Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10757Conference ProceedingsComparative effectiveness of local hemostatic agents in stopping experimental bleeding from spleen woundsKomarYana Vladimirovna<p>student</p>komaryana125@gmail.comhttps://orcid.org/0009-0001-9510-7825GuschaTatiana Stepanovna<p>Senior Lecturer at the Department of Operative Surgery and Topographic Anatomy</p>gushcha.t@gmail.comhttps://orcid.org/0000-0002-5276-4286Grodno State Medical UniversityGrodno State Medical University, Grodno, Belarus2504202514S12492532303202525032025Copyright © 2025, Komar Y.V., Guscha T.S.2025<p>In surgical practice, the problem of hemostasis has remained and remains one of the main problems. The study and comparison of methods for stopping bleeding makes it possible to choose one of them optimally in case of damage to any organ. This article will consider the methods of hemostasis in traumatic injuries of the spleen. The aim. To analyze the reparative processes of splenic tissue after stopping bleeding with Fibrinostat, omentoplasty and bipolar electrocoagulation, as well as exposure to low-intensity laser irradiation (LILI) on the wound in an experiment. Materials and methods. The experiment was conducted on 10 outbred white rats with spleen wound modeling, hemostasis using one of the methods described above, and subsequent withdrawal from the experiment after 72 hours with an assessment of macro- and micro-pictures. Results. According to the results of microscopic examination during omentoplasty and electrocoagulation, an extensive necrosis zone was observed: in the first case, with pronounced infiltration, in the second with scant inflammation. LILI during omentoplasty reduced the inflammatory response, no changes were observed during electrocoagulation. The drug Fibrinostat was determined as a homogeneous mass with pronounced infiltration, however, under the influence of LILI, the degree of inflammation was less pronounced. Conclusions. The method of hemostasis with Fibrinostat has the most effective hemostatic effect in the early stages, and when combined with LILI has the most beneficial effect on the reparative process of the spleen tissue.</p>injuryspleenelectrocoagulationbleedingomentoplasty«Fibrinostat»травмаселезёнкаэлектрокоагуляциякровотечениеоментопластика«Фибриностат»1.Waseem M, Bjerke S. Splenic Injury. In: StatPearls. Treasure Island (FL): StatPearls Publishing; April 7, 2024 https://www.ncbi.nlm.nih.gov/books/NBK441993/2.Arvieux C, Frandon J, Tidadini F, et al. Effect of Prophylactic Embolization on Patients With Blunt Trauma at High Risk of Splenectomy: A Randomized Clinical Trial. JAMA Surg. 2020;155(12):1102-1111 https://doi.org/10.1001/jamasurg.2020.3672