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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Молодежный инновационный вестник</journal-id><journal-title-group><journal-title>Молодежный инновационный вестник</journal-title></journal-title-group><issn publication-format="print">2415-7805</issn><publisher><publisher-name>Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">11250</article-id><article-categories><subj-group subj-group-type="heading"><subject>Conference Proceedings</subject></subj-group></article-categories><title-group><article-title>Paraproteinemic (IgM-associated) Nephropathy and Cardiorenal Syndrome in Waldenström's Macroglobulinemia: A Case Report</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Chalova</surname><given-names>Alina Evgenievna</given-names></name><email>tchalovaalina@gmail.com</email><uri content-type="orcid">https://orcid.org/0009-0000-4727-1594</uri><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Derevyanchenko</surname><given-names>Maria Vladimirovna</given-names></name><email>derevjanchenko@gmail.com</email><uri content-type="orcid">https://orcid.org/0000-0002-6232-4583</uri><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Volgograd State Medical University</aff><pub-date date-type="epub" iso-8601-date="2026-10-01" publication-format="electronic"><day>01</day><month>10</month><year>2026</year></pub-date><volume>15</volume><issue>S1</issue><fpage>96</fpage><lpage>97</lpage><history><pub-date date-type="received" iso-8601-date="2026-02-24"><day>24</day><month>02</month><year>2026</year></pub-date><pub-date date-type="accepted" iso-8601-date="2026-04-05"><day>05</day><month>04</month><year>2026</year></pub-date></history><permissions><copyright-statement>Copyright © 2026, Chalova A.E., Derevyanchenko M.V.</copyright-statement><copyright-year>2026</copyright-year></permissions><abstract>&lt;p&gt;&lt;em&gt;Waldenstrm's macroglobulinemia (WM) is a rare lymphoproliferative disorder that can be complicated by kidney damage with the development of paraproteinemic nephropathy and systemic disorders, including cardiorenal syndrome. The difficulty of timely diagnosis is due to the polymorphism of the clinical picture.Objective.To present a clinical case of WM associated with severe kidney damage and the development of cardiorenal syndrome.Methods.An analysis of the medical history, laboratory and instrumental data of a 71-year-old patient with a verified diagnosis of Waldenstrm's macroglobulinemia was carried out.Results.The patient exhibited progressive proteinuria (up to 9.5 g/L), an increase in creatinine (up to 259.6 mol/L), hypoalbuminemia (up to 27.1 g/L), as well as cardiac dysfunction with a left ventricular ejection fraction of 46% and bilateral hydrothorax. The diagnosis of WM was confirmed by immunophenotyping and immunohistochemistry of the bone marrow.Conclusion.This case demonstrates the need for interdisciplinary interaction for the early diagnosis of paraproteinemic nephropathies and the correction of life-threatening complications in patients with WM.&lt;/em&gt;&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>proteinuria</kwd><kwd>paraproteinemic nephropathy</kwd><kwd>Waldenström's macroglobulinemia</kwd><kwd>cardiorenal syndrome</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>протеинурия</kwd><kwd>парапротеинемическая нефропатия</kwd><kwd>макроглобулинемия Вальденстрема</kwd><kwd>кардиоренальный синдром</kwd><kwd>клинический случай</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Патогенез, диагностика и лечение болезни Вальденстрёма: клинические рекомендации / под ред. И. В. Поддубной, В. Г. Савченко. – Москва: Профи-Пресс, 2021. – 48 с.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Козловская Н. Л., Николаев А. Ю., Милованова Л. Ю., Рамеев В. В. Поражение почек при моноклональных гаммапатиях // Клиническая нефрология. – 2020. – № 3. – С. 73–80.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Харазишвили Д. В., Рыжкин И. С., Шевченко А. О., Моисеев С. В. Болезнь отложения моноклональных иммуноглобулинов (моноклональная иммуноглобулин-ассоциированная болезнь почек) // Нефрология. – 2022. – Т. 26, № 3. – С. 25–39.</mixed-citation></ref></ref-list></back></article>
