Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10600Conference ProceedingsModern views on the etiopathogenesis of endometriosis: clinical demonstration of problematic issuesBeshirovaElina Takhirovna<p>student</p>remol_dobronog@mail.ruhttps://orcid.org/0000-0003-1102-1133KonakMaria Alekseyevna<p>student</p>remol_dobronog@mail.ruPetrovsky Medical University "Petrovsky National Research Center of Surgery"30062025141690103202525032025Copyright © 2025, Beshirova E.T., Konak M.A.2025<p><span style="font-family: Times New Roman, serif;"><span style="font-size: large;"><em>Endometriosis is a disease directly related to the proliferation of endometrial-like tissue and affecting both the genitals and the abdominal cavity, pelvic cavity, in some cases the intestines, pleura, kidneys and other distant localizations. Since the term "endometriosis" appeared, many theories have been proposed to explain the occurrence and development of endometriosis, but the complex underlying causes of its development remain uncertain, and none of them can explain all types of endometriosis in general and is not generally recognized and proven. The aim of the study is to highlight the problems of the etiopathogenesis of endometriosis in the context of the presented case of extragenital endometriosis of mammary localization. As part of the work, an assessment of the medical history of a patient with a clinical case of endometriosis of the right mammary gland was made. For histological evaluation of the affected tissue, both routine histological methods and immunohistochemical ones (CK7, p16, p53, vimentin, Ki67, GATA3, GCDFP15, mammoglobin, Cdx2) were used. Thus, to date, the mechanism of occurrence and spread of endometriosis has not been fully studied, and none of the theories has provided an exhaustive explanation for all aspects of this disease. In some clinical cases, the development of extragenital endometriosis cannot be explained within the framework of one or even several related theories. The etiopathogenesis of endometriosis is complex and includes many factors and processes, and only through a deeper understanding can effective treatment methods be developed.</em></span></span></p>etiopathogenesisendometriosisextragenital endometriosispathological anatomyэтиопатогенезэндометриозэкстрагенитальный эндометриозпатологическая анатомия[Shafrir AL, Farland LV, Shah DK, et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018;51:1-15. doi:10.1016/j.bpobgyn.2018.06.001][Chamié LP, Ribeiro DMFR, Tiferes DA, Macedo Neto AC, Serafini PC. Atypical Sites of Deeply Infiltrative Endometriosis: Clinical Characteristics and Imaging Findings. Radiographics. 2018;38(1):309-328. doi:10.1148/rg.2018170093][Benagiano G, Brosens I, Lippi D. The history of endometriosis. Gynecol Obstet Invest. 2014;78(1):1-9. doi:10.1159/000358919][Smolarz B, Szyłło K, Romanowicz H. Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature). Int J Mol Sci. 2021;22(19):10554. Published 2021 Sep 29. doi:10.3390/ijms221910554][Sampson JA. Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. Am J Pathol. 1927;3(2):93-110.43.][Halme J, Hammond MG, Hulka JF, Raj SG, Talbert LM. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64(2):151-154.][Han SJ, Jung SY, Wu SP, et al. Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015;163(4):960-974. doi:10.1016/j.cell.2015.10.034][Santamaria X, Mas A, Cervelló I, Taylor H, Simon C. Uterine stem cells: from basic research to advanced cell therapies. Hum Reprod Update. 2018;24(6):673-693. doi:10.1093/humupd/dmy028][Marsh EE, Laufer MR. Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly. Fertil Steril. 2005;83(3):758-760. doi:10.1016/j.fertnstert.2004.08.025][Brosens I, Brosens J, Benagiano G. Neonatal uterine bleeding as antecedent of pelvic endometriosis. Hum Reprod. 2013;28(11):2893-2897. doi:10.1093/humrep/det359]