Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7413Conference ProceedingsREACTIVE CHANGES OF CONNECTIVE TISSUE TO HERNIOPLASTY IMPLANTSPonomarevaIrina<p>Assistant of the Department of Surgical Diseases № 1 Kursk State Medical University</p>ira.ponomareva92@mail.ruhttps://orcid.org/0000-0003-1850-6491TsukanovAndrey Viktorovich<p>Associate Professor of the Department of Surgical Diseases №1</p>tsandrej@yandex.ruhttps://orcid.org/0000-0001-7578-6835ZatolokinaMaria Alekseevna<p>Professor, Department of Histology, Embryology, Cytology Kursk State Medical University</p>marika1212@mail.ruIvanovIlya Sergeevich<p>Professor of the Department of Surgical Diseases № 1 Kursk State Medical University</p>ivanov.is@mail.ruIvanovSergey Viktorovich<p>Professor of the Department of Surgical Diseases № 1Kursk State Medical University</p>ivanovsv@kursksmu.nethttps://orcid.org/0000-0001-7540-5748Kursk State Medical University2604202211137380303202202042022Copyright © 2022, Ponomareva I., Tsukanov A.V., Zatolokina M.A., Ivanov I.S., Ivanov S.V.2022<p>The change in the ratio of type I and type III collagens, as a manifestation of connective tissue dysplasia, has attracted the attention of surgeons in recent years. In this connection, hernioimplants with collagen-stimulating coating are of great interest to surgeons.</p>connective tissueimplantshernioplastyсоединительная тканьимплантыгерниопластика<p>Relevance: The change in the ratio of collagens of types I and III, as a manifestation of connective tissue dysplasia, has attracted the attention of surgeons in recent years [1,2]. In this connection, hernioimplants with collagen-stimulating coating are of great interest to surgeons [3].The aim of the study was to compare morphological changes in the tissues of the anterior abdominal wall of animals at the site of endoprosthesis.Material and methods: the experimental part of the study was performed on 45 rats who underwent endoprosthetics with a supra-aponeurotic prosthesis arrangement. In group 1, a polypropylene mesh hernioimplant was used. In group 2, a polypropylene hernioimplant coated with dexpanthenol was used. In group 3, a polypropylene hernioimplant coated with ascorbic acid was used. The animals were removed from the experiment on the 7th, 30th, 90th day. Results: as a result of the study of experimental samples in all three groups, around the threads of hernia implants, at the late stages of the experiment, the formation of a connective tissue capsule was noted, in which mature collagen fibers were present. In group 3, the most optimal morphological picture of implant engraftment was revealed. Such changes could occur due to the stimulation of collagenogenesis by the coating used in the experiment. Conclusions: The observed morphological signs in the tissue surrounding the hernioimplant indicated an optimal reaction in the group with ascorbic acid coating. It was also revealed that this material had the best biological inertia, integrated well into the surrounding tissue, and the coating reduced the reaction of body tissues to the implant.</p>[Абалян А.К. и др. Особенности соотношения коллагенов в апоневрозе передней брюшной стенки у пациентов с послеоперационными вентральными грыжами и признаками дисплазии соединительной ткани // Медицинский вестник Северного Кавказа. – 2016. – Т. 11. – №. 2. С. 2.][Иванов С.В., Иванов И.С., Цуканов А.В., Гафаров Г.Н., Объедков Е.Г. Влияние витамина с на динамику соотношения коллагена I и III типов в области имплантации герниопротеза у мышей. //Цитология. -2016. -Т. 58. -№ 9. С. 714-719.][Кириенко А.И., Никишков А.С., Селиверстов Е.И., Андрияшкин А.В. Эпидемиология грыж передней брюшной стенки // Эндоскопическая хирургия. - 2016. - №4. - С. 55-60.]