Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10457Conference ProceedingsStudy of antiproliferative effects of glycyrrhizic and glycyrrhetic acids in tumor cell cultureDanilovaIrina Miroslavovna<p>Senior Lecturer of the Department of Pharmacology, Clinical Pharmacology and Biochemistry</p>medicine345@mail.ruhttps://orcid.org/0009-0000-7836-8081PavlovaSvetlana Ivanovna<p>Doctor of Medical Sciences, Full Professor, Head of the Department of Pharmacology, Clinical Pharmacology and Biochemistry</p>flavonoid@yandex.ruhttps://orcid.org/0000-0001-9976-7866Chuvash State University named after I.N. Ulyanov2504202514S13403432502202511032025Copyright © 2025, Danilova I.M., Pavlova S.I.2025<p><em>In 2023, the most common malignant tumor in Russia among women was breast cancer (22.5%), and among men - prostate cancer (19.1%). Due to the fact that currently existing anticancer drugs for the treatment of malignant tumors have a number of disadvantages, the search for and development of new drugs with antitumor activity is extremely important. The scientific acticles contains information on the antitumor properties of licorice root triterpenoids - glycyrrhizic acid and its metabolite glycyrrhetic acid. The aim of this article is to study the antiproliferative properties of glycyrrhizic and glycyrrhetic acids on the HeLa, PC-3, MCF-7 human tumor cells. Antitumor activity was evaluated by the MTT test with exposure of cells with these substances for 72 hours. As a result of the study, glycyrrhetic acid showed dose-dependent growth inhibitory activity against prostate cancer and breast cancer cells in the concentration ranges of 1-100 g/ml and 0.1-100 g/ml, respectively, as well as an antiproliferative effect against a cervical adenocarcinoma cell line only at a concentration of 100 g/ml.</em></p>glycyrrhizic acidglycyrrhetic acidtriterpenoidsantiproliferative activityoncologyantitumor drugstumor cellsHeLaPC-3MCF-7глицирризиновая кислотаглицирретовая кислотатритерпеноидыантипролиферативная активностьонкологияпротивоопухолевые препаратыопухолевые клеткиHeLaPC-3MCF-71.Вахидова, К. Р. Онкология - основная проблема всего человечества. Изучение и исследование уже существующих методов лечения злокачественных опухолей / К. Р. Вахидова // Мировая и российская наука: области развития и инноваций : Сборник научных статей. Том Ч. V. – Москва : Издательство "Перо", 2021. – С. 15-19. – EDN WTHATP.2.Злокачественные новообразования в России в 2023 году (заболеваемость и смертность) / под ред. А.Д. Каприна [и др.] − М.: МНИОИ им. П.А. Герцена − филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2024. − илл. – 276 с.3.Juin SK, Ghosh S, Majumdar S. Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach. Int Immunopharmacol. 2020 Nov;88:106932. doi: 10.1016/j.intimp.2020.106932. Epub 2020 Sep 2. PMID: 32890791.4.Klein I, Isensee J, Wiesen MHJ, Imhof T, Wassermann MK, Müller C, Hucho T, Koch M, Lehmann HC. Glycyrrhizic Acid Prevents Paclitaxel-Induced Neuropathy via Inhibition of OATP-Mediated Neuronal Uptake. Cells. 2023 Apr 25;12(9):1249. doi: 10.3390/cells12091249. PMID: 37174648; PMCID: PMC10177491.5.Cheng Y, Zhong X, Nie X, Gu H, Wu X, Li R, Wu Y, Lv K, Leung GP, Fu C, Lee SM, Zhang J, Li J. Glycyrrhetinic acid suppresses breast cancer metastasis by inhibiting M2-like macrophage polarization via activating JNK1/2 signaling. Phytomedicine. 2023 Jun;114:154757. doi: 10.1016/j.phymed.2023.154757. Epub 2023 Mar 12. PMID: 37011418.