Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации11373Conference ProceedingsSafety analysis of calcium and colecalciferol medicines used in the treatment of osteoporosisBeitullaevAsan M.<p>assistant professor of the Department of Basic and Clinical Pharmacology</p>
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</div>asan25.2001@gmail.comhttps://orcid.org/0000-0002-8059-7075EgorovaElena Aleksandrovna<p>associate professor of the Department of Basic and Clinical Pharmacology</p>
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</div>egorovapharm@mail.ruhttps://orcid.org/0000-0003-4012-2523Order of the Red Banner of Labour Medical institute named after S. I. Georgievsky of Vernadsky Crimean Federal University0110202615S11831860103202605042026Copyright © 2026, Beitullaev A.M., Egorova E.A.2026<p style="text-align: justify;">Osteoporosis is a systemic disease of the musculoskeletal system that requires long-term pharmacotherapy, including the use of calcium and colecalciferol preparations.The aim of this study was to analyze adverse reactions (ARs) associated with the use of medications for osteoporosis treatment, identifying the characteristics of their manifestation and the factors contributing to the occurrence of side effects.Materials and methods. An analysis was conducted based on relevant criteria of spontaneous reports registered in the automated information system "Pharmakonadzor" from 2009 to 2024.Results. A typical patient profile for those experiencing ARs from calcium and colecalciferol preparations was identifiedelderly women. The most frequently reported ARs were allergic reactions, dyspeptic disorders, and cases of treatment ineffectiveness. Cases of reactions leading to life-threatening conditions and fatal outcomes were described separately. Differences in the information submitted in spontaneous reports across various versions of the "Pharmacovigilance" system were examined.Conclusions. The study of AR development cases allows for the assessment of potential risks of ongoing pharmacotherapy, modifications to existing therapeutic approaches, identification of patient characteristics that serve as risk factors for AR development, and patient education about possible ARs. This, in turn, increases treatment adherence rates and thereby enhances the effectiveness of the therapy.</p>osteoporosisadverse drug reactionscalcium medicinescolecalciferol medicinesостеопорознежелательные реакциипрепараты кальцияпрепараты колекальциферола[Лесняк О.М., Баранова И.А., Белова К.Ю., Гладкова Е.Н., Евстигнеева Л.П., Ершова О.Б., Каронова Т.Л., Кочиш А.Ю., Никитинская О.А., Скрипникова И.А., Торопцова Н.В., Арамисова Р.М. Остеопороз в Российской Федерации: эпидемиология, медико-социальные и экономические аспекты проблемы (обзор литературы) // Травматология и ортопедия России. - 2018. - Т. 24. - №1. - C. 155-168. https://doi.org/10.21823/2311-2905-2018-24-1-155-168][Остеопороз. Клинические рекомендации. / Министерство здравоохранения Российской Федерации. – Москва, 2025. – Текст: электронный / Рубрикатор клинических рекомендаций МЗ РФ: [сайт]. – URL: https://cr.minzdrav.gov.ru/view-cr/87_5][Патологические переломы, осложняющие остеопороз. Клинические рекомендации. / Министерство здравоохранения Российской Федерации. – Москва, 2025. – Текст: электронный / Рубрикатор клинических рекомендаций МЗ РФ: [сайт]. – URL: https://cr.minzdrav.gov.ru/view-cr/614_3][Jiao D, Jiang C. Nutritional therapy of older osteoporotic people with supplemental calcium and vitamin D: side effects, fracture rates, and survival - an internationalised meta-analysis. Asia Pac J Clin Nutr. 2024;33(1):1-10. https://doi.org/10.6133/apjcn.202403_33(1).0001][Сафонова Ю.А., Торопцова Н.В. Дефицит и недостаточность витамина D, факторы риска и его коррекция у людей пожилого возраста // РМЖ. – 2021. – Т. 29, № 6. – С. 96-100. – EDN KYDHXP.][Chiodini I, Bolland MJ. Calcium supplementation in osteoporosis: useful or harmful?. Eur J Endocrinol. 2018;178(4):D13-D25. https://doi.org/10.1530/EJE-18-0113]