Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10766Conference ProceedingsThe Influence of Gene-Engineered Therapy on the Degree of Asthma Control in Children with ObesityЕремчукМарияmariaeremcuk307@gmail.comhttps://orcid.org/0009-0005-2382-7881GladkayaTatyana Sergeevnatatyanka.gladkaya.2004@mail.ruhttps://orcid.org/0009-0005-9097-1621Voronezh State Medical University named after N.N.Burdenko2504202514S16786822703202502042025Copyright © 2025, Еремчук М., Gladkaya T.S.2025<p><em>Bronchial asthma (BA) is one of the most common chronic diseases in childhood, significantly impacting patients' quality of life and requiring a comprehensive approach to diagnosis and treatment. This study highlights the role of obesity in the development and management of BA, with a focus on the use of gene-engineered therapy aimed at preventing the deterioration of disease control. Obesity leads to the accumulation of adipose tissue in the chest area, which restricts diaphragm mobility and complicates the course of asthma. Objective. To analyze the effectiveness of gene-engineered therapy in controlling BA in children with obesity. Materials and methods. A retrospective analysis of medical records of 32 patients aged 5 to 17 years treated at the pulmonology department of the VDKH VSMU named after N. N. Burdenko was conducted. The study assessed the number of comorbid patients and the relationship between disease progression and treatment with biological drugs. Results. The findings indicate that the combination of BA and obesity necessitates the use of innovative and modern treatment methods, among which gene-engineered therapy plays a significant role. This approach has demonstrated high efficacy in improving asthma control and reducing the frequency of exacerbations. Conclusion. Gene-engineered therapy is a promising treatment for BA in children with obesity, contributing to better disease control and a reduction in exacerbation rates.</em></p>bronchial asthmaobesitygenetically engineered therapycomorbiditychildrenбронхиальная астмаожирениегенно-инженерная терапиякоморбидностьдети1.Глобальная стратегия введения и профилактики астмы (GINA 2024) [Электронный ресурс] // Режим доступа: URL: https://ginasthma.org/2024-report/ (дата обращения 12.02.2025).2.Бронхиальная астма. Клинические рекомендации РФ 2024 (Россия) [Электронный ресурс] // Режим доступа: URL: https://raaci.ru/dat/pdf/clin_BA.pdf (дата обращения 15.01.2025).3.Jaffuel D, Fabry-Vendrand C, Darnal E, Wilczynski O, Pain E, Bourdin A. Perception of oral corticosteroids in adult patients with asthma in France. J Asthma. 2020 Apr 14:1-12. doi: 10.1080/02770903.2020.1748048. Epub ahead of print. PMID: 32285714.4.Авдеев С. Н., Айсанов З. Р., Белевский А. С., Емельянов А. В., Курбачева О. М., Лещенко И. В., Ненашева Н. М., Фассахов Р. С. Пути улучшения диагностики и лечения больных бронхиальной астмой врачами первичного звена // Пульмонология. – 2019. - №29. С. 457-467.