Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10404Conference ProceedingsInflammatory tumor microenvironment in the pathogenesis of colorectal cancerDenisovaKira AndreevnaStdenkat31@mail.ruhttps://orcid.org/0009-0006-8107-8783ShishkinaVictoria Victorovna4128069@gmail.comhttps://orcid.org/0000-0001-9185-4578FilinAndrey Anatolevichfilinan@yandex.ruhttps://orcid.org/0000-0003-1670-3694Voronezh State Medical University named after N. N. BurdenkoBurdenko Voronezh State Medical University2504202514S12352392502202525022025Copyright © 2025, Denisova K.A., Shishkina V.V., Filin A.A.2025<p style="text-align: justify;">Absract. Previously, CRC was considered a monolithic tumor consisting of homogeneous cells. Now we understand that it is a complex, dynamic system characterized by significant intratumor heterogeneity. This heterogeneity is manifested not only at the level of genetic mutations, but also at the level of epigenetic modifications that affect gene accessibility and, consequently, protein expression. These changes are regulated by a complex network of interactions between genetic, epigenetic factors and tumor microenvironment signals. The tumor microenvironment plays a critical role in the progression of CRC. The inflammatory response, characterized by a specific cytokine profile, activates signaling pathways that promote epithelial cell dedifferentiation and stimulate angiogenesis (the formation of new blood vessels that feed the tumor). Moreover, stromal cells, immune cells (both mast cells and T lymphocytes, both CD8+ cytotoxic and regulatory T-lymphocytes, both CD8+ cytotoxic and regulatory T cells, whose balance is critical for response to therapy), and the extracellular matrix all closely interact and influence tumor cell behavior. Objective. To analyze the scientific literature and summarize data on the influence of the tumor microenvironment on the pathogenesis of colorectal cancer. Materials and methods. The study of literary sources was carried out in the leading Russian and international databases of medical topics (eLibrary, PubMed, Cochrane) and additional sources (Google Scholar) using the keywords: "colorectal cancer", "microenvironment", "mast cells", "fibroblasts", "lymphocytes" over the past 10 years. Results. The obtained data indicate an extremely complex and multifaceted nature of the interaction of tumor cells with the components of the OME. Conclusion. Further research should be aimed at a more in-depth study of the interrelationships of the OME, with the aim of developing new therapeutic strategies aimed at modulating the OME and increasing the effectiveness of CRC treatment. Particular attention should be paid to the development of methods that allow for accurate characterization of the composition and the functional state of the CMO in specific patients, which will allow for a personalized approach to treatment and improve the prognosis for patients with CRC.</p>colorectal cancertumor microenvironmentT cellsколоректальный ракопухолевое микроокружениеТ-клетки1.WHO: Global cancer burden growing amidst mounting need for services.2.Стукань А.И., Мурашко Р.А., Порханов В.А., Барышев А.Г., Гилевич И.В., Бодня В.Н. Воспалительное опухолевое микроокружение и пластичность опухолевой клетки в патогенезе колоректального рака. Онкология. Журнал им. П.А. Герцена. 2021;10(4):66‑74.3.Stukan AI, Murashko RA, Porkhanov VA, Baryshev AG, Gilevich IV, Bodnya VN. The inflammatory tumor microenvironment and tumor cell plasticity in the pathogenesis of colorectal cancer. P.A. Herzen Journal of Oncology. 2021;10(4):66‑74. (In Russ.)https://doi.org/10.17116/onkolog202110041664.Schmitt, M., Greten, F.R. The inflammatory pathogenesis of colorectal cancer. Nat Rev Immunol 21, 653–667 (2021). https://doi.org/10.1038/s41577-021-00534-x5.Xie, Z., Niu, L., Zheng, G. et al. Single-cell analysis unveils activation of mast cells in colorectal cancer microenvironment. Cell Biosci 13, 217 (2023). https://doi.org/10.1186/s13578-023-01144-x