Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10425Conference ProceedingsThe effect of vitamin D deficiency on inflammation, apoptosis and glucose metabolism: a comparison of patients with type 2 diabetes mellitus and a control groupDugushevaValeria Alexandrovna<p>Assistant, Department of Clinical Laboratory Diagnostics</p>semikolenovaval@yandex.ruhttps://orcid.org/0000-0002-7342-2218ShchegolevaViktoria Evgenievna<p>Student</p>vikaut0vaz@list.ruhttps://orcid.org/0009-0008-3336-5758KotovaYulia Alexandrovna<p>MD, PhD, Associate Professor, Head of the Department of Clinical Laboratory Diagnostics</p>kotova_u@inbox.ruhttps://orcid.org/0000-0003-0236-2411Voronezh State Medical University named after N. N. Burdenko2504202514S146492502202525022025Copyright © 2025, Dugusheva V.A., Shchegoleva V.E., Kotova Y.A.2025<p>Vitamin D is an important modulator of immune response, inflammatory reactions, and apoptosis mechanisms. Its deficiency is widespread among patients with type 2 diabetes mellitus (T2DM) and is associated with disease progression, as well as dysfunction of the endothelium, immune system, and cellular defense mechanisms. One of the key factors involved in these processes is the heat shock protein HSP-70, which possesses cytoprotective properties, along with netrin-1, which regulates inflammation and apoptosis. However, the correlation between changes in these biomarker levels and the severity of vitamin D deficiency, as well as the underlying mechanisms of these processes, remains insufficiently studied. The aim. To assess the impact of varying levels of vitamin D deficiency on inflammatory processes, apoptosis, and carbohydrate metabolism in patients with T2DM, with a focus on changes in netrin-1 and HSP-70 levels. Materials and Methods. The study included 160 participants, comprising 130 patients diagnosed with T2DM and 30 healthy individuals. All participants were further divided into groups based on their vitamin D levels. Biomarker analysis was performed using enzyme-linked immunosorbent assay (ELISA), and statistical data processing was conducted using nonparametric statistical methods. Results. Patients with severe vitamin D deficiency exhibited reduced levels of netrin-1 and HSP-70, indicating impaired protective mechanisms. After vitamin D correction, a positive trend was observed, accompanied by a decrease in inflammatory and apoptotic processes. Conclusions. Vitamin D deficiency is a significant factor contributing to the progression of pathological changes in T2DM. Its supplementation may have a beneficial effect on inflammatory and apoptotic processes, highlighting the need for further research in this area.</p>type 2 diabetes mellitusvitamin Dinflammationapoptosisnetrin-1HSP-70сахарный диабет 2 типавитамин Dвоспалениеапоптознетрин-1БТШ-701.Степанова, А.П. Роль дефицита витамина D в развитии сахарного диабета 2 типа и диабетической нейропатии / А.П. Степанова, Т.Л. Каронова, А.А. Быстрова, В.Б. Бреговский // Сахарный диабет. – 2018. – №4–21. – С. 301-306. DOI: 10.14341/DM9583.2.Булгакова, С.В. Дефицит витамина D у больных сахарным диабетом 2 типа пожилого возраста / С.В. Булгакова, С.А. Башинская, Н.О. Захарова // Клиническая геронтология. – 2021. – №27 – С. 50-55.3.Nekrasova, E.V. The regulation between netrin-1 and apolipoprotein A-I on the transcriptional level / E.V. Nekrasova, K.V. Danko, D.O. Kuzmina, S.V. Orlov // VI Международная конференция молодых ученых: биофизиков, биотехнологов, молекулярных биологов и вирусологов. – 2019. – C. 572-573.4.Кузнецов, Д.С. Оценка роли белка теплового шока 70 у пациентов с острым инфарктом миокарда и сахарным диабетом 2 типа / Д.С. Кузнецов, Ю.А. Котова, С.Н. Лагутина // Научно-медицинский вестник Центрального Черноземья. – 2024. – №2–96. – С. 48-50.