Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10915UnclassifiedGene-environment interactions in predicting STEM orientationAskerovaAdelina Geidarovna<p>Student</p>adelina29062003@gmail.comhttps://orcid.org/0009-0009-3919-3472YakubovskayaAnna Alekseevnayakubovskaya_2604@mail.ruhttps://orcid.org/0009-0008-2404-5293EgorovaEmilia Sergeevnajastspring@yandex.ruhttps://orcid.org/0000-0002-6210-4660ValeevaElena Valerevnavevaleeva@ya.ruhttps://orcid.org/0000-0001-7080-3878AhmetovIldus Ilyasovichgenoterra@mail.ruhttps://orcid.org/0000-0002-6335-4020Kazan State Medical UniversityKazan State Medical University,Central Research Laboratory of Kazan State Medical University0411202514218201604202505082025Copyright © 2025, Askerova A.G., Yakubovskaya A.A., Egorova E.S., Valeeva E.V., Ahmetov I.I.2025<p style="text-align: justify;">A comprehensive study of gene-mediated determinants of STEM-orientation among 790 students (mean age 21.43.9 years) was conducted. The methods employed encompassed psychological testing (Eysenck, Beck, Spielberg-Hanin, etc.), questionnaires, and genetic analysis of polymorphisms rs10048736 of the ARHGAP15 gene and rs12903858 of the SQOR gene by real-time PCR. The results of the study indicated an association of the AA rs10048736 genotype with two distinct variables: academic achievement and passion for chess. The former was defined as a 12.7% success rate compared to a 6.8% success rate amongst non-medal carriers, with a p-value of 0.03. The latter was defined as a 36.3% success rate compared to a 25.6% success rate, with a p-value of 0.006. Furthermore, STEM-oriented students were found to be more likely to participate in high-level Olympiads (p=0.02). Regression analysis demonstrated a significant contribution of environmental factors (R=9.61%, p0.0001) and, in conjunction with genetic markers, a substantial effect size was observed (R=11.53%, p0.0001). The STEM orientation of students is shaped by the complex interaction of genetic predictors and educational factors. The findings underscore the necessity of incorporating gene-medium interactions into professional orientation.</p>STEM educationgenetic polymorphismmolecular genetic markersprofessional orientationSTEM-образованиегенетический полиморфизммолекулярно-генетические маркерыпрофессиональная ориентация1.Zhu C, Zhao Q, He J, Böckerman P, Luo S, Chen Q. Genetic basis of STEM occupational choice and regional economic performance: a UK biobank genome-wide association study. Hum Genomics. 2023;17(1):40. Published 2023 May 10. doi:10.1186/s40246-023-00488-2