Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7323Conference ProceedingsASSESSMENT OF THE PHENOMENON OF ARBORIZATION OF CERVICAL MUCUS
IN FEMALE CARRIERS OF THE HUMAN PAPILLOMAVIRUS (HPV)HaprovaKristina OlegovnaKristinaHaprova@yandex.ruObernikhinKirill Igorevichkirill.obernixin@yandex.ru300620221123251502202215032022Copyright © 2022, Haprova K.O., Obernikhin K.I.2022<p>Relevance: Human papillomavirus (HPV) is the most common viral infection of the genital tract in the world. The peak period of infection for both women and men begins shortly after they become sexually active. The introduction of the virus into the body occurs when the integrity of the tissues is violated. HPV infects stem cells of the basal layer of the epithelium. The introsomal form of persistence determines the leading role of HPV in the pathogenesis of cervical cancer. The increase in morbidity, the high prevalence of unprotected sexual intercourse among young people, as well as the high mortality rate from cervical cancer determine the need to find new approaches to solving this problem, including the development of new methods for diagnosing HPV carriers.The purpose of the study: to identify and study the features of the phenomenon of arborization of cervical mucus in female carriers of the human papillomavirus.Materials and methods: microscopy of 100 native preparations of cervical mucus using the techniques of crystalloscopy and tachymetry at the Research Institute of EBM VSMU. N.N.Burdenko The obtained results were subjected to statistical processing in the software packages STATISTICA (StatSoft Russia 4.0) and Microsoft Office 2010.Results: during microscopy of cervical mucus preparations taken from female HPV carriers, a change in a number of crystalloscopic indicators was noted: the indices of structurality and crystallizability; the dependence of the degree of crystallization on the pH of the separated cervical canal was revealed; higher tachymetric indicators were established.Conclusion: the revealed changes in the crystalloscopic and tachymetric patterns may indicate a change in the physico-chemical parameters of cervical mucus in women infected with HPV.</p>human papillomaviruscervical cancercrystalloscopytachymetrycervical mucusвирус папилломы человекарак шейки маткикристаллоскопиятахиметрияшеечная слизь[Brown D. The clinical impact of cross-protection to nonvaccine HPV types. Presented at: 27th International Papillomavirus Conference; September 17-22, 2011. Berlin, Germany. 2011. Abstract P-18.13.][Тhe Future II Study Group. Effect of prophylactic human papillomavirus L1 virus-like-particle vaccine on risk of cervical intraepithelial neoplasia grade 2, grade 3, and adenocarcinoma in situ: a combined analysis of four randomized clinical trials. Lancet. 2007; 369: 1861-68.][The FUTURE I/II Study Group. Four year efficacy of prophylactic human papillomavirus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomized controlled trial. BMJ. 2010; 340: 3493.][Garland SM. Kjaer SK, Muñoz N et al. Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience. // CID. 2016. Vol. 63. P. 519–27.][Paavonen J, Naud P, Salmerón J et al. HPV PATRICIA Study Group. Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a doubleblind, randomised study in young women. // Lancet. 2009. Vol. 374. P. 301–14.][Guo F, Cofie LE, Berenson AB. Cervical Cancer Incidence in Young U.S. Females After Human Papillomavirus Vaccine Introduction. // Am J Prev Med. 2018. Vol. 55, N 2. P. 197–20][Залесский М. Г., Эммануэль В. Л., Краснова М.В. 2004. - Физико-химические закономерности структуризации капли биологической жидкости на примере диагностикума «Литос-система» // Клиническая лабораторная диагностика. -№ 8. С. 20-24.][Каликштейн Д. Б., Мороз Л. А., Квитко Н.Н. с соавт. 1990. - Кристаллографическое исследование биологических субстратов // Клиническая медицина. - № 4. С. 28-31.][Воробьева В. А., Воробьев А. В., Замаренов Н.А. Закономерность формирования кристаллографической картины при взаимодействии биологической жидкости человека и гомеопатического препарата с кристаллообразующим раствором / Открытие. - Диплом № 231. (Приоритет от 8.06.2002).][Волчецкий А. Л., Рувинова Л. Г., Спасенников Б. А. с соавт. Кристаллизация и кристаллография: медико-биологические аспекты. Архангельск, 1999. -374с]