Молодежный инновационный вестник

2415-7805

Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации

10714

Conference Proceedings

The Multicomponent Role of Stromal Cells in Prostate Gland Function in Norm and in Chronic Inflammatory Conditions

Avdeev

Timofey Alexeyevich

a_v_d_e_e_v222@mail.ruhttps://orcid.org/0009-0005-6469-0965Gutorova

Maya Igorevna

maya36rus@mail.ruhttps://orcid.org/0009-0007-5419-9448Sudakov

Vladislav Olegovich

Vladissudakov@gmail.comhttps://orcid.org/0009-0000-1601-0893

Voronezh State Medical University named after N.N.Burdenko

25042025

14S1210213

10032025

20032025

2025

<p><em>Prostate stromal cells are key participants in maintaining its homeostasis, actively influencing epithelial cells, the immune microenvironment, and the neurovascular network. Despite this, the complex role of the stroma in chronic inflammatory diseases of the prostate, such as chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), is not fully understood. The relevance of the work is due to the increasing prevalence of CP/CPPS and the limited effective treatments, which requires a deeper understanding of the pathogenetic mechanisms underlying these diseases. This review systematizes current knowledge about the multicomponent contribution of stromal cells to the functioning of the prostate gland in normal conditions and in chronic inflammation, analyzes the interaction of stromal cells with various cell populations and signaling pathways, and also considers potential therapeutic targets for the development of new treatment strategies for CP/CPPS based on modulation of stromal cell activity</em>.</p>

prostate glandinflammationstromamast cells

предстательная железавоспалениестроматучные клетки

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