Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7470Conference ProceedingsOXIDATIVE STRESS IN THE CURE OF CHRONIC OSTEOMYELITIS WITH THE APPLICATION OF MARAL PANTSZolotukhinVladimir Olegovichvladimir.zolotuxin@gmail.comhttps://orcid.org/0000-0002-8513-39662604202211118191503202218032022Copyright © 2022, Zolotukhin v.O.2022<p>Relevance: The recurrence rate in acute osteomyelitis ranges from 20% to 30%, and disability of patients reaches 25% of cases. Complications in the treatment of this pathology can be traced in 14-32%, and according to some sources in 54.6% of patients.Goal: Determination of the effect of deer antlers in combination with amikacin on the course of chronic osteomyelitis.Materials and methods: The study was conducted at the Research Institute of Experimental Biology and Medicine on laboratory rats of the Wistar line with a mass of 270-290 grams. The study was carried out on 180 laboratory animals, which were divided into 5 groups: 2 control and 3 experimental: in the first control group, treatment was not carried out, in the remaining groups, 2-stage surgical rehabilitation was performed. In the first experimental group, powdered deer antlers with a particle size of 200-250 microns were introduced into the formed cavity before it was filled. In the second experimental group - a semi-synthetic antibiotic amikacin at a dose of 15 mg/ kg, and an inorganic component - calcium hydroxyapatite until the cavity is completely filled. In the third experimental group - amikacin at a dosage of 15 mg / kg and maral antlers in a ratio of 2:1, the remaining volume of the cavity was filled with hydroxyapatite. The effectiveness was evaluated by evaluating the indicators of oxidative stress and X-ray methods of investigation on 7, 14, 28, 60, 90- the e and 120th days of the study. Research results: in the 1st control group, there was no decrease in the indicators of DFNG and MDA during the entire experiment. In the 2nd control group, the indicators decreased by 53.8% and 28.12% by the 120th day. In the 1st experimental group, the indicators of MDA and DFNG decreased by about 6%, by the 120th day. In the 3rd experimental group, the indicators returned to normal by the 90th day. Conclusions: The most effective method of relieving chronic osteomyelitis is a technique based on the use of surgical sanitation, amikacin at a dosage of 15 mg / kg / day and deer antlers in a ratio of 2:1.</p>oxidative stresschronic osteomyelitistreatmentокислительный стрессхронический остеомиелитлечение