapyexperimentcisplatincarboplatinABRототоксичностьхимиотерапияэкспериментцисплатинкарбоплатинКСВП1.Rybak LP, Husain K, Whitworh SSM (1999) Dose dependent protection by lipoic acid against cisplatin-induced ototoxicity in rats antioxidant defense system. Toxicol Sci 47(2):195–2022.Breglio AM, Rusheen AE, Shide ED et all. (2017) Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun 8:16543.Konrad-Martin D, Poling GL, Garinis AC et all. (2018) Applying U.S. national guidelines for ototoxicity monitoring in adult patients: perspectives on patient populations, service gaps, barriers and solutions. Int J Audiol 57:S3–s184.Fetoni AR, Ruggiero A, Lucidi D et all. (2016) Audiological monitoring in children treated with platinum chemotherapy. Audiol Neurootol 21:203–2115.Rossi A, Di Maio M, Chiodini P et all. (2012) Carboplatin- or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data. J Clin Oncol 30:1692–16986.Andersson A, Fagerberg J, Lewensohn R et all (1996) Pharmacokinetics of cisplatin and its monohydrated complex in humans. J Pharm Sci 85:824–827