Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации6761UnclassifiedIntraoperative correction of risk factors for acute liver failure during liver resectionAndreevAlexander Asugery@mail.ruhttps://orcid.org/0000-0002-5242-6105OstroushkoAnton Petrovich<p>associate Professor of General surgery</p>antonostroushko@yandex.ruhttps://orcid.org/0000-0003-3656-5954GlukhovAlexander Aaaglukhov@vrngmu.ruhttps://orcid.org/0000-0002-1825-0097LaptiyovaAnastasiya Yulatievaa@mail.ruhttps://orcid.org/0000-0002-3307-1425AntakovaLubov N.tsvn@bk.ruhttps://orcid.org/0000-0002-1825-0097N. N. Burdenko Voronezh State Medical UniversityVoronezh State Medical University named after N.N.BurdenkoVoronezh State Medical University2408202110118192104202121042021Copyright © 2021, Молодежный инновационный вестник2021<p style="text-align: justify;"><span data-contrast="auto"><strong>Relevance.</strong> The introduction of new methods of liver resection has contributed to a significant expansion of the indications for liver resections, but acute liver failure remains a difficult problem among postoperative complications.</span><span data-ccp-props="{201341983:0,335551550:6,335551620:6,335559739:160,335559740:259}"></span></p>
<p style="text-align: justify;"><span data-contrast="auto"><strong>Aim of the study.</strong> Reducing the risk of acute liver failure during liver resection, by intraoperative administration of cyanocobalamin in an experiment.</span><span data-ccp-props="{201341983:0,335551550:6,335551620:6,335559739:160,335559740:259}"></span></p>
<p style="text-align: justify;"><span data-contrast="auto"><strong>Materials and methods.</strong> The experiments were performed on 96 male Wistar rats. All animals underwent typical liver resection (TRP); in the 2nd control group-additional intrahepatic injections of 1 ml of 0.9% NaCl were performed; in the 1st experimental group intrahepatic injections of 1 ml of cyanocobalamin; in the 2nd experimental group-1 ml of cyanocobalamin was administered intraperitoneally. On days 1, 5, 7, and 14, blood was collected for biochemical testing. Statistical processing was performed using the program</span><span data-contrast="auto">Statistica</span><span data-contrast="auto">6.0.</span><span data-ccp-props="{201341983:0,335551550:6,335551620:6,335559739:160,335559740:259}"></span></p>
<p style="text-align: justify;"><span data-contrast="auto"><strong>Results.</strong> On the 14th day of the study, normalization of the indicators of cytolysis, cholestasis and hepatic cell insufficiency syndromes was observed in the 1st experimental group in almost all animals, in the control groups and the 2nd experimental group, the results were significantly lower.</span><span data-ccp-props="{201341983:0,335551550:6,335551620:6,335559739:160,335559740:259}"></span></p>
<p style="text-align: justify;"><span data-contrast="auto"><strong>Conclusion.</strong> The proposed method provides normalization of the metabolic processes of the liver in the early postoperative period, prevents the development of acute liver failure.</span><span data-ccp-props="{201341983:0,335551550:6,335551620:6,335559739:160,335559740:259}"></span></p>resectionliverpreventionliver failureрезекцияпеченьпрофилактикапеченочная недостаточность[1. Назыров Ф., Акбаров М., Девятов А., и др. Результаты резекционных вмешательств на печени на фоне хронической диффузной гепатопатии // Вестник экспериментальной и клинической хирургии. - 2015. - Т. 8. - №2. - C. 142-150.][2. Затолокин В., Перков А., Лунева Н. Влияние гептрала на состояние ткани печени после ее резекции // Вестник экспериментальной и клинической хирургии. - 2012. - Т. 5. - №2. - C. 320-324.][3. Власов A., Саксин А., Анаскин С., и др. Мембраностабилизирующий компонент в предупреждении печеночной дисфункции при остром панкреатите // Вестник экспериментальной и клинической хирургии. - 2015. - Т. 8. - №3. - C. 269-276.][4. Тарасенко C., Натальский A., Луньков И., и др. К вопросу о патогенезе и классификации печеночной недостаточности // Вестник экспериментальной и клинической хирургии. - 2014. - Т. 7. - №3. - C. 286-292.][5. Глухов А.А., Андреев А.А., Лаптиёва А.Ю., Остроушко А.П. Первичная профилактика пострезекционной печеночной недостаточности. Профилактическая медицина. 2020. Т. 23. № 5-2. С. 44-45.][6. Laptiyova A.Yu. Prevention of post-resection acute liver failure by various methods of cyanocobalamin administration in the experiment / A.Yu. Laptiyova, A.A. Andreev, A.А. Glukhov and etr. // International Journal of Biomedicine. - 2020. - Т. 10. - № 3. - С. 257-261.]