Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7939UnclassifiedINFLUENCE OF THE LARGE INTESTINE MICROBIOTA ON THE SYMPTOMS OF AUTISM SPECTRUM DISORDERSAkulininDmitry Aleksandrovich<p>Student</p>akulinin-02@mail.ruhttps://orcid.org/0000-0002-9444-4686SpitsinIlya Romanovich<p>Student</p>spitsynillya@yandex.ruhttps://orcid.org/0000-0003-1235-8723Ryazan State Medical University named after Academician I. P. Pavlov2004202312S22222240301202321022023Copyright © 2023, Akulinin D.A., Spitsin I.R.2023<p>Relevance: Nowadays, the theory that the gut microbiome affects not only the physiological, but also the mental state of the host's organism, is increasingly being confirmed.</p> <p>There have been carried out many clinical trials that suggest a connection between pathological conditions and the composition of the intestinal microbiota.The basis of this connection is neurotransmitters and other substances produced by representatives of the normal or altered intestinal microbiota and capable of influencing the course of the disease.</p> <p>Such relationship is observed in autism spectrum disorders (ASD), which represent a group of biological disorders associated with metabolic disorders. While monitoring the patients with ASD it was noted that many of them had gastrointestinal (GI) symptoms (abdominal pain, constipation, diarrhea, etc.), correlating with worsening of psychological symptoms of ASD.In such patients, there was an increase in anxiety, irritability, and isolation compared to children without GI disorders, which, apparently, is caused by quantitative and qualitative disturbances in the composition of the intestinal microbiota.</p> <p>Every year the incidence of autism is increasing, and in this connection there is a need for a more detailed study of the pathogenesis of this disease. </p> <p>Objective: To investigate the relationship between changes in the gut microflora producing short-chain fatty acids (SCFAs) and symptoms of ASD. </p> <p>Materials and methods: A number of sources of native and foreign literature on the basis of the Pubmed and CyberLeninka database were analyzed.</p> <p>Results: It was found that the shift in the intestinal microflora affects the manifestations of ASD through changes in the concentration of SCFAs.</p> <p>Conclusion: A large number of trials of the composition of the microbiota in ASD and changes in the concentration of SCFAs produced by it have proven scientific interest and the perspectiveof further study of this question.Confirmation of the proposed pathogenetic chains can become the basis for the development of a new direction in the pharmacotherapy of ASD, which confirms the relevance of the considered problem.</p>short-chain fatty acids (SCFAs)microbiomeautism spectrum disorders (ASD)короткоцепочечные жирные кислоты (КЦЖК)микробиомрасстройства аутистического спектра (РАС)1.Chaidez V., Hansen R.L., Hertz-Picciotto I. 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