Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10724Conference ProceedingsFeatures of the reactivity of immunocompetent cells due to the effects of the molecular hydrogen in oral mucositis in the experimentRastrosaMariamariya.rastrosa06@mail.ruhttps://orcid.org/0009-0008-7216-6137DerevyankoAlinadavdyan.work@mail.ruhttps://orcid.org/0009-0003-4966-1838ShishkinaVictoria4128069@gmail.comhttps://orcid.org/0000-0001-9185-4578KorotkikhNatalyakornat78@mail.ruhttps://orcid.org/0000-0002-0308-513XGrebennikovaIrinairina_voronezh@inbox.ruhttps://orcid.org/0000-0003-0213-9383Voronezh State Medical University named after N.N. Burdenko2504202514S12622651003202510032025Copyright © 2025, Rastrosa M., Derevyanko A., Shishkina V., Korotkikh N., Grebennikova I.2025<p>Oral mucositis is a common and serious complication of antitumor therapy, causing severe discomfort in patients, limiting their ability to eat and communicate. The importance of studying the reactivity of immunocompetent cells in this condition is due to the need to find effective methods of treatment and prevention. Objective. To study the effect of molecular hydrogen (H2) on the reactivity of immune cells in oral mucositis in an experiment. Materials and methods. Modeling of oral radiation mucositis was carried out at the Research Institute of Experimental biology and Medicine of the Voronezh State Medical University named after N.N. Burdenko with the participation of 30 sexually mature male Wistar rats. Then, for 14 days, the affected areas of the oral mucosa were irrigated with an aqueous solution of molecular hydrogen at a dose of 1 ppm. Histological micropreparations were made and stained with a further stage of morphometry. Results. A quantitative and qualitative assessment of some parameters of the inflammatory process of the mucous membrane was carried out using histochemistry and immunohistochemistry methods for the reactivity of mast cells and the features of macrophage plasticity. Conclusion. The study emphasizes the importance of further scientific research in the field of developing means for the prevention of oral mucositis. The data obtained confirm that molecular hydrogen can have a protective effect, minimizing the induction of an inflammatory response and improving the profile of the immune response. The prospects of using H2 as a therapeutic agent for the correction of the immune response in oral mucositis may be important for improving the quality of life of patients suffering from this condition.</p>mucositisoral mucosamast cells, macrophages, molecular hydrogenмукозитслизистая оболочка полости ртатучные клетки, макрофаги, молекулярной водород1.Клинические рекомендации «Злокачественные новообразования полости рта», Ассоциация онкологов России, 2024.2.Свидетельство о государственной регистрации базы данных № 2024620166 Российская Федерация. Злокачественные новообразования органов головы и шеи. Показатели качества жизни и клинико-морфологические данные: № 2024620013 : заявл. 05.01.2024 : опубл. 12.01.2024 / А. С. Буракова, И. П. Мошуров, С. А. Стикина.3.Семиглазова Т.Ю., Беляк Н.П., Владимирова Л.Ю., Корниецкая А.Л., Королева И.А., Нечаева М.Н. и соавт. Практические рекомендации по лечению и профилактике мукозитов. Злокачественные опухоли :Практические рекомендации RUSSCO #3s2, 2021 (том 11). 514.Lee CT, Galloway TJ. Pathogenesis and Amelioration of Radiation-Induced Oral Mucositis. Curr Treat Options Oncol. 2022; 23(3):311-324. doi: 10.1007/s11864-022-00959-z.5.Atiakshin D, Kostin A, Volodkin A, Nazarova A, Shishkina V, Esaulenko D, Buchwalow I, Tiemann M, Noda M. Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment. Pharmaceuticals (Basel). 2023; 16(6):817. doi: 10.3390/ph16060817.