Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10696Conference ProceedingsThe effect of disturbance of light regime in the first trimester of pregnancy on the offspring of Wistar ratsBorisenkoMarina Bmarina-borisenko-2000@mail.ruhttps://orcid.org/0000-0002-2684-2017AnurkinaAnna Ianyaaai1925@gmail.comhttps://orcid.org/0009-0003-0011-11142504202514S17998020903202524032025Copyright © 2025, Borisenko M.B., Anurkina A.I.2025<p><em>Currently, the problem of dark deprivation is becoming more and more urgent due to the development of light pollution, which leads to light desynchronosis, which entails a decrease in melatonin production. Deficiency of melatonin as a broad-spectrum adaptogen leads to structural and functional disorders at the level of the whole organism, including the reproductive system, which is manifested by a shortening of the menstrual cycle and accelerated aging of the ovaries. Objective. To study the effect of dark deprivation on the reproductive system of rats during the first trimester of pregnancy, to assess the survival rate and weight gain rate of the offspring. Materials and methods. Wistar rats were placed in conditions of a disturbed light regime during the first trimester of pregnancy, then the survival rate and weight gain of the offspring were assessed; the control group of rats was under standard lighting conditions. Results. It was possible to establish that dark deprivation leads to an increase in the number of offspring, but the survival rate and weight gain rate in the offspring of the experimental group of rats are significantly lower. The obtained results allow us to assume that melatonin deficiency causes developmental disorders and decreased survival of offspring against the background of dysfunction of the reproductive system of female rats.</em></p>melatonindark deprivationdesynchronosisratssurvivalweight gainreproductive systemмелатонинтемновая депривациядесинхронозкрысывыживаемостьнабор весарепродуктивная система1.1. Fárková, E., Schneider, J., Šmotek, M. et al. Weight loss in conservative treatment of obesity in women is associated with physical activity and circadian phenotype: a longitudinal observational study. BioPsychoSocial Med 13, 24 (2019).2.2. Kacar E, Tan F, Sahinturk S, Zorlu G, Serhatlioglu I, Bulmus O, Ercan Z, Kelestimur H. Modulation of Melatonin Receptors Regulates Reproductive Physiology: The Impact of Agomelatine on the Estrus Cycle, Gestation, Offspring, and Uterine Contractions in Rats. Physiol Res. 2023 Dec 31;72(6):793-807. doi: 10.33549/physiolres.935064. PMID: 38215065; PMCID: PMC10805256.3.3. Tamura H, Jozaki M, Tanabe M, Shirafuta Y, Mihara Y, Shinagawa M, Tamura I, Maekawa R, Sato S, Taketani T, Takasaki A, Reiter RJ, Sugino N. Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. Int J Mol Sci. 2020 Feb 8;21(3):1135. doi: 10.3390/ijms21031135. PMID: 32046301; PMCID: PMC7036809.