Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10578Conference ProceedingsClinical Features and Diagnosis of Mental Disorders in NeurosyphilisAbdulkinMax Olegovich<p>scientific company operator</p>virko-viktor@mail.ruhttps://orcid.org/0009-0002-9061-2475VirkoViktor Andreevichvirko-viktor@mail.ruMilitary Medical Academy named after S. M. Kirov2504202514S14584602802202523032025Copyright © 2025, Abdulkin M.O., Virko V.A.2025<p>Neurosyphilis has a historically complex reputation, but in recent decades, due to improvements in diagnostics and medical technologies, its diagnosis and treatment have gained importance. The aim. To conduct a comprehensive analysis of the clinical features of mental disorders in neurosyphilis, as well as to evaluate modern diagnostic methods of this disease in the context of its epidemiological significance, particularly in the Russian Federation. Materials and methods. The review was prepared using data from domestic and international studies, including epidemiological reports, works in neurology, psychiatry, and laboratory diagnostics. Special attention was paid to recent publications reflecting the specifics of neurosyphilis in Russia, as well as studies describing the association of the disease with HIV infection and the variability of clinical manifestations (from asymptomatic forms to severe dementia and psychoses). Results. Neurosyphilis manifests a wide range of mental disorders, including progressive dementia, psychoses with delusions and hallucinations, manic-depressive states, and neurotic disorders. Diagnosis is complicated by the lack of a unified standard. Conclusions. Neurosyphilis remains a relevant interdisciplinary problem requiring the integration of neurological, psychiatric, and laboratory diagnostic methods. Early detection and antibiotic therapy are critically important to prevent irreversible cognitive and mental impairments. Physicians are recommended to consider neurosyphilis in the differential diagnosis of mental disorders, especially in patients with atypical symptoms or concomitant infections.</p>mental disordersdiagnosisserological testsneuroimagingdementiapsychosiscognitive impairmentepidemiologyпсихические расстройствадиагностикасерологические тестынейровизуализациядеменцияпсихозыкогнитивные нарушенияэпидемиология1.1. Ropper A. H. Neurosyphilis //New England Journal of Medicine. – 2019. – Т. 381. – №. 14. – С. 1358-1363.2.2. Емельянов В. Н. и др. ЭПИДЕМИОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА НЕЙРОСИФИЛИСА В РОССИЙСКОЙ ФЕДЕРАЦИИ //Кремлевская медицина. Клинический вестник. – 2024. – №. 4. – С. 104-107.3.3. Boog G. H. P. et al. Diagnostic tools for neurosyphilis: a systematic review //BMC Infectious Diseases. – 2021. – Т. 21. – №. 1. – С. 568.4.4. Hamill M. M., Ghanem K. G., Tuddenham S. State-of-the-art review: neurosyphilis //Clinical Infectious Diseases. – 2024. – Т. 78. – №. 5. – С. e57-e68.5.5. Абибулаев С. А., Осипова Е. П., Русановская Ю. В. ОСОБЕННОСТИ КОГНИТИВНЫХ НАРУШЕНИЙ У БОЛЬНЫХ С ПОЗДНИМИ ФОРМАМИ НЕЙРОСИФИЛИСА //ИННОВАЦИИ. – №. 48. – С. 2485-2488.6.6. Kaur B., Khanna D. A narrative review of the many psychiatric manifestations of neurosyphilis: the great imitator //Cureus. – 2023. – Т. 15. – №. 9.7.7. Айзберг А. А., Гусар А. И., Дубровская О. В. Нейросифилис в практике психиатра. Описание случая и обзор литературы //Психиатрия. – 2022. – Т. 13. – №. 1.8.8. Nagappa M. et al. Neurosyphilis: MRI features and their phenotypic correlation in a cohort of 35 patients from a tertiary care university hospital //Neuroradiology. – 2013. – Т. 55. – С. 379-388.9.9. Емельянов В. Н., Бурко Ю. А., Горичный В. А., Маркелов В. В. Эпидемиологические особенности распространения ВИЧ-инфекции у детей в Российской Федерации // Клиническая патофизиология. — 2024. — Т. 30, № 2. — С. 22–25.