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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" article-type="research-article" dtd-version="1.1d1" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher">Молодежный инновационный вестник</journal-id><journal-title-group><journal-title>Молодежный инновационный вестник</journal-title></journal-title-group><issn publication-format="print">2415-7805</issn><publisher><publisher-name>Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10617</article-id><article-categories><subj-group subj-group-type="heading"><subject>Conference Proceedings</subject></subj-group></article-categories><title-group><article-title>Immunity and sleep: mechanisms of two-way interaction and applied findings</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Sviridkin</surname><given-names>Pavel Andreevich</given-names></name><email>sviridkin2003@mail.ru</email><uri content-type="orcid">https://orcid.org/0009-0002-3190-6203</uri><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Naraeva</surname><given-names>Natalia Yurievna</given-names></name><bio>&lt;p&gt;candidate of Medical Sciences, Associate Professor of the Department of Microbiology&lt;/p&gt;</bio><email>naraewa.nat@yandex.ru</email><uri content-type="orcid">https://orcid.org/0000-0001-7848-7013</uri><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Shikhalieva</surname><given-names>Ksenia Dzhamilievna</given-names></name><bio>&lt;p&gt;candidate of Biological Sciences, Associate Professor of the Department of Microbiology&lt;/p&gt;</bio><email>ksunya-shik@mail.ru</email><uri content-type="orcid">https://orcid.org/0009-0009-1428-4757</uri><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff id="aff-1">Voronezh State Medical University named after N.N.Burdenko</aff><pub-date date-type="epub" iso-8601-date="2025-04-25" publication-format="electronic"><day>25</day><month>04</month><year>2025</year></pub-date><volume>14</volume><issue>S1</issue><fpage>544</fpage><lpage>546</lpage><history><pub-date date-type="received" iso-8601-date="2025-03-01"><day>01</day><month>03</month><year>2025</year></pub-date><pub-date date-type="accepted" iso-8601-date="2025-03-08"><day>08</day><month>03</month><year>2025</year></pub-date></history><permissions><copyright-statement>Copyright © 2025, Sviridkin P.A., Naraeva N.Y., Shikhalieva K.D.</copyright-statement><copyright-year>2025</copyright-year></permissions><abstract>&lt;p&gt;The prevalence of sleep disorders and immunopathologies in modern society is continuously increasing. Understanding the mechanisms of bilateral interaction between sleep and the immune system opens avenues for the development of preventive strategies and therapeutic approaches aimed at breaking pathological cycles and promoting health. Objective. To study the relationship between sleep quality and immune function in students, and to evaluate the impact of sleep disturbances on the incidence of infectious diseases and immunological indices under conditions of academic loads. Materials and methods. 200 students took part in the study. Sleep quality was assessed using the Pittsburgh Sleep Quality Questionnaire (PSQI), where a score of 5 indicated impairment. Additionally, participants were asked questions about the frequency of infectious diseases in the last year. Statistical processing of the data was performed using StatTech software v. 4.7.3 (developer - StatTech LLC, Russia). Results. Sleep disorders (PSQI 5) were detected in 68% of participants. In this group, the incidence of infections was 3.2  1.4 cases/year, significantly higher (p  0.001) than in the group without disturbances (1.8  0.9). A two-way interaction was found: sleep disturbances provoke an imbalance of circadian rhythms and cortisol hyperproduction, suppressing immunity, while chronic inflammation exacerbates insomnia. Academic stress leading to sleep deprivation was a key risk factor. Conclusion. The results support the critical role of sleep quality in maintaining immune resistance in undergraduates. Sleep disturbances are associated not only with increased susceptibility to infections but also with biochemical markers of immunodeficiency.&lt;/p&gt;</abstract><kwd-group xml:lang="en"><kwd>immunity</kwd><kwd>sleep</kwd><kwd>students</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>иммунитет</kwd><kwd>сон</kwd><kwd>студенты</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.	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