Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации11276Conference ProceedingsComparative assessment of NSAID gastrotoxicity and new heterocyclic derivatives in a chronic experimentIvanovaElina Ruslanovnaivanovaelina03@mail.ruhttps://orcid.org/0009-0003-1437-6498BibikElena Yurievnahelen_bibik@mail.ruhttps://orcid.org/0000-0001-7470-608XSt. Luke's Lugansk State Medical University0110202615S11981992502202605042026Copyright © 2026, Ivanova E.R., Bibik E.Y.2026<p style="text-align: justify;">Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in clinical practice; however, their long-term administration is limited by the development of gastropathies from erosions to perforated ulcers. The search for new compounds with anti-inflammatory activity devoid of ulcerogenic effects is a priority in pharmacology. The aim of the study was to compare the gastrotoxicity of classical NSAIDs (indomethacin, nimesulide) and two novel alpha-cyanothioacetamide derivatives (TD-0331 and AS-144) following a 14-day intragastric administration in rats. The experiment was performed on 50 outbred male rats divided into 5 groups (n=10): intact (NaCl); comparison group 1 (indomethacin, 7 mg/kg); comparison group 2 (nimesulide, 16 mg/kg); experimental groups (TD-0331 and AS-144, 5 mg/kg each). Compounds were administered daily by oral gavage. On day 15, gastric mucosa was macroscopically assessed using a 5-point scale, and the ulcer index was calculated. Indomethacin caused 100% mortality by day 7 and severe ulcerative lesions (ulcer index 1.13). Nimesulide did not induce ulceration but produced diffuse mucosal hyperemia in all animals. Both TD-0331 and AS-144 caused no visible damage to the gastric mucosa (score 0, ulcer index 0), matching the intact group parameters. The novel alpha-cyanothioacetamide derivatives TD-0331 and AS-144 demonstrate complete gastroprotection and surpass traditional NSAIDs in safety profile, positioning them as promising candidates for the development of next-generation anti-inflammatory drugs.</p>индометациннимесулидальфа-цианотиоацетамидульцерогенное действиегастропатия1.Mazumder, S. Induction of mitochondrial toxicity by non-steroidal anti-inflammatory drugs (NSAIDs): The ultimate trade-off governing the therapeutic merits and demerits of these wonder drugs / S. Mazumder, S. Bindu, S. Debsharma [et al.] // Biochemical Pharmacology. – 2024. – Vol. 228. – P. 116283.2.Liu, Y. Recent progress in adverse events of carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) and their association with the metabolism: the consequences on mitochondrial dysfunction and oxidative stress, and prevention with natural plant extracts / Y. Liu, C. Yang, J. Zhang [et al.] // Expert Opinion on Drug Metabolism & Toxicology. – 2024. – Vol. 20, № 8. – P. 765–785.3.Baba, Y. Relevance of oxidative stress for small intestinal injuries induced by nonsteroidal anti-inflammatory drugs: A multicenter prospective study / Y. Baba, S. Kawano, A. Takaki [et al.] // Medicine (Baltimore). – 2024. – Vol. 103, № 50. – P. e40849.4.Sohail, R. Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review / R. Sohail, M. Mathew, K.K. Patel [et al.] // Cureus. – 2023. – Vol. 15, № 4. – P. e37080.5.Бибик, И.В. Синтез и анальгетическая активность новых гетероциклических производных цианотиоацетамида / И.В. Бибик, Е.Ю. Бибик, В.В. Доценко [и др.] // Журнал общей химии. – 2021. – Т. 91, № 2. – С. 190–204.6.Кривоколыско, Д.С. Новые 4-(2-фурил)-1,4-дигидроникотинонитрилы и 1,4,5,6-тетрагидроникотинонитрилы: синтез, строение и анальгетическая активность / Д.С. Кривоколыско, В.В. Доценко, Е.Ю. Бибик [и др.] // Журнал общей химии. – 2021. – Т. 91, № 9. – С. 1359–1374.7.Савохина, М.В. Изучение ульцерогенного и местнораздражающего действия метакрукса / М.В. Савохина, А.В. Таран // СМБ. – 2011. – № 2. – С. 45–49.