Молодежный инновационный вестникМолодежный инновационный вестник2415-7805Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный медицинский университет имени Н.Н. Бурденко" Министерства здравоохранения Российской Федерации10369Conference ProceedingsThe effect of melatonin on the morphofunctional state of the rat liver under experimental toxic damageGrabeklisSevil A.anyaaai@yandex.ruhttps://orcid.org/0009-0002-3290-3768AnurkinaAnna I.anyaaai1925@gmail.comhttps://orcid.org/0009-0003-0011-1114AreshidzeDavid A.labcelpat@mail.ruhttps://orcid.org/0000-0003-3006-62812504202514S12322342402202524022025Copyright © 2025, Grabeklis S.A., Anurkina A.I., Areshidze D.A.2025<p>Carbon tetrachloride (CCl4, CHC) has been used for decades as a hepatotoxic agent in the study of the mechanisms of liver damage and recovery after the action of this substance. The complex of morphofunctional changes occurring in the liver under the action of CChU includes morphological and functional changes of hepatocytes, their organoids, and, first of all, mitochondria. Melatonin is considered as a broad-spectrum adaptogen with hepatoprotective effect, but it is unknown how effective the use of exogenous melatonin as a hepatoprotective agent in model toxic liver damage by CCl4 will be. The aim. To study the effect of melatonin on the morphofunctional state of the liver in experimental toxic damage. Materials and methods. The work was performed on 120 male Wistar rats aged 6 months divided into 3 equal groups. The control group was kept in standard vivarium conditions. Group I was given intraperitoneal injection of CCl4 once every three days under the same conditions. Group II was kept under conditions similar to group I with additional intragastrically injected aqueous melatonin solution. Three weeks later, the animals were slaughtered by ether overdose followed by liver evisceration. Results The morphologic picture of the liver of the animals of the control group corresponded to the age norm. Significant structural changes of the liver were observed in animals of group I. The liver of animals of group II had similar changes, but they were much less precipitated.</p>hepatocytesratmelatoninгепатоцитыкрысамелатонин1.Devaraj E, Roy A, Royapuram Veeraragavan G, Magesh A, Varikalam Sleeba A, Arivarasu L, Marimuthu Parasuraman B. β-Sitosterol attenuates carbon tetrachloride-induced oxidative stress and chronic liver injury in rats. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jun;393(6):1067-1075. doi: 10.1007/s00210-020-01810-8.2.Диатроптов М. Е., Косырева А. М., Макарова О. В., Кондашевская М. В., Нечай В. В. Инфрадианные ритмы уровня кортикостерона и выраженности альтеративных изменений печени у крыс Вистар при системном воспалительном ответе //Морфологические ведомости. – 2013. – №. 2. – С. 25-32.3.Лазебник Л. Б. и др. Неалкогольная жировая болезнь печени: клиника, диагностика, лечение рекомендации утверждены XV съездом НОГР в 2015 году // Экспериментальная и клиническая гастроэнтерология. – 2015. – №. 7. – С. 85-96.