Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации6551UnclassifiedTHE COMPARATIVE ANALYSIS OF FUNCTIONAL INDICES IN PATIENTS WITH OSTEOARTHRITIS AND COMORBID OBESITYАбакумоваСофия Александровнаabakumovasof@yandex.ruhttps://orcid.org/0000-0002-2273-8474KorneevRoman Vyacheslavovichon.romka@yandex.ruhttps://orcid.org/0000-0002-7697-6902Voronezh State Medical University named after Nikolai Nilovich BurdenkoVSMU um N.N Burdenko1405202110S15485482802202114032021Copyright © 2021, Молодежный инновационный вестник2021<p class="p1"><span class="s1">Objectives: assessment of knee joints in patients with osteoarthritis and obesity</span></p>
<p class="p1"><span class="s1"> Methods: The study included 40 patients with osteoarthritis in the age group from 45 to 65 years, 80% women and 20% men.<span class="Apple-converted-space"> </span>The patients were divided into 2 groups.<span class="Apple-converted-space"> </span>In the first group of patients, in addition to OA, concomitant obesity was diagnosed.<span class="Apple-converted-space"> </span>In group 2, patients suffered from osteoarthritis</span></p>
<p class="p1"><span class="s1"> Results: The result of the analysis was that the people who were included in the second group differed significantly from patients with OA and concomitant obesity.</span></p>
<p class="p1"><span class="s1"> Conclusion: in patients with OA and without comorbid obesity, there was an increase in the functional activity of the knee joints and a decrease in pain according to the VAS, compared with patients with OA and concomitant obesity.</span></p>key words: osteoarthritis, obesity, risk factors, functional activity, comorbid condition.Ключевые слова: остеоартроз, ожирение, факторы риска, функциональная активность, коморбидное состояние.<p class="s3"><span class="s2"><span class="bumpedFont15">The comparative analysis of functional indices in patients with osteoarthritis and comorbid obesity</span></span></p>
<p class="s4"></p>
<p class="s4"><span class="s2"><span class="bumpedFont15">Background. Ob</span></span><span class="s2"><span class="bumpedFont15">esity is one of the most important risk factors for the manifestation and further deterioration </span></span><span class="s2"><span class="bumpedFont15">of oste</span></span><span class="s2"><span class="bumpedFont15">oarthritis (OA)</span></span><span class="s2"><span class="bumpedFont15">. It is well known the relationship between the risk of association and progression of knee osteoarthritis and level of BMI [1, 2, 3].</span></span></p>
<p class="s4"><span class="s2"><span class="bumpedFont15">Objectives. To analyze th</span></span><span class="s2"><span class="bumpedFont15">e limitations physical activity </span></span><span class="s2"><span class="bumpedFont15">of patients with osteoarthritis (OA) in combination with obesity.</span></span></p>
<p class="s5"><span class="s2"><span class="bumpedFont15">Material and method. </span></span><span class="s2"><span class="bumpedFont15">40 patients with OA with the mean age 52.310.2 were included in the trial. 80% females and 20% males participated in the study. The diagnosis of osteoarthritis was established according to the criteria of Kellgren and Lawrence. </span></span><span class="s2"><span class="bumpedFont15">The duration of OA is from 5 to 10 years. </span></span><span class="s2"><span class="bumpedFont15">Inclusion criteria: informed consent of partici</span></span><span class="s2"><span class="bumpedFont15">pation in the study, age over 42</span></span><span class="s2"><span class="bumpedFont15"> years, mainly knee joint damage (knee OA), </span></span><span class="s2"><span class="bumpedFont15">The stage according to X-ray is </span></span><span class="s2"><span class="bumpedFont15">II, </span></span><span class="s2"><span class="bumpedFont15">no comorbid </span></span><span class="s2"><span class="bumpedFont15">liver and kidney diseases in the stage of functional decompensation, </span></span><span class="s2"><span class="bumpedFont15">absent of previous </span></span><span class="s2"><span class="bumpedFont15">intra-articular injections </span></span><span class="s2"><span class="bumpedFont15">at least </span></span><span class="s2"><span class="bumpedFont15">3 months</span></span><span class="s2"><span class="bumpedFont15"> before the trial. The patients were classified </span></span><span class="s2"><span class="bumpedFont15">into 2 groups. Patients with O</span></span><span class="s2"><span class="bumpedFont15">A of group 1 (n=40) had comorbid </span></span><span class="s2"><span class="bumpedFont15">obesity. In group 2 (control</span></span><span class="s2"><span class="bumpedFont15">) (n=40), patients had only</span></span><span class="s2"><span class="bumpedFont15"> OA. Functional activity in the compared groups was assessed using a visual analog scale (pain on VAS), as well as the Lequesne and WOMAC functional indices.</span></span></p>
<p class="s5"><span class="s2"><span class="bumpedFont15"> Results. As a result of the comparative analysis, the values of the pain on VAS, WOMAC and Lequesne in group 2 were 411.51 (p0.001), 89.91.49 (p0.001) and 9.750.28 (p0.001), respectively, and significantly differed from patients with OA and concomitant obesity. The values of the studied parameters in group 1 of patients exceeded the values in the control group by an average of 15-20%. </span></span></p>
<p class="s5"><span class="s6"><span class="bumpedFont15">Conclusion </span></span><span class="s2"><span class="bumpedFont15">In patients with osteoarthritis in combination with obesity, there was a decrease in the functional activity of the knee joints and increased pain on VAS compared to patients with OA without a comorbid condition.</span></span></p>
<p class="s4"><span class="s2"><span class="bumpedFont15">References: 1. Tukker A.,Visscher T.L.S., Picavet H.S.J. Overweight and health problems of the lower extremities: osteoarthritis, pain and disability.</span></span></p>
<p class="s4"><span class="s2"><span class="bumpedFont15">Public Health Nutr 2007;12:3359-368.</span></span></p>
<p class="s4"><span class="s2"><span class="bumpedFont15">2. Zhang Y., Jordan J.M. Epidemiology of Osteoarthritis. Clin Geriatr Med 2010;26:3:355-369.</span></span></p>
<p class="s4"><span class="s2"><span class="bumpedFont15">3. Manek Nisha J., Hart D., Spector T. D., MacGredor Alexander J. The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influence. Arthrit Rheum 2003;48:4:1024-1029.</span></span></p>[1. Tukker A.,Visscher T.L.S., Picavet H.S.J. Overweight and health problems of the lower extremities: osteoarthritis, pain and disability.][Public Health Nutr 2007;12:3359-368.][2. Zhang Y., Jordan J.M. Epidemiology of Osteoarthritis. Clin Geriatr Med 2010;26:3:355-369.][3. Manek Nisha J., Hart D., Spector T. D., MacGredor Alexander J. The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influence. Arthrit Rheum 2003;48:4:1024-1029.][4. Reijman M., Pols H.A., Bergink A.P. et al. Body mass index associated with onset and progression of Osteoarthritis of the knee but not of the hip. The Rotterdam Study. Ann Rheum Dis 2007;66:158-162.]