Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10698Conference ProceedingsThe prognostic value of mast cells in the histocellular diagnosis of cervical cancerFedotovaEkaterina Igorevnafedotovaekaterina307@mail.ruhttps://orcid.org/0000-0002-2132-9257FilinAndrey Anatolyevichfilinan@yandex.ruhttps://orcid.org/0000-0003-1670-3694SertakovIgor Alexandrovichiasertakov1994@mail.ruhttps://orcid.org/0009-0007-3782-7465Voronezh State Medical University named after N.N. Burdenko2504202514S12692720903202510032025Copyright © 2025, Fedotova E.I., Filin A.A., Sertakov I.A.2025<p>Currently, malignant neoplasms of the cervix occupy the fourth position in the list of the most common oncological diseases among women in Russia. In our country, in 2023, more than 16.4 thousand patients were diagnosed with cervical cancer (cervical cancer) for the first time in their lives. Mast cells (TC) are one of the frequent representatives of the microenvironment with the potential for local regulation at the tissue and cellular levels. However, the role of TC in tumor morphogenesis is not fully understood and is sometimes contradictory. Goal. The study of the role of TC in the morphogenesis of breast cancer and their prognostic significance. Materials and methods. The study performed a morphometric analysis of biopsies of squamous cell carcinoma of the cervix taken from 21 patients aged 25-74 years. Chymase and tryptase in TK were immunohistochemically detected using monoclonal mouse antibodies to the corresponding enzymes. Results. Comparing chymase and tryptase TK in the tumor and separately in the periphery, we found that the difference between the number of cells in both cases is not significant. This means that they are in approximately the same number at a given location. However, after conducting a statistical analysis individually for each of the enzymes, depending on the localization, we obtained statistically significant differences in the number of cells. Conclusions. TCS tend to congregate on the periphery. The number of cells decreased linearly as the depth of invasion and the number of mitoses increased. The lower the degree of tumor differentiation, the more TC increases. It becomes obvious that an increase in the number of TCS along the periphery of the tumor signals an unfavorable prognosis of the underlying disease.</p>cervical cancermast cellstryptasechymosisрак шейки маткитучные клеткитриптазахимаза1.Коротких И.Н., Сертаков И.А., Филин А.А. к вопросу о клинико-морфологических особенностях цервикального рака в воронежском регионе. В сборнике: Однораловские морфологические чтения. Сборник материалов Всероссийской научной конференции с международным участием. 2019. С. 132-135.2.Состояние онкологической помощи населению России в 2022 году. Под ред. А.Д. Каприна, В.В. Старинского, А.О. Шахзадовой. М.: МНИОИ им. П.А. Герцена - филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2023. С.115-117.3.Федотова Е.И., Макеева А.В., Енькова Е.В., Хоперская О.В. Клинический случай цервикальной интраэпителиальной неоплазии шейки матки высокой степени // Материалы XVI Международной студенческой научной конференции «Студенческий научный форум».4.Andreev P.Yu., Bugrimov D.Yu., Filin A.A. et others. Pathomorphological markers of overcoming radioresistance in the treatment of cervical cancer. International Journal of Biomedicine. 2020. Т. 10. №2. С. 120-123.5.Guo F, Kong W-N, Li D-W, et al. Low Tumor Infiltrating Mast Cell Density Reveals Prognostic Benefit in Cervical Carcinoma. Technology in Cancer Research & Treatment. 2022.