Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10595Conference ProceedingsToxicity of breast cancer drug treatment during antiretroviral therapyAntyukhovYuri Yuryevich<p>scientific company operator</p>virko-viktor@mail.ruhttps://orcid.org/0009-0004-6468-2132VirkoViktor Andreevichvirko-viktor@mail.ruMilitary Medical Academy named after S. M. Kirov3006202514144472802202531032025Copyright © 2025, Antyukhov Y.Y., Virko V.A.2025<p></p>
<p>Breast cancer, like HIV infection, represents global challenges for healthcare. The combination of HAART (highly active antiretroviral therapy) and chemotherapeutic treatment poses risks of increased toxicity due to drug interactions and comorbidities. The relevance of this topic stems from the need to optimize treatment regimens to reduce toxicity and improve patient survival rates. Objective:To analyze current data on cross-toxicity in HIV-infected patients with breast cancer undergoing HAART and chemotherapy. Materials and Methods.The literature review utilized data from clinical studies focused on breast cancer treatment in the context of HIV therapy. Research was conducted using epidemiological data from the WHO and UNAIDS websites, as well as PubMed and eLibrary databases. Results.The study revealed that the risk of increased cross-toxicity during HAART and antitumor drug use depends on pharmacokinetic and pharmacodynamic interactions. Modern evidence-based online tools for assessing pharmacokinetic interactions and cross-reactions between antiretroviral and cytotoxic anticancer drugs enable the development of personalized treatment plans aimed at mitigating risks associated with these drug combinations. Conclusion:Addressing the issue of increased toxicity during antitumor treatment and HIV therapy is a critical healthcare challenge that requires a personalized approach.</p>HIVmedicinebreast cancertoxicityhighly active antiretroviral therapychemotherapydrug interactionsВИЧмедицинарак молочной железытоксичностьвысокоактивная антиретровирусная терапияхимиотерапиялекарственные взаимодействия[ВОЗ. 2022. [(по состоянию на 10 февраля 2024 г.)]. Доступно онлайн: https://www.who.int/news-room/fact-sheets/detail/breast-cancer][UNAIDS. Global HIV Statistics 2023. Доступно онлайн: https://www.unaids.org/en/resources/fact-sheet][Marino A, Pavone G, Martorana F, Fisicaro V, Motta L, Spampinato S, Celesia BM, Cacopardo B, Vigneri P, Nunnari G. Navigating the Nexus: HIV and Breast Cancer-A Critical Review. Int J Mol Sci. 2024 Mar 12;25(6):3222. doi: 10.3390/ijms25063222. PMID: 38542195; PMCID: PMC10970700.][Эпидемиологические особенности распространения ВИЧ-инфекции у детей в Российской Федерации / В. Н. Емельянов, Ю. А. Бурко, В. А. Горичный, В. В. Маркелов // Клиническая патофизиология. – 2024. – Т. 30, № 2. – С. 22-25. – EDN SMXMMM.][Singh MS, Francis PA, Michael M. Tamoxifen, cytochrome P450 genes and breast cancer clinical outcomes. Breast. 2011 Apr;20(2):111-8. doi: 10.1016/j.breast.2010.11.003. Epub 2010 Dec 24. PMID: 21185724.][van Eijk M, Boosman RJ, Schinkel AH, Huitema ADR, Beijnen JH. Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes. Cancer Chemother Pharmacol. 2019 Sep;84(3):487-499. doi: 10.1007/s00280-019-03905-3. Epub 2019 Jul 15. PMID: 31309254; PMCID: PMC6682574.][Brandão M, Bruzzone M, Franzoi MA, De Angelis C, Eiger D, Caparica R, Piccart-Gebhart M, Buisseret L, Ceppi M, Dauby N, Carrilho C, Lunet N, de Azambuja E, Lambertini M. Impact of HIV infection on baseline characteristics and survival of women with breast cancer. AIDS. 2021 Mar 15;35(4):605-618. doi: 10.1097/QAD.0000000000002810. PMID: 33394680.][Medscape Drug Interaction Checker. [(по состоянию на 22 января 2024 г.)]. Доступно онлайн: https://reference.medscape.com/drug-interactionchecker][Инфекции, передающиеся половым путем : Пособие для слушателей факультетов подготовки иностранных специалистов / В. Н. Болехан, Е. С. Орлова, И. М. Улюкин [и др.]. – Санкт-Петербург : Военно-медицинская академия имени С.М.Кирова, 2016. – 59 с. – EDN YZJNGV.][Lurain K. Treating Cancer in People With HIV. J Clin Oncol. 2023 Jul 20;41(21):3682-3688. doi: 10.1200/JCO.23.00737. Epub 2023 Jun 2. PMID: 37267514; PMCID: PMC10351946.][Емельянов В. Н., Сысоев А. Е., Шевченко В. А. УСОВЕРШЕНСТВОВАНИЕ МОТИВАЦИИ РАБОТЫ МЕДИЦИНСКИХ СПЕЦИАЛИСТОВ НА ОСНОВАНИИ СИСТЕМНОГО ПОДХОДА //Клиническая патофизиология. – 2017. – Т. 23. – №. 4. – С. 94-96.]