Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации11541Conference ProceedingsDifferential diagnostic criteria for purulent and serous lesions of the central nervous system in childrenAvdeevaElizaveta Sergeevnaeavdeeva03@bk.ruhttps://orcid.org/0009-0003-0175-9350SolopovaEkaterina VladimirovnaEkaterinaa.16@mail.ruhttps://orcid.org/0009-0005-9686-4894PozhidaevaDarya Nikolaevnapozhidaeva.dasha@bk.ruhttps://orcid.org/0000-0003-4954-6509MikhailukYaroslava Konstantinovnalacerta.c8@gmail.comhttps://orcid.org/0000-0002-6334-1449KotlovaVeronika BorisovnaKotlova.65@mail.ruBurdenko Voronezh State Medical University0110202615S11581601703202611042026Copyright © 2026, Avdeeva E.S., Solopova E.V., Pozhidaeva D.N., Mikhailuk Y.K., Kotlova V.B.2026<p style="text-align: justify;">The relevance of neuroinfections stems from their high disability and mortality rates, which depend on diagnostic accuracy and treatment timing.Aim: To assess clinical and laboratory features of purulent and serous nervous system lesions.Methods: A retrospective analysis of 95 pediatric cases (20242025) was performed. Group 1 included 9 children with purulent CNS lesions; Group 2 included 86 with serous lesions. All underwent clinical exams, blood biochemistry, and lumbar puncture.Results: Meningococcal infection accounted for 66.7% of purulent cases, predominantly in early childhood. Among specified viral etiologies, enterovirus (27.9%) was most common, followed by cytomegalovirus (4.7%) and HHV6 (1.2%), primarily in schoolchildren (58.3%). Mean pleocytosis in purulent meningitis was 4400.96 780.1 10⁶/L, versus 195.42 32.87 10⁶/L in serous cases. In 20% of viral meningitis, CSF neutrophil percentage reached 98% with normal lactate, whereas lactate was elevated in purulent meningitis.Conclusion: Enterovirus is the leading viral neuroinfection, peaking in schoolchildren during autumn-summer; meningococcus predominates in purulent cases, peaking in young children during winter-autumn. Neutrophilic pleocytosis occurs in 20% of viral meningitis, necessitating CSF lactate measurement for differential diagnosisnormal in viral, elevated in bacterial infections.</p> <p></p>neuroinfectionsserous meningitispurulent meningitispleocytosiscerebrospinal fluid lactateнейроинфекциисерозные менингитыгнойные менингитыплеоцитозлактат ликвора1.Barichello T, Rocha Catalão CH, Rohlwink UK, et al. Bacterial meningitis in Africa. Frontiers in Neurology. 2023;14:822575. https://doi.org/10.3389/fneur.2023.8225752.Snoek L, Gonçalves BP, Horváth-Puhó E, et al. Short-term and longterm risk of mortality and neurodevelopmental impairments after bacterial meningitis during infancy in children in Denmark and the Netherlands: a nationwide matched cohort study. Lancet. Child & Adolescent Health. 2022;6(9):633-642. https://doi.org/10.1016/S2352-4642(22)00155 Иванова Г.П.3.Скрипченко Н.В., Иванова Г.П., Скрипченко Е.Ю., Голева О.В., Голубева А.В. Диагностика нейроинфекций у детей.Журнал неврологии и психиатрии им.С.С.Корсакова. Спецвыпуски.2024;124(11 2):51 59.4.Barichello T, Rocha Catalão CH, Rohlwink UK, et al. Bacterial meningitis in Africa.Frontiers in Neurology.2023;14:822575.https://doi.org/10.3389/fneur.2023.8225755.Кокорева С.П., Казарцева Н.В., Котлова В.Б. Эволюция клинико-лабораторных особенностей энтеровирусного менингита у детей // Детские инфекции. 2019. Т. 18. № 4 (69). С. 43-48.