Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7299Conference ProceedingsCOMPARATIVE EVALUATION OF THE EFFICACY OF ANTITHROMBOTIC THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION IN THE EARLY POST-INFARCTION PERIODBabkinMaxim O.dr.m.babkin@gmail.comhttps://orcid.org/0000-0002-6870-8027KondrashovaJulia А.baazingalu@gmail.comhttps://orcid.org/0000-0003-2482-100930062022111111151502202226022022Copyright © 2022, Babkin M.O., Kondrashova J.А.2022<p>The article shows a scheme of the effectiveness of the use of various antithrombotic therapy in patients with myocardial infarction in the focus of the postinfarction period. Relevance. Myocardial infarction is one of the causes of disability and decline among the population of developing and export countries. For the prevention of secondary thrombotic complications and myocardial infarction, often fatal for patients with an early post-infarction period, lifelong maintenance therapy with antiplatelet agents. For this reason, the expected effectiveness of such therapy in patients with suspected post-infarction period. Objective: to evaluate the effectiveness of antithrombotic therapy with acetylsalicylic acid in combination with clopidogrel and ticagrelor in patients with acute non-ST elevation myocardial infarction in the identified postinfarction period. Materials and methods. For the study, 54 patients aged 58 to 74 years who had acute subendocardial myocardial infarction without ST segment elevation and without a pathological Q tooth, who were present in the postinfarction period, were identified. The patients were divided into two groups of 27 people. Patients from the first observation group were treated with acetylsalicylic acid 75 mg/day and clopidogrel 75 mg/day, in the second group - acetylsalicylic acid 75 mg/day and ticagrelor 180 mg/day (90 mg divided into two doses per day). To evaluate the effectiveness of therapy, the VerifyNow test system and the flow cytometry method with the determination of P-selectin expression were used. Results. It was found that aspirin monotherapy is not a sufficiently high-quality method for the prevention of cardiovascular complications. From the above results, it follows that both treatment regimens have a pronounced antithrombotic effect. However, the combination of acetylsalicylic acid and ticagrelor in general showed a more rapid decrease in P-selectin expression and PRU, resulting in a significantly greater effect. 1 patient from the first group and 2 patients from the second group were weakly receptive to the proposed choice, which subsequently occupied a special place in individual therapy and drugs. Conclusion. Thus, it was found that clopidogrel and ticagrelor are quite effective drugs in the context of the ongoing early post-infarction phase, which was manifested in a more pronounced use of control of platelet system parameters. It was noted that combination therapy with ticagrelor and acetylsalicylic acid has a more pronounced effect than therapy with clopidogrel and acetylsalicylic acid. However, the features of the features and the presence of mechanisms of resistance of patients to the approach to the use of these drugs should be strictly individualized.</p>myocardial infarctionischemic heart diseaseantithrombotic therapyplatelet activityP-selectinclopidogrelticagrelorинфаркт миокардаИБСантитромботическая терапияактивность тромбоцитовР-селектинклопидогрелтикагрелор1.Жунусов Е.С. Современная антитромботическая терапия у больных кардиологического профиля / Е.С. Жунусов // Научные исследования и разработки молодых ученых. – 2015. – №7. – С. 36-41.2.Пучиньян Н.Ф., Фурман Н.В., Малинова Л.И., Долотовская П.В. Проблема контроля эффективности антитромбоцитарной терапии в кардиологической практике / Н.Ф. Пучиньян, Н.В. Фурман, Л.И. Малинова, П.В. Долотовская // Рациональная Фармакотерапия в Кардиологии. –2017. –Т. 13, №1. – С. 107-115.3.Семелев В.Н., Тыренко В.В., Никитин В.Ю., и др. Определение количества гликопротеиновых рецепторов iib/iiia и экспрессии Р-селектина на поверхности тромбоцитов методом проточной цитофлуориметрии у больных острым миелоидным лейкозом / В.Н. Семелев, В.В. Тыренко, В.Ю. Никитин, и др. // Гены и клетки. – 2016. – Т.11, №3. – С. 140-143.4.Авдушкина Л.А., Бычкова Н.В., Вавилова Т.В. новый маркер активации тромбоцитов Р-селектин / Л.А. Авдушкина, Н.В. Бычкова, Т.В. Вавилова // Никифоровские чтения – 2012: передовые отечественные и зарубежные медицинские технологии. 12 сентября 2012 г. – Сборник материалов. – СПб, 2012. – С. 10-12.5.Игла Р.Е. Параметрический анализ данных проточной цитометрии / Р.Е. Игла // Вестник Московского университета. Серия 15. Вычислительная математика и кибернетика. –2008. – №2. – С. 21-29.6.Колбин А.С., Курылев А.А., Балыкина Ю.Е., Проскурин М.А. Сравнительный экономический анализ клопидогрела и тикагрелора при остром коронарном синдроме / А.С. Колбин, А.А. Курылев, Ю.Е. Балыкина, М.А. Проскурин // Качественная клиническая практика. – 2012. – №2. – С. 2-12.