Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации11476Conference ProceedingsSeverity clusters of patients with Herpes ZosterBabenkovaDaria Vladimirovnagrindera1@yandex.ruhttps://orcid.org/0000-0002-5857-6841GridnevaMariia Аleksandrovna<p>student</p>gridnevamary101@gmail.comhttps://orcid.org/0009-0003-3719-1760KrasnorutskayaOlga Nikolaevnaibri@vrngmu.ruhttps://orcid.org/0000-0003-4796-7334Burdenko Voronezh State Medical University0110202615S11701711303202605042026Copyright © 2026, Babenkova D.V., gridneva m.А., Krasnorutskaya O.N.2026<p style="text-align: justify;">Varicella-ZosterVirus persists lifelong in the bodyafterinitialinfection, itsreactivation causes herpeszoster.Despite its highprevalence(556.8per100,000populationin2025), there is nounified severity scale exists, complicating therapy and outcome prediction. Objective: to evaluateclusteranalysisfordeterminingherpeszosterseverity usingclinicalsymptomsandlaboratorydata.Materials and methods: 40 patients with OH were included in the study. Toobjectivelyassess the clinicalstatusandseverity of the disease, a two-stageclusteranalysis(CHAIDmethod) applied using three variables: the area of the skinlesion, the intensity of painsyndrome(VAS), andinterleukin-6 level.Results:Threestableclusters were identified(silhouettemeasure0.6). The firstcluster(37.5% of patients)-mild, was characterized by minimalvalues of indicators(151cm2,6points,4.2pg/ml). The secondcluster(40% of patients)reflected the averageseverity(169.5cm2,8points,6.9pg/ml). The thirdcluster(22.5% of patients)unitedpatientswithseverecourse(197cm2,10points,12pg/ml). Differences between groups were statistically significant(p0.05).Conclusions: Cluster analysis allows us to objectively stratify patients with herpes zoster by severity (mild, moderate, severe), which can be used to optimize therapy and predict outcome.</p>herpes zostercluster analysisherpes virusопоясывающий герпескластерный анализHerpes Zoster1.https://www.rosstat.gov.ru/storage/mediabank/Zdravooxran_2025.pdf от 13.02.20262.Giannelos N, Curran D, Nguyen C, Kagia C, Vroom N, Vroling H. The Incidence of Herpes Zoster Complications: A Systematic Literature Review. Infect Dis Ther. 2024 Jul;13(7):1461-1486. doi: 10.1007/s40121-024-01002-4. Epub 2024 Jun 19. PMID: 38896390; PMCID: PMC112196813.Опоясывающий герпес : клинические рекомендации / Общероссийская общественная организация «Российское общество дерматовенерологов и косметологов». – Москва, 2020. – 35 с4.Wang JP, Kurt-Jones EA, Shin OS, Manchak MD, Levin MJ, Finberg RW. Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. J Virol. 2005 Oct;79(20):12658-66. doi: 10.1128/JVI.79.20.12658-12666.2005. PMID: 16188968; PMCID: PMC1235827.5.Como CN, Pearce CM, Cohrs RJ, Baird NL. Interleukin-6 and type 1 interferons inhibit varicella zoster virus replication in human neurons. Virology. 2018 Sep;522:13-18. doi: 10.1016/j.virol.2018.06.013. Epub 2018 Jul 4. PMID: 29979960; PMCID: PMC6087493.