Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации7283Conference ProceedingsANALYSIS OF THYROID PROFILE CHANGES IN CHILDREN DEPENDING ON OBESITYGaldaOlgagalda.ol@yandex.ruhttps://orcid.org/0000-0003-2891-0906N.N. Burdenko All-Russian State Medical University Children's Hospital30062022113253281402202222022022Copyright © 2022, Galda O.2022<p>Relevance: The universal prevalence of obesity in children and adolescents is a huge problem for world health. Studying the mechanisms of thyroid gland influence on this pathology, can make a significant contribution to the understanding of obesity pathogenesis.<br />Objective: To study thyroid changes in children with different degrees of obesity <br />Materials and Methods: Retrospective analysis of case histories of patients undergoing inpatient treatment in the endocrinology department of the Voronezh Children's Clinical Hospital with a primary diagnosis of exogenous-constitutional obesity and morbid obesity.</p>
<p>Results: Twenty-seven case histories of children were analyzed. Of these, 15 (55.6%) were boys and 12 (44.4%) girls. There were 6 children (22.2%) with 1st degree obesity, 8 (29.7%) children with 2nd degree obesity, 6 (22.2%) children with 3rd degree obesity, and 7 (25.9%) children with morbid obesity. Of the total group of children, 7 patients had a history of diffuse nontoxic goiter. In the group of children with 1st degree obesity, the median age was 12.5 years, TTG 4.520.51 uIU/ml, with 2nd degree obesity the median age was 14.5 years, TTG 4.630.64 uIU/ml, with 3rd degree obesity the median age was 9.5 years, TTG 4.750.40 uIU/ml. In the group of children with morbid obesity, the median age was 7 years, TTG 5.350.59 uIU/ml.<br />Conclusion: In the study sample of children, there was an increase in TTG concentration, proportional to the severity of obesity.</p>оbesitysubclinical hypothyroidismchildrenadolescentsожирениесубклинический гипотиреоздетиподростки[Peterkova V.A., Remizov O.V. Ожирение в детском возрасте// Ожирение и метаболизм. -2004. –т. 1, №1.-с. 17-23. https://doi.org/10.14341/2071-8713-5174][Zakharova S.M. Ожирение и гипотиреоз / S.M. Zakharova, L.V. Savelieva, M.I. Fadeeva // Ожирение и метаболизм. -2013. -т. 10, №2. - с. 54-58. https://doi.org/10.14341/2071-8713-4826][Salerno M, Capalbo D, Cerbone M, et al. Subclinical hypothyroidism in childhood - current knowledge and open issues// Nat Rev Endocrinol.-2016 т. 12, №12. – с.734-746. https://doi.org/10.1038/nrendo.2016.100.][Patel, R., Dave, C., Mehta, et.al. Metabolic Impact of Subclinical Hypothyroidism in Obese Children and Adolescents //The Indian Journal of Pediatrics. -2020 –т. 88, №50-с.437-440 doi:10.1007/s12098-020-03463-0 (https://doi.org/10.1007/s12098-020-03463-0)][Необходимо ли рутинное определение тиреотропного гормона у всех детей и подростков с ожирением? Собственное исследование и начало дискуссии / Kijaev A.V., Savelev L.I., Pollak O.J., et al. // Клиническая и экспериментальная тиреоидология. – 2008. т. 4, №4. -с.30-33. https://doi.org/10.14341/ket20084430-33]